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Volumn 66, Issue 11, 2017, Pages 1473-1484

Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy

Author keywords

Acute myeloid leukemia; IL 2; Immunotherapy; Regulatory T cells

Indexed keywords

ALDESLEUKIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HISTAMINE; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA;

EID: 85024499249     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-017-2040-9     Document Type: Article
Times cited : (46)

References (61)
  • 1
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • COI: 1:CAS:528:DC%2BD2MXht1KqsLnI, PID: 16287710
    • Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK (2005) Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202:1375–1386
    • (2005) J Exp Med , vol.202 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 3
    • 84883679673 scopus 로고    scopus 로고
    • Peripherally induced tregs—role in immune homeostasis and autoimmunity
    • COI: 1:CAS:528:DC%2BC3sXhsFOrsLfP, PID: 23966994
    • Yadav M, Stephan S, Bluestone JA (2013) Peripherally induced tregs—role in immune homeostasis and autoimmunity. Front Immunol 4:232
    • (2013) Front Immunol , vol.4 , pp. 232
    • Yadav, M.1    Stephan, S.2    Bluestone, J.A.3
  • 4
    • 79960453738 scopus 로고    scopus 로고
    • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
    • COI: 1:CAS:528:DC%2BC3MXpt1ait7w%3D, PID: 21723159
    • Haribhai D, Williams JB, Jia S et al (2011) A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 35:109–122
    • (2011) Immunity , vol.35 , pp. 109-122
    • Haribhai, D.1    Williams, J.B.2    Jia, S.3
  • 5
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • COI: 1:CAS:528:DC%2BD1MXhsFKnsbrO, PID: 20016504
    • Wing K, Sakaguchi S (2010) Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 11:7–13
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 6
    • 84935832371 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmune and viral chronic hepatitis
    • PID: 26106627
    • Lapierre P, Lamarre A (2015) Regulatory T cells in autoimmune and viral chronic hepatitis. J Immunol Res 2015:479703
    • (2015) J Immunol Res , vol.2015 , pp. 479703
    • Lapierre, P.1    Lamarre, A.2
  • 7
    • 84937931525 scopus 로고    scopus 로고
    • Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
    • PID: 26220086
    • Littwitz-Salomon E, Akhmetzyanova I, Vallet C, Francois S, Dittmer U, Gibbert K (2015) Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection. Retrovirology 12:66
    • (2015) Retrovirology , vol.12 , pp. 66
    • Littwitz-Salomon, E.1    Akhmetzyanova, I.2    Vallet, C.3    Francois, S.4    Dittmer, U.5    Gibbert, K.6
  • 8
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • COI: 1:CAS:528:DC%2BD28XivVyru7k%3D, PID: 16557261
    • Zou W (2006) Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6:295–307
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 9
    • 15444377017 scopus 로고    scopus 로고
    • Intratumor depletion of CD4 + cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    • COI: 1:CAS:528:DC%2BD2MXitl2rt7s%3D, PID: 15753211
    • Yu P, Lee Y, Liu W, Krausz T, Chong A, Schreiber H, Fu YX (2005) Intratumor depletion of CD4 + cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med 201:779–791
    • (2005) J Exp Med , vol.201 , pp. 779-791
    • Yu, P.1    Lee, Y.2    Liu, W.3    Krausz, T.4    Chong, A.5    Schreiber, H.6    Fu, Y.X.7
  • 11
    • 84944386317 scopus 로고    scopus 로고
    • Prognostic value of tumor-infiltrating FoxP3 + regulatory T cells in cancers: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC2MXhs1Kks7bE, PID: 26462617
    • Shang B, Liu Y, Jiang SJ, Liu Y (2015) Prognostic value of tumor-infiltrating FoxP3 + regulatory T cells in cancers: a systematic review and meta-analysis. Sci Rep 5:15179
    • (2015) Sci Rep , vol.5 , pp. 15179
    • Shang, B.1    Liu, Y.2    Jiang, S.J.3    Liu, Y.4
  • 12
    • 84992758686 scopus 로고    scopus 로고
    • Characteristics of immunosuppressive regulatory T cells in cutaneous squamous cell carcinomas and role in metastasis
    • PID: 26312881
    • Lai C, August S, Behar R, Polak M, Ardern-Jones M, Theaker J, Al-Shamkhani A, Healy E (2015) Characteristics of immunosuppressive regulatory T cells in cutaneous squamous cell carcinomas and role in metastasis. Lancet 385(Suppl 1):S59
    • (2015) Lancet , vol.385 , pp. S59
    • Lai, C.1    August, S.2    Behar, R.3    Polak, M.4    Ardern-Jones, M.5    Theaker, J.6    Al-Shamkhani, A.7    Healy, E.8
  • 13
    • 28544433483 scopus 로고    scopus 로고
    • The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer
    • COI: 1:CAS:528:DC%2BD2MXht1KjsrnM, PID: 16322292
    • Wolf D, Wolf AM, Rumpold H et al (2005) The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res 11:8326–8331
    • (2005) Clin Cancer Res , vol.11 , pp. 8326-8331
    • Wolf, D.1    Wolf, A.M.2    Rumpold, H.3
  • 15
    • 84883554292 scopus 로고    scopus 로고
    • Immunotherapeutic strategies for relapse control in acute myeloid leukemia
    • COI: 1:CAS:528:DC%2BC3sXhtFeksLvO, PID: 23871358
    • Martner A, Thoren FB, Aurelius J, Hellstrand K (2013) Immunotherapeutic strategies for relapse control in acute myeloid leukemia. Blood Rev 27:209–216
    • (2013) Blood Rev , vol.27 , pp. 209-216
    • Martner, A.1    Thoren, F.B.2    Aurelius, J.3    Hellstrand, K.4
  • 16
    • 79960898228 scopus 로고    scopus 로고
    • Elevated frequencies of CD4(+) CD25(+) CD127lo regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia
    • PID: 21105040
    • Shenghui Z, Yixiang H, Jianbo W, Kang Y, Laixi B, Yan Z, Xi X (2011) Elevated frequencies of CD4(+) CD25(+) CD127lo regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia. Int J Cancer 129:1373–1381
    • (2011) Int J Cancer , vol.129 , pp. 1373-1381
    • Shenghui, Z.1    Yixiang, H.2    Jianbo, W.3    Kang, Y.4    Laixi, B.5    Yan, Z.6    Xi, X.7
  • 18
    • 0035889912 scopus 로고    scopus 로고
    • Microenvironment produced by acute myeloid leukemia cells prevents T cell activation and proliferation by inhibition of NF-kappaB, c-Myc, and pRb pathways
    • COI: 1:CAS:528:DC%2BD3MXotlalsrk%3D, PID: 11698483
    • Buggins AG, Milojkovic D, Arno MJ, Lea NC, Mufti GJ, Thomas NS, Hirst WJ (2001) Microenvironment produced by acute myeloid leukemia cells prevents T cell activation and proliferation by inhibition of NF-kappaB, c-Myc, and pRb pathways. J Immunol 167:6021–6030
    • (2001) J Immunol , vol.167 , pp. 6021-6030
    • Buggins, A.G.1    Milojkovic, D.2    Arno, M.J.3    Lea, N.C.4    Mufti, G.J.5    Thomas, N.S.6    Hirst, W.J.7
  • 19
    • 0037093066 scopus 로고    scopus 로고
    • Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia
    • COI: 1:CAS:528:DC%2BD38XjvVGnsLc%3D, PID: 11986221
    • Costello RT, Sivori S, Marcenaro E et al (2002) Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia. Blood 99:3661–3667
    • (2002) Blood , vol.99 , pp. 3661-3667
    • Costello, R.T.1    Sivori, S.2    Marcenaro, E.3
  • 20
    • 33845987986 scopus 로고    scopus 로고
    • Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction
    • COI: 1:CAS:528:DC%2BD2sXivVyru7o%3D, PID: 16940427
    • Fauriat C, Just-Landi S, Mallet F, Arnoulet C, Sainty D, Olive D, Costello RT (2007) Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction. Blood 109:323–330
    • (2007) Blood , vol.109 , pp. 323-330
    • Fauriat, C.1    Just-Landi, S.2    Mallet, F.3    Arnoulet, C.4    Sainty, D.5    Olive, D.6    Costello, R.T.7
  • 21
    • 84862490496 scopus 로고    scopus 로고
    • Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91(phox) expression and the PARP-1/PAR pathway of apoptosis
    • COI: 1:CAS:528:DC%2BC38XhtVGns7zL, PID: 22550344
    • Aurelius J, Thoren FB, Akhiani AA, Brune M, Palmqvist L, Hansson M, Hellstrand K, Martner A (2012) Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91(phox) expression and the PARP-1/PAR pathway of apoptosis. Blood 119:5832–5837
    • (2012) Blood , vol.119 , pp. 5832-5837
    • Aurelius, J.1    Thoren, F.B.2    Akhiani, A.A.3    Brune, M.4    Palmqvist, L.5    Hansson, M.6    Hellstrand, K.7    Martner, A.8
  • 22
    • 0028113354 scopus 로고
    • Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites
    • COI: 1:CAS:528:DyaK2MXit1Gjsrg%3D, PID: 7963557
    • Hellstrand K, Asea A, Dahlgren C, Hermodsson S (1994) Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites. J Immunol 153:4940–4947
    • (1994) J Immunol , vol.153 , pp. 4940-4947
    • Hellstrand, K.1    Asea, A.2    Dahlgren, C.3    Hermodsson, S.4
  • 23
    • 0034284333 scopus 로고    scopus 로고
    • Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine
    • COI: 1:CAS:528:DC%2BD3cXmt1Omu7c%3D, PID: 10961901
    • Mellqvist UH, Hansson M, Brune M, Dahlgren C, Hermodsson S, Hellstrand K (2000) Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine. Blood 96:1961–1968
    • (2000) Blood , vol.96 , pp. 1961-1968
    • Mellqvist, U.H.1    Hansson, M.2    Brune, M.3    Dahlgren, C.4    Hermodsson, S.5    Hellstrand, K.6
  • 24
    • 0029829358 scopus 로고    scopus 로고
    • NK cell-mediated killing of AML blasts: role of histamine, monocytes and reactive oxygen metabolites
    • COI: 1:CAS:528:DyaK2sXkvVSrtg%3D%3D, PID: 8982295
    • Brune M, Hansson M, Mellqvist UH, Hermodsson S, Hellstrand K (1996) NK cell-mediated killing of AML blasts: role of histamine, monocytes and reactive oxygen metabolites. Eur J Haematol 57:312–319
    • (1996) Eur J Haematol , vol.57 , pp. 312-319
    • Brune, M.1    Hansson, M.2    Mellqvist, U.H.3    Hermodsson, S.4    Hellstrand, K.5
  • 25
    • 0030027630 scopus 로고    scopus 로고
    • Histaminergic regulation of natural killer cell-mediated clearance of tumour cells in mice
    • COI: 1:CAS:528:DyaK28Xhtl2rtrs%3D, PID: 8560202
    • Asea A, Hermodsson S, Hellstrand K (1996) Histaminergic regulation of natural killer cell-mediated clearance of tumour cells in mice. Scand J Immunol 43:9–15
    • (1996) Scand J Immunol , vol.43 , pp. 9-15
    • Asea, A.1    Hermodsson, S.2    Hellstrand, K.3
  • 26
    • 84899434062 scopus 로고    scopus 로고
    • Recombinant interleukin-2 in patients aged younger than 60 years with acute myeloid leukemia in first complete remission: results from Cancer and Leukemia Group B 19808
    • COI: 1:CAS:528:DC%2BC2cXkslCktL0%3D, PID: 24382782
    • Kolitz JE, George SL, Benson DM Jr et al (2014) Recombinant interleukin-2 in patients aged younger than 60 years with acute myeloid leukemia in first complete remission: results from Cancer and Leukemia Group B 19808. Cancer 120:1010–1017
    • (2014) Cancer , vol.120 , pp. 1010-1017
    • Kolitz, J.E.1    George, S.L.2    Benson, D.M.3
  • 27
    • 54449095992 scopus 로고    scopus 로고
    • Low-dose interleukin-2 immunotherapy does not improve outcome of patients age 60 years and older with acute myeloid leukemia in first complete remission: cancer and Leukemia Group B Study 9720
    • COI: 1:CAS:528:DC%2BD1cXhtlGitrzE, PID: 18591543
    • Baer MR, George SL, Caligiuri MA et al (2008) Low-dose interleukin-2 immunotherapy does not improve outcome of patients age 60 years and older with acute myeloid leukemia in first complete remission: cancer and Leukemia Group B Study 9720. J Clin Oncol 26:4934–4939
    • (2008) J Clin Oncol , vol.26 , pp. 4934-4939
    • Baer, M.R.1    George, S.L.2    Caligiuri, M.A.3
  • 28
    • 0034114681 scopus 로고    scopus 로고
    • Randomized study of recombinant interleukin-2 after autologous bone marrow transplantation for acute leukemia in first complete remission
    • COI: 1:CAS:528:DC%2BD3cXisVSjs7s%3D, PID: 10705305
    • Blaise D, Attal M, Reiffers J et al (2000) Randomized study of recombinant interleukin-2 after autologous bone marrow transplantation for acute leukemia in first complete remission. Eur Cytokine Netw 11:91–98
    • (2000) Eur Cytokine Netw , vol.11 , pp. 91-98
    • Blaise, D.1    Attal, M.2    Reiffers, J.3
  • 29
    • 77649202987 scopus 로고    scopus 로고
    • Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: results of the ALFA-9801 study
    • COI: 1:CAS:528:DC%2BC3cXksVyrtrs%3D, PID: 20048183
    • Pautas C, Merabet F, Thomas X et al (2010) Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: results of the ALFA-9801 study. J Clin Oncol 28:808–814
    • (2010) J Clin Oncol , vol.28 , pp. 808-814
    • Pautas, C.1    Merabet, F.2    Thomas, X.3
  • 30
    • 38949185746 scopus 로고    scopus 로고
    • Outcomes in CCG-2961, a children’s oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: a report from the children’s oncology group
    • COI: 1:CAS:528:DC%2BD1cXhvFejsb4%3D, PID: 18000167
    • Lange BJ, Smith FO, Feusner J et al (2008) Outcomes in CCG-2961, a children’s oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: a report from the children’s oncology group. Blood 111:1044–1053
    • (2008) Blood , vol.111 , pp. 1044-1053
    • Lange, B.J.1    Smith, F.O.2    Feusner, J.3
  • 31
    • 84964694315 scopus 로고    scopus 로고
    • Interleukin-2 as maintenance therapy for children and adults with acute myeloid leukaemia in first complete remission
    • Mao C, Fu XH, Yuan JQ et al (2015) Interleukin-2 as maintenance therapy for children and adults with acute myeloid leukaemia in first complete remission. Cochrane Database Syst Rev 11:CD010248
    • (2015) Cochrane Database Syst Rev , vol.11 , pp. CD010248
    • Mao, C.1    Fu, X.H.2    Yuan, J.Q.3
  • 32
    • 33745714215 scopus 로고    scopus 로고
    • Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial
    • COI: 1:CAS:528:DC%2BD28XmsVOmtLg%3D, PID: 16556892
    • Brune M, Castaigne S, Catalano J et al (2006) Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial. Blood 108:88–96
    • (2006) Blood , vol.108 , pp. 88-96
    • Brune, M.1    Castaigne, S.2    Catalano, J.3
  • 33
    • 84941784875 scopus 로고    scopus 로고
    • Control of regulatory T cell migration, function, and homeostasis
    • COI: 1:CAS:528:DC%2BC2MXhsVygs7bK, PID: 26342103
    • Campbell DJ (2015) Control of regulatory T cell migration, function, and homeostasis. J Immunol 195:2507–2513
    • (2015) J Immunol , vol.195 , pp. 2507-2513
    • Campbell, D.J.1
  • 34
    • 77954141914 scopus 로고    scopus 로고
    • FOXP3 + regulatory T cells in the human immune system
    • COI: 1:CAS:528:DC%2BC3cXnsFKitLY%3D, PID: 20559327
    • Sakaguchi S, Miyara M, Costantino CM, Hafler DA (2010) FOXP3 + regulatory T cells in the human immune system. Nat Rev Immunol 10:490–500
    • (2010) Nat Rev Immunol , vol.10 , pp. 490-500
    • Sakaguchi, S.1    Miyara, M.2    Costantino, C.M.3    Hafler, D.A.4
  • 35
    • 84898940914 scopus 로고    scopus 로고
    • Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity
    • COI: 1:CAS:528:DC%2BC2cXmtl2mtbs%3D, PID: 24573552
    • Kennedy-Nasser AA, Ku S, Castillo-Caro P et al (2014) Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity. Clin Cancer Res 20:2215–2225
    • (2014) Clin Cancer Res , vol.20 , pp. 2215-2225
    • Kennedy-Nasser, A.A.1    Ku, S.2    Castillo-Caro, P.3
  • 36
    • 84947976049 scopus 로고    scopus 로고
    • Therapeutic potential of low-dose IL-2 in a chronic GVHD patient by in vivo expansion of regulatory T cells
    • PID: 26624506
    • Kim N, Jeon YW, Nam YS, Lim JY, Im KI, Lee ES, Cho SG (2015) Therapeutic potential of low-dose IL-2 in a chronic GVHD patient by in vivo expansion of regulatory T cells. Cytokine 78:22–26
    • (2015) Cytokine , vol.78 , pp. 22-26
    • Kim, N.1    Jeon, Y.W.2    Nam, Y.S.3    Lim, J.Y.4    Im, K.I.5    Lee, E.S.6    Cho, S.G.7
  • 37
    • 82555168440 scopus 로고    scopus 로고
    • Interleukin-2 and regulatory T cells in graft-versus-host disease
    • COI: 1:CAS:528:DC%2BC3MXhs1Smtb7O, PID: 22129252
    • Koreth J, Matsuoka K, Kim HT et al (2011) Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med 365:2055–2066
    • (2011) N Engl J Med , vol.365 , pp. 2055-2066
    • Koreth, J.1    Matsuoka, K.2    Kim, H.T.3
  • 38
    • 84876012054 scopus 로고    scopus 로고
    • Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
    • PID: 23552371
    • Matsuoka K, Koreth J, Kim HT et al (2013) Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med 5:179ra43
    • (2013) Sci Transl Med , vol.5 , pp. 179ra43
    • Matsuoka, K.1    Koreth, J.2    Kim, H.T.3
  • 39
    • 84958779561 scopus 로고    scopus 로고
    • Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia
    • PID: 26863635
    • Sander FE, Rydström A, Bernson E et al (2016) Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia. Oncotarget 7:7586–7596
    • (2016) Oncotarget , vol.7 , pp. 7586-7596
    • Sander, F.E.1    Rydström, A.2    Bernson, E.3
  • 41
    • 84952332380 scopus 로고    scopus 로고
    • NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance
    • PID: 26544512
    • Martner A, Rydström A, Riise RE, Aurelius J, Brune M, Foa R, Hellstrand K, Thoren FB (2015) NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance. Oncotarget 6:42569–42574
    • (2015) Oncotarget , vol.6 , pp. 42569-42574
    • Martner, A.1    Rydström, A.2    Riise, R.E.3    Aurelius, J.4    Brune, M.5    Foa, R.6    Hellstrand, K.7    Thoren, F.B.8
  • 42
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • PID: 19880497
    • Dohner H, Estey EH, Amadori S et al (2010) Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 115:453–474
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3
  • 43
    • 34548755672 scopus 로고    scopus 로고
    • DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    • COI: 1:CAS:528:DC%2BD2sXhtFahs7bE, PID: 17694575
    • Baron U, Floess S, Wieczorek G et al (2007) DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol 37:2378–2389
    • (2007) Eur J Immunol , vol.37 , pp. 2378-2389
    • Baron, U.1    Floess, S.2    Wieczorek, G.3
  • 44
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • COI: 1:CAS:528:DC%2BD3MXis1yluw%3D%3D, PID: 11137993
    • Bennett CL, Christie J, Ramsdell F et al (2001) The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 27:20–21
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 45
    • 63349111567 scopus 로고    scopus 로고
    • Telomere length measurement by a novel monochrome multiplex quantitative PCR method
    • PID: 19129229
    • Cawthon RM (2009) Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 37:e21
    • (2009) Nucleic Acids Res , vol.37
    • Cawthon, R.M.1
  • 46
    • 84897935715 scopus 로고    scopus 로고
    • Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells
    • COI: 1:CAS:528:DC%2BC2cXmtV2ntbg%3D, PID: 24712467
    • Morikawa H, Sakaguchi S (2014) Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells. Immunol Rev 259:192–205
    • (2014) Immunol Rev , vol.259 , pp. 192-205
    • Morikawa, H.1    Sakaguchi, S.2
  • 47
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3 + T regulatory cells
    • COI: 1:CAS:528:DC%2BC3cXjs1Wrt78%3D, PID: 20181882
    • Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM (2010) Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3 + T regulatory cells. J Immunol 184:3433–3441
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6    Shevach, E.M.7
  • 49
    • 84904542856 scopus 로고    scopus 로고
    • Impaired NK cells and increased T regulatory cell numbers during cytotoxic maintenance therapy in AML
    • COI: 1:CAS:528:DC%2BC2cXhtVanurbF, PID: 24957413
    • Lichtenegger FS, Lorenz R, Gellhaus K, Hiddemann W, Beck B, Subklewe M (2014) Impaired NK cells and increased T regulatory cell numbers during cytotoxic maintenance therapy in AML. Leuk Res 38:964–969
    • (2014) Leuk Res , vol.38 , pp. 964-969
    • Lichtenegger, F.S.1    Lorenz, R.2    Gellhaus, K.3    Hiddemann, W.4    Beck, B.5    Subklewe, M.6
  • 50
    • 84863262306 scopus 로고    scopus 로고
    • CD4 + CD25highFoxP3 + regulatory T-cells in hematologic diseases
    • COI: 1:CAS:528:DC%2BC3MXhsVylsr3L, PID: 22016675
    • Moon HW, Kim BH, Park CM, Hur M, Yun YM, Kim SY, Lee MH (2011) CD4 + CD25highFoxP3 + regulatory T-cells in hematologic diseases. Korean J Lab Med 31:231–237
    • (2011) Korean J Lab Med , vol.31 , pp. 231-237
    • Moon, H.W.1    Kim, B.H.2    Park, C.M.3    Hur, M.4    Yun, Y.M.5    Kim, S.Y.6    Lee, M.H.7
  • 51
    • 79958021546 scopus 로고    scopus 로고
    • IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3 + T cells in vivo
    • COI: 1:CAS:528:DC%2BC3MXmtlykt70%3D, PID: 21525380
    • Chen Q, Kim YC, Laurence A, Punkosdy GA, Shevach EM (2011) IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3 + T cells in vivo. J Immunol 186:6329–6337
    • (2011) J Immunol , vol.186 , pp. 6329-6337
    • Chen, Q.1    Kim, Y.C.2    Laurence, A.3    Punkosdy, G.A.4    Shevach, E.M.5
  • 53
    • 84904899365 scopus 로고    scopus 로고
    • HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
    • COI: 1:CAS:528:DC%2BC2cXht1Ggu7zK, PID: 24923299
    • Martelli MF, Di Ianni M, Ruggeri L et al (2014) HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse. Blood 124:638–644
    • (2014) Blood , vol.124 , pp. 638-644
    • Martelli, M.F.1    Di Ianni, M.2    Ruggeri, L.3
  • 54
    • 84883680231 scopus 로고    scopus 로고
    • The impact of aging on regulatory T-cells
    • COI: 1:CAS:528:DC%2BC3sXhsVGitbbM, PID: 23964277
    • Fessler J, Ficjan A, Duftner C, Dejaco C (2013) The impact of aging on regulatory T-cells. Front Immunol 4:231
    • (2013) Front Immunol , vol.4 , pp. 231
    • Fessler, J.1    Ficjan, A.2    Duftner, C.3    Dejaco, C.4
  • 57
    • 51649084785 scopus 로고    scopus 로고
    • Combination therapy using IL-2 and anti-CD25 results in augmented natural killer cell-mediated antitumor responses
    • COI: 1:CAS:528:DC%2BD1cXht1KlurbJ
    • Hallett WH, Ames E, Alvarez M, Barao I, Taylor PA, Blazar BR, Murphy WJ (2008) Combination therapy using IL-2 and anti-CD25 results in augmented natural killer cell-mediated antitumor responses. Biol Blood Marrow Transpl 14:1088–1099
    • (2008) Biol Blood Marrow Transpl , vol.14 , pp. 1088-1099
    • Hallett, W.H.1    Ames, E.2    Alvarez, M.3    Barao, I.4    Taylor, P.A.5    Blazar, B.R.6    Murphy, W.J.7
  • 58
    • 84902682889 scopus 로고    scopus 로고
    • Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
    • COI: 1:CAS:528:DC%2BC2cXhtFWhu7jK, PID: 24719405
    • Bachanova V, Cooley S, Defor TE et al (2014) Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein. Blood 123:3855–3863
    • (2014) Blood , vol.123 , pp. 3855-3863
    • Bachanova, V.1    Cooley, S.2    Defor, T.E.3
  • 59
    • 84949727634 scopus 로고    scopus 로고
    • Interleukin-2: biology, design and application
    • COI: 1:CAS:528:DC%2BC2MXhslGmu7zI, PID: 26572555
    • Arenas-Ramirez N, Woytschak J, Boyman O (2015) Interleukin-2: biology, design and application. Trends Immunol 36:763–777
    • (2015) Trends Immunol , vol.36 , pp. 763-777
    • Arenas-Ramirez, N.1    Woytschak, J.2    Boyman, O.3
  • 60
    • 84896737880 scopus 로고    scopus 로고
    • Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Ralpha-Fc chimera
    • COI: 1:CAS:528:DC%2BC2cXmtFahtrs%3D, PID: 24512738
    • Votavova P, Tomala J, Kovar M (2014) Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Ralpha-Fc chimera. Immunol Lett 159:1–10
    • (2014) Immunol Lett , vol.159 , pp. 1-10
    • Votavova, P.1    Tomala, J.2    Kovar, M.3
  • 61
    • 84871939748 scopus 로고    scopus 로고
    • Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: implications for adoptive T cell-based therapies for lymphoma
    • COI: 1:CAS:528:DC%2BC3sXktFGisw%3D%3D, PID: 23149818
    • Perna SK, De Angelis B, Pagliara D et al (2013) Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: implications for adoptive T cell-based therapies for lymphoma. Clin Cancer Res 19:106–117
    • (2013) Clin Cancer Res , vol.19 , pp. 106-117
    • Perna, S.K.1    De Angelis, B.2    Pagliara, D.3


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