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Volumn 78, Issue , 2016, Pages 22-26

Therapeutic potential of low-dose IL-2 in a chronic GVHD patient by in vivo expansion of regulatory T cells

Author keywords

Allogeneic hematopoietic stem cell transplantation; Chronic graft versus host disease; Immunotherapy; Interleukin 2; Regulatory T cell

Indexed keywords

ALDESLEUKIN; BUSULFAN; FLUDARABINE PHOSPHATE; MYCOPHENOLATE MOFETIL; PREDNISOLONE; TACROLIMUS; CYTOKINE; INTERLEUKIN 2; RECOMBINANT PROTEIN;

EID: 84947976049     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2015.11.020     Document Type: Article
Times cited : (17)

References (14)
  • 2
    • 36348980530 scopus 로고    scopus 로고
    • Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease
    • Chen X., Vodanovic-Jankovic S., Johnson B., Keller M., Komorowski R., Drobyski W.R. Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. Blood 2007, 110:3804-3813.
    • (2007) Blood , vol.110 , pp. 3804-3813
    • Chen, X.1    Vodanovic-Jankovic, S.2    Johnson, B.3    Keller, M.4    Komorowski, R.5    Drobyski, W.R.6
  • 3
    • 27144500976 scopus 로고    scopus 로고
    • Reduced frequency of FOXP3+ CD4+ CD25+ regulatory T cells in patients with chronic graft-versus-host disease
    • Zorn E., Kim H.T., Lee S.J., Floyd B.H., Litsa D., Arumugarajah S., et al. Reduced frequency of FOXP3+ CD4+ CD25+ regulatory T cells in patients with chronic graft-versus-host disease. Blood 2005, 106:2903-2911.
    • (2005) Blood , vol.106 , pp. 2903-2911
    • Zorn, E.1    Kim, H.T.2    Lee, S.J.3    Floyd, B.H.4    Litsa, D.5    Arumugarajah, S.6
  • 5
    • 84876012054 scopus 로고    scopus 로고
    • Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
    • 179ra43
    • Matsuoka K., Koreth J., Kim H.T., Bascug G., McDonough S., Kawano Y., et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci. Transl. Med. 2013, 5:179ra43.
    • (2013) Sci. Transl. Med. , vol.5
    • Matsuoka, K.1    Koreth, J.2    Kim, H.T.3    Bascug, G.4    McDonough, S.5    Kawano, Y.6
  • 6
    • 84898940914 scopus 로고    scopus 로고
    • Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity
    • Kennedy-Nasser A.A., Ku S., Castillo-Caro P., Hazrat Y., Wu M.F., Liu H., et al. Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity. Clin. Cancer Res. 2014, 20:2215-2225.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 2215-2225
    • Kennedy-Nasser, A.A.1    Ku, S.2    Castillo-Caro, P.3    Hazrat, Y.4    Wu, M.F.5    Liu, H.6
  • 7
    • 84881367948 scopus 로고    scopus 로고
    • Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells
    • Satake A., Schmidt A.M., Archambault A., Leichner T.M., Wu G.F., Kambayashi T. Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells. J. Autoimmun. 2013, 44:13-20.
    • (2013) J. Autoimmun. , vol.44 , pp. 13-20
    • Satake, A.1    Schmidt, A.M.2    Archambault, A.3    Leichner, T.M.4    Wu, G.F.5    Kambayashi, T.6
  • 8
    • 33745633856 scopus 로고    scopus 로고
    • Inhibition of CD4+ CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
    • Zeiser R., Nguyen V.H., Beilhack A., Buess M., Schulz S., Baker J., et al. Inhibition of CD4+ CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006, 108:390-399.
    • (2006) Blood , vol.108 , pp. 390-399
    • Zeiser, R.1    Nguyen, V.H.2    Beilhack, A.3    Buess, M.4    Schulz, S.5    Baker, J.6
  • 9
    • 84899105427 scopus 로고    scopus 로고
    • Inhibition of calcineurin abrogates while inhibition of mTOR promotes regulatory T cell expansion and graft-versus-host disease protection by IL-2 in allogeneic bone marrow transplantation
    • Satake A., Schmidt A.M., Nomura S., Kambayashi T. Inhibition of calcineurin abrogates while inhibition of mTOR promotes regulatory T cell expansion and graft-versus-host disease protection by IL-2 in allogeneic bone marrow transplantation. PLoS ONE 2014, 9:e92888.
    • (2014) PLoS ONE , vol.9 , pp. e92888
    • Satake, A.1    Schmidt, A.M.2    Nomura, S.3    Kambayashi, T.4
  • 10
    • 84912073625 scopus 로고    scopus 로고
    • Potential limitations of IL-2 administration for the treatment of experimental acute graft-versus-host disease
    • Perol L., Martin G.H., Maury S., Cohen J.L., Piaggio E. Potential limitations of IL-2 administration for the treatment of experimental acute graft-versus-host disease. Immunol. Lett. 2014, 162:173-184.
    • (2014) Immunol. Lett. , vol.162 , pp. 173-184
    • Perol, L.1    Martin, G.H.2    Maury, S.3    Cohen, J.L.4    Piaggio, E.5
  • 11
    • 84910637672 scopus 로고    scopus 로고
    • Administration of low doses of IL-2 combined to rapamycin promotes allogeneic skin graft survival in mice
    • Pilon C.B., Petillon S., Naserian S., Martin G.H., Badoual C., Lang P., et al. Administration of low doses of IL-2 combined to rapamycin promotes allogeneic skin graft survival in mice. Am. J. Transplant. 2014, 14:2874-2882.
    • (2014) Am. J. Transplant. , vol.14 , pp. 2874-2882
    • Pilon, C.B.1    Petillon, S.2    Naserian, S.3    Martin, G.H.4    Badoual, C.5    Lang, P.6
  • 12
    • 80052157997 scopus 로고    scopus 로고
    • Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+ CD25+ Foxp3+ regulatory T cells
    • Shin H.J., Baker J., Leveson-Gower D.B., Smith A.T., Sega E.I., Negrin R.S. Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+ CD25+ Foxp3+ regulatory T cells. Blood 2011, 118:2342-2350.
    • (2011) Blood , vol.118 , pp. 2342-2350
    • Shin, H.J.1    Baker, J.2    Leveson-Gower, D.B.3    Smith, A.T.4    Sega, E.I.5    Negrin, R.S.6
  • 13
    • 84869791967 scopus 로고    scopus 로고
    • Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways
    • Lee S.Y., Cho M.L., Oh H.J., Ryu J.G., Park M.J., Jhun J.Y., et al. Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways. Immunology 2012, 137:305-316.
    • (2012) Immunology , vol.137 , pp. 305-316
    • Lee, S.Y.1    Cho, M.L.2    Oh, H.J.3    Ryu, J.G.4    Park, M.J.5    Jhun, J.Y.6
  • 14
    • 84928591321 scopus 로고    scopus 로고
    • The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
    • Klatzmann D., Abbas A.K. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat. Rev. Immunol. 2015, 15:283-294.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 283-294
    • Klatzmann, D.1    Abbas, A.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.