Elevated frequencies of CD4+CD25+CD127lo regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia

International Journal of Cancer

Volumn 129, Issue 6, 2011, Pages 1373-1381

  Shenghui, Zhang ^a   Yixiang, Han ^a   Jianbo, Wu ^a   Kang, Yu ^a,b   Laixi, Bi ^a   Yan, Zhuang ^a   Xi, Xu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

acute myeloid leukemia; CD127; prognosis; regulatory T cells; suppressive function

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER RELAPSE; CD4+ CD25+ T LYMPHOCYTE; CELL LABELING; CELL SELECTION; COCULTURE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMOGENESIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REGULATORY T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BONE MARROW; CD4-POSITIVE T-LYMPHOCYTES; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LEUKEMIA, MYELOID, ACUTE; LYMPHOCYTE COUNT; MIDDLE AGED; PROGNOSIS; RECURRENCE; REMISSION INDUCTION; T-LYMPHOCYTES, REGULATORY;

EID: 79960898228     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25791     Document Type: Article

References (33)

1. Nakamura K, Kitani A, Strober W,. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001; 194: 629-44. (Pubitemid 32844773)
2. Collison LW, Pillai MR, Chaturvedi V, Vignali DA,. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol 2009; 182: 6121-8.
3. Fontenot JD, Gavin MA, Rudensky AY,. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-6. (Pubitemid 36432314)
4. Hori S, Nomura T, Sakaguchi S,. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61. (Pubitemid 36222930)
5. Roncador G, Brown PJ, Maestre L, Hue S, Martinez-Torrecuadrada JL, Ling KL, Pratap S, Toms C, Fox BC, Cerundolo V, Powrie F, Banham AH,. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur. J. Immunol. 2005; 35: 1681-91. (Pubitemid 40862316)
6. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, et al,. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203: 1701-11. (Pubitemid 44036276)
7. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R, Kelleher A, Fazekas de St Groth B,. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203: 1693-700. (Pubitemid 44036275)
8. Beyer M, Schultze JL,. Regulatory T cells in cancer. Blood 2006; 108: 804-11. (Pubitemid 44154611)
9. Ju S, Qiu H, Zhou X, Zhu B, Lv X, Huang X, Li J, Zhang Y, Liu L, Ge Y, Johnson DE, Ju S, et al,. CD13+CD4+CD25hi regulatory T cells exhibit higher suppressive function and increase with tumor stage in non-small cell lung cancer patients. Cell Cycle 2009; 8: 2578-85.
10. Perez SA, Karamouzis MV, Skarlos DV, Ardavanis A, Sotiriadou NN, Iliopoulou EG, Salagianni ML, Orphanos G, Baxevanis CN, Rigatos G, Papamichail M,. CD4+CD25+ regulatory T-cell frequency in HER-2/neu (HER)-positive and HER-negative advanced-stage breast cancer patients. Clin Cancer Res 2007; 13: 2714-21. (Pubitemid 46788040)
11. Ahmadzadeh M, Felipe-Silva A, Heemskerk B, Powell DJ, Jr, Wunderlich JR, Merino MJ, Rosenberg SA,. FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions. Blood 2008; 112: 4953-60.
12. Lau KM, Cheng SH, Lo KW, Lee SA, Woo JK, van Hasselt CA, Lee SP, Rickinson AB, Ng MH,. Increase in circulating Foxp3+CD4+CD25(high) regulatory T cells in nasopharyngeal carcinoma patients. Br J Cancer 2007; 96: 617-22.
13. Mittal S, Marshall NA, Duncan L, Culligan DJ, Barker RN, Vickers MA,. Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma. Blood 2008; 111: 5359-70.
14. Beyer M, Kochanek M, Darabi K, Popov A, Jensen M, Endl E, Knolle PA, Thomas RK, von Bergwelt-Baildon M, Debey S, Hallek M, Schultze JL,. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 2005; 106: 2018-25. (Pubitemid 41291715)
15. Jak M, Mous R, Remmerswaal EB, Spijker R, Jaspers A, Yague A, Eldering E, Van Lier RA, Van Oers MH,. Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia. Leuk Lymphoma 2009; 50: 788-801.
16. Wang X, Zheng J, Liu J, Yao J, He Y, Li X, Yu J, Yang J, Liu Z, Huang S,. Increased population of CD4(+)CD25(high), regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients. Eur J Haematol 2005; 75: 468-76. (Pubitemid 41687780)
17. Beyer M, Kochanek M, Giese T, Endl E, Weihrauch MR, Knolle PA, Classen S, Schultze JL,. In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma. Blood 2006; 107: 3940-9. (Pubitemid 43726800)
18. Kordasti SY, Ingram W, Hayden J, Darling D, Barber L, Afzali B, Lombardi G, Wlodarski MW, Maciejewski JP, Farzaneh F, Mufti GJ,. CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS). Blood 2007; 110: 847-50. (Pubitemid 47267420)
19. Szczepanski MJ, Szajnik M, Czystowska M, Mandapathil M, Strauss L, Welsh A, Foon KA, Whiteside TL, Boyiadzis M,. Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia. Clin Cancer Res 2009; 15: 3325-32.
20. Lowenberg B, Downing JR, Burnett A,. Acute myeloid leukemia. N Engl J Med 1999; 341: 1051-62. (Pubitemid 29451802)
21. Shen LS, Wang J, Shen DF, Yuan XL, Dong P, Li MX, Xue J, Zhang FM, Ge HL, Xu D,. CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression. Clin Immunol 2009; 131: 109-18.
22. Nishikawa H, Sakaguchi S,. Regulatory T cells in tumor immunity. Int J Cancer 2010; 127: 759-67.
23. Erdman SE, Poutahidis T,. Cancer inflammation and regulatory T cells. Int J Cancer 2010; 127: 768-79.
24. Wilke CM, Wu K, Zhao E, Wang G, Zou W,. Prognostic significance of regulatory T cells in tumor. Int J Cancer 2010; 127: 748-58.
25. Fontenot JD, Rudensky AY,. A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005; 6: 331-7. (Pubitemid 41716769)
26. Baecher-Allan C, Viglietta V, Hafler DA,. Human CD4+CD25+ regulatory T cells. Semin Immunol 2004; 16: 89-98.
27. Levings MK, Sangregorio R, Sartirana C, Moschin AL, Battaglia M, Orban PC, Roncarolo MG,. Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J Exp Med 2002; 196: 1335-46. (Pubitemid 35375552)
28. Verma ND, Plain KM, Nomura M, Tran GT, Robinson C, Boyd R, Hodgkinson SJ, Hall BM,. CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses. Blood 2009; 113: 479-87.
29. Strauss L, Bergmann C, Gooding W, Johnson JT, Whiteside TL,. The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 2007; 13: 6301-11. (Pubitemid 350075018)
30. Zeiser R, Nguyen VH, Beilhack A, Buess M, Schulz S, Baker J, Contag CH, Negrin RS,. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006; 108: 390-9. (Pubitemid 43990654)
31. Varona R, Cadenas V, Lozano M, Moreno-Ortiz MC, Kremer L, Martinez AC, Marquez G,. CCR6 regulates the function of alloreactive and regulatory CD4+ T cells during acute graft-versus-host disease. Leuk Lymphoma 2006; 47: 1469-76. (Pubitemid 44364009)
32. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S,. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008; 322: 271-5.
33. Jarnicki AG, Lysaght J, Todryk S, Mills KH,. Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: Influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. J Immunol 2006; 177: 896-904. (Pubitemid 44036590)