Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Lapierre, Pascal ^a   Lamarre, Alain ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DACLIZUMAB; AUTOANTIGEN; VIRUS ANTIGEN;

AUTOIMMUNE HEPATITIS; CHRONIC HEPATITIS; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; LIVER GRAFT; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; VIRAL CHRONIC HEPATITIS; VIRUS HEPATITIS; ANIMAL; AUTOIMMUNITY; HEPATITIS, AUTOIMMUNE; HEPATITIS, VIRAL, HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; LIVER; METABOLISM; PATHOLOGY; T LYMPHOCYTE SUBPOPULATION; VIROLOGY;

ANIMALS; ANTIGENS, VIRAL; AUTOANTIGENS; AUTOIMMUNITY; HEPATITIS, AUTOIMMUNE; HEPATITIS, VIRAL, HUMAN; HUMANS; IMMUNE TOLERANCE; IMMUNOTHERAPY; LIVER; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84935832371     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/479703     Document Type: Review

References (76)

1. R. Y. Calne, R. A. Sells, J. R. Pena, et al., "Induction of immunological tolerance by porcine liver allografts, " Nature, vol. 223, no. 5205, pp. 472-476, 1969.
2. R. Yang, Q. Liu, J. L. Grosfeld, and M. D. Pescovitz, "Intestinal venous drainage through the liver is a prerequisite for oral tolerance induction, " Journal of Pediatric Surgery, vol. 29, no. 8, pp. 1145-1148, 1994.
3. L. E. Holz, V. Benseler, M. Vo, et al., " Naive CD8 T cell activation by liver bone marrow-derived cells leads to a neglected IL-2low Bimhigh phenotype, poor CTL function and cell death, " Journal of Hepatology, vol. 57, no. 4, pp. 830-836, 2012.
4. S. Sakaguchi, M. Miyara, C. M. Costantino, and D. A. Hafler, "FOXP3+ regulatory T cells in the human immune system, " Nature Reviews Immunology, vol. 10, no. 7, pp. 490-500, 2010.
5. S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono, "Regulatory T cells and immune tolerance, " Cell, vol. 133, no. 5, pp. 775-787, 2008.
6. H. W. Virgin, E. J. Wherry, and R. Ahmed, "Redefining chronic viral infection, " Cell, vol. 138, no. 1, pp. 30-50, 2009.
7. H. Ebinuma, N. Nakamoto, Y. Li, et al., "Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection, " Journal of Virology, vol. 82, no. 10, pp. 5043-5053, 2008.
8. S. Luth, S. Huber, C. Schramm, et al., "Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs, " The Journal of Clinical Investigation, vol. 118, no. 10, pp. 3403-3410, 2008.
9. A. Carambia, B. Freund, D. Schwinge, et al., "Nanoparticlebased autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice, " Journal of Hepatology, vol. 62, no. 6, pp. 1349-1356, 2015.
10. A. Carambia, B. Freund, D. Schwinge, et al., "TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells, " Journal of Hepatology, vol. 61, no. 3, pp. 594-599, 2014.
11. P. J. Johnson and I. G. Mcfarlane, "Meeting report: international autoimmune hepatitis group, " Hepatology, vol. 18, no. 4, pp. 998-1005, 1993.
12. F. Alvarez, "Autoimmune hepatitis, " in Liver Disease in Childhood, F. Suchy, R. Sokol, and W. Baliestreri, Eds., Lippincott Williams &Wilkins, 2001.
13. E. L. Krawitt, "Autoimmune hepatitis, "The New England Journal of Medicine, vol. 354, no. 1, pp. 54-66, 2006.
14. K. Beland, P. Lapierre, and F. Alvarez, "Influence of genes, sex, age and environment on the onset of autoimmune hepatitis, " World Journal of Gastroenterology, vol. 15, no. 9, pp. 1025-1034, 2009.
15. J. C. Homberg, N. Abuaf, O. Bernard, et al., "Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of autoimmune hepatitis, " Hepatology, vol. 7, no. 6, pp. 1333-1339, 1987.
16. G. Maggiore, O. Bernard, J.-C. Homberg, et al., "Liver disease associated with anti-liver-kidney microsome antibody in children, " TheJournal of Pediatrics, vol. 108, no. 3, pp. 399-404, 1986.
17. G. Maggiore, F. Veber, O. Bernard, et al., "Autoimmune hepatitis associated with anti-actin antibodies in children and adolescents, " Journal of Pediatric Gastroenterology and Nutrition, vol. 17, no. 4, pp. 376-381, 1993.
18. G. V. Gregorio, B. Portmann, F. Reid, et al., "Autoimmune hepatitis in childhood: a 20-year experience, " Hepatology, vol. 25, no. 3, pp. 541-547, 1997.
19. I. Djilali-Saiah, R. Renous, S. Caillat-Zucman, D. Debray, and F. Alvarez, "Linkage disequilibrium between HLA class II region and autoimmune hepatitis in pediatric patients, " Journal of Hepatology, vol. 40, no. 6, pp. 904-909, 2004.
20. E. Martini, N. Abuaf, F. Cavalli, V. Durand, C. Johanet, and J.-C. Homberg, "Antibody to liver cytosol (anti-LC1) in patients with autoimmune chronic active hepatitis type 2, " Hepatology, vol. 8, no. 6, pp. 1662-1666, 1988.
21. N. Abuaf, C. Johanet, P. Chretien, et al., "Characterization of the liver cytosol antigen type 1 reacting with autoantibodies in chronic active hepatitis, " Hepatology, vol. 16, no. 4, pp. 892-898, 1992.
22. P. Lapierre, O. Hajoui, J.-C. Homberg, and F. Alvarez, "Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis, " Gastroenterology, vol. 116, no. 3, pp. 643-649, 1999.
23. M. Gueguen, O. Boniface, O. Bernard, F. Clerc, T. Cartwright, and F. Alvarez, "Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibody, " Journal of Autoimmunity, vol. 4, no. 4, pp. 607-615, 1991.
24. A. M. Yamamoto, D. Cresteil, O. Boniface, F. F. Clerc, and F. Alvarez, "Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti liver-kidney microsome type antibodies (LKM1), " European Journal of Immunology, vol. 23, no. 5, pp. 1105-1111, 1993.
25. M. P. Manns, E. F. Johnson, K. J. Griffin, E. M. Tan, and K. F. Sullivan, "Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1, " The Journal of Clinical Investigation, vol. 83, no. 3, pp. 1066-1072, 1989.
26. Y. Ma, D. P. Bogdanos, M. J. Hussain, et al., "Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2, " Gastroenterology, vol. 130, no. 3, pp. 868-882, 2006.
27. M. S. Longhi, M. J. Hussain, D. P. Bogdanos, et al., "Cytochrome P450IID6-specific CD8 T cellimmune responses mirror disease activity in autoimmune hepatitis type 2, " Hepatology, vol. 46, no. 2, pp. 472-484, 2007.
28. A. J. Czaja, "Autoimmune hepatitis. Part A: pathogenesis, " Expert Review of Gastroenterology & Hepatology, vol. 1, no. 1, pp. 113-128, 2007.
29. M. Holdener, E. Hintermann, M. Bayer, et al., "Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection, " Journal of Experimental Medicine, vol. 205, no. 6, pp. 1409-1422, 2008.
30. C. Piche, K. Beland, P. Lapierre, B. Massie, and F. Alvarez, "Different sites of xenoantigen delivery lead to a virally induced late-onset hepatitis in mice through molecular mimicry, " Liver International, vol. 31, no. 9, pp. 1306-1314, 2011.
31. M. Hardtke-Wolenski, K. Fischer, F. Noyan, et al., "Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells, " Hepatology, vol. 58, no. 2, pp. 718-728, 2013.
32. G. Marceau, R. Yang, P. Lapierre, K. Beland, and F. Alvarez, "Low-dose anti-CD3 antibody induces remission of active autoimmune hepatitis in xenoimmunized mice, " Liver International, vol. 35, no. 1, pp. 275-284, 2015.
33. P. Lapierre, K. Beland, R. Yang, and F. Alvarez, "Adoptive transfer of ex vivo expand ed regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance, " Hepatology, vol. 57, no. 1, pp. 217-227, 2013.
34. P. Lapierre, K. Beland, C. Martin, and F. Alvarez Jr., "Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis, " Hepatology, vol. 51, no. 5, pp. 1789-1798, 2010.
35. P. Lapierre, K. Beland, I. Djilali-Saiah, and F. Alvarez, "Type 2 autoimmune hepatitis murine model: the influence of genetic background in disease development, " Journal of Autoimmunity, vol. 26, no. 2, pp. 82-89, 2006.
36. P. Lapierre, I. Djilali-Saiah, S. Vitozzi, and F. Alvarez, "Amurine model of type 2 autoimmune hepatitis:Xenoimmunizationwith human antigens, " Hepatology, vol. 39, no. 4, pp. 1066-1074, 2004.
37. P. Lapierre, K. Beland, and F. Alvarez, "Pathogenesis of autoimmune hepatitis: from break of tolerance to immune-mediated hepatocyte apoptosis, " Translational Research, vol. 149, no. 3, pp. 107-113, 2007.
38. L. Muratori, M. Cataleta, P. Muratori, M. Lenzi, and F. B. Bianchi, "Liver/kidney microsomal antibody type 1 and liver cytosol antibody type 1 concentrations in type 2 autoimmune hepatitis, " Gut, vol. 42, no. 5, pp. 721-726, 1998.
39. V. Viglietta, C. Baecher-Allan, H. L. Weiner, and D. A. Hafler, "Loss of functional suppression by CD4+CD25+ regulatory T cells in patients withmultiple sclerosis, " Journal of Experimental Medicine, vol. 199, no. 7, pp. 971-979, 2004.
40. J. C. Crispin, A. Martinez, and J. Alcocer-Varela, "Quantification of regulatory T cells in patients with systemic lupus erythematosus, " Journal of Autoimmunity, vol. 21, no. 3, pp. 273-276, 2003.
41. M. S. Longhi, Y. Ma, D. P. Bogdanos, P. Cheeseman, G. Mieli-Vergani, and D. Vergani, "Impairment of CD4+CD25+ regulatory T-cells in autoimmune liver disease, " Journal of Hepatology, vol. 41, no. 1, pp. 31-37, 2004.
42. M. Peiseler, M. Sebode, B. Franke, et al., "FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency, " Journal of Hepatology, vol. 57, no. 1, pp. 125-132, 2012.
43. J. Wang, A. Ioan-Facsinay, E. I. H. van der Voort, T. W. J. Huizinga, and R. E. M. Toes, "Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells, " European Journal of Immunology, vol. 37, no. 1, pp. 129-138, 2007.
44. C. R. Grant, R. Liberal, B. S. Holder, et al., "Dysfunctional CD39 POS regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis, " Hepatology, vol. 59, no. 3, pp. 1007-1015, 2014.
45. J. M. Fletcher, R. Lonergan, L. Costelloe, et al., "CD39+Foxp3+ regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis, " Journal of Immunology, vol. 183, no. 11, pp. 7602-7610, 2009.
46. J. D. Fontenot, M. A. Gavin, and A. Y. Rudensky, "Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, " Nature Immunology, vol. 4, no. 4, pp. 330-336, 2003.
47. M. S. Longhi, Y. Ma, R. R. Mitry, et al., "Effect of CD4+CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis, " Journal of Autoimmunity, vol. 25, no. 1, pp. 63-71, 2005.
48. M. S. Longhi, M. J. Hussain, R. R. Mitry, et al., "Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis, " The Journal of Immunology, vol. 176, no. 7, pp. 4484-4491, 2006.
49. M. S. Longhi, F. Meda, P. Wang, et al., "Expansion and de novo generation of potentially therapeutic regulatory T cells in patients with autoimmune hepatitis, " Hepatology, vol. 47, no. 2, pp. 581-591, 2008.
50. M. S. Longhi, M. J. Hussain, W. W. Kwok, G. Mieli-Vergani, Y. Ma, and D. Vergani, "Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis, " Hepatology, vol. 53, no. 2, pp. 536-547, 2011.
51. J. M. Vierling, "Autoimmune hepatitis and antigen-specific T regulatory cells: when can we send in the regulators?" Hepatology, vol. 53, no. 2, pp. 385-388, 2011.
52. R. Liberal, C. R. Grant, B. S. Holder, et al., "The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9/tim-3 pathway, " Hepatology, vol. 56, no. 2, pp. 677-686, 2012.
53. Y. H. Oo, C. J. Weston, P. F. Lalor, et al., "Distinct roles forCCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver, " Journal of Immunology, vol. 184, no. 6, pp. 2886-2898, 2010.
54. Y. L. Li, N. Liu, D. T. Zhao, et al., "Investigate circulating levels of chemokines and evaluate the correlation between these chemokines and liver function indicators in autoimmune hepatitis, " Chinese Journal of Hepatology, vol. 21, pp. 299-303, 2013.
55. A. Erhardt, C. Wegscheid, B. Claass, et al., "CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis, " The Journal of Immunology, vol. 186, no. 9, pp. 5284-5293, 2011.
56. M. S. Longhi, R. Liberal, B. Holder, et al., "Inhibition of interleukin-17 promotes differentiation of CD25-cells into stable T regulatory cells in patients with autoimmune hepatitis, " Gastroenterology, vol. 142, no. 7, pp. 1526. e6-1535. e6, 2012.
57. R. Tao, E. F. de Zoeten, E. Ozkaynak, et al., "Deacetylase inhibition promotes the generation and function of regulatory T cells, " Nature Medicine, vol. 13, no. 11, pp. 1299-1307, 2007.
58. U. Protzer, M. K. Maini, and P. A. Knolle, "Living in the liver: hepatic infections, " Nature Reviews Immunology, vol. 12, no. 3, pp. 201-213, 2012.
59. R. Thimme, D. Oldach, K.-M. Chang, C. Steiger, S. C. Ray, and F. V. Chisari, "Determinants of viral clearance and persistence during acute hepatitis C virus infection, " Journal of Experimental Medicine, vol. 194, no. 10, pp. 1395-1406, 2001.
60. S.-H. Park, N. S. Veerapu, E.-C. Shin, et al., "Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection, " Nature Medicine, vol. 19, no. 12, pp. 1638-1642, 2013.
61. N. Sturm, M.-A. Thelu, X. Camous, et al., "Characterization and role of intra-hepatic regulatory T cells in chronic hepatitis C pathogenesis, " Journal of Hepatology, vol. 53, no. 1, pp. 25-35, 2010.
62. P. T. Losikoff, A. A. Self, and S. H. Gregory, "Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C, " Virulence, vol. 3, no. 7, pp. 610-620, 2012.
63. A. J. MacDonald, M. Duffy, M. T. Brady, et al., "CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons, " Journal of Infectious Diseases, vol. 185, no. 6, pp. 720-727, 2002.
64. R. Cabrera, Z. Tu, Y. Xu, et al., "An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection, " Hepatology, vol. 40, no. 5, pp. 1062-1071, 2004.
65. K. Sugimoto, F. Ikeda, J. Stadanlick, F. A. Nunes, H. J. Alter, and K.-M. Chang, "Suppression ofHCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection, " Hepatology, vol. 38, no. 6, pp. 1437-1448, 2003.
66. X. Zhou, S. Ramachand ran, M. Mann, and D. L. Popkin, "Role of lymphocytic choriomeningitis virus (LCMV) in understand ing viral immunology: past, present and future, " Viruses, vol. 4, no. 11, pp. 2650-2669, 2012.
67. D. Moskophidis, F. Lechner, H. Pircher, and R. M. Zinkernagel, "Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells, " Nature, vol. 362, no. 6422, pp. 758-761, 1993.
68. E. J. Wherry, "T cell exhaustion, " Nature Immunology, vol. 12, no. 6, pp. 492-499, 2011.
69. P. Penaloza-MacMaster, A. O. Kamphorst, A. Wieland, et al., "Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection, " Journal of Experimental Medicine, vol. 211, no. 9, pp. 1905-1918, 2014.
70. P. Lapierre, V. Janelle, M. Langlois, E. Tarrab, T. Charpentier, and A. Lamarre, "Expression of viral antigen by the liver leads to chronic infection through the generation of regulatory T cells, " CMGH Cellular and Molecular Gastroenterology and Hepatology, vol. 1, no. 3, pp. 325. e1-341. e1, 2015.
71. B. T. Rouse and S. Suvas, "Regulatory cells and infectious agents: detentes cordiale and contraire, " Journal of Immunology, vol. 173, no. 4, pp. 2211-2215, 2004.
72. J. R. Teijaro, C. Ng, A. M. Lee, et al., "Persistent LCMV infection is controlled by blockade of type I interferon signaling, " Science, vol. 340, no. 6129, pp. 207-211, 2013.
73. E. B. Wilson, D. H. Yamada, H. Elsaesser, et al., "Blockade of chronic type I interferon signaling to control persistent LCMV infection, " Science, vol. 340, no. 6129, pp. 202-207, 2013.
74. F. Vincenti, R. Kirkman, S. Light, et al., "Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation, " New England Journal of Medicine, vol. 338, no. 3, pp. 161-165, 1998.
75. A. J. Rech and R. H. Vonderheide, "Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells, " Annals of the New York Academy of Sciences, vol. 1174, pp. 99-106, 2009.
76. D. J. Huss, D. S. Mehta, A. Sharma, et al., "In vivomaintenance of human regulatory T cells duringCD25 blockade, "TheJournal of Immunology, vol. 194, pp. 84-92, 2015.