메뉴 건너뛰기




Volumn 1, Issue 2, 2004, Pages 165-176

Downregulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth

Author keywords

angiogenesis; gliomas; invasion; RNA interference

Indexed keywords


EID: 85022917932     PISSN: 1740925X     EISSN: 17410533     Source Type: Journal    
DOI: 10.1017/S1740925X04000237     Document Type: Article
Times cited : (98)

References (67)
  • 6
    • 0000391746 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biology
    • Bergers G., Brekken R., McMahon G., Vu T.H., Itoh T., Tamaki K., Tanzawa K., Thorpe P. et al. (2000) Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biology 2, 737–744.
    • (2000) , vol.2 , pp. 737-744
    • Bergers, G.1    Brekken, R.2    McMahon, G.3    Vu, T.H.4    Itoh, T.5    Tamaki, K.6    Tanzawa, K.7    Thorpe, P.8
  • 8
    • 0033066858 scopus 로고    scopus 로고
    • A cell surface, regulated chemokine
    • APMIS
    • Blasi F (1999) The urokinase receptor. A cell surface, regulated chemokine. APMIS 107, 96–101.
    • (1999) The urokinase receptor. , vol.107 , pp. 96-101
    • Blasi, F.1
  • 13
    • 0032698213 scopus 로고    scopus 로고
    • Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. Cancer Research
    • Carriero M.V., Del Vecchio S., Capozzoli M., Franco P., Fontana L., Zannetti A., Botti G., D’Aiuto G. et al. (1999) Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. Cancer Research 59, 5307–5314.
    • (1999) , vol.59 , pp. 5307-5314
    • Carriero, M.V.1    Del Vecchio, S.2    Capozzoli, M.3    Franco, P.4    Fontana, L.5    Zannetti, A.6    Botti, G.7    D’Aiuto, G.8
  • 15
    • 0034961718 scopus 로고    scopus 로고
    • Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial—endothelial cell interactions. Clinical Experimental Metastasis
    • Chandrasekar N., Jasti S., Alfred-Yung W.K., Ali-Osman F., Dinh D.H., Olivero W.C., Gujrati M., Kyritsis A.P. et al. (2000) Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial—endothelial cell interactions. Clinical Experimental Metastasis 18, 337–342.
    • (2000) , vol.18 , pp. 337-342
    • Chandrasekar, N.1    Jasti, S.2    Alfred-Yung, W.K.3    Ali-Osman, F.4    Dinh, D.H.5    Olivero, W.C.6    Gujrati, M.7    Kyritsis, A.P.8
  • 26
    • 0033038483 scopus 로고    scopus 로고
    • Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MTi-MMP) are involved in different aspects of the pathophysiology of malignant gliomas. British Journal of Cancer
    • Forsyth P.A., Wong H., Laing T.D., Rewcastle N.B., Morris D.G., Muzik H., Leco K.J., Johnston R.N. et al. (1999) Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MTi-MMP) are involved in different aspects of the pathophysiology of malignant gliomas. British Journal of Cancer 79,1828-1835.
    • (1999) , vol.79 , pp. 1828-1835
    • Forsyth, P.A.1    Wong, H.2    Laing, T.D.3    Rewcastle, N.B.4    Morris, D.G.5    Muzik, H.6    Leco, K.J.7    Johnston, R.N.8
  • 29
    • 8544254674 scopus 로고    scopus 로고
    • Inhibition of in vivo tumori-genicity and invasiveness of a human glioblastoma cell line transfected with antisense uPAR vectors. Clinical Experimental Metastasis
    • Go Y., Chintala S.K., Mohanam S., Gokaslan Z., Venkaiah B., Bjerkvig R., Oka K., Nicolson G.L. et al. (1997) Inhibition of in vivo tumori-genicity and invasiveness of a human glioblastoma cell line transfected with antisense uPAR vectors. Clinical Experimental Metastasis 15, 440–446.
    • (1997) , vol.15 , pp. 440-446
    • Go, Y.1    Chintala, S.K.2    Mohanam, S.3    Gokaslan, Z.4    Venkaiah, B.5    Bjerkvig, R.6    Oka, K.7    Nicolson, G.L.8
  • 30
    • 3042551389 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas
    • Gondi C.S., Lakka S.S., Yanamandra N., Olivero W.C., Dinh D.H., Gujrati M., Tung C.H., Weissleder R. et al. (2004) Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas. Cancer Research 64, 4069–4077.
    • (2004) Cancer Research , vol.64 , pp. 4069-4077
    • Gondi, C.S.1    Lakka, S.S.2    Yanamandra, N.3    Olivero, W.C.4    Dinh, D.H.5    Gujrati, M.6    Tung, C.H.7    Weissleder, R.8
  • 40
    • 0034671911 scopus 로고    scopus 로고
    • Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion. Cancer Research
    • Kondraganti S., Mohanam S., Chintala S.K., Kin Y., Jasti S.L., Nirmala C., Lakka S.S., Adachi Y. et al. (2000) Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion. Cancer Research 60, 6851–6855.
    • (2000) , vol.60 , pp. 6851-6855
    • Kondraganti, S.1    Mohanam, S.2    Chintala, S.K.3    Kin, Y.4    Jasti, S.L.5    Nirmala, C.6    Lakka, S.S.7    Adachi, Y.8
  • 42
    • 2942718949 scopus 로고    scopus 로고
    • Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
    • Lakka S.S., Gondi C.S., Yanamandra N., Olivero W.C., Dinh D.H., Gujrati M. and Rao J.S. (2004) Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 23, 4681–4689.
    • (2004) Oncogene , vol.23 , pp. 4681-4689
    • Lakka, S.S.1    Gondi, C.S.2    Yanamandra, N.3    Olivero, W.C.4    Dinh, D.H.5    Gujrati, M.6    Rao, J.S.7
  • 43
    • 0037103912 scopus 로고    scopus 로고
    • Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro. Oncogene
    • Lakka S.S., Jasti S.L., Gondi C., Boyd D., Chandrasekar N., Dinh D.H., Olivero W.C., Gujrati M. et al. (2002) Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro. Oncogene 21, 5601–5608.
    • (2002) , vol.21 , pp. 5601-5608
    • Lakka, S.S.1    Jasti, S.L.2    Gondi, C.3    Boyd, D.4    Chandrasekar, N.5    Dinh, D.H.6    Olivero, W.C.7    Gujrati, M.8
  • 45
    • 18744377966 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion. Oncogene
    • Lakka S.S., Rajan M., Gondi C., Yanamandra N., Chandrasekar N., Jasti S.L., Adachi Y., Siddique K. et al. (2002) Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion. Oncogene 21, 8011–8019.
    • (2002) , vol.21 , pp. 8011-8019
    • Lakka, S.S.1    Rajan, M.2    Gondi, C.3    Yanamandra, N.4    Chandrasekar, N.5    Jasti, S.L.6    Adachi, Y.7    Siddique, K.8
  • 47
    • 7344262560 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. Gene Therapy
    • Belin
    • Li H., Lu H., Griscelli F., Opolon P., Sun L.Q., Ragot T., Legrand Y., Belin D. et al. (1998) Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. Gene Therapy 5,1105-1113.
    • (1998) , vol.5 , pp. 1105-1113
    • Li, H.1    Lu, H.2    Griscelli, F.3    Opolon, P.4    Sun, L.Q.5    Ragot, T.6    Legrand, Y.7
  • 51
    • 0033565613 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth. Cancer Research
    • Mohan P.M., Chintala S.K., Mohanam S., Gladson C.L., Kim E.S., Gokaslan Z.L., Lakka S.S., Roth J.A. et al. (1999) Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth. Cancer Research 59,3369-3373.
    • (1999) , vol.59 , pp. 3369-3373
    • Mohan, P.M.1    Chintala, S.K.2    Mohanam, S.3    Gladson, C.L.4    Kim, E.S.5    Gokaslan, Z.L.6    Lakka, S.S.7    Roth, J.A.8
  • 54
    • 0034885886 scopus 로고    scopus 로고
    • Stable transfection of urokinase-type plasminogen activator antisense construct modu-lates invasion of human glioblastoma cells. Clinical Cancer Research
    • Mohanam S., Jasti S.L., Kondraganti S.R., Chandrasekar N., Kin Y., Fuller G.N., Lakka S.S., Kyritsis A.P. et al. (2001) Stable transfection of urokinase-type plasminogen activator antisense construct modu-lates invasion of human glioblastoma cells. Clinical Cancer Research 7, 2519–2526.
    • (2001) , vol.7 , pp. 2519-2526
    • Mohanam, S.1    Jasti, S.L.2    Kondraganti, S.R.3    Chandrasekar, N.4    Kin, Y.5    Fuller, G.N.6    Lakka, S.S.7    Kyritsis, A.P.8
  • 55
    • 0028852956 scopus 로고
    • Expression of tissue inhibitors of metalloproteinases: negative regulators of human glioblastoma invasion in vivo. Clinical and Experimental Metastasis
    • Mohanam S., Wang S.W., Rayford A., Yamamoto M., Sawaya R., Nakajima M., Liotta L.A., Nicolson G.L. et al. (1995) Expression of tissue inhibitors of metalloproteinases: negative regulators of human glioblastoma invasion in vivo. Clinical and Experimental Metastasis 13, 57–62.
    • (1995) , vol.13 , pp. 57-62
    • Mohanam, S.1    Wang, S.W.2    Rayford, A.3    Yamamoto, M.4    Sawaya, R.5    Nakajima, M.6    Liotta, L.A.7    Nicolson, G.L.8
  • 56
    • 0032540943 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells
    • Tang H., Kerins D.M., Hao Q., Inagami T. and Vaughan D.E. (1998) The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. Journal of Biological Chemistry 273,18268-18272.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 18268-18272
    • Tang, H.1    Kerins, D.M.2    Hao, Q.3    Inagami, T.4    Vaughan, D.E.5
  • 61
    • 0028026686 scopus 로고
    • Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo. Cancer Research
    • Yamamoto M., Sawaya R., Mohanam S., Bindal A.K., Bruner J.M., Oka K., Rao V.H., Tomonaga M. et al. (1994) Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo. Cancer Research 54,3656-3661.
    • (1994) , vol.54 , pp. 3656-3661
    • Yamamoto, M.1    Sawaya, R.2    Mohanam, S.3    Bindal, A.K.4    Bruner, J.M.5    Oka, K.6    Rao, V.H.7    Tomonaga, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.