Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades

Clinical and Experimental Metastasis

Volumn 18, Issue 3, 2000, Pages 245-252

  Lakka, Sajani S ^a   Jasti, Sushma L ^b   Kyritsis, Anthanassios P ^b   Yung, W K Alfred ^b   Ali Osman, Francis ^a   Nicolson, Garth L ^c   Rao, Jasti S ^a  

^a Departments of Neurosurgery   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c INSTITUTE FOR MOLECULAR MEDICINE   (United States)

Author keywords

ERK; Glioblastoma; JNK; MMP 9; Type IV collagenase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; ENZYME SYNTHESIS; EXPRESSION VECTOR; GLIOBLASTOMA; HUMAN; HUMAN CELL; PROMOTER REGION; SIGNAL TRANSDUCTION; ZYMOGRAPHY;

BRAIN NEOPLASMS; ENZYME INHIBITORS; FLAVONOIDS; GLIOMA; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0035062438     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006724826083     Document Type: Article

References (47)

1. Mr 92,000 gelatinase release corelates with the metastatic phenotype in transformed rat embryo cells
2. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells
3. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages
4. Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinase prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin
5. Serum and Plasma Mr 92, 000 progelatinase levels correlate with spontaneous metastasis of rat 13762NF mammary adenosarcoma
6. Immunohistolocalization of ECM proteins in human glioblastoma cells in vitro
7. The effect of type III collagen on migration and invasion of human glioblastoma cells in vitro
8. Laminin: A potential inhibitor of rat glioma cell invasion in vitro
9. Growth factors and gangliosides stimulate laminin production by human glioma cells in vitro
10. Migration of brain tumor cells on extracellular matrix proteins in vitro correlates with tumor type and grade and involves α5 and β1 integrins
11. Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells
12. Elevated levels of Mr 92,000 type IV collagenase in human brain tumors
13. Expression and localization of a 92 kDa type IV collagenase in human astrocytomas in vivo
14. Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinase in human gliomas
15. Expression and localization of 72-kDa type IV collagenase in human malignant gliomas in vivo
16. Elevated levels of Mr 92,000 type IV collagenase during tumor growth in vivo
17. Effect of synthetic matrixmetalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro
18. The influence of sequential, in vitro passages on secretion of matrix metalloproteinases by human brain tumor cells
19. Glioma invasion in vitro: Regulation of matrix metalloprotease-2 and protein kinase C
20. Mechanisms of glioma invasion: Role of matrix-metalloproteinases
21. Suppression of matrix metalloproteinase-2-mediated cell invasion in U87MG, human glioma cells by anti-microtubule agent
22. Regulatory mechanism of 92-kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells
23. v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements
24. Stimulation of 92 kDa type collagenase promoter activity by ras is MEK1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP1 sequences
25. Suppression of oncogene-induced transformation by a deletion mutant of c-jun
26. Serum-, TPA- and Ras-induced expression from Ap-Ets-driven promoters requires Rafkinase
27. A requirement for extracellular signal-regulated kinase (ERK) function in the activation of APby HA-ras, phorbol 2 myristat 13 acetate and serum
28. JNKI: A protein kinase stimulated by uv light and Ha-ras that binds and phosphorylates the c-jun activation domain
29. Differential activation of ERK and JNK mitogen-activated protein kinases by raf- and MEKK
30. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
31. Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody
32. Integration of MAP kinase signal transduction pathways at the serum response element
33. tcf by MAP kinase stimulates ternary complex formation at c-fos promoter
34. Transcription factor ATF2 regulation by the JNK signal transduction pathway
35. ATF2 is preferentially activated by stress-activated protein kinases to mediate c-Jun induction in response to genotoxic agents
36. 38 MAP Kinases on apoptosis
37. Requirement for ceramide initiated SAPK/JNK signaling in stress-induced apoptosis
38. The role of c-Jun-terminal kinase JNK in apoptosis induced by ultraviolet C and υ radiation
39. Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor
40. v-src induced prostglandin synthase 2 gene expression by activation of the c-Jun terminal kinase and the c-Jun transcription factor
41. Cytokine-mediated regulation of rat ovarian funciton: Interleukin- 1 stimulates the accumulation of a 92-kilodlton gelatinase
42. Regulation of 92 KDa type IV collagenase exopresion by the Jun aminoterminal kinase and the extracellular signal-regulated kinase-dependent signaling cascades
43. Inhibition of the p38 mitogen-activated protein kinase by SB203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion
44. Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity
45. Role of Extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis
46. Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors
47. Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas