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Volumn 97, Issue 3, 1996, Pages 870-878

Generation and characterization of urokinase receptor-deficient mice

Author keywords

embryonic stem cells; extracellular proteolysis; fibrinolysis; gene targeting; homologous recombination

Indexed keywords

CELL RECEPTOR; DNA; NEOMYCIN; SCLEROPROTEIN; THIOGLYCOLIC ACID; UROKINASE;

EID: 0030045209     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118489     Document Type: Article
Times cited : (199)

References (37)
  • 2
    • 0027981123 scopus 로고
    • The urokinase receptor
    • Vassalli, J.D 1994. The urokinase receptor. Fibrinolysis. 8(Suppl. 1):172-181.
    • (1994) Fibrinolysis , vol.8 , Issue.1 SUPPL. , pp. 172-181
    • Vassalli, J.D.1
  • 4
    • 0027994264 scopus 로고
    • The urokinase receptor. Protein structure and role in plasmmogen activation and cancer invasion
    • Danø, K., N. Behrendt, N. Brünner, V. Ellis, M. Ploug, and C. Pyke 1994. The urokinase receptor. Protein structure and role in plasmmogen activation and cancer invasion Fibrinolysis 8(Suppl 1):189-203.
    • (1994) Fibrinolysis , vol.8 , Issue.1 SUPPL. , pp. 189-203
    • Danø, K.1    Behrendt, N.2    Brünner, N.3    Ellis, V.4    Ploug, M.5    Pyke, C.6
  • 5
    • 0025336879 scopus 로고
    • The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes
    • Estreicher, A., J. Mülhauser, J.L. Carpentier, L. Orci, and J.D. Vassalli. 1990. The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J. Cell Biol. 111:783-792.
    • (1990) J. Cell Biol. , vol.111 , pp. 783-792
    • Estreicher, A.1    Mülhauser, J.2    Carpentier, J.L.3    Orci, L.4    Vassalli, J.D.5
  • 6
    • 0028327420 scopus 로고
    • The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds
    • Rømer, J., L.R. Lund, J. Eriksen, C. Pyke, P. Kristensen, and K. Danø. 1994. The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds. J. Invest. Dermatol 102:519-522.
    • (1994) J. Invest. Dermatol , vol.102 , pp. 519-522
    • Rømer, J.1    Lund, L.R.2    Eriksen, J.3    Pyke, C.4    Kristensen, P.5    Danø, K.6
  • 7
    • 0023197175 scopus 로고
    • Urokinase-type plasminogen activator: Proenzyme, receptor and inhibitors
    • Blasi, F., J.D. Vassalli, and K. Danø. 1987. Urokinase-type plasminogen activator: proenzyme, receptor and inhibitors. J. Cell Biol. 104:801-804.
    • (1987) J. Cell Biol. , vol.104 , pp. 801-804
    • Blasi, F.1    Vassalli, J.D.2    Danø, K.3
  • 8
    • 0026063532 scopus 로고
    • Cellular receptor for urokinase plasminogen activator: Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
    • Plough, M., E. Rønne, N. Behrendt, A.L. Jensen, F Blasi, and K. Danø. 1991. Cellular receptor for urokinase plasminogen activator: carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J. Biol. Chem. 266:1926-1933.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1926-1933
    • Plough, M.1    Rønne, E.2    Behrendt, N.3    Jensen, A.L.4    Blasi, F.5    Danø, K.6
  • 9
    • 0026516219 scopus 로고
    • Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator
    • Solberg, H., D. Lober, J. Eriksen, M. Ploug, E. Rønne, N. Behrendt, K. Danø, and G. Høyer-Hansen. 1992. Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator. Eur. J. Biochem. 205:451-458.
    • (1992) Eur. J. Biochem. , vol.205 , pp. 451-458
    • Solberg, H.1    Lober, D.2    Eriksen, J.3    Ploug, M.4    Rønne, E.5    Behrendt, N.6    Danø, K.7    Høyer-Hansen, G.8
  • 10
    • 0025900910 scopus 로고
    • The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator
    • Behrendt, N , M. Plough, L. Patthy, G. Houen, F. Blasi, and K. Danø. 1991 The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator. J. Biol. Chem. 266:7842-7847.
    • (1991) J. Biol. Chem. , vol.266 , pp. 7842-7847
    • Behrendt, N.1    Plough, M.2    Patthy, L.3    Houen, G.4    Blasi, F.5    Danø, K.6
  • 11
    • 0025273735 scopus 로고
    • Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1
    • Cubellis, M.V., T.C. Wun, and F. Blasi. 1990. Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J 9:1079-1085
    • (1990) EMBO J , vol.9 , pp. 1079-1085
    • Cubellis, M.V.1    Wun, T.C.2    Blasi, F.3
  • 13
    • 0025882214 scopus 로고
    • An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines
    • Nusrat, A.R., and H.A Chapman, Jr. 1991. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. J. Clin. Invest. 87:1091-1097.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1091-1097
    • Nusrat, A.R.1    Chapman Jr., H.A.2
  • 14
    • 0026643491 scopus 로고
    • Structural requirements for the growth factor activity of the amino-terminal domain of urokinase
    • Rabbani, S.A., A.P. Mazar, S.M. Bernier, M. Haq, I. Bolivar, J. Henkin, and D. Goltzman. 1992 Structural requirements for the growth factor activity of the amino-terminal domain of urokinase. J. Biol. Chem. 267:14151-14156.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14151-14156
    • Rabbani, S.A.1    Mazar, A.P.2    Bernier, S.M.3    Haq, M.4    Bolivar, I.5    Henkin, J.6    Goltzman, D.7
  • 15
    • 0027983565 scopus 로고
    • Production of second messengers following chemotactic and mitogenic urokinase-receptor interaction in human fibroblasts and mouse fibroblasts transfected with human urokinase receptor
    • Anichini, E., G. Fibbi, M. Pucci, R. Caldini, M. Chevanne, and M. Del Rosso. 1994. Production of second messengers following chemotactic and mitogenic urokinase-receptor interaction in human fibroblasts and mouse fibroblasts transfected with human urokinase receptor Exp Cell Res. 213:438-448.
    • (1994) Exp Cell Res. , vol.213 , pp. 438-448
    • Anichini, E.1    Fibbi, G.2    Pucci, M.3    Caldini, R.4    Chevanne, M.5    Del Rosso, M.6
  • 17
    • 0345340044 scopus 로고
    • Arterial neointima formation after trauma in mice with inactivation of the t-PA, u-PA or PAI-1 genes
    • Abstr. 280
    • Carmeliet, P., J.M. Stassen, M. De Mol, C. Declercq, A. Bouché, and D. Collen 1994. Arterial neointima formation after trauma in mice with inactivation of the t-PA, u-PA or PAI-1 genes. Fibrinolysis 8(Suppl. 1):101 (Abstr. 280).
    • (1994) Fibrinolysis , vol.8 , Issue.1 SUPPL. , pp. 101
    • Carmeliet, P.1    Stassen, J.M.2    De Mol, M.3    Declercq, C.4    Bouché, A.5    Collen, D.6
  • 18
    • 0022879079 scopus 로고
    • Comparative kinetic analysis of the activation of human plasminogen by natural and recombinant single-chain urokinase-type plasminogen activator
    • Lijnen, H.R., B. Van Hoef, and D. Collen. 1986. Comparative kinetic analysis of the activation of human plasminogen by natural and recombinant single-chain urokinase-type plasminogen activator. Biochim. Biophys Acta. 884:402-408.
    • (1986) Biochim. Biophys Acta , vol.884 , pp. 402-408
    • Lijnen, H.R.1    Van Hoef, B.2    Collen, D.3
  • 19
    • 0025780879 scopus 로고
    • Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
    • Tybulewicz, V.L., C.E. Crawford, P.K. Jackson, R.T. Bronson, and R.C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153-1163.
    • (1991) Cell , vol.65 , pp. 1153-1163
    • Tybulewicz, V.L.1    Crawford, C.E.2    Jackson, P.K.3    Bronson, R.T.4    Mulligan, R.C.5
  • 20
    • 0028130192 scopus 로고
    • The murine urokinase-type plasminogen activator receptor gene
    • Suh, T.T., C. Nerlov, K. Danø, and J.L. Degen. 1994. The murine urokinase-type plasminogen activator receptor gene. J. Biol. Chem. 269:25992-25998.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25992-25998
    • Suh, T.T.1    Nerlov, C.2    Danø, K.3    Degen, J.L.4
  • 21
    • 0026338740 scopus 로고
    • Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract
    • Kristensen, P . J. Eriksen, F. Blasi, and K. Danø. 1991. Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract. J. Cell Biol. 115:1763-1771.
    • (1991) J. Cell Biol. , vol.115 , pp. 1763-1771
    • Kristensen1    Eriksen, P.J.2    Blasi, F.3    Danø, K.4
  • 22
    • 0021891053 scopus 로고
    • The in vitro development of blastocyst-derived embryonic stem cell lines; formation of visceral yolk sac, blood islands and myocardium
    • Doetschman, T.C., H. Eistetter, M. Katz, W. Schmidt, and R Kemler. 1985 The in vitro development of blastocyst-derived embryonic stem cell lines; formation of visceral yolk sac, blood islands and myocardium. J. Embryol Exp Morphol. 87:27-45.
    • (1985) J. Embryol Exp Morphol. , vol.87 , pp. 27-45
    • Doetschman, T.C.1    Eistetter, H.2    Katz, M.3    Schmidt, W.4    Kemler, R.5
  • 26
    • 0002429430 scopus 로고
    • Production of targeted embryonic stem cell clones
    • A.L. Joyner, editor. IRL Press, Oxford
    • Wurst, W., and A.L. Joyner. 1993. Production of targeted embryonic stem cell clones. In Gene Targeting. A Practical Approach. A.L. Joyner, editor. IRL Press, Oxford. 33-61.
    • (1993) Gene Targeting. A Practical Approach , pp. 33-61
    • Wurst, W.1    Joyner, A.L.2
  • 27
    • 0025040901 scopus 로고
    • A hamster pulmonary embolism model for the evaluation of the thrombolytic and pharmacokinetic properties of thrombolytic agents
    • Stassen, J.M., I. Vanlinthout, H.R. Lijnen, and D. Collen. 1990. A hamster pulmonary embolism model for the evaluation of the thrombolytic and pharmacokinetic properties of thrombolytic agents. Fibrinolysis. 4(Suppl 2):15-21.
    • (1990) Fibrinolysis , vol.4 , Issue.2 SUPPL. , pp. 15-21
    • Stassen, J.M.1    Vanlinthout, I.2    Lijnen, H.R.3    Collen, D.4
  • 28
    • 0025354463 scopus 로고
    • Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects on extracellular matrix degradation
    • Baker, M.S., P. Bleakley, G.C. Woodrow, and W.F. Doe. 1990. Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects on extracellular matrix degradation. Cancer Res. 50:4676-4684.
    • (1990) Cancer Res. , vol.50 , pp. 4676-4684
    • Baker, M.S.1    Bleakley, P.2    Woodrow, G.C.3    Doe, W.F.4
  • 29
    • 0028024011 scopus 로고
    • Characterization of the murine plasma fibrinolytic system
    • Lijnen, H.R., B. Van Hoef, V. Beelen, and D. Collen. 1994. Characterization of the murine plasma fibrinolytic system. Eur. J Biochem. 224:863-871.
    • (1994) Eur. J Biochem. , vol.224 , pp. 863-871
    • Lijnen, H.R.1    Van Hoef, B.2    Beelen, V.3    Collen, D.4
  • 30
    • 0023223148 scopus 로고
    • The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases
    • Appella, E., E.A. Robinson, S.J. Ullrich, M.P. Stoppelli, A. Corti, G Cassani, and F. Blasi. 1987. The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J. Biol. Chem. 262. 4437-4440.
    • (1987) J. Biol. Chem. , vol.262 , pp. 4437-4440
    • Appella, E.1    Robinson, E.A.2    Ullrich, S.J.3    Stoppelli, M.P.4    Corti, A.5    Cassani, G.6    Blasi, F.7
  • 31
    • 0024597669 scopus 로고
    • Characterization of the cellular binding site for the urokinase-type plasminogen activator
    • Estreicher, A., A. Wohlwend, D. Belin, W.D. Schleuning, and J.-D Vassalli. 1989. Characterization of the cellular binding site for the urokinase-type plasminogen activator. J. Biol Chem. 264:1180-1189.
    • (1989) J. Biol Chem. , vol.264 , pp. 1180-1189
    • Estreicher, A.1    Wohlwend, A.2    Belin, D.3    Schleuning, W.D.4    Vassalli, J.-D.5
  • 32
    • 0015990028 scopus 로고
    • Secretion of plasminogen activator by stimulated macrophages
    • Unkeless, J.C., S. Gordon, and E. Reich. 1974. Secretion of plasminogen activator by stimulated macrophages. J. Exp Med. 139:834-850.
    • (1974) J. Exp Med. , vol.139 , pp. 834-850
    • Unkeless, J.C.1    Gordon, S.2    Reich, E.3
  • 33
  • 36
    • 0026439778 scopus 로고
    • LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation
    • Herz, J., D.E. Clouthier, and R.E. Hammer. 1992. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell. 71:411-421.
    • (1992) Cell , vol.71 , pp. 411-421
    • Herz, J.1    Clouthier, D.E.2    Hammer, R.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.