메뉴 건너뛰기




Volumn 174, Issue 24, 2017, Pages 4716-4724

Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

6 [[2 [[4 (2,4 DICHLOROPHENYL) 5 (4 METHYL 1H IMIDAZOL 2 YL) 2 PYRIMIDINYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; BETA CATENIN; CT 99021; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; POLO LIKE KINASE 1; WNT3A PROTEIN;

EID: 85022340007     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13871     Document Type: Review
Times cited : (16)

References (66)
  • 3
    • 55849125793 scopus 로고    scopus 로고
    • Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo
    • Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L et al. (2008). Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One 3: e3517.
    • (2008) Plos One , vol.3
    • Andersson, E.R.1    Prakash, N.2    Cajanek, L.3    Minina, E.4    Bryja, V.5    Bryjova, L.6
  • 4
    • 84873730294 scopus 로고    scopus 로고
    • Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells
    • Andersson ER, Saltó C, Villaescusa JC, Cajanek L, Yang S, Bryjova L et al. (2013). Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc Natl Acad Sci U S A 110: E602–E610.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E602-E610
    • Andersson, E.R.1    Saltó, C.2    Villaescusa, J.C.3    Cajanek, L.4    Yang, S.5    Bryjova, L.6
  • 5
    • 84896846861 scopus 로고    scopus 로고
    • Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson’s disease
    • Arenas E (2014). Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson’s disease. J Mol Cell Biol 6: 42–53.
    • (2014) J Mol Cell Biol , vol.6 , pp. 42-53
    • Arenas, E.1
  • 6
    • 84929884392 scopus 로고    scopus 로고
    • How to make a midbrain dopaminergic neuron
    • Arenas E, Denham M, Villaescusa JC (2015). How to make a midbrain dopaminergic neuron. Development 142: 1918–1936.
    • (2015) Development , vol.142 , pp. 1918-1936
    • Arenas, E.1    Denham, M.2    Villaescusa, J.C.3
  • 8
    • 84870772482 scopus 로고    scopus 로고
    • Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson’s disease
    • Barker RA, Barrett J, Mason SL, Björklund A (2013). Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson’s disease. Lancet Neurol 12: 84–91.
    • (2013) Lancet Neurol , vol.12 , pp. 84-91
    • Barker, R.A.1    Barrett, J.2    Mason, S.L.3    Björklund, A.4
  • 9
    • 84941022742 scopus 로고    scopus 로고
    • Cell-based therapies for Parkinson disease—past insights and future potential
    • Barker RA, Drouin-Ouellet J, Parmar M (2015a). Cell-based therapies for Parkinson disease—past insights and future potential. Nat Rev Neurol 11: 492–503.
    • (2015) Nat Rev Neurol , vol.11 , pp. 492-503
    • Barker, R.A.1    Drouin-Ouellet, J.2    Parmar, M.3
  • 10
    • 84963754200 scopus 로고    scopus 로고
    • G-Force PD: A global initiative in coordinating stem cell-based dopamine treatments for Parkinson’s disease
    • Barker RA, Studer L, Cattaneo E, Takahashi J (2015b). G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson’s disease. Npj Park Dis 1: 15017.
    • (2015) Npj Park Dis , vol.1 , pp. 15017
    • Barker, R.A.1    Studer, L.2    Cattaneo, E.3    Takahashi, J.4
  • 12
    • 42549096546 scopus 로고    scopus 로고
    • Beyond Wnt inhibition: New functions of secreted Frizzled-related proteins in development and disease
    • Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J (2008). Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 121: 737–746.
    • (2008) J Cell Sci , vol.121 , pp. 737-746
    • Bovolenta, P.1    Esteve, P.2    Ruiz, J.M.3    Cisneros, E.4    Lopez-Rios, J.5
  • 13
    • 78649835886 scopus 로고    scopus 로고
    • WNT unrelated activities in commercially available preparations of recombinant WNT3a
    • Cajanek L, Adlerz L, Bryja V, Arenas E (2010). WNT unrelated activities in commercially available preparations of recombinant WNT3a. J Cell Biochem 111: 1077–1079.
    • (2010) J Cell Biochem , vol.111 , pp. 1077-1079
    • Cajanek, L.1    Adlerz, L.2    Bryja, V.3    Arenas, E.4
  • 14
    • 84964664290 scopus 로고    scopus 로고
    • Chemical control of grafted human PSC-derived neurons in a mouse model of Parkinson’s disease
    • Chen Y, Xiong M, Dong Y, Haberman A, Cao J, Liu H et al. (2016). Chemical control of grafted human PSC-derived neurons in a mouse model of Parkinson’s disease. Cell Stem Cell 18: 817–826.
    • (2016) Cell Stem Cell , vol.18 , pp. 817-826
    • Chen, Y.1    Xiong, M.2    Dong, Y.3    Haberman, A.4    Cao, J.5    Liu, H.6
  • 15
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers H, Nusse R (2012). Wnt/β-catenin signaling and disease. Cell 149: 1192–1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 16
    • 84877131537 scopus 로고    scopus 로고
    • Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/β-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis
    • Das DS, Wadhwa N, Kunj N, Sarda K, Pradhan BS, Majumdar SS (2013). Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/β-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis. PLoS One 8: e63603.
    • (2013) Plos One , vol.8
    • Das, D.S.1    Wadhwa, N.2    Kunj, N.3    Sarda, K.4    Pradhan, B.S.5    Majumdar, S.S.6
  • 17
    • 84867911591 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage
    • Denham M, Bye C, Leung J, Conley BJ, Thompson LH, Dottori M (2012). Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. Stem Cells 30: 2400–2411.
    • (2012) Stem Cells , vol.30 , pp. 2400-2411
    • Denham, M.1    Bye, C.2    Leung, J.3    Conley, B.J.4    Thompson, L.H.5    Dottori, M.6
  • 18
    • 34249311572 scopus 로고    scopus 로고
    • Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/betacatenin signaling shown by using an allelic series of embryonic stem cell lines
    • Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR (2007). Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/betacatenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell 12: 957–971.
    • (2007) Dev Cell , vol.12 , pp. 957-971
    • Doble, B.W.1    Patel, S.2    Wood, G.A.3    Kockeritz, L.K.4    Woodgett, J.R.5
  • 19
    • 84896084435 scopus 로고    scopus 로고
    • Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation
    • Doi D, Samata B, Katsukawa M, Kikuchi T, Morizane A, Ono Y et al. (2014). Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation. Stem Cell Reports 2: 337–350.
    • (2014) Stem Cell Reports , vol.2 , pp. 337-350
    • Doi, D.1    Samata, B.2    Katsukawa, M.3    Kikuchi, T.4    Morizane, A.5    Ono, Y.6
  • 20
    • 0038727936 scopus 로고    scopus 로고
    • Description of Parkinson’s disease as a clinical syndrome
    • Fahn S (2003). Description of Parkinson’s disease as a clinical syndrome. Ann N Y Acad Sci 991: 1–14.
    • (2003) Ann N Y Acad Sci , vol.991 , pp. 1-14
    • Fahn, S.1
  • 21
    • 84906573208 scopus 로고    scopus 로고
    • Diverse roles for Wnt7a in ventral midbrain neurogenesis and dopaminergic axon morphogenesis
    • Fernando C, Kele J, Bye C, Niclis JC, Alsanie W, Blakely BD et al. (2014). Diverse roles for Wnt7a in ventral midbrain neurogenesis and dopaminergic axon morphogenesis. Stem Cells Dev 23: 1991–2003.
    • (2014) Stem Cells Dev , vol.23 , pp. 1991-2003
    • Fernando, C.1    Kele, J.2    Bye, C.3    Niclis, J.C.4    Alsanie, W.5    Blakely, B.D.6
  • 22
    • 84942924480 scopus 로고    scopus 로고
    • Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse
    • Fukusumi Y, Meier F, Gotz S, Matheus F, Irmler M, Beckervordersandforth R et al. (2015). Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse. J Neurosci 35: 13385–13401.
    • (2015) J Neurosci , vol.35 , pp. 13385-13401
    • Fukusumi, Y.1    Meier, F.2    Gotz, S.3    Matheus, F.4    Irmler, M.5    Beckervordersandforth, R.6
  • 23
    • 84868665485 scopus 로고    scopus 로고
    • Wnt regulation of planar cell polarity (PCP)
    • Gao B (2012). Wnt regulation of planar cell polarity (PCP). Curr Top Dev Biol 101: 263–295.
    • (2012) Curr Top Dev Biol , vol.101 , pp. 263-295
    • Gao, B.1
  • 24
    • 84870054767 scopus 로고    scopus 로고
    • Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability
    • Giovannantonio LGD, Salvio MD, Acampora D, Prakash N, Wurst W, Simeone A (2013). Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability. Dev Biol 373: 176–183.
    • (2013) Dev Biol , vol.373 , pp. 176-183
    • Giovannantonio, L.1    Salvio, M.D.2    Acampora, D.3    Prakash, N.4    Wurst, W.5    Simeone, A.6
  • 25
    • 79960240783 scopus 로고    scopus 로고
    • Planar cell polarity: Coordinating morphogenetic cell behaviors with embryonic polarity
    • Gray RS, Roszko I, Solnica-Krezel L (2011). Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity. Dev Cell 21: 120–133.
    • (2011) Dev Cell , vol.21 , pp. 120-133
    • Gray, R.S.1    Roszko, I.2    Solnica-Krezel, L.3
  • 26
    • 84922662454 scopus 로고    scopus 로고
    • Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson’s disease
    • Grealish S, Diguet E, Kirkeby A, Mattsson B, Heuer A, Bramoulle Y et al. (2014). Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson’s disease. Cell Stem Cell 15: 653–665.
    • (2014) Cell Stem Cell , vol.15 , pp. 653-665
    • Grealish, S.1    Diguet, E.2    Kirkeby, A.3    Mattsson, B.4    Heuer, A.5    Bramoulle, Y.6
  • 27
    • 0035967897 scopus 로고    scopus 로고
    • Regulation of GSK-3: A cellular multiprocessor
    • Harwood AJ (2001). Regulation of GSK-3: a cellular multiprocessor. Cell 105: 821–824.
    • (2001) Cell , vol.105 , pp. 821-824
    • Harwood, A.J.1
  • 28
    • 75549087261 scopus 로고    scopus 로고
    • Emerging roles of Wnts in the adult nervous system
    • Inestrosa NC, Arenas E (2010). Emerging roles of Wnts in the adult nervous system. Nat Rev Neurosci 11: 77–86.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 77-86
    • Inestrosa, N.C.1    Arenas, E.2
  • 30
    • 79959403670 scopus 로고    scopus 로고
    • Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq
    • Islam S, Kjällquist U, Moliner A, Zajac P, Fan JB, Lönnerberg P et al. (2011). Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq. Genome Res 21: 1160–1167.
    • (2011) Genome Res , vol.21 , pp. 1160-1167
    • Islam, S.1    Kjällquist, U.2    Moliner, A.3    Zajac, P.4    Fan, J.B.5    Lönnerberg, P.6
  • 31
    • 84895069488 scopus 로고    scopus 로고
    • Quantitative single-cell RNA-seq with unique molecular identifiers
    • Islam S, Zeisel A, Joost S, Manno GL, Zajac P, Kasper M et al. (2014). Quantitative single-cell RNA-seq with unique molecular identifiers. Nat Methods 11: 163–166.
    • (2014) Nat Methods , vol.11 , pp. 163-166
    • Islam, S.1    Zeisel, A.2    Joost, S.3    Manno, G.L.4    Zajac, P.5    Kasper, M.6
  • 32
    • 85018920897 scopus 로고    scopus 로고
    • SurrogateWnt agonists that phenocopy canonicalWnt and β-catenin signalling
    • Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA et al. (2017). SurrogateWnt agonists that phenocopy canonicalWnt and β-catenin signalling. Nature: 1–19.
    • (2017) Nature , pp. 1-19
    • Janda, C.Y.1    Dang, L.T.2    You, C.3    Chang, J.4    De Lau, W.5    Zhong, Z.A.6
  • 33
    • 73349119711 scopus 로고    scopus 로고
    • A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion
    • Jenei V, Sherwood V, Howlin J, Linnskog R, Säfholm A, Axelsson L et al. (2009). A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci U S A 106: 19473–19478.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 19473-19478
    • Jenei, V.1    Sherwood, V.2    Howlin, J.3    Linnskog, R.4    Säfholm, A.5    Axelsson, L.6
  • 34
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of theWnt signalling pathway
    • Kawano Y, Kypta R (2003). Secreted antagonists of theWnt signalling pathway. J Cell Sci 116: 2627–2634.
    • (2003) J Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 35
    • 84892394291 scopus 로고    scopus 로고
    • Long-term clinical outcome of fetal cell transplantation for Parkinson disease: Two case reports
    • Kefalopoulou Z, Politis M, Piccini P, Mencacci N, Bhatia K, Jahanshahi M et al. (2014). Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reports. JAMA Neurol 71: 83–87.
    • (2014) JAMA Neurol , vol.71 , pp. 83-87
    • Kefalopoulou, Z.1    Politis, M.2    Piccini, P.3    Mencacci, N.4    Bhatia, K.5    Jahanshahi, M.6
  • 36
    • 84860505844 scopus 로고    scopus 로고
    • SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells
    • Kele J, Andersson ER, Villaescusa JC, Cajanek L, Parish CL, Bonilla S et al. (2012). SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells 30: 865–875.
    • (2012) Stem Cells , vol.30 , pp. 865-875
    • Kele, J.1    Ersson, E.R.2    Villaescusa, J.C.3    Cajanek, L.4    Parish, C.L.5    Bonilla, S.6
  • 37
    • 80054777961 scopus 로고    scopus 로고
    • New insights into the mechanism of Wnt signaling pathway activation
    • Kikuchi A, Yamamoto H, Sato A, Matsumoto S (2011). New insights into the mechanism of Wnt signaling pathway activation. Int Rev Cell Mol Biol 291: 21–71.
    • (2011) Int Rev Cell Mol Biol , vol.291 , pp. 21-71
    • Kikuchi, A.1    Yamamoto, H.2    Sato, A.3    Matsumoto, S.4
  • 39
    • 84863094725 scopus 로고    scopus 로고
    • Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
    • Kirkeby A, Grealish S, Wolf DA, Nelander J, Wood J, Lundblad M et al. (2012). Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Rep 1: 703–714.
    • (2012) Cell Rep , vol.1 , pp. 703-714
    • Kirkeby, A.1    Grealish, S.2    Wolf, D.A.3    Nelander, J.4    Wood, J.5    Lundblad, M.6
  • 40
    • 84995653443 scopus 로고    scopus 로고
    • Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson’s disease
    • Kirkeby A, Nolbrant S, Tiklova K, Heuer A, Kee N, Cardoso T et al. (2017). Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson’s disease. Cell Stem Cell 20: 135–148.
    • (2017) Cell Stem Cell , vol.20 , pp. 135-148
    • Kirkeby, A.1    Nolbrant, S.2    Tiklova, K.3    Heuer, A.4    Kee, N.5    Cardoso, T.6
  • 42
    • 84355166561 scopus 로고    scopus 로고
    • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
    • Kriks S, Shim J-W, Piao J, Ganat YM, Wakeman DR, Xie Z et al. (2011). Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature 480: 547–551.
    • (2011) Nature , vol.480 , pp. 547-551
    • Kriks, S.1    Shim, J.-W.2    Piao, J.3    Ganat, Y.M.4    Wakeman, D.R.5    Xie, Z.6
  • 43
    • 84990876505 scopus 로고    scopus 로고
    • Molecular diversity of midbrain development in mouse, human, and stem cells
    • La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A et al. (2016). Molecular diversity of midbrain development in mouse, human, and stem cells. Cell 167: 566–580. e19.
    • (2016) Cell , vol.167 , pp. 566-580
    • La Manno, G.1    Gyllborg, D.2    Codeluppi, S.3    Nishimura, K.4    Salto, C.5    Zeisel, A.6
  • 44
    • 84973324671 scopus 로고    scopus 로고
    • Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain
    • Li W, Englund E, Widner H, Mattsson B, vanWesten D, Lätt J et al. (2016). Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain. Proc Natl Acad Sci U S A 113: 6544–6549.
    • (2016) Proc Natl Acad Sci U S A , vol.113 , pp. 6544-6549
    • Li, W.1    Englund, E.2    Widner, H.3    Mattsson, B.4    Vanwesten, D.5    Lätt, J.6
  • 45
    • 0032908043 scopus 로고    scopus 로고
    • FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression
    • Martinez S, Crossley PH, Cobos I, Rubenstein JL, Martin GR (1999). FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development 126: 1189–1200.
    • (1999) Development , vol.126 , pp. 1189-1200
    • Martinez, S.1    Crossley, P.H.2    Cobos, I.3    Rubenstein, J.L.4    Martin, G.R.5
  • 46
    • 0025188130 scopus 로고
    • The Wnt-1 (Int-1) proto-oncogene is required for development of a large region of the mouse brain
    • McMahon AP, Bradley A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62: 1073–1085.
    • (1990) Cell , vol.62 , pp. 1073-1085
    • McMahon, A.P.1    Bradley, A.2
  • 47
    • 39549091698 scopus 로고    scopus 로고
    • Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina
    • Nakamura REI, Hunter DD, Yi H, Brunken WJ, Hackam AS (2007). Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina. BMC Cell Biol 8: 52.
    • (2007) BMC Cell Biol , vol.8 , pp. 52
    • Nakamura, R.1    Hunter, D.D.2    Yi, H.3    Brunken, W.J.4    Hackam, A.S.5
  • 48
    • 33845359084 scopus 로고    scopus 로고
    • Function and biological roles of the Dickkopf family of Wnt modulators
    • Niehrs C (2006). Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 25: 7469–7481.
    • (2006) Oncogene , vol.25 , pp. 7469-7481
    • Niehrs, C.1
  • 49
    • 84870252814 scopus 로고    scopus 로고
    • The complex world ofWNT receptor signalling
    • Niehrs C (2012). The complex world ofWNT receptor signalling. Nat Rev Mol Cell Biol 13: 767–779.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 767-779
    • Niehrs, C.1
  • 50
    • 84908356894 scopus 로고    scopus 로고
    • Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons
    • Panman L, Papathanou M, Laguna A, Oosterveen T, Volakakis N, Acampora D et al. (2014). Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons. Cell Rep 8: 1018–1025.
    • (2014) Cell Rep , vol.8 , pp. 1018-1025
    • Panman, L.1    Papathanou, M.2    Laguna, A.3    Oosterveen, T.4    Volakakis, N.5    Acampora, D.6
  • 51
    • 69549084753 scopus 로고    scopus 로고
    • Non-motor symptoms in Parkinson’s disease
    • Park A, Stacy M (2009). Non-motor symptoms in Parkinson’s disease. J Neurol 256 (Suppl): 293–298.
    • (2009) J Neurol , vol.256 , pp. 293-298
    • Park, A.1    Stacy, M.2
  • 52
    • 85009348240 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A kinase for all pathways?
    • Patel P, Woodgett JR (2017). Glycogen synthase kinase 3: a kinase for all pathways? Curr Top Dev Biol 123: 277–302.
    • (2017) Curr Top Dev Biol , vol.123 , pp. 277-302
    • Patel, P.1    Woodgett, J.R.2
  • 53
    • 31644448700 scopus 로고    scopus 로고
    • A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
    • Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A et al. (2006). A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133: 89–98.
    • (2006) Development , vol.133 , pp. 89-98
    • Prakash, N.1    Brodski, C.2    Naserke, T.3    Puelles, E.4    Gogoi, R.5    Hall, A.6
  • 54
    • 84866511789 scopus 로고    scopus 로고
    • Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens
    • Ribeiro D, Laguna Goya R, Ravindran G, Vuono R, Parish CL, Foldi C et al. (2013). Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens. Neurobiol Dis 49: 118–127.
    • (2013) Neurobiol Dis , vol.49 , pp. 118-127
    • Ribeiro, D.1    Laguna Goya, R.2    Ravindran, G.3    Vuono, R.4    Parish, C.L.5    Foldi, C.6
  • 55
    • 33645789040 scopus 로고    scopus 로고
    • A formylated hexapeptide ligand mimics the ability ofWnt-5a to impair migration of human breast epithelial cells
    • Säfholm A, Leandersson K, Dejmek J, Nielsen CK, Villoutreix BO, Andersson T (2006). A formylated hexapeptide ligand mimics the ability ofWnt-5a to impair migration of human breast epithelial cells. J Biol Chem 281: 2740–2749.
    • (2006) J Biol Chem , vol.281 , pp. 2740-2749
    • Säfholm, A.1    Leandersson, K.2    Dejmek, J.3    Nielsen, C.K.4    Villoutreix, B.O.5    Ersson, T.6
  • 56
    • 58149190789 scopus 로고    scopus 로고
    • The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility
    • Säfholm A, Tuomela J, Rosenkvist J, Dejmek J, Härkönen P, Andersson T (2008). The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res 14: 6556–6563.
    • (2008) Clin Cancer Res , vol.14 , pp. 6556-6563
    • Säfholm, A.1    Tuomela, J.2    Rosenkvist, J.3    Dejmek, J.4    Härkönen, P.5    Ersson, T.6
  • 58
    • 84976865494 scopus 로고    scopus 로고
    • The IUPHAR/BPS guide to PHARMACOLOGY in 2016: Towards curated quantitative interactions between 1300 protein targets and 6000 ligands
    • Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH et al. (2016). The IUPHAR/BPS guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Res 44: D1054–D1068.
    • (2016) Nucleic Acids Res , vol.44 , pp. D1054-D1068
    • Southan, C.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Pawson, A.J.5    Alexander, S.6
  • 59
    • 84923294447 scopus 로고    scopus 로고
    • Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson’s disease model
    • Steinbeck JA, Choi SJ, Mrejeru A, Ganat Y, Deisseroth K, Sulzer D et al. (2015). Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson’s disease model. Nat Biotechnol 33: 204–209.
    • (2015) Nat Biotechnol , vol.33 , pp. 204-209
    • Steinbeck, J.A.1    Choi, S.J.2    Mrejeru, A.3    Ganat, Y.4    Deisseroth, K.5    Sulzer, D.6
  • 60
    • 78650484935 scopus 로고    scopus 로고
    • Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes
    • Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I et al. (2010). Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell 143: 1136–1148.
    • (2010) Cell , vol.143 , pp. 1136-1148
    • Taelman, V.F.1    Dobrowolski, R.2    Plouhinec, J.L.3    Fuentealba, L.C.4    Vorwald, P.P.5    Gumper, I.6
  • 61
    • 0025074908 scopus 로고
    • Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
    • Thomas KR, Capecchi MR (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346: 847–850.
    • (1990) Nature , vol.346 , pp. 847-850
    • Thomas, K.R.1    Capecchi, M.R.2
  • 62
    • 84862171364 scopus 로고    scopus 로고
    • The many faces and functions of β-catenin
    • Valenta T, Hausmann G, Basler K (2012). The many faces and functions of β-catenin. EMBO J 31: 2714–2736.
    • (2012) EMBO J , vol.31 , pp. 2714-2736
    • Valenta, T.1    Hausmann, G.2    Basler, K.3
  • 63
    • 84978757601 scopus 로고    scopus 로고
    • Inhibitors of glycogen synthase kinase 3 with exquisite kinome-wide selectivity and their functional effects
    • Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J et al. (2016). Inhibitors of glycogen synthase kinase 3 with exquisite kinome-wide selectivity and their functional effects. ACS Chem Biol 11: 1952–1963.
    • (2016) ACS Chem Biol , vol.11 , pp. 1952-1963
    • Wagner, F.F.1    Bishop, J.A.2    Gale, J.P.3    Shi, X.4    Walk, M.5    Ketterman, J.6
  • 65
    • 84864353544 scopus 로고    scopus 로고
    • Specification of midbrain dopamine neurons from primate pluripotent stem cells
    • Xi J, Liu Y, Liu H, Chen H, Emborg ME, Zhang S-C (2012). Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells 30: 1655–1663.
    • (2012) Stem Cells , vol.30 , pp. 1655-1663
    • Xi, J.1    Liu, Y.2    Liu, H.3    Chen, H.4    Emborg, M.E.5    Zhang, S.-C.6
  • 66
    • 84888341007 scopus 로고    scopus 로고
    • Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells
    • Xiang T, Li L, Yin X, Zhong L, Peng W, Qiu Z et al. (2013). Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells. J Cell Mol Med 17: 1236–1246.
    • (2013) J Cell Mol Med , vol.17 , pp. 1236-1246
    • Xiang, T.1    Li, L.2    Yin, X.3    Zhong, L.4    Peng, W.5    Qiu, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.