Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease

Cell Stem Cell

Volumn 20, Issue 1, 2017, Pages 135-148

  Kirkeby, Agnete ^a,b   Nolbrant, Sara ^a,b   Tiklova, Katarina ^c   Heuer, Andreas ^a,b   Kee, Nigel ^c   Cardoso, Tiago ^a,b   Ottosson, Daniella Rylander ^a,b   Lelos, Mariah J ^d   Rifes, Pedro ^a,b   Dunnett, Stephen B ^d   Grealish, Shane ^a,b   Perlmann, Thomas ^c   Parmar, Malin ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

diencephalon; dopaminergic neurons; FGF8; GMP; good manufacturing practice; hESCs; human embryonic stem cells; MHB; midbrain hindbrain boundary; Parkinson's disease; STN; subthalamic nucleus; transplantation; ventral midbrain; VM

Indexed keywords

AADC PROTEIN; BARHL1 PROTEIN; BARHL2 PROTEIN; CELL MARKER; CNPY1 PROTEIN; CORIN; DOPAMINE; EN1 PROTEIN; EN2 PROTEIN; ETV4 PROTEIN; ETV5 PROTEIN; FIBROBLAST GROWTH FACTOR 8; HEPATOCYTE NUCLEAR FACTOR 3BETA; LMX1A PROTEIN; LMX1B PROTEIN; NUCLEAR RECEPTOR RELATED FACTOR 1; RNA; SP5 PROTEIN; TLE4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP1; TRANSCRIPTION FACTOR FOXP2; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR PAX8; TRANSCRIPTION FACTOR PITX2; TRANSCRIPTION FACTOR SIX3; TRANSCRIPTION FACTOR SIX6; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; WNT1 PROTEIN; BIOLOGICAL MARKER; LAMININ;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FATE; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FEMALE; GENE EXPRESSION; GOOD MANUFACTURING PRACTICE; GRAFT SIZE; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; MESENCEPHALON; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PARKINSON DISEASE; PREDICTION; PRIORITY JOURNAL; RAT; RNA SEQUENCE; SEQUENCE ANALYSIS; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; EXTRACELLULAR MATRIX; METABOLISM; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; SUBTHALAMIC NUCLEUS; TIME FACTOR; TRANSLATIONAL RESEARCH; TRANSPLANTATION;

ANIMALS; BIOMARKERS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; DOPAMINE; DOPAMINERGIC NEURONS; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST GROWTH FACTOR 8; HUMAN EMBRYONIC STEM CELLS; HUMANS; LAMININ; MESENCEPHALON; PARKINSON DISEASE; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SEQUENCE ANALYSIS, RNA; STEM CELL TRANSPLANTATION; SUBTHALAMIC NUCLEUS; TIME FACTORS; TRANSLATIONAL MEDICAL RESEARCH; TREATMENT OUTCOME;

EID: 84995653443     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.09.004     Document Type: Article

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