Network-assisted target identification for haploinsufficiency and homozygous profiling screens

PLoS Computational Biology

Volumn 13, Issue 6, 2017, Pages

  Wang, Sheng ^a   Peng, Jian ^a  

^a University of Illinois at Urbana Champaign   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFECTS; DRUG INTERACTIONS; GENES;

ANALYSIS METHOD; DRUG DISCOVERY; DRUG TARGET IDENTIFICATION; GENETIC INTERACTION; GENOMICS; HIGH-THROUGHPUT SCREENS; INTERACTION NETWORKS; MECHANISM OF ACTION; SCORING METHODS; TARGET'S IDENTIFICATIONS;

GENOME;

BAFILOMYCIN A1; CAMPTOTHECIN; CURCUMIN; CYCLOHEXIMIDE; FENPROPIMORPH; FLUCONAZOLE; FLUOROURACIL; GELDANAMYCIN; HYDROCHLORIC ACID; HYDROXYUREA; LATRUNCULIN A; METHOTREXATE; NOCODAZOLE; RADICICOL; RAPAMYCIN; SPHINGOSINE; STAUROSPORINE; TRICLOSAN; ANTIFUNGAL AGENT;

ARTICLE; CHEMICAL GENETICS; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; GENE DELETION; GENE INTERACTION; GENETIC INTERACTION NETWORK ASSISTED TARGET IDENTIFICATION; GENETIC PROCEDURES; GENOME ANALYSIS; HAPLOINSUFFICIENCY PROFILING; HOMOZYGOUS PROFILING; PHENOTYPE; YEAST; BIOASSAY; DRUG DEVELOPMENT; DRUG EFFECTS; FUNGAL GENOME; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; HAPLOINSUFFICIENCY; HOMOZYGOTE; NETWORK META-ANALYSIS; PROCEDURES; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

ANTIFUNGAL AGENTS; BIOLOGICAL ASSAY; DRUG DISCOVERY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; GENE TARGETING; GENOME, FUNGAL; HAPLOINSUFFICIENCY; HOMOZYGOTE; NETWORK META-ANALYSIS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 85021707614     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1005553     Document Type: Article

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