MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

PLoS Biology

Volumn 15, Issue 6, 2017, Pages

  Shaler, Christopher R ^a   Choi, Joshua ^a   Rudak, Patrick T ^a   Memarnejadian, Arash ^a   Szabo, Peter A ^a   Tun Abraham, Mauro E ^a   Rossjohn, Jamie ^b,c,d   Corbett, Alexandra J ^e   McCluskey, James ^e   McCormick, John K ^a,f   Lantz, Olivier ^g   Hernandez Alejandro, Roberto ^a,h   Haeryfar, S M Mansour ^a,f  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MONASH UNIVERSITY   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^g PSL RESEARCH UNIVERSITY   (France)

^h UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CELL PROTEIN; GAMMA INTERFERON; HEPATITIS A VIRUS CELLULAR RECEPTOR 2; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 2; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY COMPLEX RELATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PROGRAMMED DEATH 1 RECEPTOR; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL PROTECTION; CHIMERA; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HYPERSENSITIVITY; IMMUNOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INTRACELLULAR SIGNALING; KLEBSIELLA PNEUMONIAE; MOUSE; MUCOSAL-ASSOCIATED INVARIANT T CELL; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; BLOOD; BONE MARROW CELL; CELL CULTURE; CELL LINE; COMPARATIVE STUDY; CROSS BREEDING; CYTOLOGY; DRUG EFFECTS; FEMALE; GERMFREE ANIMAL; HISTOCOMPATIBILITY; HYBRIDOMA; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; MONONUCLEAR CELL; NONOBESE DIABETIC MOUSE; SCID MOUSE; SECRETION (PROCESS); STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, BACTERIAL; BONE MARROW CELLS; CELL LINE; CELLS, CULTURED; CLONAL ANERGY; CROSSES, GENETIC; ENTEROTOXINS; FEMALE; HUMANS; HYBRIDOMAS; IMMUNITY, INNATE; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; MUCOSAL-ASSOCIATED INVARIANT T CELLS; SPECIFIC PATHOGEN-FREE ORGANISMS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; SUPERANTIGENS; TRANSPLANTATION CHIMERA;

EID: 85021689065     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.2001930     Document Type: Article

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