Selective requirement of p38α MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses

Journal of Immunology

Volumn 176, Issue 8, 2006, Pages 4616-4621

  Berenson, Lisa S ^a   Yang, Jianfei ^a,b   Sleckman, Barry P ^a   Murphy, Theresa L ^a   Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD4 ANTIGEN; COMPLEMENTARY DNA; CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; GENOMIC DNA; INTERLEUKIN 12; INTERLEUKIN 18; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; T LYMPHOCYTE RECEPTOR; IMIDAZOLE DERIVATIVE; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROVIRUS; SPLEEN CELL; TH1 CELL; VIRUS INFECTION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CYTOKINES; DNA, COMPLEMENTARY; IMIDAZOLES; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 14; PROTEIN KINASE INHIBITORS; PYRIDINES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TH1 CELLS;

EID: 33645773184     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.8.4616     Document Type: Article

References (30)

1. Szabo, S. J., S. T. Kim, G. L. Costa, X. K. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
2. + T cells. Nat. Immunol. 3: 549-557.
3. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181: 1755-1762.
4. Thierfelder, W. E., J. M. van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. Vignali, P. C. Doherty, G. C. Grosveld, et al. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382: 171-174.
5. + T cells: evidence for two distinct pathways for promoter activation. Eur. J. Immunol. 29: 548-555.
6. Robinson, D., K. Shibuya, A. Mui, F. Zonin, E. Murphy, T. Sana, S. B. Hartley, S. Menon, R. Kastelein, F. Bazan, et al. 1997. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB. Immunity 7: 571-581.
7. Yang, J., H. Zhu, T. L. Murphy, W. J. Ouyang, and K. M. Murphy. 2001. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nat. Immunol. 2: 157-164.
8. Yu, J. J., C. S. Tripp, and J. H. Russell. 2003. Regulation and phenotype of an innate Th1 cell: role of cytokines and the p38 kinase pathway. J. Immunol. 171: 6112-6118.
9. Rincon, M., H. Enslen, J. Raingeaud, M. Recht, T. Zapton, M. S. Su, L. A. Penix, R. J. Davis, and R. A. Flavell. 1998. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17: 2817-2829.
10. Hale, K. K., D. Trollinger, M. Rihanek, and C. L. Manthey. 1999. Differential expression and activation of p38 mitogen-activated protein kinase α, β, γ, and δ in inflammatory cell lineages. J. Immunol. 162: 4246-4252.
11. Rincon, M. 2001. MAP-kinase signaling pathways in T cells. Curr. Opin. Immunol. 13: 339-345.
12. Brancho, D., N. Tanaka, A. Jaeschke, J. J. Ventura, N. Kelkar, Y. Tanaka, M. Kyuuma, T. Takeshita, R. A. Flavell, and R. J. Davis. 2003. Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 17: 1969-1978.
13. Dong, C., R. J. Davis, and R. A. Flavell. 2002. MAP kinases in the immune response. Annu. Rev. Immunol. 20: 55-72.
14. Takekawa, M., and H. Saito. 1998. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95: 521-530.
15. Lu, B., H. Yu, C. Chow, B. Li, W. Zheng, R. J. Davis, and R. A. Flavell. 2001. GADD45γ mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity 14: 583-590.
16. Lu, H. T., D. D. Yang, M. Wysk, E. Gatti, I. Mellman, R. J. Davis, and R. A. Flavell. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18: 1845-1857.
17. Chi, H., B. Lu, M. Takekawa, R. J. Davis, and R. A. Flavell. 2004. GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNγ production in T cells. EMBO J. 23: 1576-1586.
18. Lu, B., A. F. Ferrandino, and R. A. Flavell. 2004. Gadd45β is important for perpetuating cognate and inflammatory signals in T cells. Nat. Immunol. 5: 38-44.
19. Adams, R. H., A. Porras, G. Alonso, M. Jones, K. Vintersten, S. Panelli, A. Valladares, L. Perez, R. Klein, and A. R. Nebreda. 2000. Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development. Mol. Cell 6: 109-116.
20. Allen, M., L. Svensson, M. Roach, J. Hambor, J. McNeish, and C. A. Gabel. 2000. Deficiency of the stress kinase p38α results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J. Exp. Med. 191: 859-869.
21. Mudgett, J. S., J. X. Ding, L. Guh-Siesel, N. A. Chartrain, L. Yang, S. Gopal, and M. M. Shen. 2000. Essential role for p38α mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. USA 97: 10454-10459.
22. Tamura, K., T. Sudo, U. Senftleben, A. M. Dadak, R. Johnson, and M. Karin. 2000. Requirement for p38α in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-231.
23. lo thymocytes in vivo. Science 250: 1720-1723.
24. Kim, J. M., J. M. White, A. S. Shaw, and B. P. Sleckman. 2005. MAPK p38α is dispensable for lymphocyte development and proliferation. J. Immunol. 174: 1239-1244.
25. Ranganath, S., W. Ouyang, D. Bhattarcharya, W. C. Sha, A. Grupe, G. Peltz, and K. M. Murphy. 1998. GATA-3-dependent enhancer activity in IL-4 gene regulation. J. Immunol. 161: 3822-3826.
26. Berenson, L. S., J. D. Farrar, T. L. Murphy, and K. M. Murphy. 2004. Absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-α. Eur. J. Immunol. 34: 2365-2374.
27. Lee, J. C., S. Kassis, S. Kumar, A. Badger, and J. L. Adams. 1999. p38 mitogen-activated protein kinase inhibitors: mechanisms and therapeutic potentials. Pharmacol. Ther. 82: 389-397.
28. Bird, J. J., D. R. Brown, A. C. Mullen, N. H. Moskowitz, M. A. Mahowald, J. R. Sider, T. F. Gajewski, C. R. Wang, and S. L. Reiner. 1998, Helper T cell differentiation is controlled by the cell cycle. Immunity 9: 229-237.
29. Yang, L. L., X. F. Qin, D. Baltimore, and L. Van Parijs. 2002. Generation of functional antigen-specific T cells in denned genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells. Proc. Natl. Acad. Sci. USA 99: 6204-6209.
30. Mavropoulos, A., G. Sully, A. P. Cope, and A. R. Clark. 2005. Stabilization of IFN-γ mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells. Blood 105: 282-288.