MAIT recognition of a stimulatory bacterial antigen bound to MR1

Journal of Immunology

Volumn 191, Issue 10, 2013, Pages 5268-5277

  López Sagaseta, Jacinto ^a   Dulberger, Charles L ^a   McFedries, Amanda ^b   Cushman, Mark ^c   Saghatelian, Alan ^b   Adams, Erin J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b HARVARD UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYMETHYL 8 (1 DEXTRO RIBITYL); BACTERIAL ANTIGEN; CHEMICAL COMPOUND; PROTEIN MR1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 1; LYMPHOCYTE ANTIGEN RECEPTOR; MR1 PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PROTEIN BINDING;

ALPHA CHAIN; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; MASS SPECTROMETRY; MOLECULAR DOCKING; NUCOSAL ASSOCIATED INVARIANT T CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; T LYMPHOCYTE; ANTIGEN PRESENTATION; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PROTEIN TERTIARY STRUCTURE; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; T LYMPHOCYTE SUBPOPULATION; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LYMPHOCYTE ACTIVATION; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SALMONELLA TYPHIMURIUM; T-LYMPHOCYTE SUBSETS;

EID: 84887704603     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301958     Document Type: Article

References (32)

1. Tilloy, F., E. Treiner, S. H. Park, C. Garcia, F. Lemonnier, H. De La Salle, A. Bendelac, M. Bonneville, and O. Lantz. 1999. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J. Exp. Med. 189:1907-1921.
2. Treiner, E., L. Duban, S. Bahram, M. Radosavljevic, V. Wanner, F. Tilloy, P. Affaticati, S. Gilfillan, and O. Lantz. 2003. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422:164-169.
3. Porcelli, S., C. E. Yockey, M. B. Brenner, and S. P. Balk. 1993. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8-alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain. J. Exp. Med. 178:1-16.
4. Dusseaux, M., E. Martin, N. Serriari, I. Péguillet, V. Premel, D. Louis, M. Milder, L. Le Bourhis, C. Soudais, E. Treiner, and O. Lantz. 2011. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 117:1250-1259.
5. Gold, M. C., S. Cerri, S. Smyk-Pearson, M. E. Cansler, T. M. Vogt, J. Delepine, E. Winata, G. M. Swarbrick, W. J. Chua, Y. Y. Yu, et al. 2010. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 8:e1000407.
6. Martin, E., E. Treiner, L. Duban, L. Guerri, H. Laude, C. Toly, V. Premel, A. Devys, I. C. Moura, F. Tilloy, et al. 2009. Stepwise development of MAIT cells in mouse and human. PLoS Biol. 7:e54.
7. Huang, S., E. Martin, S. Kim, L. Yu, C. Soudais, D. H. Fremont, O. Lantz, and T. H. Hansen. 2009. MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. Proc. Natl. Acad. Sci. USA 106:8290-8295.
8. Riegert, P., V. Wanner, and S. Bahram. 1998. Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene. J. Immunol. 161:4066-4077.
9. López-Sagaseta, J., C. L. Dulberger, J. E. Crooks, C. D. Parks, A. M. Luoma, A. McFedries, I. Van Rhijn, A. Saghatelian, and E. J. Adams. 2013. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proc. Natl. Acad. Sci. USA 110:E1771-E1778.
10. Kjer-Nielsen, L., O. Patel, A. J. Corbett, J. Le Nours, B. Meehan, L. Liu, M. Bhati, Z. Chen, L. Kostenko, R. Reantragoon, et al. 2012. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491:717-723.
11. Le Bourhis, L., Y. K. Mburu, and O. Lantz. 2013. MAIT cells, surveyors of a new class of antigen: development and functions. Curr. Opin. Immunol. 25:174-180.
12. Le Bourhis, L., E. Martin, I. Péguillet, A. Guihot, N. Froux, M. Coré, E. Lévy, M. Dusseaux, V. Meyssonnier, V. Premel, et al. 2010. Antimicrobial activity of mucosal-associated invariant T cells [Published erratum appears in 2010 Nat. Immunol.11:969.] Nat. Immunol. 11:701-708.
13. Huang, S., S. Gilfillan, S. Kim, B. Thompson, X. Wang, A. J. Sant, D. H. Fremont, O. Lantz, and T. H. Hansen. 2008. MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells. J. Exp. Med. 205:1201-1211.
14. Young, M. H., L. U'Ren, S. Huang, T. Mallevaey, J. Scott-Browne, F. Crawford, O. Lantz, T. H. Hansen, J. Kappler, P. Marrack, and L. Gapin. 2013. MAIT cell recognition of MR1 on bacterially infected and uninfected cells. PLoS ONE 8:e53789.
15. Reantragoon, R., L. Kjer-Nielsen, O. Patel, Z. Chen, P. T. Illing, M. Bhati, L. Kostenko, M. Bharadwaj, B. Meehan, T. H. Hansen, et al. 2012. Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. J. Exp. Med. 209:761-774.
16. Patel, O., L. Kjer-Nielsen, J. Le Nours, S. B. Eckle, R. Birkinshaw, T. Beddoe, A. J. Corbett, L. Liu, J. J. Miles, B. Meehan, et al. 2013. Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat. Commun. 4:2142.
17. Garcia, K. C., and E. J. Adams. 2005. How the T cell receptor sees antigen - a structural view. Cell 122:333-336.
18. Girardi, E., I. Maricic, J. Wang, T. T. Mac, P. Iyer, V. Kumar, and D. M. Zajonc. 2012. Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens. Nat. Immunol. 13:851-856.
19. Patel, O., D. G. Pellicci, S. Gras, M. L. Sandoval-Romero, A. P. Uldrich, T. Mallevaey, A. J. Clarke, J. Le Nours, A. Theodossis, S. L. Cardell, et al. 2012. Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nat. Immunol. 13:857-863.
20. López-Sagaseta, J., J. E. Kung, P. B. Savage, J. Gumperz, and E. J. Adams. 2012. The molecular basis for recognition of CD1d/a-galactosylceramide by a human non-Va24 T cell receptor. PLoS Biol. 10:e1001412.
21. López-Sagaseta, J., L. V. Sibener, J. E. Kung, J. Gumperz, and E. J. Adams. 2012. Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor. EMBO J. 31:2047-2059.
22. Otwinowski, Z., and W. Minor. 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276:307-326.
23. Adams, P. D., P. V. Afonine, G. Bunkóczi, V. B. Chen, I. W. Davis, N. Echols, J. J. Headd, L. W. Hung, G. J. Kapral, R. W. Grosse-Kunstleve, et al. 2010. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66:213-221.
24. McCoy, A. J., R. W. Grosse-Kunstleve, P. D. Adams, M. D. Winn, L. C. Storoni, and R. J. Read. 2007. Phaser crystallographic software. J. Appl. Cryst. 40:658-674.
25. Painter, J., and E. A. Merritt. 2006. Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr. D Biol. Crystallogr. 62:439-450.
26. Emsley, P., and K. Cowtan. 2004. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60:2126-2132.
27. Schüttelkopf, A. W., and D. M. Van Aalten. 2004. PRODRG: a tool for highthroughput crystallography of protein-ligand complexes. Acta Crystallogr. D Biol. Crystallogr. 60:1355-1363.
28. Collaborative Computational Project, Number4. 1994. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50:760-763.
29. Miyazaki, Y., S. Miyake, A. Chiba, O. Lantz, and T. Yamamura. 2011. Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis. Int. Immunol. 23:529-535.
30. Croxford, J. L., S. Miyake, Y. Y. Huang, M. Shimamura, and T. Yamamura. 2006. Invariant V (alpha) 19i T cells regulate autoimmune inflammation. Nat. Immunol. 7:987-994.
31. Illés, Z., M. Shimamura, J. Newcombe, N. Oka, and T. Yamamura. 2004. Accumulation of Valpha7.2-Jalpha33 invariant T cells in human autoimmune inflammatory lesions in the nervous system. Int. Immunol. 16:223-230.
32. Peterfalvi, A., E. Gomori, T. Magyarlaki, J. Pal, M. Banati, A. Javorhazy, J. Szekeres-Bartho, L. Szereday, and Z. Illes. 2008. Invariant Valpha7.2-Jalpha33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells. Int. Immunol. 20:1517-1525.