메뉴 건너뛰기




Volumn 58, Issue 4, 2017, Pages 1109-1119

Transport of Non-Transferrin Bound Iron to the Brain: Implications for Alzheimer's Disease

Author keywords

Alzheimer's disease; brain; inflammation; kidney; non transferrin bound iron

Indexed keywords

NON TRANSFERRIN BOUND IRON FE 59; RADIOPHARMACEUTICAL AGENT; TRANSFERRIN FE 59; UNCLASSIFIED DRUG; HEPCIDIN; IRON; IRON-59; LIPID-LINKED OLIGOSACCHARIDES; LIPOPOLYSACCHARIDE; TRANSFERRIN;

EID: 85021286117     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-170097     Document Type: Article
Times cited : (15)

References (56)
  • 1
    • 34247198450 scopus 로고    scopus 로고
    • Human brain myelination and amyloid beta deposition in Alzheimer's disease
    • Bartzokis G, Lu PH, Mintz J (2007) Human brain myelination and amyloid beta deposition in Alzheimer's disease. Alzheimers Dement 3, 122-125.
    • (2007) Alzheimers Dement , vol.3 , pp. 122-125
    • Bartzokis, G.1    Lu, P.H.2    Mintz, J.3
  • 3
    • 84930225631 scopus 로고    scopus 로고
    • Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
    • Ayton S, Faux NG, Bush AI, Alzheimer's Disease Neuroimaging I (2015) Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nat Commun 6, 6760.
    • (2015) Nat Commun , vol.6 , pp. 6760
    • Ayton, S.1    Faux, N.G.2    Bush, A.I.3
  • 4
    • 38049072727 scopus 로고    scopus 로고
    • The role of iron in restless legs syndrome
    • Allen RP, Earley CJ (2007) The role of iron in restless legs syndrome. Mov Disord 22(Suppl 18), S440-S448.
    • (2007) Mov Disord , vol.22 , pp. S440-S448
    • Allen, R.P.1    Earley, C.J.2
  • 5
    • 58149396754 scopus 로고    scopus 로고
    • Brain iron deficiency and excess; Cognitive impairment and neurodegeneration with involvement of striatum and hippocampus
    • Youdim MB (2008) Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus. Neurotox Res 14, 45-56.
    • (2008) Neurotox Res , vol.14 , pp. 45-56
    • Youdim, M.B.1
  • 6
    • 85028253570 scopus 로고    scopus 로고
    • Iron neurochemistry in Alzheimer's disease and Parkinson's disease: Targets for therapeutics
    • Belaidi AA, Bush AI (2016) Iron neurochemistry in Alzheimer's disease and Parkinson's disease: Targets for therapeutics. J Neurochem 139(Suppl 1), 179-197.
    • (2016) J Neurochem , vol.139 , pp. 179-197
    • Belaidi, A.A.1    Bush, A.I.2
  • 9
    • 73449115641 scopus 로고    scopus 로고
    • The blood-brain and the blood-cerebrospinal fluid barriers: Function and dysfunction
    • Engelhardt B, Sorokin L (2009) The blood-brain and the blood-cerebrospinal fluid barriers: Function and dysfunction. Semin Immunopathol 31, 497-511.
    • (2009) Semin Immunopathol , vol.31 , pp. 497-511
    • Engelhardt, B.1    Sorokin, L.2
  • 11
    • 0030739637 scopus 로고    scopus 로고
    • Transport of iron in the blood-braincerebrospinal fluid system
    • Bradbury MW (1997) Transport of iron in the blood-braincerebrospinal fluid system. J Neurochem 69, 443-454.
    • (1997) J Neurochem , vol.69 , pp. 443-454
    • Bradbury, M.W.1
  • 14
    • 84864915735 scopus 로고    scopus 로고
    • Mechanistic analysis of iron accumulation by endothelial cells of the BBB
    • McCarthy RC, Kosman DJ (2012) Mechanistic analysis of iron accumulation by endothelial cells of the BBB. Biometals 25, 665-675.
    • (2012) Biometals , vol.25 , pp. 665-675
    • McCarthy, R.C.1    Kosman, D.J.2
  • 15
    • 84940985387 scopus 로고    scopus 로고
    • Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier
    • McCarthy RC, Kosman DJ (2015) Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier. Front Mol Neurosci 8, 31.
    • (2015) Front Mol Neurosci , vol.8 , pp. 31
    • McCarthy, R.C.1    Kosman, D.J.2
  • 16
    • 79951960174 scopus 로고    scopus 로고
    • Accumulation of non-transferrin-bound iron by neurons, astrocytes, and microglia
    • Bishop GM, Dang TN, Dringen R, Robinson SR (2011) Accumulation of non-transferrin-bound iron by neurons, astrocytes, and microglia. Neurotox Res 19, 443-451.
    • (2011) Neurotox Res , vol.19 , pp. 443-451
    • Bishop, G.M.1    Dang, T.N.2    Dringen, R.3    Robinson, S.R.4
  • 18
    • 53449097764 scopus 로고    scopus 로고
    • Ascorbyl free radical reflects catalytically active iron after intravenous iron saccharate injection
    • Stefansson BV, Haraldsson B, Nilsson U (2008) Ascorbyl free radical reflects catalytically active iron after intravenous iron saccharate injection. Free Radic Biol Med 45, 1302-1307.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1302-1307
    • Stefansson, B.V.1    Haraldsson, B.2    Nilsson, U.3
  • 19
    • 42549148867 scopus 로고    scopus 로고
    • Nontransferrin-bound iron in plasma following administration of oral iron drugs
    • Dresow B, Petersen D, Fischer R, Nielsen P (2008) Nontransferrin-bound iron in plasma following administration of oral iron drugs. Biometals 21, 273-276.
    • (2008) Biometals , vol.21 , pp. 273-276
    • Dresow, B.1    Petersen, D.2    Fischer, R.3    Nielsen, P.4
  • 20
    • 84884950378 scopus 로고    scopus 로고
    • The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: Insights into the potential of various iron therapies to induce oxidative and nitrosative stress
    • Koskenkorva-Frank TS, Weiss G, Koppenol WH, Burckhardt S (2013) The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: Insights into the potential of various iron therapies to induce oxidative and nitrosative stress. Free Radic Biol Med 65, 1174-1194.
    • (2013) Free Radic Biol Med , vol.65 , pp. 1174-1194
    • Koskenkorva-Frank, T.S.1    Weiss, G.2    Koppenol, W.H.3    Burckhardt, S.4
  • 21
    • 84857373097 scopus 로고    scopus 로고
    • Nontransferrin bound iron: A key role in iron overload and iron toxicity
    • Brissot P, Ropert M, Le Lan C, Loreal O (2012) Nontransferrin bound iron: A key role in iron overload and iron toxicity. Biochim Biophys Acta 1820, 403-410.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 403-410
    • Brissot, P.1    Ropert, M.2    Le Lan, C.3    Loreal, O.4
  • 22
    • 84907816645 scopus 로고    scopus 로고
    • NTBI unveiled by chelatable fluorescent beads
    • Sebastiani G, Pantopoulos K (2014) NTBI unveiled by chelatable fluorescent beads. Biochem J 463, e7-e9.
    • (2014) Biochem J , vol.463 , pp. e7-e9
    • Sebastiani, G.1    Pantopoulos, K.2
  • 24
    • 84920517373 scopus 로고    scopus 로고
    • Kinetics of iron import into developing mouse organs determined by a pup-swapping method
    • Chakrabarti M, Barlas MN, McCormick SP, Lindahl LS, Lindahl PA (2015) Kinetics of iron import into developing mouse organs determined by a pup-swapping method. J Biol Chem 290, 520-528.
    • (2015) J Biol Chem , vol.290 , pp. 520-528
    • Chakrabarti, M.1    Barlas, M.N.2    McCormick, S.P.3    Lindahl, L.S.4    Lindahl, P.A.5
  • 27
    • 0032533743 scopus 로고    scopus 로고
    • Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid
    • Moos T, Morgan EH (1998) Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid. J Neurosci Res 54, 486-494.
    • (1998) J Neurosci Res , vol.54 , pp. 486-494
    • Moos, T.1    Morgan, E.H.2
  • 28
    • 15444362927 scopus 로고    scopus 로고
    • CSF iron, ferritin and transferrin levels in restless legs syndrome
    • Mizuno S, Mihara T, Miyaoka T, Inagaki T, Horiguchi J (2005) CSF iron, ferritin and transferrin levels in restless legs syndrome. J Sleep Res 14, 43-47.
    • (2005) J Sleep Res , vol.14 , pp. 43-47
    • Mizuno, S.1    Mihara, T.2    Miyaoka, T.3    Inagaki, T.4    Horiguchi, J.5
  • 30
    • 0011938460 scopus 로고
    • Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: A rodent model for hemochromatosis
    • Craven CM, Alexander J, Eldridge M, Kushner JP, Bernstein S, Kaplan J (1987) Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: A rodent model for hemochromatosis. Proc Natl Acad Sci U S A 84, 3457-3461.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 3457-3461
    • Craven, C.M.1    Alexander, J.2    Eldridge, M.3    Kushner, J.P.4    Bernstein, S.5    Kaplan, J.6
  • 32
    • 84868118216 scopus 로고    scopus 로고
    • Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia)
    • Aydemir TB, Chang SM, Guthrie GJ, Maki AB, Ryu MS, Karabiyik A, Cousins RJ (2012) Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PLoS One 7, e48679.
    • (2012) PLoS One , vol.7 , pp. e48679
    • Aydemir, T.B.1    Chang, S.M.2    Guthrie, G.J.3    Maki, A.B.4    Ryu, M.S.5    Karabiyik, A.6    Cousins, R.J.7
  • 34
    • 84960075598 scopus 로고    scopus 로고
    • Prion protein-hemin interaction upregulates hemoglobin synthesis: Implications for cerebral hemorrhage and sporadic Creutzfeldt-Jakob disease
    • Tripathi AK, Singh N (2016) Prion protein-hemin interaction upregulates hemoglobin synthesis: Implications for cerebral hemorrhage and sporadic Creutzfeldt-Jakob disease. J Alzheimers Dis 51, 107-121.
    • (2016) J Alzheimers Dis , vol.51 , pp. 107-121
    • Tripathi, A.K.1    Singh, N.2
  • 35
    • 84887212524 scopus 로고    scopus 로고
    • Prion protein modulates cellular iron uptake:Anovel function with implications for prion disease pathogenesis
    • Singh A, Mohan ML, Isaac AO, Luo X, Petrak J, Vyoral D, Singh N (2009) Prion protein modulates cellular iron uptake:Anovel function with implications for prion disease pathogenesis. PLoS One 4, e4468.
    • (2009) PLoS One , vol.4 , pp. e4468
    • Singh, A.1    Mohan, M.L.2    Isaac, A.O.3    Luo, X.4    Petrak, J.5    Vyoral, D.6    Singh, N.7
  • 37
    • 84978142028 scopus 로고    scopus 로고
    • Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease
    • Baksi S, Tripathi AK, Singh N (2016) Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease. Free Radic Biol Med 97, 292-306.
    • (2016) Free Radic Biol Med , vol.97 , pp. 292-306
    • Baksi, S.1    Tripathi, A.K.2    Singh, N.3
  • 39
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 40
    • 77955600573 scopus 로고    scopus 로고
    • Iron homeostasis and the inflammatory response
    • Wessling-Resnick M (2010) Iron homeostasis and the inflammatory response. Annu Rev Nutr 30, 105-122.
    • (2010) Annu Rev Nutr , vol.30 , pp. 105-122
    • Wessling-Resnick, M.1
  • 41
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918-934.
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 43
    • 84866146120 scopus 로고    scopus 로고
    • Longterm impact of systemic bacterial infection on the cerebral vasculature and microglia
    • Puntener U, Booth SG, Perry VH, Teeling JL (2012) Longterm impact of systemic bacterial infection on the cerebral vasculature and microglia. J Neuroinflammation 9, 146.
    • (2012) J Neuroinflammation , vol.9 , pp. 146
    • Puntener, U.1    Booth, S.G.2    Perry, V.H.3    Teeling, J.L.4
  • 45
    • 84937979159 scopus 로고    scopus 로고
    • Iron homeostasis in host defence and inflammation
    • Ganz T, Nemeth E (2015) Iron homeostasis in host defence and inflammation. Nat Rev Immunol 15, 500-510.
    • (2015) Nat Rev Immunol , vol.15 , pp. 500-510
    • Ganz, T.1    Nemeth, E.2
  • 50
    • 84899418231 scopus 로고    scopus 로고
    • Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration
    • Andersen HH, Johnsen KB, Moos T (2014) Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration. Cell Mol Life Sci 71, 1607-1622.
    • (2014) Cell Mol Life Sci , vol.71 , pp. 1607-1622
    • Andersen, H.H.1    Johnsen, K.B.2    Moos, T.3
  • 51
    • 84885953717 scopus 로고    scopus 로고
    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
    • Urrutia P, Aguirre P, Esparza A, Tapia V, Mena NP, Arredondo M, Gonzalez-Billault C, Nunez MT (2013) Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. J Neurochem 126, 541-549.
    • (2013) J Neurochem , vol.126 , pp. 541-549
    • Urrutia, P.1    Aguirre, P.2    Esparza, A.3    Tapia, V.4    Mena, N.P.5    Arredondo, M.6    Gonzalez-Billault, C.7    Nunez, M.T.8
  • 52
    • 84961282418 scopus 로고    scopus 로고
    • The blood-brain barrier in systemic inflammation
    • Varatharaj A, Galea I (2017) The blood-brain barrier in systemic inflammation. Brain Behav Immun 60, 1-12.
    • (2017) Brain Behav Immun , vol.60 , pp. 1-12
    • Varatharaj, A.1    Galea, I.2
  • 53
    • 0036310725 scopus 로고    scopus 로고
    • Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice
    • Canonne-Hergaux F, Gros P (2002) Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int 62, 147-156.
    • (2002) Kidney Int , vol.62 , pp. 147-156
    • Canonne-Hergaux, F.1    Gros, P.2
  • 54
    • 84863671736 scopus 로고    scopus 로고
    • Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells
    • Fujishiro H, Yano Y, Takada Y, Tanihara M, Himeno S (2012) Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. Metallomics 4, 700-708.
    • (2012) Metallomics , vol.4 , pp. 700-708
    • Fujishiro, H.1    Yano, Y.2    Takada, Y.3    Tanihara, M.4    Himeno, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.