메뉴 건너뛰기




Volumn 60, Issue , 2017, Pages 1-12

The blood-brain barrier in systemic inflammation

Author keywords

Alzheimer's disease; Blood brain barrier; Delirium; Lipopolysaccharide; Multiple sclerosis; Septic encephalopathy; Sickness behaviour; Systemic inflammation

Indexed keywords

AMINO ACID TRANSPORTER; AMYLOID BETA PROTEIN; BETA INTERFERON; GLYCOPROTEIN GP 120; I KAPPA B KINASE ALPHA; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; LEUKEMIA INHIBITORY FACTOR; LIPOPOLYSACCHARIDE; LYSOSOME ENZYME; MONOAMINE; MONOCARBOXYLATE TRANSPORTER; MULTIDRUG RESISTANCE PROTEIN; ORGANIC ANION TRANSPORTER; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR;

EID: 84961282418     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2016.03.010     Document Type: Review
Times cited : (753)

References (145)
  • 1
    • 0033962411 scopus 로고    scopus 로고
    • Inflammatory mediators and modulation of blood-brain barrier permeability
    • Abbott, N.J., Inflammatory mediators and modulation of blood-brain barrier permeability. Cell. Mol. Neurobiol. 20:2 (2000), 131–147.
    • (2000) Cell. Mol. Neurobiol. , vol.20 , Issue.2 , pp. 131-147
    • Abbott, N.J.1
  • 2
    • 33645869560 scopus 로고    scopus 로고
    • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
    • Agrawal, S., Anderson, P., Durbeej, M., van Rooijen, N., Ivars, F., Opdenakker, G., Sorokin, L.M., Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J. Exp. Med. 203:4 (2006), 1007–1019.
    • (2006) J. Exp. Med. , vol.203 , Issue.4 , pp. 1007-1019
    • Agrawal, S.1    Anderson, P.2    Durbeej, M.3    van Rooijen, N.4    Ivars, F.5    Opdenakker, G.6    Sorokin, L.M.7
  • 4
    • 85007301966 scopus 로고    scopus 로고
    • Importance of the quotient of albumin, quotient of immunoglobulin G and Reibergram in inflammatory neurological disorders with disease-specific patterns of blood-brain barrier permeability
    • Akaishi, T., Narikawa, K., Suzuki, Y., Mitsuzawa, S., Tsukita, K., Kuroda, H., Nakashima, I., Fujihara, K., Aoki, M., Importance of the quotient of albumin, quotient of immunoglobulin G and Reibergram in inflammatory neurological disorders with disease-specific patterns of blood-brain barrier permeability. Neurol. Clin. Neurosci. 3:3 (2015), 94–100.
    • (2015) Neurol. Clin. Neurosci. , vol.3 , Issue.3 , pp. 94-100
    • Akaishi, T.1    Narikawa, K.2    Suzuki, Y.3    Mitsuzawa, S.4    Tsukita, K.5    Kuroda, H.6    Nakashima, I.7    Fujihara, K.8    Aoki, M.9
  • 5
    • 84862206258 scopus 로고    scopus 로고
    • Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole
    • Akanuma, S.-I., Uchida, Y., Ohtsuki, S., Tachikawa, M., Terasaki, T., Hosoya, K.-I., Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole. Fluids Barriers CNS, 8(1), 2011, 24.
    • (2011) Fluids Barriers CNS , vol.8 , Issue.1 , pp. 24
    • Akanuma, S.-I.1    Uchida, Y.2    Ohtsuki, S.3    Tachikawa, M.4    Terasaki, T.5    Hosoya, K.-I.6
  • 6
    • 78651188642 scopus 로고
    • The effect of bacterial pyrogen on the blood-brain barrier for trypan blue
    • Allen, I.V., The effect of bacterial pyrogen on the blood-brain barrier for trypan blue. J. Pathol. Bacteriol. 89:2 (1965), 481–494.
    • (1965) J. Pathol. Bacteriol. , vol.89 , Issue.2 , pp. 481-494
    • Allen, I.V.1
  • 8
    • 85007287595 scopus 로고    scopus 로고
    • Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier
    • Asgari, N., Berg, C.T., Mørch, M.T., Khorooshi, R., Owens, T., Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier. Ann. Clin. Transl. Neurol. 2:8 (2015), 857–863.
    • (2015) Ann. Clin. Transl. Neurol. , vol.2 , Issue.8 , pp. 857-863
    • Asgari, N.1    Berg, C.T.2    Mørch, M.T.3    Khorooshi, R.4    Owens, T.5
  • 9
    • 14744289048 scopus 로고    scopus 로고
    • Blood-brain barrier transport of cytokines: a mechanism for neuropathology
    • Banks, W.A., Blood-brain barrier transport of cytokines: a mechanism for neuropathology. Curr. Pharm. Des. 11:8 (2005), 973–984.
    • (2005) Curr. Pharm. Des. , vol.11 , Issue.8 , pp. 973-984
    • Banks, W.A.1
  • 10
    • 0033030441 scopus 로고    scopus 로고
    • Adsorptive endocytosis of HIV-1gp120 by blood-brain barrier is enhanced by lipopolysaccharide
    • Banks, W.A., Kastin, A.J., Brennan, J.M., Vallance, K.L., Adsorptive endocytosis of HIV-1gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Exp. Neurol. 156:1 (1999), 165–171.
    • (1999) Exp. Neurol. , vol.156 , Issue.1 , pp. 165-171
    • Banks, W.A.1    Kastin, A.J.2    Brennan, J.M.3    Vallance, K.L.4
  • 11
    • 84866858942 scopus 로고    scopus 로고
    • Pharmacokinetics and modeling of immune cell trafficking: quantifying differential influences of target tissues versus lymphocytes in SJL and lipopolysaccharide-treated mice
    • Banks, W.A., Niehoff, M.L., Ponzio, N.M., Erickson, M.A., Zalcman, S.S., Pharmacokinetics and modeling of immune cell trafficking: quantifying differential influences of target tissues versus lymphocytes in SJL and lipopolysaccharide-treated mice. J. Neuroinflammation, 9(1), 2012, 231.
    • (2012) J. Neuroinflammation , vol.9 , Issue.1 , pp. 231
    • Banks, W.A.1    Niehoff, M.L.2    Ponzio, N.M.3    Erickson, M.A.4    Zalcman, S.S.5
  • 13
    • 0029988267 scopus 로고    scopus 로고
    • Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion
    • Barkalow, F.J., Goodman, M.J., Gerritsen, M.E., Mayadas, T.N., Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Blood 88:12 (1996), 4585–4593.
    • (1996) Blood , vol.88 , Issue.12 , pp. 4585-4593
    • Barkalow, F.J.1    Goodman, M.J.2    Gerritsen, M.E.3    Mayadas, T.N.4
  • 14
    • 33845727067 scopus 로고    scopus 로고
    • What is the blood–brain barrier (not)?
    • Bechmann, I., Galea, I., Perry, V.H., What is the blood–brain barrier (not)?. Trends Immunol. 28:1 (2007), 5–11.
    • (2007) Trends Immunol. , vol.28 , Issue.1 , pp. 5-11
    • Bechmann, I.1    Galea, I.2    Perry, V.H.3
  • 15
    • 0032524174 scopus 로고    scopus 로고
    • No increase in blood-brain barrier permeability after intraperitoneal injection of endotoxin in the rat
    • Bickel, U., Grave, B., Kang, Y.S., del Rey, A., Voigt, K., No increase in blood-brain barrier permeability after intraperitoneal injection of endotoxin in the rat. J. Neuroimmunol. 85:2 (1998), 131–136.
    • (1998) J. Neuroimmunol. , vol.85 , Issue.2 , pp. 131-136
    • Bickel, U.1    Grave, B.2    Kang, Y.S.3    del Rey, A.4    Voigt, K.5
  • 18
    • 0029794737 scopus 로고    scopus 로고
    • Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in multiple sclerosis lesions
    • Bö, L., Peterson, J.W., Mørk, S., Hoffman, P.A., Gallatin, W.M., Ransohoff, R.M., Trapp, B.D., Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in multiple sclerosis lesions. J. Neuropathol. Exp. Neurol. 55:10 (1996), 1060–1072.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , Issue.10 , pp. 1060-1072
    • Bö, L.1    Peterson, J.W.2    Mørk, S.3    Hoffman, P.A.4    Gallatin, W.M.5    Ransohoff, R.M.6    Trapp, B.D.7
  • 19
    • 0035214647 scopus 로고    scopus 로고
    • Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency
    • Bohatschek, M., Werner, A., Raivich, G., Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency. Exp. Neurol. 172:1 (2001), 137–152.
    • (2001) Exp. Neurol. , vol.172 , Issue.1 , pp. 137-152
    • Bohatschek, M.1    Werner, A.2    Raivich, G.3
  • 20
    • 84860366574 scopus 로고    scopus 로고
    • Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
    • Booth, R., Kim, H., Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB). Lab Chip 12:10 (2012), 1784–1792.
    • (2012) Lab Chip , vol.12 , Issue.10 , pp. 1784-1792
    • Booth, R.1    Kim, H.2
  • 22
    • 0033152442 scopus 로고    scopus 로고
    • Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
    • Bush, T.G., Puvanachandra, N., Horner, C.H., Polito, A., Ostenfeld, T., Svendsen, C.N., Mucke, L., Johnson, M.H., Sofroniew, M.V., Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 23:2 (1999), 297–308.
    • (1999) Neuron , vol.23 , Issue.2 , pp. 297-308
    • Bush, T.G.1    Puvanachandra, N.2    Horner, C.H.3    Polito, A.4    Ostenfeld, T.5    Svendsen, C.N.6    Mucke, L.7    Johnson, M.H.8    Sofroniew, M.V.9
  • 23
    • 0028846219 scopus 로고
    • Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response
    • Cao, C., Matsumura, K., Yamagata, K., Watanabe, Y., Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res. 697:1–2 (1995), 187–196.
    • (1995) Brain Res. , vol.697 , Issue.1-2 , pp. 187-196
    • Cao, C.1    Matsumura, K.2    Yamagata, K.3    Watanabe, Y.4
  • 24
    • 77956344034 scopus 로고    scopus 로고
    • Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches
    • Cardoso, F.L., Brites, D., Brito, M.A., Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches. Brain Res. Rev. 64:2 (2010), 328–363.
    • (2010) Brain Res. Rev. , vol.64 , Issue.2 , pp. 328-363
    • Cardoso, F.L.1    Brites, D.2    Brito, M.A.3
  • 25
    • 84860624746 scopus 로고    scopus 로고
    • Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells
    • Cardoso, F.L., Kittel, A., Veszelka, S., Palmela, I., Tóth, A., Brites, D., Deli, M.A., Brito, M.A., Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells. PLoS ONE, 7(5), 2012, e35919.
    • (2012) PLoS ONE , vol.7 , Issue.5 , pp. e35919
    • Cardoso, F.L.1    Kittel, A.2    Veszelka, S.3    Palmela, I.4    Tóth, A.5    Brites, D.6    Deli, M.A.7    Brito, M.A.8
  • 27
    • 0034623813 scopus 로고    scopus 로고
    • A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature
    • Carvalho-Tavares, J., Hickey, M.J., Hutchison, J., Michaud, J., Sutcliffe, I.T., Kubes, P., A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature. Circ. Res. 87:12 (2000), 1141–1148.
    • (2000) Circ. Res. , vol.87 , Issue.12 , pp. 1141-1148
    • Carvalho-Tavares, J.1    Hickey, M.J.2    Hutchison, J.3    Michaud, J.4    Sutcliffe, I.T.5    Kubes, P.6
  • 29
    • 0022966985 scopus 로고
    • Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries
    • Choi, T.B., Pardridge, W.M., Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries. J. Biol. Chem. 261:14 (1986), 6536–6541.
    • (1986) J. Biol. Chem. , vol.261 , Issue.14 , pp. 6536-6541
    • Choi, T.B.1    Pardridge, W.M.2
  • 30
    • 76749086081 scopus 로고    scopus 로고
    • Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide
    • Chui, R., Dorovini-Zis, K., Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide. J. Neuroinflammation, 7(1), 2010, 1.
    • (2010) J. Neuroinflammation , vol.7 , Issue.1 , pp. 1
    • Chui, R.1    Dorovini-Zis, K.2
  • 31
    • 0024826077 scopus 로고
    • Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis
    • Claudio, L., Kress, Y., Norton, W.T., Brosnan, C.F., Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis. Am. J. Pathol. 135:6 (1989), 1157–1168.
    • (1989) Am. J. Pathol. , vol.135 , Issue.6 , pp. 1157-1168
    • Claudio, L.1    Kress, Y.2    Norton, W.T.3    Brosnan, C.F.4
  • 32
    • 33747705430 scopus 로고    scopus 로고
    • The risk of relapses in multiple sclerosis during systemic infections
    • Correale, J., Fiol, M., Gilmore, W., The risk of relapses in multiple sclerosis during systemic infections. Neurology 67:4 (2006), 652–659.
    • (2006) Neurology , vol.67 , Issue.4 , pp. 652-659
    • Correale, J.1    Fiol, M.2    Gilmore, W.3
  • 33
    • 84891289780 scopus 로고    scopus 로고
    • Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI.
    • Cramer, S.P., Simonsen, H., Frederiksen, J.L., Rostrup, E., Larsson, H.B.W., Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI. Neuroimage Clin. 4 (2014), 182–189.
    • (2014) Neuroimage Clin. , vol.4 , pp. 182-189
    • Cramer, S.P.1    Simonsen, H.2    Frederiksen, J.L.3    Rostrup, E.4    Larsson, H.B.W.5
  • 34
    • 84908428514 scopus 로고    scopus 로고
    • Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals
    • e01476-14
    • Daniels, B.P., Holman, D.W., Cruz-Orengo, L., Jujjavarapu, H., Durrant, D.M., Klein, R.S., Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals. mBio, 5(5), 2014 e01476-14.
    • (2014) mBio , vol.5 , Issue.5
    • Daniels, B.P.1    Holman, D.W.2    Cruz-Orengo, L.3    Jujjavarapu, H.4    Durrant, D.M.5    Klein, R.S.6
  • 37
    • 82055164124 scopus 로고    scopus 로고
    • Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
    • Denes, A., Ferenczi, S., Kovács, K.J., Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size. J. Neuroinflammation, 8(1), 2011, 164.
    • (2011) J. Neuroinflammation , vol.8 , Issue.1 , pp. 164
    • Denes, A.1    Ferenczi, S.2    Kovács, K.J.3
  • 38
    • 0034783461 scopus 로고    scopus 로고
    • Comparative analysis of lipopolysaccharide-induced tumor necrosis factor alpha activity in serum and lethality in mice and rabbits pretreated with the staphylococcal superantigen toxic shock syndrome toxin 1
    • Dinges, M.M., Schlievert, P.M., Comparative analysis of lipopolysaccharide-induced tumor necrosis factor alpha activity in serum and lethality in mice and rabbits pretreated with the staphylococcal superantigen toxic shock syndrome toxin 1. Infect. Immun. 69:11 (2001), 7169–7172.
    • (2001) Infect. Immun. , vol.69 , Issue.11 , pp. 7169-7172
    • Dinges, M.M.1    Schlievert, P.M.2
  • 39
    • 41149130585 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway
    • Dohgu, S., Banks, W.A., Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway. Exp. Neurol. 210:2 (2008), 740–749.
    • (2008) Exp. Neurol. , vol.210 , Issue.2 , pp. 740-749
    • Dohgu, S.1    Banks, W.A.2
  • 40
    • 84879488912 scopus 로고    scopus 로고
    • Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro bloodbrain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk
    • Dohgu, S., Banks, W.A., Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro bloodbrain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk. Fluids Barriers CNS, 10(1), 2013, 1.
    • (2013) Fluids Barriers CNS , vol.10 , Issue.1 , pp. 1
    • Dohgu, S.1    Banks, W.A.2
  • 41
    • 82255169278 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF
    • Dohgu, S., Fleegal-DeMotta, M.A., Banks, W.A., Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF. J. Neuroinflammation, 8(1), 2011, 167.
    • (2011) J. Neuroinflammation , vol.8 , Issue.1 , pp. 167
    • Dohgu, S.1    Fleegal-DeMotta, M.A.2    Banks, W.A.3
  • 42
    • 84942850510 scopus 로고    scopus 로고
    • Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier
    • Doll, D.N., Hu, H., Sun, J., Lewis, S.E., Simpkins, J.W., Ren, X., Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier. Stroke 46:6 (2015), 1681–1689.
    • (2015) Stroke , vol.46 , Issue.6 , pp. 1681-1689
    • Doll, D.N.1    Hu, H.2    Sun, J.3    Lewis, S.E.4    Simpkins, J.W.5    Ren, X.6
  • 43
    • 0022391447 scopus 로고
    • E. coli peritonitis and bacteremia cause increased blood-brain barrier permeability
    • du Moulin, G.C., Paterson, D., Hedley-Whyte, J., Broitman, S.A., E. coli peritonitis and bacteremia cause increased blood-brain barrier permeability. Brain Res. 340:2 (1985), 261–268.
    • (1985) Brain Res. , vol.340 , Issue.2 , pp. 261-268
    • du Moulin, G.C.1    Paterson, D.2    Hedley-Whyte, J.3    Broitman, S.A.4
  • 44
    • 84885018413 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease
    • Erickson, M.A., Banks, W.A., Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J. Cereb. Blood Flow Metab. 33:10 (2013), 1500–1513.
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , Issue.10 , pp. 1500-1513
    • Erickson, M.A.1    Banks, W.A.2
  • 45
    • 84863005570 scopus 로고    scopus 로고
    • Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier
    • Erickson, M.A., Hartvigson, P.E., Morofuji, Y., Owen, J.B., Butterfield, D.A., Banks, W.A., Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier. J. Neuroinflammation, 9(1), 2012, 150.
    • (2012) J. Neuroinflammation , vol.9 , Issue.1 , pp. 150
    • Erickson, M.A.1    Hartvigson, P.E.2    Morofuji, Y.3    Owen, J.B.4    Butterfield, D.A.5    Banks, W.A.6
  • 46
    • 0028885890 scopus 로고
    • Type 1 interleukin-1 receptor in the rat brain: distribution, regulation, and relationship to sites of IL-1-induced cellular activation
    • Ericsson, A., Liu, C., Hart, R.P., Sawchenko, P.E., Type 1 interleukin-1 receptor in the rat brain: distribution, regulation, and relationship to sites of IL-1-induced cellular activation. J. Comp. Neurol. 361:4 (1995), 681–698.
    • (1995) J. Comp. Neurol. , vol.361 , Issue.4 , pp. 681-698
    • Ericsson, A.1    Liu, C.2    Hart, R.P.3    Sawchenko, P.E.4
  • 47
    • 34248355132 scopus 로고    scopus 로고
    • Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models
    • Fabis, M.J., Scott, G.S., Kean, R.B., Koprowski, H., Hooper, D.C., Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. PNAS 104:13 (2007), 5656–5661.
    • (2007) PNAS , vol.104 , Issue.13 , pp. 5656-5661
    • Fabis, M.J.1    Scott, G.S.2    Kean, R.B.3    Koprowski, H.4    Hooper, D.C.5
  • 48
    • 84907216717 scopus 로고    scopus 로고
    • Systemic inflammation induces a profound long term brain cell injury in rats
    • Fan, L., Wang, T., Chang, L., Song, Y., Wu, Y., Ma, D., Systemic inflammation induces a profound long term brain cell injury in rats. Acta. Neurobiol. Exp. (Wars.) 74:3 (2014), 298–306.
    • (2014) Acta. Neurobiol. Exp. (Wars.) , vol.74 , Issue.3 , pp. 298-306
    • Fan, L.1    Wang, T.2    Chang, L.3    Song, Y.4    Wu, Y.5    Ma, D.6
  • 49
    • 0344701055 scopus 로고    scopus 로고
    • Experimental acute pancreatitis results in increased blood–brain barrier permeability in the rat: a potential role for tumor necrosis factor and interleukin 6
    • Farkas, G., Márton, J., Nagy, Z., Mándi, Y., Takács, T., Experimental acute pancreatitis results in increased blood–brain barrier permeability in the rat: a potential role for tumor necrosis factor and interleukin 6. Neuroscience 242:3 (1998), 147–150.
    • (1998) Neuroscience , vol.242 , Issue.3 , pp. 147-150
    • Farkas, G.1    Márton, J.2    Nagy, Z.3    Mándi, Y.4    Takács, T.5
  • 50
    • 45549102801 scopus 로고    scopus 로고
    • Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier
    • Förster, C., Burek, M., Romero, I.A., Weksler, B., Couraud, P.-O., Drenckhahn, D., Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J. Physiol. (Lond.) 586:7 (2008), 1937–1949.
    • (2008) J. Physiol. (Lond.) , vol.586 , Issue.7 , pp. 1937-1949
    • Förster, C.1    Burek, M.2    Romero, I.A.3    Weksler, B.4    Couraud, P.-O.5    Drenckhahn, D.6
  • 51
    • 0037288494 scopus 로고    scopus 로고
    • Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro
    • Gaillard, P.J., de Boer, A.B.G., Breimer, D.D., Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro. Microvasc. Res. 65:1 (2003), 24–31.
    • (2003) Microvasc. Res. , vol.65 , Issue.1 , pp. 24-31
    • Gaillard, P.J.1    de Boer, A.B.G.2    Breimer, D.D.3
  • 52
    • 0017103317 scopus 로고
    • Pathologenesis of hematogenous bacterial meningitis in rabbits
    • Gregorius, F.K., Johnson, B.L., Stern, W.E., Brown, W.J., Pathologenesis of hematogenous bacterial meningitis in rabbits. J. Neurosurg. 45:5 (1976), 561–567.
    • (1976) J. Neurosurg. , vol.45 , Issue.5 , pp. 561-567
    • Gregorius, F.K.1    Johnson, B.L.2    Stern, W.E.3    Brown, W.J.4
  • 53
    • 84939207867 scopus 로고    scopus 로고
    • Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20
    • Han, D., Fang, W., Zhang, R., Wei, J., Kodithuwakku, N.D., Sha, L., Ma, W., Liu, L., Li, F., Li, Y., Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20. Brain Behav. Immun. 51 (2016), 56–69.
    • (2016) Brain Behav. Immun. , vol.51 , pp. 56-69
    • Han, D.1    Fang, W.2    Zhang, R.3    Wei, J.4    Kodithuwakku, N.D.5    Sha, L.6    Ma, W.7    Liu, L.8    Li, F.9    Li, Y.10
  • 54
    • 0024159821 scopus 로고
    • Biological basis of the behavior of sick animals
    • Hart, B.L., Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12:2 (1988), 123–137.
    • (1988) Neurosci. Biobehav. Rev. , vol.12 , Issue.2 , pp. 123-137
    • Hart, B.L.1
  • 55
    • 31044447881 scopus 로고    scopus 로고
    • Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide
    • Hartz, A.M.S., Bauer, B., Fricker, G., Miller, D.S., Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. Mol. Pharmacol. 69:2 (2006), 462–470.
    • (2006) Mol. Pharmacol. , vol.69 , Issue.2 , pp. 462-470
    • Hartz, A.M.S.1    Bauer, B.2    Fricker, G.3    Miller, D.S.4
  • 56
    • 0033014362 scopus 로고    scopus 로고
    • Experimental colitis increases blood-brain barrier permeability in rabbits
    • Hathaway, C.A., Appleyard, C.B., Percy, W.H., Williams, J.L., Experimental colitis increases blood-brain barrier permeability in rabbits. Am. J. Physiol. 276:5 (1999), G1174–G1180.
    • (1999) Am. J. Physiol. , vol.276 , Issue.5 , pp. G1174-G1180
    • Hathaway, C.A.1    Appleyard, C.B.2    Percy, W.H.3    Williams, J.L.4
  • 57
    • 79958772442 scopus 로고    scopus 로고
    • RhoA and NF-κB are involved in lipopolysaccharide-induced brain microvascular cell line hyperpermeability
    • He, F., Peng, J., Deng, X.L., Yang, L.F., Wu, L.W., Zhang, C.L., Yin, F., RhoA and NF-κB are involved in lipopolysaccharide-induced brain microvascular cell line hyperpermeability. Neuroscience 188 (2011), 35–47.
    • (2011) Neuroscience , vol.188 , pp. 35-47
    • He, F.1    Peng, J.2    Deng, X.L.3    Yang, L.F.4    Wu, L.W.5    Zhang, C.L.6    Yin, F.7
  • 58
    • 84905401438 scopus 로고    scopus 로고
    • Cell-culture models of the blood-brain barrier
    • He, Y., Yao, Y., Tsirka, S.E., Cao, Y., Cell-culture models of the blood-brain barrier. Stroke 45:8 (2014), 2514–2526.
    • (2014) Stroke , vol.45 , Issue.8 , pp. 2514-2526
    • He, Y.1    Yao, Y.2    Tsirka, S.E.3    Cao, Y.4
  • 60
    • 3543068669 scopus 로고    scopus 로고
    • Temporal and spatial patterns of c-fos mRNA induced by intravenous interleukin-1: a cascade of non-neuronal cellular activation at the blood-brain barrier
    • Herkenham, M., Lee, H.Y., Baker, R.A., Temporal and spatial patterns of c-fos mRNA induced by intravenous interleukin-1: a cascade of non-neuronal cellular activation at the blood-brain barrier. J. Comp. Neurol. 400:2 (1998), 175–196.
    • (1998) J. Comp. Neurol. , vol.400 , Issue.2 , pp. 175-196
    • Herkenham, M.1    Lee, H.Y.2    Baker, R.A.3
  • 61
    • 3543115693 scopus 로고    scopus 로고
    • Biochemical markers in acute ischemic stroke
    • Hill, M.D., Jackowski, G., Bayer, N., Lawrence, M., Jaeschke, R., Biochemical markers in acute ischemic stroke. CMAJ 162:8 (2000), 1139–1140.
    • (2000) CMAJ , vol.162 , Issue.8 , pp. 1139-1140
    • Hill, M.D.1    Jackowski, G.2    Bayer, N.3    Lawrence, M.4    Jaeschke, R.5
  • 64
    • 0025834158 scopus 로고
    • Angiotensin II, vasopressin and GTP[gamma-S] inhibit inward-rectifying K+ channels in porcine cerebral capillary endothelial cells
    • Hoyer, J., Popp, R., Meyer, J., Galla, H.J., Gögelein, H., Angiotensin II, vasopressin and GTP[gamma-S] inhibit inward-rectifying K+ channels in porcine cerebral capillary endothelial cells. J. Membr. Biol. 123:1 (1991), 55–62.
    • (1991) J. Membr. Biol. , vol.123 , Issue.1 , pp. 55-62
    • Hoyer, J.1    Popp, R.2    Meyer, J.3    Galla, H.J.4    Gögelein, H.5
  • 65
    • 0036784006 scopus 로고    scopus 로고
    • Blood-brain barrier tight junctions are altered during a 72-h exposure to λ-carrageenan-induced inflammatory pain
    • Huber, J.D., Hau, V.S., Borg, L., Campos, C.R., Egleton, R.D., Davis, T.P., Blood-brain barrier tight junctions are altered during a 72-h exposure to λ-carrageenan-induced inflammatory pain. Am. J. Physiol. Heart Circ. Physiol. 283:4 (2002), H1531–H1537.
    • (2002) Am. J. Physiol. Heart Circ. Physiol. , vol.283 , Issue.4 , pp. H1531-H1537
    • Huber, J.D.1    Hau, V.S.2    Borg, L.3    Campos, C.R.4    Egleton, R.D.5    Davis, T.P.6
  • 67
    • 0034697293 scopus 로고    scopus 로고
    • Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment
    • Iwase, K., Miyanaka, K., Shimizu, A., Nagasaki, A., Gotoh, T., Mori, M., Takiguchi, M., Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment. J. Biol. Chem. 275:16 (2000), 11929–11933.
    • (2000) J. Biol. Chem. , vol.275 , Issue.16 , pp. 11929-11933
    • Iwase, K.1    Miyanaka, K.2    Shimizu, A.3    Nagasaki, A.4    Gotoh, T.5    Mori, M.6    Takiguchi, M.7
  • 69
    • 78650829169 scopus 로고    scopus 로고
    • Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra
    • 823–10
    • Jeong, H.-K., Jou, I., Joe, E.-H., Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. Exp. Mol. Med., 42(12), 2010 823–10.
    • (2010) Exp. Mol. Med. , vol.42 , Issue.12
    • Jeong, H.-K.1    Jou, I.2    Joe, E.-H.3
  • 72
    • 67449149646 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK
    • Karahashi, H., Michelsen, K.S., Arditi, M., Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK. J. Immunol. 182:11 (2009), 7280–7286.
    • (2009) J. Immunol. , vol.182 , Issue.11 , pp. 7280-7286
    • Karahashi, H.1    Michelsen, K.S.2    Arditi, M.3
  • 73
    • 0035756597 scopus 로고    scopus 로고
    • Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls
    • Kastin, A.J., Akerstrom, V., Pan, W., Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides 22:12 (2001), 2127–2136.
    • (2001) Peptides , vol.22 , Issue.12 , pp. 2127-2136
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.3
  • 74
    • 0037100456 scopus 로고    scopus 로고
    • Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis
    • Kerfoot, S.M., Kubes, P., Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis. J. Immunol. 169:2 (2002), 1000–1006.
    • (2002) J. Immunol. , vol.169 , Issue.2 , pp. 1000-1006
    • Kerfoot, S.M.1    Kubes, P.2
  • 75
    • 0028388750 scopus 로고
    • Application of the double-indicator technique for measurement of blood-brain barrier permeability in humans
    • Knudsen, G.M., Application of the double-indicator technique for measurement of blood-brain barrier permeability in humans. Cerebrovasc. Brain Metab. Rev. 6:1 (1994), 1–30.
    • (1994) Cerebrovasc. Brain Metab. Rev. , vol.6 , Issue.1 , pp. 1-30
    • Knudsen, G.M.1
  • 77
    • 0025968981 scopus 로고
    • Fluid replacement protection of rabbits challenged subcutaneous with toxic shock syndrome toxins
    • Lee, P.K., Deringer, J.R., Kreiswirth, B.N., Novick, R.P., Schlievert, P.M., Fluid replacement protection of rabbits challenged subcutaneous with toxic shock syndrome toxins. Infect. Immun. 59:3 (1991), 879–884.
    • (1991) Infect. Immun. , vol.59 , Issue.3 , pp. 879-884
    • Lee, P.K.1    Deringer, J.R.2    Kreiswirth, B.N.3    Novick, R.P.4    Schlievert, P.M.5
  • 78
    • 84862139767 scopus 로고    scopus 로고
    • The endothelial glycocalyx as a barrier to leukocyte adhesion and its mediation by extracellular proteases
    • Lipowsky, H., The endothelial glycocalyx as a barrier to leukocyte adhesion and its mediation by extracellular proteases. Ann. Biomed. Eng. 40:4 (2012), 840–848.
    • (2012) Ann. Biomed. Eng. , vol.40 , Issue.4 , pp. 840-848
    • Lipowsky, H.1
  • 80
    • 1842588603 scopus 로고    scopus 로고
    • Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions
    • Lossinsky, A.S., Shivers, R.R., Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions. Histol. Histopathol. 19:2 (2004), 535–564.
    • (2004) Histol. Histopathol. , vol.19 , Issue.2 , pp. 535-564
    • Lossinsky, A.S.1    Shivers, R.R.2
  • 81
    • 0026706704 scopus 로고
    • Viral neuroinvasion and encephalitis induced by lipopolysaccharide and its mediators
    • Lustig, S., Danenberg, H.D., Kafri, Y., Kobiler, D., Ben-Nathan, D., Viral neuroinvasion and encephalitis induced by lipopolysaccharide and its mediators. J. Exp. Med. 176:3 (1992), 707–712.
    • (1992) J. Exp. Med. , vol.176 , Issue.3 , pp. 707-712
    • Lustig, S.1    Danenberg, H.D.2    Kafri, Y.3    Kobiler, D.4    Ben-Nathan, D.5
  • 83
    • 0031835797 scopus 로고    scopus 로고
    • Ultrastructural and immunohistochemical changes of fluorescent granular perithelial cells and the interaction of FGP cells to microglia after lipopolysaccharide administration
    • Mato, M., Sakamoto, A., Ookawara, S., Takeuchi, K., Suzuki, K., Ultrastructural and immunohistochemical changes of fluorescent granular perithelial cells and the interaction of FGP cells to microglia after lipopolysaccharide administration. Anat. Rec. 251:3 (1998), 330–338.
    • (1998) Anat. Rec. , vol.251 , Issue.3 , pp. 330-338
    • Mato, M.1    Sakamoto, A.2    Ookawara, S.3    Takeuchi, K.4    Suzuki, K.5
  • 85
    • 0031911038 scopus 로고    scopus 로고
    • Roles of nitric oxide and prostaglandins in the increased permeability of the blood-brain barrier caused by lipopolysaccharide
    • Minami, T., Okazaki, J., Kawabata, A., Kawaki, H., Okazaki, Y., Tohno, Y., Roles of nitric oxide and prostaglandins in the increased permeability of the blood-brain barrier caused by lipopolysaccharide. Environ. Toxicol. Pharmacol. 5:1 (1998), 35–41.
    • (1998) Environ. Toxicol. Pharmacol. , vol.5 , Issue.1 , pp. 35-41
    • Minami, T.1    Okazaki, J.2    Kawabata, A.3    Kawaki, H.4    Okazaki, Y.5    Tohno, Y.6
  • 86
    • 0023851897 scopus 로고
    • Eicosanoid metabolism in cerebromicrovascular endothelium
    • Moore, S.A., Spector, A.A., Hart, M.N., Eicosanoid metabolism in cerebromicrovascular endothelium. Am. J. Physiol. 254:1 (1988), 37–44.
    • (1988) Am. J. Physiol. , vol.254 , Issue.1 , pp. 37-44
    • Moore, S.A.1    Spector, A.A.2    Hart, M.N.3
  • 88
    • 0031593176 scopus 로고    scopus 로고
    • Degradation of glycosaminoglycans by reactive oxygen species derived from stimulated polymorphonuclear leukocytes
    • Moseley, R., Waddington, R.J., Embery, G., Degradation of glycosaminoglycans by reactive oxygen species derived from stimulated polymorphonuclear leukocytes. Biochim. Biophys. Acta 1362:2–3 (1997), 221–231.
    • (1997) Biochim. Biophys. Acta , vol.1362 , Issue.2-3 , pp. 221-231
    • Moseley, R.1    Waddington, R.J.2    Embery, G.3
  • 89
    • 0032952972 scopus 로고    scopus 로고
    • Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge
    • Nadeau, S., Rivest, S., Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge. J. Neuropathol. Exp. Neurol. 58:1 (1999), 61–77.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , Issue.1 , pp. 61-77
    • Nadeau, S.1    Rivest, S.2
  • 91
    • 3042516972 scopus 로고    scopus 로고
    • Effects of lipopolysaccharide on leptin transport across the blood–brain barrier
    • Nonaka, N., Hileman, S.M., Shioda, S., Vo, T.Q., Banks, W.A., Effects of lipopolysaccharide on leptin transport across the blood–brain barrier. Brain Res. 1016:1 (2004), 58–65.
    • (2004) Brain Res. , vol.1016 , Issue.1 , pp. 58-65
    • Nonaka, N.1    Hileman, S.M.2    Shioda, S.3    Vo, T.Q.4    Banks, W.A.5
  • 92
    • 10044228406 scopus 로고    scopus 로고
    • Effect of lipopolysaccharide on the transport of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier
    • Nonaka, N., Shioda, S., Banks, W.A., Effect of lipopolysaccharide on the transport of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier. Exp. Neurol. 191:1 (2005), 137–144.
    • (2005) Exp. Neurol. , vol.191 , Issue.1 , pp. 137-144
    • Nonaka, N.1    Shioda, S.2    Banks, W.A.3
  • 93
    • 0036838512 scopus 로고    scopus 로고
    • Effect of endotoxin on expression of TNF receptors and transport of TNF-α at the blood-brain barrier of the rat
    • Osburg, B., Peiser, C., Dömling, D., Schomburg, L., Ko, Y.T., Voigt, K., Bickel, U., Effect of endotoxin on expression of TNF receptors and transport of TNF-α at the blood-brain barrier of the rat. Am. J. Physiol. Endocrinol. Metab. 283:5 (2002), E899–E908.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283 , Issue.5 , pp. E899-E908
    • Osburg, B.1    Peiser, C.2    Dömling, D.3    Schomburg, L.4    Ko, Y.T.5    Voigt, K.6    Bickel, U.7
  • 94
    • 85047682447 scopus 로고    scopus 로고
    • Penetration of oseltamivir and its active metabolite into the brain after lipopolysaccharide-induced inflammation in mice
    • Oshima, S., Nemoto, E., Kuramochi, M., Saitoh, Y., Kobayashi, D., Penetration of oseltamivir and its active metabolite into the brain after lipopolysaccharide-induced inflammation in mice. J. Pharm. Pharmacol. 61:10 (2009), 1397–1400.
    • (2009) J. Pharm. Pharmacol. , vol.61 , Issue.10 , pp. 1397-1400
    • Oshima, S.1    Nemoto, E.2    Kuramochi, M.3    Saitoh, Y.4    Kobayashi, D.5
  • 95
    • 84868301247 scopus 로고    scopus 로고
    • The viral mimetic polyinosinic:polycytidylic acid (poly I:C) induces cellular responses in primary cultures from rat brain sites with an incomplete blood-brain barrier
    • Ott, D., Wuchert, F., Murgott, J., Rummel, C., Gerstberger, R., Roth, J., The viral mimetic polyinosinic:polycytidylic acid (poly I:C) induces cellular responses in primary cultures from rat brain sites with an incomplete blood-brain barrier. Neurosci. Lett. 530:1 (2012), 64–68.
    • (2012) Neurosci. Lett. , vol.530 , Issue.1 , pp. 64-68
    • Ott, D.1    Wuchert, F.2    Murgott, J.3    Rummel, C.4    Gerstberger, R.5    Roth, J.6
  • 96
    • 24944465335 scopus 로고    scopus 로고
    • Assessment of relations between clinical outcome of ischemic stroke and activity of inflammatory processes in the acute phase based on examination of selected parameters
    • Palasik, W., Fiszer, U., Lechowicz, W., Czartoryska, B., Krzesiewicz, M., Lugowska, A., Assessment of relations between clinical outcome of ischemic stroke and activity of inflammatory processes in the acute phase based on examination of selected parameters. Eur. Neurol. 53:4 (2005), 188–193.
    • (2005) Eur. Neurol. , vol.53 , Issue.4 , pp. 188-193
    • Palasik, W.1    Fiszer, U.2    Lechowicz, W.3    Czartoryska, B.4    Krzesiewicz, M.5    Lugowska, A.6
  • 97
    • 0029908222 scopus 로고    scopus 로고
    • Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha
    • Pan, W., Banks, W.A., Kennedy, M.K., Gutierrez, E.G., Kastin, A.J., Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha. Am. J. Physiol. 271:4 (1996), E636–E642.
    • (1996) Am. J. Physiol. , vol.271 , Issue.4 , pp. E636-E642
    • Pan, W.1    Banks, W.A.2    Kennedy, M.K.3    Gutierrez, E.G.4    Kastin, A.J.5
  • 98
    • 47249153639 scopus 로고    scopus 로고
    • Neuroinflammation facilitates LIF entry into brain: role of TNF
    • Pan, W., Yu, C., Hsuchou, H., Zhang, Y., Kastin, A.J., Neuroinflammation facilitates LIF entry into brain: role of TNF. Am. J. Physiol. Cell Physiol. 294:6 (2008), C1436–C1442.
    • (2008) Am. J. Physiol. Cell Physiol. , vol.294 , Issue.6 , pp. C1436-C1442
    • Pan, W.1    Yu, C.2    Hsuchou, H.3    Zhang, Y.4    Kastin, A.J.5
  • 99
    • 0032912159 scopus 로고    scopus 로고
    • Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex
    • Papadopoulos, M.C., Lamb, F.J., Moss, R.F., Davies, D.C., Tighe, D., Bennett, E.D., Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex. Clin. Sci. 96:5 (1999), 461–466.
    • (1999) Clin. Sci. , vol.96 , Issue.5 , pp. 461-466
    • Papadopoulos, M.C.1    Lamb, F.J.2    Moss, R.F.3    Davies, D.C.4    Tighe, D.5    Bennett, E.D.6
  • 100
    • 0031026780 scopus 로고    scopus 로고
    • Brain microvascular and astrocyte localization of P-glycoprotein
    • Pardridge, W.M., Golden, P.L., Kang, Y.S., Bickel, U., Brain microvascular and astrocyte localization of P-glycoprotein. J. Neurochem. 68:3 (1997), 1278–1285.
    • (1997) J. Neurochem. , vol.68 , Issue.3 , pp. 1278-1285
    • Pardridge, W.M.1    Golden, P.L.2    Kang, Y.S.3    Bickel, U.4
  • 101
    • 0020956774 scopus 로고
    • Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data
    • Patlak, C.S., Blasberg, R.G., Fenstermacher, J.D., Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metab. 3:1 (1983), 1–7.
    • (1983) J. Cereb. Blood Flow Metab. , vol.3 , Issue.1 , pp. 1-7
    • Patlak, C.S.1    Blasberg, R.G.2    Fenstermacher, J.D.3
  • 102
    • 84897976299 scopus 로고    scopus 로고
    • Microglial priming in neurodegenerative disease
    • Perry, V.H., Holmes, C., Microglial priming in neurodegenerative disease. Nat. Rev. Neurol. 10:4 (2014), 217–224.
    • (2014) Nat. Rev. Neurol. , vol.10 , Issue.4 , pp. 217-224
    • Perry, V.H.1    Holmes, C.2
  • 103
    • 84880328646 scopus 로고    scopus 로고
    • Pericytes support neutrophil transmigration via interleukin-8 across a porcine co-culture model of the blood–brain barrier
    • Pieper, C., Pieloch, P., Galla, H.-J., Pericytes support neutrophil transmigration via interleukin-8 across a porcine co-culture model of the blood–brain barrier. Brain Res. 1524 (2013), 1–11.
    • (2013) Brain Res. , vol.1524 , pp. 1-11
    • Pieper, C.1    Pieloch, P.2    Galla, H.-J.3
  • 104
    • 17044431775 scopus 로고    scopus 로고
    • Th1 and Th2 lymphocyte migration across the human BBB is specifically regulated by interferon β and copolymer-1
    • Prat, A., Biernacki, K., Antel, J.P., Th1 and Th2 lymphocyte migration across the human BBB is specifically regulated by interferon β and copolymer-1. J. Autoimmun. 24:2 (2005), 119–124.
    • (2005) J. Autoimmun. , vol.24 , Issue.2 , pp. 119-124
    • Prat, A.1    Biernacki, K.2    Antel, J.P.3
  • 105
    • 84939189305 scopus 로고    scopus 로고
    • LPS induces occludin dysregulation in cerebral microvascular endothelial cells via MAPK signaling and augmenting MMP-2 levels
    • 120641
    • Qin, L.-H., Huang, W., Mo, X.-A., Chen, Y.-L., Wu, X.-H., LPS induces occludin dysregulation in cerebral microvascular endothelial cells via MAPK signaling and augmenting MMP-2 levels. Oxid. Med. Cell. Longev., 2015, 120641.
    • (2015) Oxid. Med. Cell. Longev.
    • Qin, L.-H.1    Huang, W.2    Mo, X.-A.3    Chen, Y.-L.4    Wu, X.-H.5
  • 106
    • 0037441577 scopus 로고    scopus 로고
    • Endothelial activation is an intermediate step for peripheral lipopolysaccharide induced activation of paraventricular nucleus
    • Quan, N., He, L., Lai, W., Endothelial activation is an intermediate step for peripheral lipopolysaccharide induced activation of paraventricular nucleus. Brain Res. Bull. 59:6 (2003), 447–452.
    • (2003) Brain Res. Bull. , vol.59 , Issue.6 , pp. 447-452
    • Quan, N.1    He, L.2    Lai, W.3
  • 108
    • 0027049962 scopus 로고
    • Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies
    • Sánchez del Pino, M.M., Hawkins, R.A., Peterson, D.R., Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies. J. Biol. Chem. 267:36 (1992), 25951–25957.
    • (1992) J. Biol. Chem. , vol.267 , Issue.36 , pp. 25951-25957
    • Sánchez del Pino, M.M.1    Hawkins, R.A.2    Peterson, D.R.3
  • 109
    • 53749096762 scopus 로고    scopus 로고
    • Blood-brain barrier tight junction permeability and ischemic stroke
    • Sandoval, K.E., Witt, K.A., Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol. Dis. 32:2 (2008), 200–219.
    • (2008) Neurobiol. Dis. , vol.32 , Issue.2 , pp. 200-219
    • Sandoval, K.E.1    Witt, K.A.2
  • 112
    • 84879708787 scopus 로고    scopus 로고
    • A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1B, TNF-α and IL-6 challenges in C57BL/6 mice
    • e69123-20
    • Skelly, D.T., Hennessy, E., Dansereau, M., Cunningham, C., A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1B, TNF-α and IL-6 challenges in C57BL/6 mice. PLoS ONE, 8(7), 2013 e69123-20.
    • (2013) PLoS ONE , vol.8 , Issue.7
    • Skelly, D.T.1    Hennessy, E.2    Dansereau, M.3    Cunningham, C.4
  • 113
    • 84928122606 scopus 로고    scopus 로고
    • Astrocyte barriers to neurotoxic inflammation
    • Sofroniew, M.V., Astrocyte barriers to neurotoxic inflammation. Nat. Rev. Neurosci. 16:5 (2015), 249–263.
    • (2015) Nat. Rev. Neurosci. , vol.16 , Issue.5 , pp. 249-263
    • Sofroniew, M.V.1
  • 115
    • 21244479671 scopus 로고    scopus 로고
    • Breakdown of the blood-brain barrier to proteins in white matter of the developing brain following systemic inflammation
    • Stolp, H.B., Dziegielewska, K.M., Ek, C.J., Habgood, M.D., Lane, M.A., Potter, A.M., Saunders, N.R., Breakdown of the blood-brain barrier to proteins in white matter of the developing brain following systemic inflammation. Cell Tissue Res. 320:3 (2005), 369–378.
    • (2005) Cell Tissue Res. , vol.320 , Issue.3 , pp. 369-378
    • Stolp, H.B.1    Dziegielewska, K.M.2    Ek, C.J.3    Habgood, M.D.4    Lane, M.A.5    Potter, A.M.6    Saunders, N.R.7
  • 116
    • 84877586983 scopus 로고    scopus 로고
    • Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model
    • Takeda, S., Sato, N., Ikimura, K., Nishino, H., Rakugi, H., Morishita, R., Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model. Neurobiol. Aging 34:8 (2013), 2064–2070.
    • (2013) Neurobiol. Aging , vol.34 , Issue.8 , pp. 2064-2070
    • Takeda, S.1    Sato, N.2    Ikimura, K.3    Nishino, H.4    Rakugi, H.5    Morishita, R.6
  • 117
    • 77954341974 scopus 로고    scopus 로고
    • Shear stress and the endothelial transport barrier
    • Tarbell, J.M., Shear stress and the endothelial transport barrier. Cardiovasc. Res. 87:2 (2010), 320–330.
    • (2010) Cardiovasc. Res. , vol.87 , Issue.2 , pp. 320-330
    • Tarbell, J.M.1
  • 118
    • 0032193213 scopus 로고    scopus 로고
    • Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice
    • Tran, E.H., Hoekstra, K., van Rooijen, N., Dijkstra, C.D., Owens, T., Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J. Immunol. 161:7 (1998), 3767–3775.
    • (1998) J. Immunol. , vol.161 , Issue.7 , pp. 3767-3775
    • Tran, E.H.1    Hoekstra, K.2    van Rooijen, N.3    Dijkstra, C.D.4    Owens, T.5
  • 119
    • 0034873862 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha causes an increase in blood-brain barrier permeability during sepsis
    • Tsao, N., Hsu, H.P., Wu, C.M., Liu, C.C., Lei, H.Y., Tumour necrosis factor-alpha causes an increase in blood-brain barrier permeability during sepsis. J. Med. Microbiol. 50:9 (2001), 812–821.
    • (2001) J. Med. Microbiol. , vol.50 , Issue.9 , pp. 812-821
    • Tsao, N.1    Hsu, H.P.2    Wu, C.M.3    Liu, C.C.4    Lei, H.Y.5
  • 120
    • 0025734979 scopus 로고
    • Blood-brain barrier alterations in bacterial meningitis: development of an in vitro model and observations on the effects of lipopolysaccharide
    • Tunkel, A.R., Rosser, S.W., Hansen, E.J., Scheld, W.M., Blood-brain barrier alterations in bacterial meningitis: development of an in vitro model and observations on the effects of lipopolysaccharide. Vitro Cell Dev. Biol. 27:2 (1991), 113–120.
    • (1991) Vitro Cell Dev. Biol. , vol.27 , Issue.2 , pp. 113-120
    • Tunkel, A.R.1    Rosser, S.W.2    Hansen, E.J.3    Scheld, W.M.4
  • 121
    • 85007327473 scopus 로고    scopus 로고
    • Pharmacologic manipulation of lysosomal enzyme transport across the blood-brain barrier
    • 0271678X15614589-11
    • Urayama, A., Grubb, J.H., Sly, W.S., Banks, W.A., Pharmacologic manipulation of lysosomal enzyme transport across the blood-brain barrier. J. Cereb. Blood Flow Metab., 2015 0271678X15614589-11.
    • (2015) J. Cereb. Blood Flow Metab.
    • Urayama, A.1    Grubb, J.H.2    Sly, W.S.3    Banks, W.A.4
  • 122
    • 1842290972 scopus 로고    scopus 로고
    • Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta
    • Vallières, L., Rivest, S., Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta. J. Neurochem. 69:4 (1997), 1668–1683.
    • (1997) J. Neurochem. , vol.69 , Issue.4 , pp. 1668-1683
    • Vallières, L.1    Rivest, S.2
  • 124
    • 84942989213 scopus 로고    scopus 로고
    • Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood-brain barrier cells toward enhanced prostaglandin E2 signalling
    • Vasilache, A.M., Qian, H., Blomqvist, A., Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood-brain barrier cells toward enhanced prostaglandin E2 signalling. Brain Behav. Immun. 48 (2015), 31–41.
    • (2015) Brain Behav. Immun. , vol.48 , pp. 31-41
    • Vasilache, A.M.1    Qian, H.2    Blomqvist, A.3
  • 125
    • 11144273976 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
    • Wang, T., Town, T., Alexopoulou, L., Anderson, J.F., Fikrig, E., Flavell, R.A., Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat. Med. 10:12 (2004), 1366–1373.
    • (2004) Nat. Med. , vol.10 , Issue.12 , pp. 1366-1373
    • Wang, T.1    Town, T.2    Alexopoulou, L.3    Anderson, J.F.4    Fikrig, E.5    Flavell, R.A.6
  • 126
    • 47749105350 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 infection increases the in vivo capacity of peripheral monocytes to cross the blood-brain barrier into the brain and the in vivo sensitivity of the blood-brain barrier to disruption by lipopolysaccharide
    • Wang, H., Sun, J., Goldstein, H., Human immunodeficiency virus type 1 infection increases the in vivo capacity of peripheral monocytes to cross the blood-brain barrier into the brain and the in vivo sensitivity of the blood-brain barrier to disruption by lipopolysaccharide. J. Virol. 82:15 (2008), 7591–7600.
    • (2008) J. Virol. , vol.82 , Issue.15 , pp. 7591-7600
    • Wang, H.1    Sun, J.2    Goldstein, H.3
  • 129
    • 84926444090 scopus 로고    scopus 로고
    • Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents
    • Wittmann, G., Szabon, J., Mohácsik, P., Nouriel, S.S., Gereben, B., Fekete, C., Lechan, R.M., Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents. Endocrinology 156:4 (2015), 1552–1564.
    • (2015) Endocrinology , vol.156 , Issue.4 , pp. 1552-1564
    • Wittmann, G.1    Szabon, J.2    Mohácsik, P.3    Nouriel, S.S.4    Gereben, B.5    Fekete, C.6    Lechan, R.M.7
  • 130
    • 84940781234 scopus 로고    scopus 로고
    • Endotoxin-induced inflammation down-regulates l-type amino acid transporter 1 (LAT1) expression at the blood–brain barrier of male rats and mice
    • Wittmann, G., Mohácsik, P., Balkhi, M.Y., Gereben, B., Lechan, R.M., Endotoxin-induced inflammation down-regulates l-type amino acid transporter 1 (LAT1) expression at the blood–brain barrier of male rats and mice. Fluids Barriers CNS, 12, 2015, 21.
    • (2015) Fluids Barriers CNS , vol.12 , pp. 21
    • Wittmann, G.1    Mohácsik, P.2    Balkhi, M.Y.3    Gereben, B.4    Lechan, R.M.5
  • 131
    • 0038819415 scopus 로고    scopus 로고
    • Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme
    • Wolburg, H., Wolburg-Buchholz, K., Kraus, J., Rascher-Eggstein, G., Liebner, S., Hamm, S., Duffner, F., Grote, E.-H., Risau, W., Engelhardt, B., Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol. 105:6 (2003), 586–592.
    • (2003) Acta Neuropathol. , vol.105 , Issue.6 , pp. 586-592
    • Wolburg, H.1    Wolburg-Buchholz, K.2    Kraus, J.3    Rascher-Eggstein, G.4    Liebner, S.5    Hamm, S.6    Duffner, F.7    Grote, E.-H.8    Risau, W.9    Engelhardt, B.10
  • 132
    • 16344368162 scopus 로고    scopus 로고
    • Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact
    • Wolburg, H., Wolburg-Buchholz, K., Engelhardt, B., Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta Neuropathol. 109:2 (2005), 181–190.
    • (2005) Acta Neuropathol. , vol.109 , Issue.2 , pp. 181-190
    • Wolburg, H.1    Wolburg-Buchholz, K.2    Engelhardt, B.3
  • 133
    • 8644246082 scopus 로고    scopus 로고
    • Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood-brain barrier
    • Wong, D., Dorovini-Zis, K., Vincent, S.R., Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood-brain barrier. Exp. Neurol. 190:2 (2004), 446–455.
    • (2004) Exp. Neurol. , vol.190 , Issue.2 , pp. 446-455
    • Wong, D.1    Dorovini-Zis, K.2    Vincent, S.R.3
  • 134
    • 84857247058 scopus 로고    scopus 로고
    • Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy
    • Woodcock, T.E., Woodcock, T.M., Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy. Br. J. Anaesth. 108:3 (2012), 384–394.
    • (2012) Br. J. Anaesth. , vol.108 , Issue.3 , pp. 384-394
    • Woodcock, T.E.1    Woodcock, T.M.2
  • 135
    • 84955186755 scopus 로고    scopus 로고
    • Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood-brain barrier and its implications to the transport of neurotoxins
    • Wu, K.-C., Lu, Y.-H., Peng, Y.-H., Hsu, L.-C., Lin, C.-J., Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood-brain barrier and its implications to the transport of neurotoxins. J. Neurochem. 135:6 (2015), 1178–1188.
    • (2015) J. Neurochem. , vol.135 , Issue.6 , pp. 1178-1188
    • Wu, K.-C.1    Lu, Y.-H.2    Peng, Y.-H.3    Hsu, L.-C.4    Lin, C.-J.5
  • 136
    • 0035970783 scopus 로고    scopus 로고
    • Effect of LPS on the permeability of the blood-brain barrier to insulin
    • Xaio, H., Banks, W.A., Niehoff, M.L., Morley, J.E., Effect of LPS on the permeability of the blood-brain barrier to insulin. Brain Res. 896:1–2 (2001), 36–42.
    • (2001) Brain Res. , vol.896 , Issue.1-2 , pp. 36-42
    • Xaio, H.1    Banks, W.A.2    Niehoff, M.L.3    Morley, J.E.4
  • 137
    • 1942469523 scopus 로고    scopus 로고
    • Cerebrovascular responses in the fetal sheep brain to low-dose endotoxin
    • Yan, E., Castillo-Meléndez, M., Nicholls, T., Hirst, J., Walker, D., Cerebrovascular responses in the fetal sheep brain to low-dose endotoxin. Pediatr. Res. 55:5 (2004), 855–863.
    • (2004) Pediatr. Res. , vol.55 , Issue.5 , pp. 855-863
    • Yan, E.1    Castillo-Meléndez, M.2    Nicholls, T.3    Hirst, J.4    Walker, D.5
  • 138
    • 84924918695 scopus 로고    scopus 로고
    • Simvastatin attenuates sepsis-induced blood-brain barrier integrity loss
    • Yang, C.-H., Kao, M.-C., Shih, P.-C., Li, K.-Y., Tsai, P.-S., Huang, C.-J., Simvastatin attenuates sepsis-induced blood-brain barrier integrity loss. J. Surg. Res. 194:2 (2015), 591–598.
    • (2015) J. Surg. Res. , vol.194 , Issue.2 , pp. 591-598
    • Yang, C.-H.1    Kao, M.-C.2    Shih, P.-C.3    Li, K.-Y.4    Tsai, P.-S.5    Huang, C.-J.6
  • 140
    • 84937553997 scopus 로고    scopus 로고
    • Activation of AMPK improves lipopolysaccharide-induced dysfunction of the blood-brain barrier in mice
    • Yu, H.-Y., Cai, Y.-B., Liu, Z., Activation of AMPK improves lipopolysaccharide-induced dysfunction of the blood-brain barrier in mice. Brain Inj. 29:6 (2015), 777–784.
    • (2015) Brain Inj. , vol.29 , Issue.6 , pp. 777-784
    • Yu, H.-Y.1    Cai, Y.-B.2    Liu, Z.3
  • 142
    • 33751554878 scopus 로고    scopus 로고
    • A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide
    • Zhou, H., Lapointe, B.M., Clark, S.R., Zbytnuik, L., Kubes, P., A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J. Immunol. 177:11 (2006), 8103–8110.
    • (2006) J. Immunol. , vol.177 , Issue.11 , pp. 8103-8110
    • Zhou, H.1    Lapointe, B.M.2    Clark, S.R.3    Zbytnuik, L.4    Kubes, P.5
  • 143
    • 77951294408 scopus 로고    scopus 로고
    • Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation
    • Zhou, H., Andonegui, G., Wong, C.H.Y., Kubes, P., Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J. Immunol. 183:8 (2009), 5244–5250.
    • (2009) J. Immunol. , vol.183 , Issue.8 , pp. 5244-5250
    • Zhou, H.1    Andonegui, G.2    Wong, C.H.Y.3    Kubes, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.