메뉴 건너뛰기




Volumn 10, Issue 12, 2010, Pages 2604-2614

Comparative transcriptional and phenotypic peripheral blood analysis of kidney recipients under cyclosporin A or sirolimus monotherapy

Author keywords

Calcineurin inhibitors; gene expression; immunosuppression; kidney transplantation; sirolimus; tolerance

Indexed keywords

AKR1C1 PROTEIN; AKR1C2 PROTEIN; AURORA A KINASE; BASILIXIMAB; BUB1B PROTEIN; CADHERIN 2; CD4 ANTIGEN; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 2; CHECK1 PROTEIN; COMPLEMENT COMPONENT C1S; CREATININE; CYCLOSPORIN A; DEPDC1 PROTEIN; GAGE PROTEIN; HBB PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LTB4DH PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MS4A1 PROTEIN; MTHFD2 PROTEIN; NCAPH PROTEIN; NR2F1 PROTEIN; OKT 3; PREDNISONE; RAPAMYCIN; SOMATOMEDIN BINDING PROTEIN 3; TACROLIMUS; TRANSCRIPTION FACTOR ELF 1; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 78649836813     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2010.03302.x     Document Type: Article
Times cited : (42)

References (52)
  • 1
    • 70350131319 scopus 로고    scopus 로고
    • Mycophenolate mofetil and calcineurin-inhibitor reduction: Recent progress
    • Grinyo JM, Cruzado JM,. Mycophenolate mofetil and calcineurin-inhibitor reduction: Recent progress. Am J Transplant 2009; 9: 2447-2452.
    • (2009) Am J Transplant , vol.9 , pp. 2447-2452
    • Grinyo, J.M.1    Cruzado, J.M.2
  • 2
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone NA, Crabtree GR,. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992; 357: 695-697.
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 3
    • 0036524050 scopus 로고    scopus 로고
    • Fibrosis and atrophy in the renal allograft: Interim report and new directions
    • Racusen LC, Solez K, Colvin R,. Fibrosis and atrophy in the renal allograft: Interim report and new directions. Am J Transplant 2002; 2: 203-206.
    • (2002) Am J Transplant , vol.2 , pp. 203-206
    • Racusen, L.C.1    Solez, K.2    Colvin, R.3
  • 5
    • 33645945017 scopus 로고    scopus 로고
    • Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients
    • Stallone G, Infante B, Schena A, et al,. Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients. J Am Soc Nephrol 2005; 16: 3755-3762.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3755-3762
    • Stallone, G.1    Infante, B.2    Schena, A.3
  • 6
    • 33644694497 scopus 로고    scopus 로고
    • A randomized controlled trial of late conversion from CNI-based to sirolimus-based immunosuppression following renal transplantation
    • Watson CJ, Firth J, Williams PF, et al,. A randomized controlled trial of late conversion from CNI-based to sirolimus-based immunosuppression following renal transplantation. Am J Transplant 2005; 5: 2496-2503.
    • (2005) Am J Transplant , vol.5 , pp. 2496-2503
    • Watson, C.J.1    Firth, J.2    Williams, P.F.3
  • 7
    • 34249284512 scopus 로고    scopus 로고
    • MTOR at the crossroads of T cell proliferation and tolerance
    • Mondino A, Mueller DL,. mTOR at the crossroads of T cell proliferation and tolerance. Semin Immunol 2007; 19: 162-172.
    • (2007) Semin Immunol , vol.19 , pp. 162-172
    • Mondino, A.1    Mueller, D.L.2
  • 8
    • 54949109311 scopus 로고    scopus 로고
    • The TSC-mTOR signaling pathway regulates the innate inflammatory response
    • Weichhart T, Costantino G, Poglitsch M, et al,. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008; 29: 565-577.
    • (2008) Immunity , vol.29 , pp. 565-577
    • Weichhart, T.1    Costantino, G.2    Poglitsch, M.3
  • 9
    • 58149483654 scopus 로고    scopus 로고
    • The pharmacodynamic effect of sirolimus: Individual variation of cytokine mRNA expression profiles in human whole blood samples
    • Muller-Steinhardt M, Wortmeier K, Fricke L, Ebel B, Hartel C,. The pharmacodynamic effect of sirolimus: Individual variation of cytokine mRNA expression profiles in human whole blood samples. Immunobiology 2009; 214: 17-26.
    • (2009) Immunobiology , vol.214 , pp. 17-26
    • Muller-Steinhardt, M.1    Wortmeier, K.2    Fricke, L.3    Ebel, B.4    Hartel, C.5
  • 10
    • 0035412393 scopus 로고    scopus 로고
    • Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages
    • Woltman AM, De Fijter JW, Kamerling SW, et al,. Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages. Blood 2001; 98: 174-180.
    • (2001) Blood , vol.98 , pp. 174-180
    • Woltman, A.M.1    De Fijter, J.W.2    Kamerling, S.W.3
  • 11
    • 13144256708 scopus 로고    scopus 로고
    • Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival
    • Taner T, Hackstein H, Wang Z, Morelli AE, Thomson AW,. Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am J Transplant 2005; 5: 228-236.
    • (2005) Am J Transplant , vol.5 , pp. 228-236
    • Taner, T.1    Hackstein, H.2    Wang, Z.3    Morelli, A.E.4    Thomson, A.W.5
  • 12
    • 33747889822 scopus 로고    scopus 로고
    • Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4 + CD25 + FOXP3+ regulatory T cells in renal transplant recipients
    • Segundo DS, Ruiz JC, Izquierdo M, et al,. Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4 + CD25 + FOXP3+ regulatory T cells in renal transplant recipients. Transplantation 2006; 82: 550-557.
    • (2006) Transplantation , vol.82 , pp. 550-557
    • Segundo, D.S.1    Ruiz, J.C.2    Izquierdo, M.3
  • 13
    • 34250156673 scopus 로고    scopus 로고
    • Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
    • Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB,. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant 2007; 7: 1722-1732.
    • (2007) Am J Transplant , vol.7 , pp. 1722-1732
    • Gao, W.1    Lu, Y.2    El Essawy, B.3    Oukka, M.4    Kuchroo, V.K.5    Strom, T.B.6
  • 14
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
    • Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW,. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007; 178: 7018-7031.
    • (2007) J Immunol , vol.178 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3    Fischer, R.T.4    Wang, Z.5    Thomson, A.W.6
  • 16
    • 58149292274 scopus 로고    scopus 로고
    • Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation
    • Reichardt W, Durr C, Von Elverfeldt D, et al,. Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation. J Immunol 2008; 181: 4770-4779.
    • (2008) J Immunol , vol.181 , pp. 4770-4779
    • Reichardt, W.1    Durr, C.2    Von Elverfeldt, D.3
  • 17
    • 0037182139 scopus 로고    scopus 로고
    • Rapamycin blocks tumor progression: Unlinking immunosuppression from antitumor efficacy
    • Luan FL, Hojo M, Maluccio M, Yamaji K, Suthanthiran M,. Rapamycin blocks tumor progression: Unlinking immunosuppression from antitumor efficacy. Transplantation 2002; 73: 1565-1572.
    • (2002) Transplantation , vol.73 , pp. 1565-1572
    • Luan, F.L.1    Hojo, M.2    Maluccio, M.3    Yamaji, K.4    Suthanthiran, M.5
  • 18
    • 33746530366 scopus 로고    scopus 로고
    • Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomised multicentre study. The Rapamune US Study Group
    • Kahan BD,. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomised multicentre study. The Rapamune US Study Group. Lancet 2000; 356: 194-202.
    • (2000) Lancet , vol.356 , pp. 194-202
    • Kahan, B.D.1
  • 19
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al,. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007; 357: 2562-2575.
    • (2007) N Engl J Med , vol.357 , pp. 2562-2575
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 20
    • 36749057967 scopus 로고    scopus 로고
    • Pneumonitis associated with sirolimus: Clinical characteristics, risk factors and outcome-a single-centre experience and review of the literature
    • Weiner SM, Sellin L, Vonend O, et al,. Pneumonitis associated with sirolimus: Clinical characteristics, risk factors and outcome-a single-centre experience and review of the literature. Nephrol Dial Transplant 2007; 22: 3631-3637.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 3631-3637
    • Weiner, S.M.1    Sellin, L.2    Vonend, O.3
  • 21
    • 28544432476 scopus 로고    scopus 로고
    • Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state
    • Thaunat O, Beaumont C, Chatenoud L, et al,. Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state. Transplantation 2005; 80: 1212-1219.
    • (2005) Transplantation , vol.80 , pp. 1212-1219
    • Thaunat, O.1    Beaumont, C.2    Chatenoud, L.3
  • 22
    • 34548859562 scopus 로고    scopus 로고
    • Sirolimus: Defining nephrotoxicity in the renal transplant recipient
    • Tomlanovich SJ, Vincenti F,. Sirolimus: Defining nephrotoxicity in the renal transplant recipient. Clin J Am Soc Nephrol 2007; 2: 198-199.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 198-199
    • Tomlanovich, S.J.1    Vincenti, F.2
  • 23
    • 33749834063 scopus 로고    scopus 로고
    • Sirolimus-challenging current perspectives
    • Buhaescu I, Izzedine H, Covic A,. Sirolimus-challenging current perspectives. Ther Drug Monit 2006; 28: 577-584.
    • (2006) Ther Drug Monit , vol.28 , pp. 577-584
    • Buhaescu, I.1    Izzedine, H.2    Covic, A.3
  • 24
    • 0344613988 scopus 로고    scopus 로고
    • Blocking both signal 1 and signal 2 of T cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
    • Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB,. Blocking both signal 1 and signal 2 of T cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999; 5: 1298-1302.
    • (1999) Nat Med , vol.5 , pp. 1298-1302
    • Li, Y.1    Li, X.C.2    Zheng, X.X.3    Wells, A.D.4    Turka, L.A.5    Strom, T.B.6
  • 25
    • 67650074206 scopus 로고    scopus 로고
    • MTOR regulates memory CD8 T cell differentiation
    • Araki K, Turner AP, Shaffer VO, et al,. mTOR regulates memory CD8 T cell differentiation. Nature 2009; 460: 108-112.
    • (2009) Nature , vol.460 , pp. 108-112
    • Araki, K.1    Turner, A.P.2    Shaffer, V.O.3
  • 26
    • 33644771449 scopus 로고    scopus 로고
    • Clinical operational tolerance after kidney transplantation
    • Roussey-Kesler G, Giral M, Moreau A, et al,. Clinical operational tolerance after kidney transplantation. Am J Transplant 2006; 6: 736-746.
    • (2006) Am J Transplant , vol.6 , pp. 736-746
    • Roussey-Kesler, G.1    Giral, M.2    Moreau, A.3
  • 27
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G,. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001; 98: 5116-5121.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 28
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar R, Domrachev M, Lash AE,. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucl Acids Res 2002; 30: 207-210.
    • (2002) Nucl Acids Res , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 29
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al,. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545-15550.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 30
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, et al,. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature genetics 2003; 34: 267-273.
    • (2003) Nature Genetics , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 31
    • 66549084876 scopus 로고    scopus 로고
    • A HaemAtlas: Characterizing gene expression in differentiated human blood cells
    • Watkins NA, Gusnanto A, De Bono B, et al,. A HaemAtlas: Characterizing gene expression in differentiated human blood cells. Blood 2009; 113: e1-e9.
    • (2009) Blood , vol.113
    • Watkins, N.A.1    Gusnanto, A.2    De Bono, B.3
  • 32
    • 34848857054 scopus 로고    scopus 로고
    • Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance
    • Brouard S, Mansfield E, Braud C, et al,. Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. Proc Natl Acad Sci USA 2007; 104: 15448-15453.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15448-15453
    • Brouard, S.1    Mansfield, E.2    Braud, C.3
  • 33
    • 0037076272 scopus 로고    scopus 로고
    • Diagnosis of multiple cancer types by shrunken centroids of gene expression
    • Tibshirani R, Hastie T, Narasimhan B, Chu G,. Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci USA 2002; 99: 6567-6572.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6567-6572
    • Tibshirani, R.1    Hastie, T.2    Narasimhan, B.3    Chu, G.4
  • 34
    • 77951879580 scopus 로고    scopus 로고
    • Immunoproteasome beta subunit 10 is increased in chronic antibody-mediated rejection
    • Ashton-Chess J, Mai HL, Jovanovic V, et al,. Immunoproteasome beta subunit 10 is increased in chronic antibody-mediated rejection. Kidney Intern 77: 880-890.
    • Kidney Intern , vol.77 , pp. 880-890
    • Ashton-Chess, J.1    Mai, H.L.2    Jovanovic, V.3
  • 35
    • 65649117029 scopus 로고    scopus 로고
    • Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients
    • Ashton-Chess J, Dugast E, Colvin RB, et al,. Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients. J Am Soc Nephrol 2009; 20: 1113-1122.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1113-1122
    • Ashton-Chess, J.1    Dugast, E.2    Colvin, R.B.3
  • 36
    • 49849103955 scopus 로고    scopus 로고
    • Contrasted blood and intragraft toll-like receptor 4 mRNA profiles in operational tolerance versus chronic rejection in kidney transplant recipients
    • Braudeau C, Ashton-Chess J, Giral M, et al,. Contrasted blood and intragraft toll-like receptor 4 mRNA profiles in operational tolerance versus chronic rejection in kidney transplant recipients. Transplantation 2008; 86: 130-136.
    • (2008) Transplantation , vol.86 , pp. 130-136
    • Braudeau, C.1    Ashton-Chess, J.2    Giral, M.3
  • 37
    • 48049088583 scopus 로고    scopus 로고
    • Tribbles-1 as a novel biomarker of chronic antibody-mediated rejection
    • Ashton-Chess J, Giral M, Mengel M, et al,. Tribbles-1 as a novel biomarker of chronic antibody-mediated rejection. J Am Soc Nephrol 2008; 19: 1116-1127.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1116-1127
    • Ashton-Chess, J.1    Giral, M.2    Mengel, M.3
  • 38
    • 0032530709 scopus 로고    scopus 로고
    • Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts
    • Vasconcellos LM, Schachter AD, Zheng XX, et al,. Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts. Transplantation 1998; 66: 562-566.
    • (1998) Transplantation , vol.66 , pp. 562-566
    • Vasconcellos, L.M.1    Schachter, A.D.2    Zheng, X.X.3
  • 39
    • 0034663959 scopus 로고    scopus 로고
    • Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection
    • Shoker A, George D, Yang H, Baltzan M,. Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection. Transplantation 2000; 70: 497-505.
    • (2000) Transplantation , vol.70 , pp. 497-505
    • Shoker, A.1    George, D.2    Yang, H.3    Baltzan, M.4
  • 40
    • 0034667745 scopus 로고    scopus 로고
    • Cytokine and cytotoxic molecule gene expression determined in peripheral blood mononuclear cells in the diagnosis of acute renal rejection
    • Dugre FJ, Gaudreau S, Belles-Isles M, Houde I, Roy R,. Cytokine and cytotoxic molecule gene expression determined in peripheral blood mononuclear cells in the diagnosis of acute renal rejection. Transplantation 2000; 70: 1074-1080.
    • (2000) Transplantation , vol.70 , pp. 1074-1080
    • Dugre, F.J.1    Gaudreau, S.2    Belles-Isles, M.3    Houde, I.4    Roy, R.5
  • 41
    • 48349097977 scopus 로고    scopus 로고
    • Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients
    • Schenk AD, Nozaki T, Rabant M, Valujskikh A, Fairchild RL,. Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients. Am J Transplant 2008; 8: 1652-1661.
    • (2008) Am J Transplant , vol.8 , pp. 1652-1661
    • Schenk, A.D.1    Nozaki, T.2    Rabant, M.3    Valujskikh, A.4    Fairchild, R.L.5
  • 42
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD4+CD25+FOXP3 +regulatory T cells of both healthy subjects and type 1 diabetic patients
    • Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG,. Rapamycin promotes expansion of functional CD4+CD25+FOXP3 +regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006; 177: 8338-8347.
    • (2006) J Immunol , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3    Horejs-Hoeck, J.4    Kaupper, T.5    Roncarolo, M.G.6
  • 43
    • 33947249410 scopus 로고    scopus 로고
    • Regulatory T cells and T cell depletion: Role of immunosuppressive drugs
    • Noris M, Casiraghi F, Todeschini M, et al,. Regulatory T cells and T cell depletion: Role of immunosuppressive drugs. J Am Soc Nephrol 2007; 18: 1007-1018.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1007-1018
    • Noris, M.1    Casiraghi, F.2    Todeschini, M.3
  • 44
    • 40449100796 scopus 로고    scopus 로고
    • Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection
    • Mariotti J, Foley J, Jung U, et al,. Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection. J Immunol 2008; 180: 89-105.
    • (2008) J Immunol , vol.180 , pp. 89-105
    • Mariotti, J.1    Foley, J.2    Jung, U.3
  • 45
    • 0038036797 scopus 로고    scopus 로고
    • Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
    • Hackstein H, Taner T, Zahorchak AF, et al,. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 2003; 101: 4457-4463.
    • (2003) Blood , vol.101 , pp. 4457-4463
    • Hackstein, H.1    Taner, T.2    Zahorchak, A.F.3
  • 46
    • 58149352480 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells
    • Schmitz F, Heit A, Dreher S, et al,. Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. Eur J Immunol 2008; 38: 2981-2992.
    • (2008) Eur J Immunol , vol.38 , pp. 2981-2992
    • Schmitz, F.1    Heit, A.2    Dreher, S.3
  • 47
    • 33745013651 scopus 로고    scopus 로고
    • Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages
    • Yang CS, Song CH, Lee JS, et al,. Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages. Cell Microbiol 2006; 8: 1158-1171.
    • (2006) Cell Microbiol , vol.8 , pp. 1158-1171
    • Yang, C.S.1    Song, C.H.2    Lee, J.S.3
  • 48
    • 68049146006 scopus 로고    scopus 로고
    • Recently discovered T cell subsets cannot keep their commitments
    • Strom TB, Koulmanda M,. Recently discovered T cell subsets cannot keep their commitments. J Am Soc Nephrol 2009; 20: 1677-1680.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1677-1680
    • Strom, T.B.1    Koulmanda, M.2
  • 49
    • 77950299026 scopus 로고    scopus 로고
    • TLR signals promote IL-6/IL-17-dependent transplant rejection
    • Chen L, Ahmed E, Wang T, et al,. TLR signals promote IL-6/IL-17-dependent transplant rejection. J Immunol 2009; 182: 6217-6225.
    • (2009) J Immunol , vol.182 , pp. 6217-6225
    • Chen, L.1    Ahmed, E.2    Wang, T.3
  • 50
  • 51
    • 77953178765 scopus 로고    scopus 로고
    • Identification of a B cell signature associated with renal transplant tolerance in humans
    • Newell KA, Asare A, Kirk AD, et al,. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 120 (6): 1836-1847.
    • J Clin Invest , vol.120 , Issue.6 , pp. 1836-1847
    • Newell, K.A.1    Asare, A.2    Kirk, A.D.3
  • 52
    • 77953209236 scopus 로고    scopus 로고
    • Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
    • Sagoo P, Perucha E, Sawitzki B, et al,. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 120: 1848-1861.
    • J Clin Invest , vol.120 , pp. 1848-1861
    • Sagoo, P.1    Perucha, E.2    Sawitzki, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.