Cortico-striatal-thalamic loop circuits of the orbitofrontal cortex: Promising therapeutic targets in psychiatric illness

Frontiers in Systems Neuroscience

Volumn 11, Issue , 2017, Pages

  Fettes, Peter ^a   Schulze, Laura ^a   Downar, Jonathan ^a,b,c,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Brain stimulation; Corticostriatal circuits; Orbitofrontal cortex (OFC); Psychiatric disease; Research domain criteria (RDoC)

Indexed keywords

BASAL GANGLION; BRAIN DEPTH STIMULATION; DECISION MAKING; DRUG DEPENDENCE; ELECTROCONVULSIVE THERAPY; EMOTIONALITY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MAJOR DEPRESSION; MEDIAL TEMPORAL LOBE; MENTAL DISEASE; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; ORBITAL CORTEX; POSTERIOR CINGULATE; REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION; REVIEW; REWARD; TRANSCRANIAL DIRECT CURRENT STIMULATION; VOXEL BASED MORPHOMETRY;

EID: 85020483296     PISSN: 16625137     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnsys.2017.00025     Document Type: Review

References (241)

1. Abe, Y., Sakai, Y., Nishida, S., Nakamae, T., Yamada, K., Fukui, K., et al. (2015). Hyper-influence of the orbitofrontal cortex over the ventral striatum in obsessive-compulsive disorder. Eur. ropsychopharmacol. 25, 1898-1905. doi: 10.1016/j.euroneuro.2015.08.017
2. Abramovitch, A., Pizzagalli, D. A., Reuman, L., and Wilhelm, S. (2014). Anhedonia in obsessive-compulsive disorder: beyond comorbid depression. Psychiatry Res. 216, 223-229. doi: 10.1016/j.psychres.2014.02.002
3. Adinoff, B., Devous, M. D., Cooper, D. B., Best, S. E., Chandler, P., Harris, T., et al. (2003). Resting regional cerebral blood flow and gambling task performance in cocaine-dependent subjects and healthy comparison subjects. Am. J. Psychiatry 160, 1892-1894. doi: 10.1176/appi.ajp.160.10.1892
4. Ahmari, S. E., and Dougherty, D. D. (2015). Dissecting OCD circuits: from animal models to targeted treatments. Depress. Anxiety 32, 550-562. doi: 10.1002/da. 22367
5. Alexander, G. E., DeLong, M. R., and Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9, 357-381. doi: 10.1146/annurev.ne.09.030186.002041
6. American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders. Arlington: American Psychiatric Association.
7. Aouizerate, B., Cuny, E., Martin-Guehl, C., Guehl, D., Amieva, H., Benazzouz, A., et al. (2004). Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression. J. Neurosurg. 101, 682-686. doi: 10.3171/jns.2004.101.4.0682
8. Averbeck, B. B., Lehman, J., Jacobson, M., and Haber, S. N. (2014). Estimates of projection overlap and zones of convergence within frontal-striatal circuits. J. Neurosci. 34, 9497-9505. doi: 10.1523/JNEUROSCI.5806-12.2014
9. Bakker, N., Shahab, S., Giacobbe, P., Blumberger, D. M., Daskalakis, Z. J., Kennedy, S. H., et al. (2015). rTMS of the dorsomedial prefrontal cortex for major depression: safety, tolerability, effectiveness and outcome predictors for 10 Hz versus intermittent theta-burst stimulation. Brain Stimul. 8, 208-215. doi: 10.1016/j.brs.2014.11.002
10. Banca, P., Voon, V., Vestergaard, M. D., Philipiak, G., and Pocinho, F. (2015). Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder. Brain 138, 798-811. doi: 10.1093/brain/awu379
11. Barbas, H. (2007). Specialized elements of orbitofrontal cortex in primates. Ann. N Y Acad. Sci. 1121, 10-32. doi: 10.1196/annals.1401.015
12. Bates, J. F., and Goldman-Rakic, P. S. (1993). Prefrontal connections of medial motor areas in the rhesus monkey. J. Comp. Neurol. 336, 211-228. doi: 10.1002/cne.903360205
13. Bation, R., Poulet, E., Haesebaert, F., Saoud, M., and Brunelin, J. (2016). Transcranial direct current stimulation in treatment-resistant obsessive-compulsive disorder: an open-label pilot study. Prog. Neuropsychopharmacol. Biol. Psychiatry 65, 153-157. doi: 10.1016/j.pnpbp.2015.10.001
14. Baxter, L. Jr. R., Schwartz, J. M., Bergman, K. S., Szuba, M. P., Guze, B. H., Mazziotta, J. C., et al. (1992). Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch. Gen. Psychiatry 49, 681-689. doi: 10.1001/archpsyc.1992.01820090009002
15. Baxter, L. Jr. R., Schwartz, J. M., Mazziotta, J. C., Phelps, M. E., Pahl, J. J., Guze, B. H., et al. (1988). Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder. Am. J. Psychiatry 145, 1560-1563. doi: 10.1176/ajp.145.12.1560
16. Baxter, L. Jr. R., Schwartz, J. M., Phelps, M. E., Mazziotta, J. C., Guze, B. H., Selin, C. E., et al. (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch. Gen. Psychiatry 46, 243-250. doi: 10.1001/archpsyc.1989.01810030049007
17. Bechara, A., Damasio, H., and Damasio, A. R. (2000). Emotion, decision making and the orbitofrontal cortex. Cereb. Cortex 10, 295-307. doi: 10.1093/cercor/10.3.295
18. Bechara, A., Damasio, H., Damasio, A. R., and Lee, G. P. (1999). Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J. Neurosci. 19, 5473-5481.
19. Berlim, M. T., McGirr, A., Van den Eynde, F., Fleck, M. P. A., and Giacobbe, P. (2014). Effectiveness and acceptability of deep brain stimulation (DBS) of the subgenual cingulate cortex for treatment-resistant depression: a systematic review and exploratory meta-analysis. J. Affect. Disord. 159, 31-38. doi: 10.1016/j.jad.2014.02.016
20. Beucke, J. C., Sepulcre, J., Talukdar, T., Linnman, C., Zschenderlein, K., Endrass, T., et al. (2013). Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder. JAMA Psychiatry 70, 619-629. doi: 10.1001/jamapsychiatry.2013.173
21. Bewernick, B. H., Hurlemann, R., Matusch, A., Kayser, S., Grubert, C., Hadrysiewicz, B., et al. (2010). Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biol. Psychiatry 67, 110-116. doi: 10.1016/j.biopsych.2009.09.013
22. Biver, F., Goldman, S., Delvenne, V., Luxen, A., Demaertelaer, V., Hubain, P., et al. (1994). Frontal and parietal metabolic disturbances in unipolar depression. Biol. Psychiatry 36, 381-388. doi: 10.1016/0006-3223(94) 91213-0
23. Bloch, M. H., Green, C., Kichuk, S. A., Philip, A., Wasylink, S., Billingslea, E., et al. (2013). Long-term outcome in adults with obsessive-compulsive disorder. Depress. Anxiety 30, 716-722. doi: 10.1002/da.22103
24. Bolla, K. I., Eldreth, D. A., London, E. D., Kiehl, K. A., Mouratidis, M., Contoreggi, C., et al. (2003). Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 19, 1085-1094. doi: 10.1016/s1053-8119(03)00113-7
25. Bonelli, R. M., and Cummings, J. L. (2007). Frontal-subcortical circuitry and behavior. Dialogues Clin. Neurosci. 9, 141-151.
26. Boorman, E. D., Behrens, T. E. J., Woolrich, M. W., and Rushworth, M. F. S. (2009). How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action. Neuron 62, 733-743. doi: 10.1016/j.neuron.2009.05.014
27. Boorman, E. D., O’Doherty, J. P., Adolphs, R., and Rangel, A. (2013). The behavioral and neural mechanisms underlying the tracking of expertise. Neuron 80, 1558-1571. doi: 10.1016/j.neuron.2013.10.024
28. Bora, E., Harrison, B. J., Davey, C. G., Yücel, M., and Pantelis, C. (2012). Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal-thalamic circuits in major depressive disorder. Psychol. Med. 42, 671-681. doi: 10.1017/s0033291711001668
29. Brody, A. L., Saxena, S., Mandelkern, M. A., Fairbanks, L. A., Ho, M. L., and Baxter, L. R. (2001). Brain metabolic changes associated with symptom factor improvement in major depressive disorder. Biol. Psychiatry 50, 171-178. doi: 10.1016/s0006-3223(01)01117-9
30. Brunoni, A. R., Nitsche, M. A., Bolognini, N., Bikson, M., Wagner, T., Merabet, L., et al. (2012). Clinical research with transcranial direct current stimulation (tDCS): challenges and future directions. Brain Stimul. 5, 175-195. doi: 10.1016/j.brs.2011.03.002
31. Carmin, C. N., Wiegartz, P. S., Yunus, U., and Gillock, K. L. (2002). Treatment of late-onset OCD following basal ganglia infarct. Depress. Anxiety 15, 87-90. doi: 10.1002/da.10024
32. Carpenter, M. B., Nakano, K., and Kim, R. (1976). Nigrothalamic projections in the monkey demonstrated by autoradiographic technics. J. Comp. Neurol. 165, 401-415. doi: 10.1002/cne.901650402
33. Cavada, C., Compañy, T., Tejedor, J., Cruz-Rizzolo, R. J., and Reinoso-Suárez, F. (2000). The anatomical connections of the macaque monkey orbitofrontal cortex. A review. Cereb. Cortex 10, 220-242. doi: 10.1093/cercor/10. 3.220
34. Chacko, R. C., Corbin, M. A., and Harper, R. G. (2000). Acquired obsessive-compulsive disorder associated with basal ganglia lesions. J. Neuropsychiatry Clin. Neurosci. 12, 269-272. doi: 10.1176/jnp.12.2.269
35. Chavis, D. A., and Pandya, D. N. (1976). Further observations on corticofrontal connections in the rhesus monkey. Brain Res. 117, 369-386. doi: 10.1016/0006-8993(76)90089-5
36. Chen, R. S., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., et al. (1997). Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 48, 1398-1403. doi: 10.1212/wnl.48. 5.1398
37. Cheng, W., Rolls, E. T., Qiu, J., Liu, W., Tang, Y., Huang, C.-C., et al. (2016). Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression. Brain 139, 3296-3309. doi: 10.1093/brain/aww255
38. Chiavaras, M. M., LeGoualher, G., Evans, A. C., and Petrides, M. (2001). Three-dimensional probabilistic atlas of the human orbitofrontal sulci in standardized stereotaxic space. Neuroimage 13, 479-496. doi: 10.1006/nimg.2000.0641
39. Chib, V. S., Yun, K., Takahashi, H., and Shimojo, S. (2013). Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex. Transl. Psychiatry 3:e268. doi: 10.1038/tp.2013.44
40. Chiu, P. H., Lohrenz, T. M., and Montague, P. R. (2008). Smokers’ brains compute, but ignore, a fictive error signal in a sequential investment task. Nat. Neurosci. 11, 514-520. doi: 10.1038/nn2067
41. Christian, C. J., Lencz, T., Robinson, D. G., Burdick, K. E., Ashtari, M., Malhotra, A. K., et al. (2008). Gray matter structural alterations in obsessive-compulsive disorder: relationship to neuropsychological functions. Psychiatry Res. 164, 123-131. doi: 10.1016/j.pscychresns.2008.03.005
42. Clark, L., Cools, R., and Robbins, T. W. (2004). The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning. Brain Cogn. 55, 41-53. doi: 10.1016/s0278-2626(03)00284-7
43. Coffey, S. F., Gudleski, G. D., Saladin, M. E., and Brady, K. T. (2003). Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals. Exp. Clin. Psychopharmacol. 11, 18-25. doi: 10.1037/1064-1297. 11.1.18
44. Coutinho, J. F., Fernandesl, S. V., Soares, J. M., Maia, L., Gonçalves, Ó. F., and Sampaio, A. (2016). Default mode network dissociation in depressive and anxiety states. Brain Imaging Behav. 10, 147-157. doi: 10.1007/s11682-015-9375-7
45. Cummings, J. L. (1993). Frontal-Subcortical circuits and human behavior. Arch. Neurol. 50, 873-880. doi: 10.1001/archneur.1993.00540080076020
46. Dalton, G. L., Wang, N. Y., Phillips, A. G., and Floresco, S. B. (2016). Multifaceted contributions by different regions of the orbitofrontal and medial prefrontal cortex to probabilistic reversal learning. J. Neurosci. 36, 1996-2006. doi: 10.1523/JNEUROSCI.3366-15.2016
47. Damasio, A. R., Tranel, D., and Damasio, H. (1990). Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav. Brain Res. 41, 81-94. doi: 10.1016/0166-4328(90) 90144-4
48. Dao-Castellana, M. H., Samson, Y., Legault, F., Martinot, J. L., Aubin, H. J., Crouzel, C., et al. (1998). Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings. Psychol. Med. 28, 1039-1048. doi: 10.1017/s0033291798006849
49. Del Casale, A., Kotzalidis, G. D., Rapinesi, C., Serata, D., Ambrosi, E., Simonetti, A., et al. (2011). Functional neuroimaging in obsessive-compulsive disorder. Neuropsychobiology 64, 61-85. doi: 10.1159/000325223
50. De Martino, B., Kumaran, D., Seymour, B., and Dolan, R. J. (2006). Frames, biases and rational decision-making in the human brain. Science 313, 684-687. doi: 10.1126/science.1128356
51. Denys, D., Mantione, M., Figee, M., van den Munckhof, P., Koerselman, F., Westenberg, H., et al. (2010). Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Arch. Gen. Psychiatry 67, 1061-1068. doi: 10.1001/archgenpsychiatry.2010.122
52. De Raedt, R., Vanderhasselt, M. A., and Baeken, C. (2015). Neurostimulation as an intervention for treatment resistant depression: from research on mechanisms towards targeted neurocognitive strategies. Clin. Psychol. Rev. 41, 61-69. doi: 10.1016/j.cpr.2014.10.006
53. Dichter, G. S., Kozink, R. V., McClernon, F. J., and Smoski, M. J. (2012). Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes. J. Affect. Disord. 136, 1126-1134. doi: 10.1016/j.jad.2011.09.048
54. Dierckx, B., Heijnen, W. T., van den Broek, W. W., and Birkenhäger, T. K. (2012). Efficacy of electroconvulsive therapy in bipolar versus unipolar major depression: a meta-analysis. Bipolar Disord. 14, 146-150. doi: 10.1111/j.1399-5618.2012.00997.x
55. Dom, G., Sabbe, B., Hulstijn, W., and van den Brink, W. (2005). Substance use disorders and the orbitofrontal cortex: systematic review of behavioural decision-making and neuroimaging studies. Br. J. Psychiatry 187, 209-220. doi: 10.1192/bjp.187.3.209
56. Downar, J., Blumberger, D. M., and Daskalakis, Z. J. (2016). The neural crossroads of psychiatric illness: an emerging target for brain stimulation. Trends Cogn. Sci. 20, 107-120. doi: 10.1016/j.tics.2015.10.007
57. Downar, J., Geraci, J., Salomons, T. V., Dunlop, K., Wheeler, S., McAndrews, M. P., et al. (2014). Anhedonia and reward-circuit connectivity distinguish nonresponders from responders to dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression. Biol. Psychiatry 76, 176-185. doi: 10.1016/j.biopsych.2013.10.026
58. Drevets, W. C. (2007). Orbitofrontal cortex function and structure in depression. Ann. N Y Acad. Sci. 1121, 499-527. doi: 10.1196/annals. 1401.029
59. Drevets, W. C., Videen, T. O., Price, J. L., Preskorn, S. H., Carmichael, S. T., and Raichle, M. E. (1992). A functional anatomical study of unipolar depression. J. Neurosci. 12, 3628-3641.
60. Drysdale, A. T., Grosenick, L., Downar, J., Dunlop, K., Mansouri, F., Meng, Y., et al. (2017). Resting-state connectivity biomarkers define neurophysiological subtypes of depression. Nat. Med. 23, 28-38. doi: 10.1038/nm.4246
61. Dunlop, K., Gaprielian, P., Blumberger, D., Daskalakis, Z. J., Kennedy, S. H., Giacobbe, P., et al. (2015). MRI-guided dmPFC-rTMS as a treatment for treatment-resistant major depressive disorder. J. Vis. Exp. 102:e53129. doi: 10.3791/53129
62. Dunlop, K. A., Woodside, B., and Downar, J. (2016a). Targeting neural endophenotypes of eating disorders with non-invasive brain stimulation. Front. Neurosci. 10:30. doi: 10.3389/fnins.2016.00030
63. Dunlop, K., Woodside, B., Olmsted, M., Colton, P., Giacobbe, P., and Downar, J. (2016b). Reductions in cortico-striatal hyperconnectivity accompany successful treatment of obsessive-compulsive disorder with dorsomedial prefrontal rTMS. Neuropsychopharmacology 41, 1395-1403. doi: 10.1038/npp.2015.292
64. Eisen, J. L., Goodman, W. K., Keller, M. B., Warshaw, M. G., DeMarco, L. M., Luce, D. D., et al. (1999). Patterns of remission and relapse in obsessive-compulsive disorder: a 2-year prospective study. J. Clin. Psychiatry 60, 346-351. doi: 10.4088/jcp.v60n0514
65. Eldaief, M. C., Halko, M. A., Buckner, R. L., and Pascual-Leone, A. (2011). Transcranial magnetic stimulation modulates the brain’s intrinsic activity in a frequency-dependent manner. Proc. Natl. Acad. Sci. U S A 108, 21229-21234. doi: 10.1073/pnas.1113103109
66. Elliott, R., Dolan, R. J., and Frith, C. D. (2000). Dissociable functions in the medial and lateral orbitofrontal cortex: evidence from human neuroimaging studies. Cereb. Cortex 10, 308-317. doi: 10.1093/cercor/10.3.308
67. Epstein, D. H., Preston, K. L., Stewart, J., and Shaham, Y. (2006). Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure. Psychopharmacology 189, 1-16. doi: 10.1007/s00213-006-0529-6
68. Ersche, K. D., Barnes, A., Simon Jones, P., Morein-Zamir, S., Robbins, T. W., and Bullmore, E. T. (2011). Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence. Brain 134, 2013-2024. doi: 10.1093/brain/awr138
69. Fawcett, J., Clark, D. C., Scheftner, W. A., and Hedeker, D. (1983). Differences between anhedonic and normally hedonic depressive states. Am. J. Psychiatry 140, 1027-1030. doi: 10.1176/ajp.140.8.1027
70. Fellows, L. K. (2007). The role of the orbitofrontal cortex in decision making: a component process account. Ann. N Y Acad. Sci. 1121, 421-430. doi: 10.1196/annals.1401.023
71. Feske, U., Mulsant, B. H., Pilkonis, P. A., Soloff, P., Dolata, D., Sackeim, H. A., et al. (2004). Clinical outcome of ECT in patients with major depression and comorbid borderline personality disorder. Am. J. Psychiatry 161, 2073-2080. doi: 10.1176/appi.ajp.161.11.2073
72. Fettes, P., Peters, S., Giacobbe, P., Blumberger, D. M., and Downar, J. (2017). Neural correlates of successful orbitofrontal 1 Hz rTMS following unsuccessful dorsolateral and dorsomedial prefrontal rTMS in major depression: a case report. Brain Stimul. 10, 165-167. doi: 10.1016/j.brs.2016.11.008
73. Figee, M., Luigjes, J., Smolders, R., Valencia-Alfonso, C.-E., van Wingen, G., de Kwaasteniet, B., et al. (2013). Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nat. Neurosci. 16, 386-387. doi: 10.1038/nn.3344
74. Fischman, M. W., Schuster, C. R., Javaid, J., Hatano, Y., and Davis, J. (1985). Acute tolerance development to the cardiovascular and subjective effects of cocaine. J. Pharmacol. Exp. Ther. 235, 677-682.
75. Foerde, K., Steinglass, J. E., Shohamy, D., and Walsh, B. T. (2015). Neural mechanisms supporting maladaptive food choices in anorexia nervosa. Nat. Neurosci. 18, 1571-1573. doi: 10.1038/nn.4136
76. Fox, M. D., Buckner, R. L., Liu, H., Chakravarty, M. M., Lozano, A. M., and Pascual-Leone, A. (2014). Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. Proc. Natl. Acad. Sci. U S A 111, 4367-4375. doi: 10.1073/pnas.1405003111
77. Franklin, T. R., Acton, P. D., Maldjian, J. A., Gray, J. D., Croft, J. R., Dackis, C. A., et al. (2002). Decreased gray matter concentration in the insular, cocaine patients. Biol. Psychiatry 51, 134-142. doi: 10.1016/s0006-3223(01) 01269-0
78. Frodl, T., Bokde, A. L. W., Scheuerecker, J., Lisiecka, D., Schoepf, V., Hampel, H., et al. (2010). Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression. Biol. Psychiatry 67, 161-167. doi: 10.1016/j.biopsych.2009.08.022
79. Fujii, T., Otsuka, Y., Suzuki, K., Endo, K., and Yamadori, A. (2005). Improvement of obsessive-compulsive disorder following left putaminal. Eur. Neurol. 54, 166-170. doi: 10.1159/000090109
80. Galynker, I. I., Cai, J., Ongseng, F., Finestone, H., Dutta, E., and Serseni, D. (1998). Hypofrontality and negative symptoms in major depressive disorder. J. Nucl. Med. 39, 608-612.
81. Gao, Q., Zou, K., He, Z., Sun, X., and Chen, H. (2016). Causal connectivity alterations of cortical-subcortical circuit anchored on reduced hemodynamic response brain regions in first-episode drug-naïve major depressive disorder. Sci. Rep. 6:21861. doi: 10.1038/srep21861
82. Gillan, C., Papmeyer, M., Morein-zamir, S., Sahakian, B. J., Fineberg, N. A., Robbins, T. W., et al. (2011). Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder. Am. J. Psychiatry 168, 718-726. doi: 10.1176/appi.ajp.2011.10071062
83. Godier, L. R., and Park, R. J. (2014). Compulsivity in anorexia nervosa: a transdiagnostic concept. Front. Psychol. 5:778. doi: 10.3389/fpsyg.2014. 00778
84. Goldstein, B. L., and Klein, D. N. (2014). A review of selected candidate endophenotypes for depression. Clin. Psychol. Rev. 34, 417-427. doi: 10.1016/j. cpr.2014.06.003
85. Goldstein, R. Z., Tomasi, D., Rajaram, S., Cottone, L. A., Zhang, L., Maloney, T., et al. (2007). Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction. Neuroscience 144, 1153-1159. doi: 10.1016/j.neuroscience.2006.11.024
86. Goldstein, R. Z., and Volkow, N. D. (2011). Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat. Rev. Neurosci. 12, 652-669. doi: 10.1038/nrn3119
87. Goodkind, M., Eickhoff, S. B., Oathes, D. J., Jiang, Y., Chang, A., Jones-Hagata, L. B., et al. (2015). Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry 72, 305-315. doi: 10.1001/jamapsychiatry.2014.2206
88. Gorwood, P. (2008). Neurobiological mechanisms of anhedonia. Dialogues Clin. Neurosci. 10, 291-299.
89. Grant, S., Contoreggi, C., and London, E. D. (2000). Drug abusers show impaired performance in a laboratory test of decision making. Neuropsychologia 38, 1180-1187. doi: 10.1016/s0028-3932(99)00158-x
90. Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., et al. (2007). Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol. Psychiatry 62, 429-437. doi: 10.1016/j.biopsych.2006. 09.020
91. Gremel, C. M., and Costa, R. M. (2013). Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions. Nat. Commun. 4:2264. doi: 10.1038/ncomms3264
92. Haber, S. N. (2003). The primate basal ganglia: parallel and integrative networks. J. Chem. Neuroanat. 26, 317-330. doi: 10.1016/j.jchemneu.2003.10.003
93. Hackett, T. A., Stepniewska, I., and Kaas, J. H. (1998). Thalamocortical connections of the parabelt auditory cortex in macaque monkeys. J. Comp. Neurol. 400, 271-286. doi: 10.1002/(SICI)1096-9861(19981019) 400:2<271::AID-CNE8>3.0.CO;2-6
94. Hallett, M. (2007). Transcranial magnetic stimulation: a primer. Neuron 55, 187-199. doi: 10.1016/j.neuron.2007.06.026
95. Hanlon, C. A., Canterberry, M., Taylor, J. J., DeVries, W., Li, X., Brown, T. R., et al. (2013). Probing the frontostriatal loops involved in executive and limbic processing via interleaved TMS and functional MRI at two prefrontal locations: a pilot study. PLoS One 8:e67917. doi: 10.1371/journal.pone.0067917
96. Hanlon, C. A., Dowdle, L. T., Austelle, C. W., Devries, W., Mithoefer, O., Badran, B. W., et al. (2015). What goes up, can come down: novel brain stimulation paradigms may attenuate craving and craving-related neural circuitry in substance dependent individuals. Brain Res. 1628, 199-209. doi: 10.1016/j.brainres.2015.02.053
97. Hanlon, C. A., Dowdle, L. T., Moss, H., Canterberry, M., and George, M. S. (2016). Mobilization of medial and lateral frontal-striatal circuits in cocaine users and controls: an interleaved TMS/BOLD functional connectivity study. Neuropsychopharmacology 41, 3032-3041. doi: 10.1038/npp.2016.114
98. Harrison, B. J., Pujol, J., Cardoner, N., Deus, J., Alonso, P., López-Solà, M., et al. (2013). Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. Biol. Psychiatry 73, 321-328. doi: 10.1016/j.biopsych.2012.10.006
99. Harrison, B. J., Soriano-Mas, C., Pujol, J., Ortiz, H., López-Solà, M., Hernández-Ribas, R., et al. (2009). Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Arch. Gen. Psychiatry 66, 1189-1200. doi: 10.1001/archgenpsychiatry.2009.152
100. Henry, M. E., Schmidt, M. E., Matochik, J. A., Stoddard, E. P., and Potter, W. Z. (2001). The effects of ECT on brain glucose: a pilot FDG PET study. J. ECT 17, 33-40. doi: 10.1097/00124509-200103000-00007
101. Henssen, A., Zilles, K., Palomero-Gallagher, N., Schleicher, A., Mohlberg, H., Gerboga, F., et al. (2016). Cytoarchitecture and probability maps of the human medial orbitofrontal cortex. Cortex 75, 87-112. doi: 10.1016/j.cortex.2015. 11.006
102. Holtzheimer, P. E., and Mayberg, H. S. (2011). Deep brain stimulation for psychiatric disorders. Annu. Rev. Neurosci. 34, 289-307. doi: 10.1146/annurev-neuro-061010-113638
103. Hornak, J., O’Doherty, J., Bramham, J., Rolls, E. T., Morris, R. G., Bullock, P. R., et al. (2002). Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J. Cogn. Neurosci. 16, 463-478. doi: 10.1162/089892904322926791
104. Huang, Y. Z., Edwards, M. J., Rounis, E., Bhatia, K. P., and Rothwell, J. C. (2005). Theta burst stimulation of the human motor cortex. Neuron 45, 201-206. doi: 10.1016/j.neuron.2004.12.033
105. Huang, Y. Z., Rothwell, J. C., Lu, C. S., Wang, J., Weng, Y. H., Lai, S. C., et al. (2009). The effect of continuous theta burst stimulation over premotor cortex on circuits in primary motor cortex and spinal cord. Clin. Neurophysiol. 120, 796-801. doi: 10.1016/j.clinph.2009.01.003
106. Ilinsky, I. A., Jouandet, M. L., and Goldman-Rakic, P. S. (1985). Organization of the nigrothalamocortical system in the rhesus monkey. J. Comp. Neurol. 236, 315-330. doi: 10.1002/cne.902360304
107. Insel, T. R. (2014). The NIMH research domain criteria (RDoC) project: precision medicine for psychiatry. Am. J. Psychiatry 171, 395-397. doi: 10.1176/appi.ajp. 2014.14020138
108. Izquierdo, A., Suda, R. K., and Murray, E. A. (2004). Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency. J. Neurosci. 24, 7540-7548. doi: 10.1523/JNEUROSCI. 1921-04.2004
109. Jarbo, K., and Verstynen, T. D. (2015). Converging structural and functional connectivity of orbitofrontal, dorsolateral prefrontal, and posterior parietal cortex in the human striatum. J. Neurosci. 35, 3865-3878. doi: 10.1523/JNEUROSCI.2636-14.2015
110. Johnson, T. N., and Rosvold, H. E. (1971). Topographic projections on the globus pallidus and the substantia nigra of selectively placed lesions in the precommissural caudate nucleus and putamen in the monkey. Exp. Neurol. 33, 584-596. doi: 10.1016/0014-4886(71)90129-4
111. Johnstone, T., van Reekum, C. M., Urry, H. L., Kalin, N. H., and Davidson, R. J. (2007). Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. J. Neurosci. 27, 8877-8884. doi: 10.1523/JNEUROSCI.2063-07.2007
112. Jollant, F., Lawrence, N. S., Olie, E., O’Daly, O., Malafosse, A., Courtet, P., et al. (2010). Decreased activation of lateral orbitofrontal cortex during risky choices under uncertainty is associated with disadvantageous decision-making and suicidal behavior. Neuroimage 51, 1275-1281. doi: 10.1016/j.neuroimage.2010. 03.027
113. Jones, B., and Mishkin, M. (1972). Limbic lesions and the problem of stimulus-Reinforcement associations. Exp. Neurol. 36, 362-377. doi: 10.1016/0014-4886(72)90030-1
114. Jonker, F. A., Jonker, C., Scheltens, P., and Scherder, E. J. (2015). The role of the orbitofrontal cortex in cognition and behavior. Rev. Neurosci. 26, 1-11. doi: 10.1515/revneuro-2014-0043
115. Kable, J. W., and Glimcher, P. W. (2009). The neurobiology of decision: consensus and controversy. Neuron 63, 733-745. doi: 10.1016/j.neuron.2009.09.003
116. Kahnt, T., Chang, L. J., Park, S. Q., Heinzle, J., and Haynes, J.-D. (2012). Connectivity-based parcellation of the human orbitofrontal cortex. J. Neurosci. 32, 6240-6250. doi: 10.1523/JNEUROSCI.0257-12.2012
117. Kaiser, R. H., Andrews-Hanna, J. R., Wager, T. D., and Pizzagalli, D. A. (2015). Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity. JAMA Psychiatry 72, 603-611. doi: 10.1001/jamapsychiatry.2015.0071
118. Kedzior, K., Azorina, V., and Reitz, S. K. (2014). More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997-2013. Neuropsychiatr. Dis. Treat. 10, 727-756. doi: 10.2147/NDT.s58405
119. Keedwell, P. A., Andrew, C., Williams, S. C. R., Brammer, M. J., and Phillips, M. L. (2005). The neural correlates of anhedonia in major depressive disorder. Biol. Psychiatry 58, 843-853. doi: 10.1016/j.biopsych.2005.05.019
120. Keiflin, R., and Janak, P. H. (2015). Dopamine prediction errors in reward learning and addiction: from theory to neural circuitry. Neuron 88, 247-263. doi: 10.1016/j.neuron.2015.08.037
121. Kekic, M., Boysen, E., Campbell, I. C., and Schmidt, U. (2016). A systematic review of the clinical efficacy of transcranial direct current stimulation (tDCS) in psychiatric disorders. J. Psychiatr. Res. 74, 70-86. doi: 10.1016/j.jpsychires. 2015.12.018
122. Ketter, T. A., and Drevets, W. C. (2002). Neuroimaging studies of bipolar depression: functional neuropathology, treatment effects and predictors of clinical response. Clin. Neurosci. Res. 2, 182-192. doi: 10.1016/s1566-2772(02)00043-9
123. Kho, K. H., van Vreeswijk, M. F., Simpson, S., and Zwinderman, A. H. (2003). A meta-analysis of electroconvulsive therapy efficacy in depression. J. ECT 19, 139-147. doi: 10.1097/00124509-200309000-00005
124. Kim, K. W., and Lee, D. Y. (2002). Obsessive-compulsive disorder associated with a left orbitofrontal infarct. J. Neuropsychiatry Clin. Neurosci. 14, 88-89. doi: 10.1176/jnp.14.1.88
125. Koenigs, M., Huey, E. D., Calamia, M., Raymont, V., Tranel, D., and Grafman, J. (2008). Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression. J. Neurosci. 28, 12341-12348. doi: 10.1523/JNEUROSCI.2324-08.2008
126. Koolschijn, P. C., van Haren, N. E., Lensvelt-Mulders, G. J., Hulshoff Pol, H. E., and Kahn, R. S. (2009). Brain volume abnormalities in major depressive disoder: a meta-analysis of magnetic resonance imaging studies. Hum. Brain Mapp. 30, 3719-3735. doi: 10.1002/hbm.20801
127. Koprivová, J., Horácek, J., Tintera, J., Prasko, J., Raszka, M., Ibrahim, I., et al. (2009). Medial frontal and dorsal cortical morphometric abnormalities are related to obsessive-compulsive disorder. Neurosci. Lett. 464, 62-66. doi: 10.1016/j.neulet.2009.08.012
128. Koran, L. M. (2000). Quality of life in obsessive-compulsive disorder. Psychiatr. Clin. North Am. 23, 509-517. doi: 10.1016/S0193-953X(05)70177-5
129. Kringelbach, M. L. (2005). The human orbitofrontal cortex: linking reward to hedonic experience. Nat. Rev. Neurosci. 6, 691-702. doi: 10.1038/nrn1747
130. Kringelbach, M. L., and Rolls, E. T. (2004). The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Prog. Neurobiol. 72, 341-372. doi: 10.1016/s0301-0082(04)00039-5
131. Kufahl, P., Li, Z., Risinger, R., Rainey, C., Piacentine, L., Wu, G., et al. (2008). Expectation modulates human brain responses to acute cocaine: a functional magnetic resonance imaging study. Biol. Psychiatry 63, 222-230. doi: 10.1016/j. biopsych.2007.03.021
132. Kuhn, J., Bauer, R., Pohl, S., Lenartz, D., Huff, W., Kim, E. H., et al. (2009). Observations on unaided smoking cessation after deep brain stimulation of the nucleus accumbens. Eur. Addict. Res. 15, 196-201. doi: 10.1159/0002 28930
133. Laakso, M. P., Gunning-Dixon, F., Vaurio, O., Repo-Tiihonen, E., Soininen, H., and Tiihonen, J. (2002). Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism. Psychiatry Res. 114, 95-102. doi: 10.1016/s0925-4927(02)00005-7
134. Lakhan, S. E., and Callaway, E. (2010). Deep brain stimulation for obsessive-compulsive disorder and treatment-resistant depression: systematic review. BMC Res. Notes 3:60. doi: 10.1186/1756-0500-3-60
135. Lawrence, N. S., Williams, A. M., Surguladze, S., Giampietro, V., Brammer, M. J., Andrew, C., et al. (2004). Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol. Psychiatry 55, 578-587. doi: 10.1016/j.biopsych.2003. 11.017
136. Leaver, A. M., Espinoza, R. T., Joshi, S. H., Vasavada, M. M., Njau, S. N., Woods, R. P., et al. (2016). Desynchronization and plasticity of striato-frontal connectivity in major depressive disorder. Cereb. Cortex 26, 4337-4346. doi: 10.1093/cercor/bhv207
137. Leshner, A. I. (1997). Drug abuse and addiction treatment research. Arch. Gen. Psychiatry 54, 691-694. doi: 10.1001/archpsyc.1997.01830200015002
138. Li, X., Lu, Z. L., D’Argembeau, A., Ng, M., and Bechara, A. (2010). The iowa gambling task in fMRI images. Hum. Brain Mapp. 31, 410-423.
139. Lipsman, N., Woodside, D. B., Giacobbe, P., Hamani, C., Carter, J. C., Norwood, S. J., et al. (2013). Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: a phase 1 pilot trial. Lancet 381, 1361-1370. doi: 10.1016/S0140-6736(12)62188-6
140. London, E. D., Ernst, M., Grant, S., Bonson, K., and Weinstein, A. (2000). Orbitofrontal cortex and human drug abuse: functional imaging. Cereb. Cortex 10, 334-342. doi: 10.1093/cercor/10.3.334
141. London, E. D., Simon, S. L., Berman, S. M., Mandelkern, M. A., Lichtman, A. M., Bramen, J., et al. (2004). Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Arch. Gen. Psychiatry 61, 73-84. doi: 10.1001/archpsyc.61.1.73
142. Lozano, A. M., Mayberg, H. S., Giacobbe, P., Hamani, C., Craddock, R. C., and Kennedy, S. H. (2008). Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol. Psychiatry 64, 461-467. doi: 10.1016/j. biopsych.2008.05.034
143. Maeda, F., Keenan, J. P., Tormos, J. M., Topka, H., and Pascual-Leone, A. (2000). Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability. Exp. Brain Res. 133, 425-430. doi: 10.1007/s002210000432
144. Mallet, L., Polosan, M., Jaafari, N., Baup, N., Welter, M. L., Fontaine, D., et al. (2008). Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N. Engl. J. Med. 359, 2121-2134. doi: 10.1056/NEJMoa0708514
145. Malone, D. A., Dougherty, D. D., Rezai, A. R., Carpenter, L. L., Friehs, G. M., Eskandar, E. N., et al. (2009). Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. Biol. Psychiatry 65, 267-275. doi: 10.1016/j.biopsych.2008.08.029
146. Mantione, M., van de Brink, W., Schuurman, P. R., and Denys, D. (2010). Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report. Neurosurgery 66:E218. doi: 10.1227/01.NEU.0000360570.40339.64
147. Martin-Elkins, C. L., and Horel, J. A. (1992). Cortical afferents to behaviorally defined regions of the inferior temporal and parahippocampal gyri as demonstrated by WGA-HRP. J. Comp. Neurol. 321, 177-192. doi: 10.1002/cne. 903210202
148. Matochik, J. A., London, E. D., Eldreth, D. A., Cadet, J.-L., and Bolla, K. I. (2003). Frontal cortical tissue composition in abstinent cocaine abusers: a magnetic resonance imaging study. Neuroimage 19, 1095-1102. doi: 10.1016/s1053-8119(03)00244-1
149. Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., et al. (2000). Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol. Psychiatry 48, 830-843. doi: 10.1016/s0006-3223(00)01036-2
150. Mayberg, H. S., Lewis, P. J., Regenold, W., and Wagner, H. N. (1994). Paralimbic hypoperfusion in unipolar depression. J. Nucl. Med. 35, 929-934.
151. Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., et al. (2005). Deep brain stimulation for treatment-resistant depression. Neuron 45, 651-660. doi: 10.1016/j.neuron.2005.02.014
152. McCabe, C., Cowen, P. J., and Harmer, C. J. (2009). Neural representation of reward in recovered depressed patients. Psychopharmacology 205, 667-677. doi: 10.1007/s00213-009-1573-9
153. McCabe, C., Mishor, Z., Cowen, P. J., and Harmer, C. J. (2010). Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment. Biol. Psychiatry 67, 439-445. doi: 10.1016/j. biopsych.2009.11.001
154. McClure, S. M., Laibson, D. I., Loewenstein, G., and Cohen, J. D. (2004). Separate neural systems value immediate and delayed monetary rewards. Science 15, 503-507. doi: 10.1126/science.1100907
155. McMakin, D. L., Olino, T. M., Porta, G., Dietz, L. J., Emslie, G., Clarke, G., et al. (2012). Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression. J. Am. Acad. Child Adolesc. Psychiatry 51, 404-411. doi: 10.1016/j.jaac.2012.01.011
156. McTeague, L. M., Goodkind, M. S., and Etkin, A. (2016). Transdiagnostic impairment of cognitive control in mental illness. J. Psychiatr. Res. 83, 37-46. doi: 10.1016/j.jpsychires.2016.08.001
157. Mega, M., Cummings, J., Salloway, S., and Malloy, P. (1997). The limbic system: an anatomic, phylogenetic, and clinical perspective. J. Neuropsychiatry Clin. Neurosci. 3, 315-330. doi: 10.1176/jnp.9.3.315
158. Menon, V. (2011). Large-scale brain networks and psychopathology: a unifying triple network model. Trends Cogn. Sci. 15, 483-506. doi: 10.1016/j.tics.2011. 08.003
159. Menzies, L., Chamberlain, S. R., Laird, A. R., Thelen, S. M., Sahakian, B. J., and Bullmore, E. T. (2008). Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci. Biobehav. Rev. 32, 525-549. doi: 10.1016/j. neubiorev.2007.09.005
160. Meron, D., Hedger, N., Garner, M., and Baldwin, D. S. (2015). Transcranial direct current stimulation (tDCS) in the treatment of depression: systematic review and meta-analysis of efficacy and tolerability. Neurosci. Biobehav. Rev. 57, 46-62. doi: 10.1016/j.neubiorev.2015.07.012
161. Milad, M. R., and Rauch, S. L. (2012). Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways. Trends Cogn. Sci. 16, 43-51. doi: 10.1016/j. tics.2011.11.003
162. Mondino, M., Haesebaert, F., Poulet, E., Saoud, M., and Brunelin, J. (2015). Efficacy of cathodal transcranial direct current stimulation over the left orbitofrontal cortex in a patient with treatment-resistant obsessive-compulsive disorder. J. ECT 31, 271-272. doi: 10.1097/YCT.0000000000000218
163. Montague, P. R., and Berns, G. S. (2002). Neural economics and the biological substrates of valuation. Neuron 36, 265-284. doi: 10.1016/s0896-6273(02)00974-1
164. Montigny, C., Castellanos-Ryan, N., Whelan, R., Banaschewski, T., Barker, G. J., Buchel, C., et al. (2013). A phenotypic structure and neural correlates of compulsive behaviors in adolescents. PLoS One 8:e80151. doi: 10.1371/journal. pone.0080151
165. Morecraft, R. J., and Van Hoesen, G. W. (1993). Frontal granular cortex input to the cingulate (M3), supplementary (M2) and primary (M1) motor cortices in the rhesus monkey. J. Comp. Neurol. 337, 669-689. doi: 10.1002/cne.9033 70411
166. Müller, U. J., Sturm, V., Voges, J., Heinze, H.-J., Galazky, I., Heldmann, M., et al. (2009). Successful treatment of chronic resistant alcoholism by deep brain stimulation of nucleus accumbens: first experience with three cases. Pharmacopsychiatry 42, 288-291. doi: 10.1055/s-0029-1233489
167. Nakao, T., Okada, K., and Kanba, S. (2014). Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings. Psychiatry Clin. Neurosci. 68, 587-605. doi: 10.1111/pcn.12195
168. Nauczyciel, C., Le Jeune, F., Naudet, F., Douabin, S., Esquevin, A., Vérin, M., et al. (2014). Repetitive transcranial magnetic stimulation over the orbitofrontal cortex for obsessive-compulsive disorder: a double-blind, crossover study. Transl. Psychiatry 4:e436. doi: 10.1038/tp.2014.62
169. Nauta, H. J. W. (1979). A proposed conceptual reorganization of the basal ganglia and telencephalon. Neuroscience 4, 1875-1881. doi: 10.1016/0306-4522(79)90061-7
170. Nobler, M. S., Oquendo, M. A., Kegeles, L. S., Malone, K. M., Campbell, C., Sackeim, H. A., et al. (2001). Decreased regional brain metabolism after ECT. Am. J. Psychiatry 158, 305-308. doi: 10.1176/appi.ajp.158.2.305
171. Nofzinger, E. A., Buysse, D. J., Germain, A., Price, J. C., Meltzer, C. C., Miewald, J. M., et al. (2005). Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression. Arch. Gen. Psychiatry 62, 387-396. doi: 10.1001/archpsyc.62.4.387
172. Noonan, M. P., Walton, M. E., Behrens, T. E. J., Sallet, J., Buckley, M. J., and Rushworth, M. F. S. (2010). Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex. Proc. Natl. Acad. Sci. U S A 107, 20547-20552. doi: 10.1073/pnas.1012246107
173. Norman, L. J., Carlisi, C. O., Lukito, S., Hart, H., Mataix-Cols, D., Radua, J., et al. (2016). Structural and functional brain abnormalities in attention-deficit/hyperactivity disorder and obsessive-compulsive disorder a comparative meta-analysis. JAMA Psychiatry 73, 815-825. doi: 10.1001/jamapsychiatry. 2016.0700
174. O’Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., Andrews, C., Centre, O., et al. (2001). Abstract reward and punishment representations in the human orbitofrontal cortex. Nat. Neurosci. 4, 95-102. doi: 10.1038/82959
175. Ogai, M., Iyo, M., Mori, N., and Takei, N. (2005). A right orbitofrontal region and ocd symptoms: a case report. Acta Psychiatr. Scand. 111, 74-76. doi: 10.1111/j. 1600-0447.2004.00395.x
176. Pagnin, D., de Queiroz, V., Pini, S., and Cassano, G. B. (2004). Efficacy of ECT in depression: a meta-analytic review. J. ECT 20, 13-20. doi: 10.1097/00124509-200403000-00004
177. Pandya, D. N., Van Hoesen, G. W., and Mesulam, M. M. (1981). Efferent connections of the cingulate gyrus in the rhesus monkey. Exp. Brain Res. 42, 319-330. doi: 10.1007/bf00237497
178. Parvaz, M. A., Konova, A. B., Proudfit, G. H., Dunning, J. P., Malaker, P., Moeller, S. J., et al. (2015). Impaired neural response to negative prediction errors in cocaine addiction. J. Neurosci. 35, 1872-1879. doi: 10.1523/JNEUROSCI.2777-14.2015
179. Pascual-Leone, A., Valls-Solé, J., Wassermann, E. M., and Hallett, M. (1994). Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain 117, 847-858. doi: 10.1093/brain/117.4.847
180. Pelizza, L., Pupo, S., and Ferrari, A. (2012). Anhedonia in schizophrenia and major depression: state or trait? Review of the literature. J. Psychopathol. 18, 145-155.
181. Petrides, G., Fink, M., Husain, M. M., Knapp, R. G., Rush, A. J., Mueller, M., et al. (2001). ECT remission rates in psychotic versus nonpsychotic depressed patients: a report from CORE. J. ECT 17, 244-253. doi: 10.1097/00124509-200112000-00003
182. Pizzagalli, D. A. (2014). Depression, stress, and anhedonia: toward a synthesis and integrated model. Annu. Rev. Clin. Psychol. 10, 393-423. doi: 10.1146/annurev-clinpsy-050212-185606
183. Polanía, R., Paulus, W., and Nitsche, M. A. (2012). Modulating cortico-striatal and thalamo-cortical functional connectivity with transcranial direct current stimulation. Hum. Brain Mapp. 33, 2499-2508. doi: 10.1002/hbm. 21380
184. Price, J. L. (2007). Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regions. Ann. N Y Acad. Sci. 1121, 54-71. doi: 10.1196/annals.1401.008
185. Price, J., Cole, V., and Goodwin, G. M. (2009). Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study. Br. J. Psychiatry 195, 211-217. doi: 10.1192/bjp.bp.108.051110
186. Puigdemont, D., Pérez-Egea, R., Portella, M. J., Molet, J., de Diego-Adeliño, J., Gironell, A., et al. (2012). Deep brain stimulation of the subcallosal cingulate gyrus: further evidence in treatment-resistant major depression. Int. J. Neuropsychopharmacol. 15, 121-133. doi: 10.1017/S14611457110 01088
187. Radua, J., and Mataix-Cols, D. (2009). Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. Br. J. Psychiatry 195, 393-402. doi: 10.1192/bjp.bp.108.055046
188. Radua, J., van den Heuvel, O. A., Surguladze, S., and Mataix-Cols, D. (2010). Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs. other anxiety disorders. Arch. Gen. Psychiatry 67, 701-711. doi: 10.1001/archgenpsychiatry.2010.70
189. Ray, J. P., and Price, J. L. (1993). The organization of projections from the mediodorsal nucleus of the thalamus to orbital and medial prefrontal cortex in macaque monkeys. J. Comp. Neurol. 337, 1-31. doi: 10.1002/cne.9033 70102
190. Robinson, O. J., Cools, R., Carlisi, C. O., Sahakian, B. J., and Drevets, W. C. (2012). Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder. Am. J. Psychiatry 169, 152-159. doi: 10.1176/appi.ajp.2011.11010137
191. Rolls, E. T. (2013). A biased activation theory of the cognitive and attentional modulation of emotion. Front. Hum. Neurosci. 7:74. doi: 10.3389/fnhum.2013. 00074
192. Rolls, E. T. (2015). Limbic systems for emotion and for memory, but no single limbic system. Cortex 62, 119-157. doi: 10.1016/j.cortex.2013.12.005
193. Rolls, E. T. (2016). A non-reward attractor theory of depression. Neurosci. Biobehav. Rev. 68, 47-58. doi: 10.1016/j.neubiorev.2016.05.007
194. Rotge, J.-Y., Langbour, N., Guehl, D., Bioulac, B., Jaafari, N., Allard, M., et al. (2010). Gray matter alterations in obsessive-compulsive disorder: an anatomic likelihood estimation meta-analysis. Neuropsychopharmacology 35, 686-691. doi: 10.1038/npp.2009.175
195. Ruffini, C., Locatelli, M., Lucca, A., Benedetti, F., Insacco, C., and Smeraldi, E. (2009). Augmentation effect of repetitive transcranial magnetic stimulation over the orbitofrontal cortex in drug-resistant obsessive-compulsive disorder patients: a controlled investigation. Prim. Care Companion J. Clin. Psychiatry 11, 226-230. doi: 10.4088/PCC.08m00663
196. Rushworth, M. F. S., Behrens, T. E. J., Rudebeck, P. H., and Walton, M. E. (2007). Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour. Trends Cogn. Sci. 11, 168-176. doi: 10.1016/j.tics.2007. 01.004
197. Rushworth, M. F. S., Noonan, M. P., Boorman, E. D., Walton, M. E., and Behrens, T. E. (2011). Frontal cortex and reward-guided learning and decision-making. Neuron 70, 1054-1069. doi: 10.1016/j.neuron.2011.05.014
198. Sakai, Y., Narumoto, J., Nishida, S., Nakamae, T., Yamada, K., Nishimura, T., et al. (2011). Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder. Eur. Psychiatry 26, 463-469. doi: 10.1016/j. eurpsy.2010.09.005
199. Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., et al. (2008). Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology 33, 368-377. doi: 10.1038/sj.npp.1301408
200. Schoenbaum, G., and Shaham, Y. (2008). The role of orbitofrontal cortex in drug addiction: a review of preclinical studies. Biol. Psychiatry 63, 256-262. doi: 10.1016/j.biopsych.2007.06.003
201. Segarra, N., Metastasio, A., Ziauddeen, H., Spencer, J., Reinders, N. R., Dudas, R. B., et al. (2016). Abnormal frontostriatal activity during unexpected reward receipt in depression and schizophrenia: relationship to anhedonia. Neuropsychopharmacology 41, 2001-2032. doi: 10.1038/npp.2015.370
202. Segawa, K., Azuma, H., Sato, K., Yasuda, T., Arahata, K., Otsuki, K., et al. (2006). Regional cerebral blood flow changes in depression after electroconvulsive therapy. Psychiatry Res. 147, 135-143. doi: 10.1016/j.pscychresns.2004. 08.006
203. Sekine, Y., Minabe, Y., Ouchi, Y., Takei, N., Iyo, M., Nakamura, K., et al. (2003). Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms. Am. J. Psychiatry 160, 1699-1701. doi: 10.1176/appi.ajp.160.9.1699
204. Selemon, L. D., and Goldman-Rakic, P. S. (1985). Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey. J. Neurosci. 5, 776-794.
205. Shalev, U., Grimm, J. W., and Shaham, Y. (2002). Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol. Rev. 54, 1-42. doi: 10.1124/pr. 54.1.1
206. Small, D. M., Gregory, M. D., Mak, Y. E., Gitelman, D., Mesulam, M. M., and Parrish, T. (2003). Dissociation of neural representation of intensity and affective valuation in human gustation. Neuron 39, 701-711. doi: 10.1016/s0896-6273(03)00467-7
207. Small, D. M., Zatorre, R. J., Dagher, A., Evans, A. C., and Jones-Gotman, M. (2001). Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain 124, 1720-1733. doi: 10.1093/brain/124.9.1720
208. Smith, D. G., Jones, P. S., Williams, G. B., Bullmore, E. T., Robbins, T. W., and Ersche, K. D. (2015). Overlapping decline in orbitofrontal gray matter volume related to cocaine use and body mass index. Addict. Biol. 20, 194-196. doi: 10.1111/adb.12081
209. Smoski, M. J., Rittenberg, A., and Dichter, G. S. (2011). Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards. Psychiatry Res. 194, 263-270. doi: 10.1016/j.pscychresns.2011. 06.012
210. Snyder, H. R. (2013). Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Psychol. Bull. 139, 81-132. doi: 10.1037/a0028727
211. Stapleton, J. M., Morgan, M. J., Phillips, R. L., Wong, D. F., Yung Babington, C.-K., Shaya, E. K., et al. (1995). Cerebral glucose utilization in polysubstance abuse. Neuropsychopharmacology 13, 21-31. doi: 10.1016/0893-133x(94)00132-j
212. Strafella, A. P., Paus, T., Barrett, J., and Dagher, A. (2001). Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J. Neurosci. 21:RC157.
213. Szabo, J. (1962). Topical distribution of the striatal efferents in the monkey. Exp. Neurol. 5, 21-36. doi: 10.1016/0014-4886(62)90067-5
214. Takano, H., Motohashi, N., Uema, T., Ogawa, K., Ohnishi, T., Nishikawa, M., et al. (2007). Changes in regional cerebral blood flow during acute electroconvulsive therapy in patients with depression: positron emission tomographic study. Br. J. Psychiatry 190, 63-68. doi: 10.1192/bjp.bp.106.023036
215. Tanabe, J., Reynolds, J., Krmpotich, T., Claus, E., Thompson, L. L., Du, Y. P., et al. (2013). Reduced neural tracking of prediction error in Substance-dependent individuals. Am. J. Psychiatry 170, 1356-1363. doi: 10.1176/appi.ajp.2013. 12091257
216. Tekin, S., and Cummings, J. L. (2002). Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J. Psychosom. Res. 53, 647-654. doi: 10.1016/s0022-3999(02)00428-2
217. Thayer, R. E., Hagerty, S. L., Sabbineni, A., Claus, E. D., Hutchison, K. E., and Weiland, B. J. (2016). Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry. Hum. Brain Mapp. 37, 2276-2292. doi: 10.1002/hbm.23172
218. Togao, O., Yoshiura, T., Nakao, T., Nabeyama, M., Sanematsu, H., Nakagawa, A., et al. (2010). Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Psychiatry Res. 184, 29-37. doi: 10.1016/j.pscychresns.2010.06.011
219. Tsuchida, A., Doll, B. B., and Fellows, L. K. (2010). Beyond reversal: a critical role for human orbitofrontal cortex in flexible learning from probabilistic feedback. J. Neurosci. 30, 16868-16875. doi: 10.1523/JNEUROSCI.1958-10.2010
220. Uher, R., Perlis, R. H., Henigsberg, N., Zobel, A., Rietschel, M., Mors, O., et al. (2012). Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms. Psychol. Med. 42, 967-980. doi: 10.1017/s0033291711001905
221. Uylings, H. B. M., Sanz-Arigita, E. J., de Vos, K., Pool, C. W., Evers, P., and Rajkowska, G. (2010). 3-D Cytoarchitectonic parcellation of human orbitofrontal cortex. Correlation with postmortem MRI. Psychiatry Res. 183, 1-20. doi: 10.1016/j.pscychresns.2010.04.012
222. Valente, A. A., Miguel, E. C., Castro, C. C., Amaro, E., Duran, F. L. S., Buchpiguel, C. A., et al. (2005). Regional gray matter abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Biol. Psychiatry 58, 479-487. doi: 10.1016/j.biopsych.2005.04.021
223. Volkow, N. D., Chang, L., Wang, G. J., Fowler, J. S., Ding, Y. S., Sedler, M., et al. (2001). Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. Am. J. Psychiatry 158, 2015-2021. doi: 10.1176/appi.ajp.158.12.2015
224. Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., and Telang, F. (2011). Addiction: beyond dopamine reward circuitry. Proc. Natl. Acad. Sci. U S A 108, 15037-15042. doi: 10.1073/pnas.1010654108
225. Volkow, N. D., Fowler, J. S., Wang, G. J., Telang, F., Logan, J., Jayne, M., et al. (2010). Cognitive control of drug craving inhibits brain reward regions in cocaine abusers. Neuroimage 49, 2536-2543. doi: 10.1016/j.neuroimage.2009. 10.088
226. Volkow, N. D., Fowler, J. S., Wolf, A. P., Hitzemann, R., Dewey, S., Bendriem, B., et al. (1991). Changes in brain glucose metabolism in cocaine dependence and withdrawal. Am. J. Psychiatry 148, 621-626. doi: 10.1176/ajp.148.5.621
227. Volkow, N. D., and Fowler, J. S. (2000). Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb. Cortex 10, 318-325. doi: 10.1093/cercor/10.3.318
228. Volkow, N. D., Wang, G. J., Ma, Y., Fowler, J. S., Wong, C., and Ding, Y. S. (2005). Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction. J. Neurosci. 25, 3932-3939. doi: 10.1523/JNEUROSCI.0433-05.2005
229. Voon, V., Derbyshire, K., Rück, C., Irvine, M. A., Worbe, Y., Enander, J., et al. (2015). Disorders of compulsivity: a common bias towards learning habits. Mol. Psychiatry 20, 345-352. doi: 10.1038/mp.2014.44
230. Wade, B. S., Joshi, S. H., Njau, S., Leaver, A. M., Vasavada, M., Woods, R. P., et al. (2016). Effect of electroconvulsive therapy on striatal morphometry in major depressive disorder. Neuropsychopharmacology 41, 2481-2491. doi: 10.1038/npp.2016.48
231. Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., and Ochsner, K. N. (2008). Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron 59, 1037-1050. doi: 10.1016/j.neuron.2008. 09.006
232. Walker, A. E. (1940). A cytoarchitectural study of the prefrontal area of the macaque monkey. J. Comp. Neurol. 73, 59-86. doi: 10.1002/cne.900730106
233. Wang, G. J., Volkow, N. D., Fowler, J. S., Cervany, P., Hitzemann, R. J., Pappas, N. R., et al. (1999). Regional brain metabolic activation during craving elicited by recall of previous drug experiences. Life Sci. 64, 775-784. doi: 10.1016/s0024-3205(98)00619-5
234. Webb, C. A., Dillon, D. G., Pechtel, P., Goer, F., Murray, L., Huys, Q. J. M., et al. (2016). Neural correlates of three promising endophenotypes of depression: evidence from the EMBARC study. Neuropsychopharmacology 41, 454-463. doi: 10.1038/npp.2015.165
235. Weber, M. J., Messing, S. B., Rao, H., Detre, J. A., and Thompson-Schill, S. L. (2014). Prefrontal transcranial direct current stimulation alters activation and connectivity in cortical and subcortical reward systems: a tDCS-fMRI study. Hum. Brain Mapp. 35, 3673-3686. doi: 10.1002/hbm. 22429
236. Wegener, I., Geiser, F., Alfter, S., Mierke, J., Imbierowicz, K., Kleiman, A., et al. (2015). Changes of explicitly and implicitly measured self-esteem in the treatment of major depression: evidence for implicit self-esteem compensation. Compr. Psychiatry 58, 57-67. doi: 10.1016/j.comppsych.2014. 12.001
237. Wiethoff, S., Hamada, M., and Rothwell, J. C. (2014). Variability in response to transcranial direct current stimulation of the motor cortex. Brain Stimul. 7, 468-475. doi: 10.1016/j.brs.2014.02.003
238. Wise, R. A. (1996). Neurobiology of addiction. Curr. Opin. Neurobiol. 6, 243-251. doi: 10.1016/S0959-4388(96)80079-1
239. Wood, J., and Ahmari, S. E. (2015). A Framework for understanding the emerging role of corticolimbic-ventral striatal networks in ocd-associated repetitive behaviors. Front. Syst. Neurosci. 9:171. doi: 10.3389/fnsys.2015. 00171
240. Yaryura-Tobias, J. A., and Neziroglu, F. (2003). Basal ganglia hemorrhagic ablation associated with temporary suppression of obsessive-compulsive symptoms. Rev. Bras. Psiquiatr. 25, 40-42. doi: 10.1590/s1516-444620030001 00008
241. Zald, D. H., McHugo, M., Ray, K. L., Glahn, D. C., Eickhoff, S. B., and Laird, A. R. (2014). Meta-analytic connectivity modeling reveals differential functional connectivity of the medial and lateral orbitofrontal cortex. Cereb. Cortex 24, 232-248. doi: 10.1093/cercor/bhs308