More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): A meta-analysis of 54 sham-controlled studies published between 1997-2013

Neuropsychiatric Disease and Treatment

Volumn 10, Issue , 2014, Pages 727-756

  De Santis, Karina Kedzior ^a   Azorina, Valeriya ^a   Reitz, Sarah Kim ^a  

^a JACOBS UNIVERSITY BREMEN   (Germany)

Author keywords

Depression; DLPFC; Meta analysis; Repetitive transcranial magnetic stimulation (rTMS); Sham controlled; Systematic review

Indexed keywords

ANTIDEPRESSANT ACTIVITY; ARTICLE; CLINICAL EFFECTIVENESS; FEMALE; HUMAN; INTERMETHOD COMPARISON; MAJOR DEPRESSION; META ANALYSIS; PREFRONTAL CORTEX; REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION; SEX DIFFERENCE; SYSTEMATIC REVIEW; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT RESPONSE;

EID: 84900436966     PISSN: 11766328     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/NDT.S58405     Document Type: Article

References (90)

1. George M, Wassermann EM, Williams WE, et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial. American Journal of Psychiatry. 1997;154:1752-1756.
2. Avery D, Claypoole K, Robinson L, et al. Repetitive transcranial magnetic stimulation in the treatment of medication-resistant depression: preliminary data. Journal of Nervous and Mental Disease. 1999;187(2):114-117.
3. Kimbrell T, Little J, Dunn R, et al. Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biological Psychiatry. 1999;46:1603-1613.
4. Klein E, Kreinin I, Chistyakov A. Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression: A double blind controlled study. Archives of General Psychiatry. 1999;56:315-320.
5. Loo C, Mitchell P, Sachdev P, McDarmont B, Parker G, Gandevia S. Double-blind controlled investigation of transcranial magnetic stimulation for the treatment of resistant major depression. American Journal of Psychiatry. 1999;156:946-948.
6. Padberg F, Zwanzger P, Thoma H, et al. Repetitive transcranial magnetic stimulation (rTMS) in pharmacotherapy-refractory major depression: comparative study of fast, slow and sham rTMS. Psychiatry Research. 1999;88:163-171.
7. Berman R, Hoffman R, Narashima M, et al. A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression. Biological Psychiatry. 2000;47:332-337.
8. Eschweiler G, Wegerer C, Schlotter W, et al. Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression. Psychiatry Research: Neuroimaging Section. 2000;99:161-172.
9. George M, Nahas Z, Molloy M, et al. A controlled trial of daily left prefrontal cortex TMS for treating depression. Biological Psychiatry. 2000;48:962-970.
10. Garcia-Toro M, Mayol A, Arnillas H, et al. Modest adjunctive benefit with transcranial magnetic stimulation in medication-resistant depression. Journal of Affective Disorders. 2001;64(2-3):271-275.
11. García-Toro M, Pascual-Leone A, Romera M, et al. Prefrontal repetitive transcranial magnetic stimulation as add on treatment in depression. Journal of Neurology, Neurosurgery and Psychiatry. 2001;71:546-548.
12. Manes F, Jorge R, Morcuende M, Yamada T, Paradiso S, Robinson R. A controlled study of repetitive transcranial magnetic stimulation as a treatment of depression in the elderly. International Psychogeriatrics. 2001;13(2):225-231.
13. Boutros N. Lack of a therapeutic effect of a 2-week sub-threshold transcranial magnetic stimulation course for treatment-resistant depression. Psychiatry Research. 2002;113(3):245-254.
14. Padberg F, Zwanzger P, Keck M, et al. Repetitive transcranial magnetic stimulation (rTMS) in major depression: relation between efficacy and stimulation intensity. Neuropsychopharmacology. 2002;27(4):638-645.
15. Fitzgerald P, Brown T, Marston N, Daskalakis Z, de Castella A, Kulkarni J. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Archives of General Psychiatry. 2003;60:1002-1008.
16. Höppner J, Schulz M, Irmisch G, Mau R, Schläfke D, Richter J. Antidepressant efficacy of two different rTMS procedures: High frequency over left versus low frequency over right prefrontal cortex compared with sham stimulation. European Archives of Psychiatry and Clinical Neuroscience. 2003;253:103-109.
17. Loo C, Mitchell P, Croker V, et al. Double-blind controlled investigation of bilateral prefrontal transcranial magnetic stimulation for the treatment of resistant major depression. Psychological Medicine. 2003;33:33-40.
18. Nahas Z, Kozel F, Li X, Anderson B, George M. Left prefrontal transcranial magnetic stimulation (rTMS) treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy. Bipolar Disorder. 2003;5(1):40-47.
19. Buchholtz H, Videbech P, Clemmensen K, Sturlason R, Jensen H, Vestergaard P. Repetitive transcranial magnetic stimulation as add-on antidepressant treatment. The applicability of the method in a clinical setting. Nordic Journal of Psychiatry. 2004;58(6):455-457.
20. Hausmann A, Kemmler G, Walpoth M, et al. No benefit derived from repetitive transcranial magnetic stimulation in depression: a prospective, single-centre, randomised, double blind, sham-controlled "add on" trial. Journal of Neurology, Neurosurgery and Psychiatry. 2004;75(2):320-322.
21. Holtzheimer III P, Russo J, Claypoole K, Roy-Byrne P, Avery D. Shorter duration of depressive episode may predict response to repetitive transcranial magnetic stimulation. Depression and Anxiety. 2004;19:24-30.
22. Kauffmann C, Cheema M, Miller B. Slow right prefrontal transcranial magnetic stimulation as a treatment for medication-resistant depression: A double-blind, placebo-controlled study. Depression and Anxiety. 2004;19:59-62.
23. Koerselman F, Laman D, van Duijn H, van Duijn M, Willems M. A 3-month, follow-up, randomized, placebo-controlled study of repetitive transcranial magnetic stimulation in depression. Journal of Clinical Psychiatry. 2004;65:1323-1328.
24. Mosimann U, Schmitt W, Greenberg B, et al. Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patients. Psychiatry Research. 2004;126:123-133.
25. Poulet E, Brunelin J, Boeuve C, et al. Repetitive transcranial magnetic stimulation does not potentiate antidepressant treatment. European Psychiatry. 2004;19:382-383.
26. Rossini D, Magri L, Lucca A, Giordani S, Smeraldi E, Zanardi R. Does rTMS hasten the response to escitalopram, sertraline, or venlafaxine in patients with major depressive disorder? A double-blind, randomized, sham-controlled trial. Journal of Clinical Psychiatry. 2005;66(12):1569-1575.
27. Rumi D, Gattaz W, Rigonatti S, et al. Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study. Biological Psychiatry. 2005;57:162-166.
28. Su T, Huang C, Wei I. Add-on rTMS for medication-resistant depression:a randomized, double-blind, sham-controlled trial in Chinese patients. Journal of Clinical Psychiatry. 2005;66(7):930-937.
29. Avery D, Holtzheimer III P, Fawaz W, et al. A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression. Biological Psychiatry. 2006;59:187-194.
30. Fitzgerald P, Benitez J, de Castella A, Daskalakis Z, Brown T, Kulkarni J. A randomized, controlled trial of sequestial bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression. American Journal of Psychiatry. 2006;163:88-94.
31. Garcia-Toro M, Salva J, Daumal J, et al. High (20-Hz) and low (1-Hz) frequency transcranial magnetic stimulation as adjuvant treatment in medication-resistant depression. Psychiatry Research: Neuroimaging. 2006;146:53-57.
32. Januel D, Dumortier G, Verdon C, et al. A double-blind sham controlled study of right prefrontal repetitive transcranial magnetic stimulation (rTMS): Therapeutic and cognitive effect in medication free unipolar depression during 4 weeks. Progress In Neuro-Psychopharmacology and Biological Psychiatry. 2006;30:126-130.
33. Anderson I, Delvai N, Ashim B, et al. Adjunctive fast repetitive transcranial magnetic stimulation in depression. British Journal of Psychiatry. 2007;190:533-534.
34. Bortolomasi M, Minelli A, Fuggetta G, et al. Long-lasting effects of high frequency repetitive transcranial magnetic stimulation in major depressed patients. Psychiatry Research. 2007;150(2):181-186.
35. Herwig U, Fallgatter A, Hoppner J, et al. Antidepressant effects of augmentative transcranial magnetic stimulation. Randomised multicentre trial. British Journal of Psychiatry. 2007;191:441-448.
36. Loo C, Mitchell P, McFarquhar T, Malhi G, Sachdev P. A sham-controlled trial of the efficacy and safety of twice-daily rTMS in major depression. Psychological Medicine. 2007;37:341-349.
37. O'Reardon J, Solvason H, Janicak P, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: A multisite randomized controlled trial. Biological Psychiatry. 2007;62:1208-1216.
38. Stern W, Tormos J, Press D, Pearlman C, Pascual-Leone A. Antidepressant effects of high and low frequency repetitive transcranial magnetic stimulation to the dorsolateral prefrontal cortex:a double-blind, randomized, placebo-controlled trial. Journal of Neuropsychiatry and Clinical Neurosciences. 2007;19(2):179-186.
39. Bretlau L, Lindberg L, Unden M, Dissing S, Bech P. Repetitive transcranial magnetic stimulation (rTMS) in combination with escitalopram in patients with treatment-resistant major depression. A double-blind, randomised, sham-controlled trial. Pharmacopsychiatry. 2008;41(2):41-47.
40. Mogg A, Pluck G, Eranti S, et al. A randomized controlled trial with 4-month follow-up of adjunctive repetitive transcranial magnetic stimulation of the left prefrontal cortex for depression. Psychological Medicine. 2008;38:323-333.
41. Aguirre I, Carretero B, Ibarra O, et al. Age predicts low-frequency transcranial magnetic stimulation efficacy in major depression. Journal of Affective Disorders. 2011;130(3):466-469.
42. Avery DH, Holtzheimer PE, 3rd, Fawaz W, et al. Transcranial magnetic stimulation reduces pain in patients with major depression: a sham-controlled study. The Journal of Nervous And Mental Disease. 2007;195(5):378-381.
43. Baeken C, De Raedt R, Vanderhasselt M-A, et al. A "hypersensitive" hypothalamic-pituitary-adrenal system could be indicative for a negative clinical high-frequency repetitive transcranial magnetic stimulation outcome in melancholic depressed patients. Brain Stimulation. 2010;3(1):54-57.
44. Bakim B, Uzun UE, Karamustafalioglu O, et al. The combination of antidepressant drug therapy and high-frequency repetitive transcranial magnetic stimulation in medication-resistant depression. Bulletin of Clinical Psychopharmacology. 2012;22(3):244-253.
45. Bares M, Kopecek M, Novak T, et al. Low frequency (1-Hz), right prefrontal repetitive transcranial magnetic stimulation (rTMS) compared with venlafaxine ER in the treatment of resistant depression: A double-blind, single-centre, randomized study. Journal of Affective Disorders. 2009;118(1-3):94-100.
46. Blumberger DM, Mulsant BH, Fitzgerald PB, et al. A randomized double-blind sham-controlled comparison of unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant major depression. The World Journal of Biological Psychiatry. 2012;13(6):423-435.
47. Brakemeier E-L, Luborzewski A, Danker-Hopfe H, Kathmann N, Bajbouj M. Positive predictors for antidepressive response to prefrontal repetitive transcranial magnetic stimulation (rTMS). Journal of Psychiatric Research. 2007;41(5):395-403.
48. Brakemeier E-L, Wilbertz G, Rodax S, et al. Patterns of response to repetitive transcranial magnetic stimulation (rTMS) in major depression: Replication study in drug-free patients. Journal of Affective Disorders. 2008;108(1-2):59-70.
49. Chen S-J, Chang C-H, Tsai H-C, Chen S-T, Lin CCH. Superior antidepressant effect occurring 1 month after rTMS: Add-on rTMS for subjects with medication-resistant depression. Neuropsychiatric Disease and Treatment. 2013;9.
50. Cohen RB, Boggio PS, Fregni F. Risk factors for relapse after remission with repetitive transcranial magnetic stimulation for the treatment of depression. Depression and Anxiety. 2009;26(7):682-688.
51. Dell'osso B, Altamura AC. Augmentative transcranial magnetic stimulation (TMS) combined with brain navigation in drug-resistant rapid cycling bipolar depression: a case report of acute and maintenance efficacy. The World Journal of Biological Psychiatry: The Official Journal of The World Federation of Societies of Biological Psychiatry. 2009;10(4 Pt 2):673-676.
52. Fitzgerald PB, Hoy KE, Herring SE, et al. A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression. Journal of Affective Disorders. 2012;139(2):193-198.
53. Furtado CP, Hoy KE, Maller JJ, Savage G, Daskalakis ZJ, Fitzgerald PB. Cognitive and volumetric predictors of response to repetitive transcranial magnetic stimulation (rTMS)-a prospective follow-up study. Psychiatry Research. 2012;202(1):12-19.
54. Galletly C, Gill S, Clarke P, Burton C, Fitzgerald PB. A randomized trial comparing repetitive transcranial magnetic stimulation given 3 days/week and 5 days/week for the treatment of major depression: Is efficacy related to the duration of treatment or the number of treatments? Psychological Medicine. 2012;42(5):981-988.
55. George MS, Lisanby SH, Avery D, et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Archives of General Psychiatry. 2010;67(5):507-516.
56. Hadley D, Anderson BS, Borckardt JJ, et al. Safety, tolerability, and effectiveness of high doses of adjunctive daily left prefrontal repetitive transcranial magnetic stimulation for treatment-resistant depression in a clinical setting. The Journal of ECT. 2011;27(1):18-25.
57. He ML, Gu ZT, Wang XY, Shi HP. Treatment of depression using sleep electroencephalogram modulated repetitive transcranial magnetic stimulation. Chinese Medical Journal. 2011;124(12):1779-1783.
58. Herbsman T, Avery D, Ramsey D, et al. More lateral and anterior prefrontal coil location is associated with better repetitive transcranial magnetic stimulation antidepressant response. Biological Psychiatry. 2009;66(5):509-515.
59. Hernández-Ribas R, Deus J, Pujol J, et al. Identifying brain imaging correlates of clinical response to repetitive transcranial magnetic stimulation (rTMS) in major depression. Brain Stimulation. 2013;6(1):54-61.
60. Herwig U, Cardenas-Morales L, Connemann BJ, Kammer T, Schönfeldt-Lecuona C. Sham or real-post hoc estimation of stimulation condition in a randomized transcranial magnetic stimulation trial. Neuroscience Letters. 2010;471(1):30-33.
61. Hoeppner J, Padberg F, Domes G, et al. Influence of repetitive transcranial magnetic stimulation on psychomotor symptoms in major depression. European Archives of Psychiatry and Clinical Neuroscience. 2010;260(3):197-202.
62. Hoy KE, Segrave RA, Daskalakis ZJ, Fitzgerald PB. Investigating the relationship between cognitive change and antidepressant response following rTMS: A large scale retrospective study. Brain Stimulation. 2012;5(4):539-546.
63. Huang C-C, Wei IH, Chou Y-H, Su T-P. Effect of age, gender, menopausal status, and ovarian hormonal level on rTMS in treatment-resistant depression. Psychoneuroendocrinology. 2008;33(6):821-831.
64. Huang Ml, Luo By, Hu Jb, et al. Repetitive transcranial magnetic stimulation in combination with citalopram in young patients with first-episode major depressive disorder: A double-blind, randomized, sham-controlled trial. Australian and New Zealand Journal of Psychiatry. 2012;46(3):257-264.
65. Jakob F, Brakemeier E-L, Schommer NC, et al. Ultrahigh frequency repetitive transcranial magnetic stimulation in unipolar depression. Journal of Clinical Psychopharmacology. 2008;28(4):474-476.
66. Kozel FA, Johnson KA, Nahas Z, et al. Fractional anisotropy changes after several weeks of daily left high-frequency repetitive transcranial magnetic stimulation of the prefrontal cortex to treat major depression. The Journal of ECT. 2011;27(1):5-10.
67. Kreuzer PM, Langguth B, Schecklmann M, Eichhammer P, Hajak G, Landgrebe M. Can repetitive transcranial magnetic stimulation prolong the antidepressant effects of sleep deprivation? Brain Stimulation. 2012;5(2):141-147.
68. Lingeswaran A. Repetitive Transcranial Magnetic Stimulation in the Treatment of depression: A Randomized, Double-blind, Placebo-controlled Trial. Indian Journal of Psychological Medicine. 2011;33(1):35-44.
69. Lisanby SH, Husain MM, Rosenquist PB, et al. Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology. 2009;34(2):522-534.
70. Myczkowski ML, Dias AM, Luvisotto T, et al. Effects of repetitive transcranial magnetic stimulation on clinical, social, and cognitive performance in postpartum depression. Neuropsychiatric Disease and Treatment. 2012;8:491-500.
71. Nongpiur A, Sinha VK, Praharaj SK, Goyal N. Theta-patterned, frequency-modulated priming stimulation enhances low-frequency, right prefrontal cortex repetitive transcranial magnetic stimulation (rTMS) in depression: A randomized, sham-controlled study. The Journal of Neuropsychiatry and Clinical Neurosciences. 2011;23(3):348-357.
72. Paillère Martinot M-L, Galinowski A, Ringuenet D, et al. Influence of prefrontal target region on the efficacy of repetitive transcranial magnetic stimulation in patients with medication-resistant depression: A [18F]-fluorodeoxyglucose PET and MRI study. International Journal of Neuropsychopharmacology. 2010;13(1):45-59.
73. Pallanti S, Bernardi S, Di Rollo A, Antonini S, Quercioli L. Unilateral low frequency versus sequential bilateral repetitive transcranial magnetic stimulation: is simpler better for treatment of resistant depression? Neuroscience. 2010;167(2):323-328.
74. Peng H, Zheng H, Li L, et al. High-frequency rTMS treatment increases white matter FA in the left middle frontal gyrus in young patients with treatment-resistant depression. Journal of Affective Disorders. 2012;136:249-257.
75. Ray S, Nizamie SH, Akhtar S, Praharaj SK, Mishra BR, Zia-ul-Haq M. Efficacy of adjunctive high frequency repetitive transcranial magnetic stimulation of left prefrontal cortex in depression: A randomized sham controlled study. Journal of Affective Disorders. 2011;128(1-2):153-159.
76. Rosenquist PB, Krystal A, Heart KL, Demitrack MA, Vaughn McCall W. Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder. Psychiatry Research. 2013;205(1-2):67-73.
77. Schrijvers DL, Baeken C, De Raedt R, Sabbe BGC. The impact of high-frequency repetitive transcranial magnetic stimulation on fine motor functions in medication-resistant major depression. Neuropsychobiology. 2012;66(4):252-258.
78. Schutter DJLG, Laman DM, van Honk J, Vergouwen AC, Koerselman GF. Partial clinical response to 2 weeks of 2 Hz repetitive transcranial magnetic stimulation to the right parietal cortex in depression. International Journal of Neuropsychopharmacology. 2009;12(5):643-650.
79. Schutter DJLG, van Honk J, Laman M, Vergouwen AC, Koerselman F. Increased sensitivity for angry faces in depressive disorder following 2 weeks of 2-Hz repetitive transcranial magnetic stimulation to the right parietal cortex. International Journal of Neuropsychopharmacology. 2010;13(9):1155-1161.
80. Simpson KN, Welch MJ, Kozel FA, Demitrack MA, Nahas Z. Cost-effectiveness of transcranial magnetic stimulation in the treatment of major depression: a health economics analysis. Advances In Therapy. 2009;26(3):346-368.
81. Spampinato C, Aguglia E, Concerto C, et al. Transcranial magnetic stimulation in the assessment of motor cortex excitability and treatment of drug-resistant major depression. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2013;21(3):391-403.
82. Speer AM, Benson BE, Kimbrell TK, et al. Opposite effects of high and low frequency rTMS on mood in depressed patients: Relationship to baseline cerebral activity on PET. Journal of Affective Disorders. 2009;115(3):386-394.
83. Speer AM, Wassermann EM, Benson BE, Herscovitch P, Post RM. Antidepressant Efficacy of High and Low Frequency rTMS at 110% of Motor Threshold versus Sham Stimulation over Left Prefrontal Cortex. Brain Stimulation. 2013.
84. Tamas RL, Menkes D, El-Mallakh RS. Stimulating research: a prospective, randomized, double-blind, sham-controlled study of slow transcranial magnetic stimulation in depressed bipolar patients. The Journal of Neuropsychiatry and Clinical Neurosciences. 2007;19(2):198-199.
85. Triggs WJ, Ricciuti N, Ward HE, et al. Right and left dorsolateral pre-frontal rTMS treatment of refractory depression: A randomized, sham-controlled trial. Psychiatry Research. 2010;178(3):467-474.
86. Trojak B, Chauvet-Gelinier J-C, Vergès B, Bonin B. Significant increase in plasma thyroid-stimulating hormone during low-frequency repetitive transcranial magnetic stimulation. The Journal of Neuropsychiatry and Clinical Neurosciences. 2011;23(1):E12-E12.
87. Ullrich H, Kranaster L, Sigges E, Andrich J, Sartorius A. Ultra-high-frequency left prefrontal transcranial magnetic stimulation as augmentation in severely ill patients with depression: a naturalistic sham-controlled, double-blind, randomized trial. Neuropsychobiology. 2012;66(3):141-148.
88. Zarkowski P, Navarro R, Pavlicova M, George MS, Avery D. The effect of daily prefrontal repetitive transcranial magnetic stimulation over several weeks on resting motor threshold. Brain Stimulation. 2009;2(3):163-167.
89. Zheng H-r, Li L-j, Zhang L. Treatment of rTMS on young patients with intractable depression. Chinese Journal of Clinical Psychology. 2010;18(1):44-46.
90. Zheng H, Zhang L, Li L, et al. High-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2010;34(7):1189-1195.