메뉴 건너뛰기




Volumn 27, Issue 9, 2017, Pages 673-684

Gasdermins: Effectors of Pyroptosis

Author keywords

apoptosis; gasdermin; inflammasome; programmed cell death; pyroptosis

Indexed keywords

CASPASE 11; GASDERMIN; GASDERMIN A; GASDERMIN B; GASDERMIN C; GASDERMIN D; GASDERMIN E; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MEMBRANE PROTEIN; PROTEIN DFNB59; UNCLASSIFIED DRUG; CASPASE; TUMOR PROTEIN;

EID: 85020444529     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2017.05.005     Document Type: Review
Times cited : (981)

References (77)
  • 1
    • 85010966276 scopus 로고    scopus 로고
    • Programmed cell death as a defence against infection
    • Jorgensen, I., et al. Programmed cell death as a defence against infection. Nat. Rev. Immunol. 17 (2017), 151–164.
    • (2017) Nat. Rev. Immunol. , vol.17 , pp. 151-164
    • Jorgensen, I.1
  • 2
    • 84988813074 scopus 로고    scopus 로고
    • Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis
    • Jorgensen, I., et al. Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis. J. Exp. Med. 213 (2016), 2113–2128.
    • (2016) J. Exp. Med. , vol.213 , pp. 2113-2128
    • Jorgensen, I.1
  • 3
    • 84995483254 scopus 로고    scopus 로고
    • IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis
    • Jorgensen, I., et al. IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis. Eur. J. Immunol. 46 (2016), 2761–2766.
    • (2016) Eur. J. Immunol. , vol.46 , pp. 2761-2766
    • Jorgensen, I.1
  • 4
    • 84867063450 scopus 로고    scopus 로고
    • Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
    • Moltke Von, J., et al. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature 490 (2012), 107–111.
    • (2012) Nature , vol.490 , pp. 107-111
    • Moltke Von, J.1
  • 5
    • 79961065571 scopus 로고    scopus 로고
    • Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity
    • Sauer, J.-D., et al. Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 12419–12424.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 12419-12424
    • Sauer, J.-D.1
  • 6
    • 84947416929 scopus 로고    scopus 로고
    • Inflammasomes coordinate pyroptosis and natural killer cell cytotoxicity to clear infection by a ubiquitous environmental bacterium
    • Maltez, V.I., et al. Inflammasomes coordinate pyroptosis and natural killer cell cytotoxicity to clear infection by a ubiquitous environmental bacterium. Immunity 43 (2015), 987–997.
    • (2015) Immunity , vol.43 , pp. 987-997
    • Maltez, V.I.1
  • 7
    • 84941317034 scopus 로고    scopus 로고
    • Canonical inflammasomes drive IFN-γ to prime caspase-11 in defense against a cytosol-invasive bacterium
    • Aachoui, Y., et al. Canonical inflammasomes drive IFN-γ to prime caspase-11 in defense against a cytosol-invasive bacterium. Cell Host Microbe 18 (2015), 320–332.
    • (2015) Cell Host Microbe , vol.18 , pp. 320-332
    • Aachoui, Y.1
  • 8
    • 84957618366 scopus 로고    scopus 로고
    • Reassessing the evolutionary importance of inflammasomes
    • Maltez, V.I., Miao, E.A., Reassessing the evolutionary importance of inflammasomes. J. Immunol. 196 (2016), 956–962.
    • (2016) J. Immunol. , vol.196 , pp. 956-962
    • Maltez, V.I.1    Miao, E.A.2
  • 9
    • 84892030409 scopus 로고    scopus 로고
    • Gasdermin superfamily: a novel gene family functioning in epithelial cells
    • J. Carrasco M. Mota Nova Science Publishers
    • Saeki, N., Sasaki, H., Gasdermin superfamily: a novel gene family functioning in epithelial cells. Carrasco, J., Mota, M., (eds.) Endothelium and Epithelium, 2012, Nova Science Publishers, 193–211.
    • (2012) Endothelium and Epithelium , pp. 193-211
    • Saeki, N.1    Sasaki, H.2
  • 10
    • 84942892037 scopus 로고    scopus 로고
    • Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
    • Shi, J., et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526 (2015), 660–665.
    • (2015) Nature , vol.526 , pp. 660-665
    • Shi, J.1
  • 11
    • 34247217928 scopus 로고    scopus 로고
    • Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner
    • Tamura, M., et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics 89 (2007), 618–629.
    • (2007) Genomics , vol.89 , pp. 618-629
    • Tamura, M.1
  • 12
    • 85008419254 scopus 로고    scopus 로고
    • Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
    • Rogers, C., et al. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat. Commun., 8, 2017, 14128.
    • (2017) Nat. Commun. , vol.8 , pp. 14128
    • Rogers, C.1
  • 13
    • 85022210909 scopus 로고    scopus 로고
    • Chemotherapy drugs induce pyroptosis through caspase -3 cleavage of a Gasdermin
    • Published online May 1, 2017
    • Wang, Y., et al. Chemotherapy drugs induce pyroptosis through caspase -3 cleavage of a Gasdermin. Nature, 2017, 10.1038/nature22393 Published online May 1, 2017.
    • (2017) Nature
    • Wang, Y.1
  • 14
    • 84942856523 scopus 로고    scopus 로고
    • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
    • Kayagaki, N., et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526 (2015), 666–671.
    • (2015) Nature , vol.526 , pp. 666-671
    • Kayagaki, N.1
  • 15
    • 84978419608 scopus 로고    scopus 로고
    • Pore-forming activity and structural autoinhibition of the gasdermin family
    • Ding, J., et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535 (2016), 111–116.
    • (2016) Nature , vol.535 , pp. 111-116
    • Ding, J.1
  • 16
    • 84949091051 scopus 로고    scopus 로고
    • Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
    • He, W.-T., et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res. 25 (2015), 1285–1298.
    • (2015) Cell Res. , vol.25 , pp. 1285-1298
    • He, W.-T.1
  • 17
    • 62449133719 scopus 로고    scopus 로고
    • Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium
    • Saeki, N., et al. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer 48 (2009), 261–271.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 261-271
    • Saeki, N.1
  • 18
    • 84978374487 scopus 로고    scopus 로고
    • Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
    • Liu, X., et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535 (2016), 153–158.
    • (2016) Nature , vol.535 , pp. 153-158
    • Liu, X.1
  • 19
    • 84978128481 scopus 로고    scopus 로고
    • GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
    • Aglietti, R.A., et al. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), 7858–7863.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , pp. 7858-7863
    • Aglietti, R.A.1
  • 20
    • 84982102736 scopus 로고    scopus 로고
    • GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
    • Sborgi, L., et al. GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J. 35 (2016), 1766–1778.
    • (2016) EMBO J. , vol.35 , pp. 1766-1778
    • Sborgi, L.1
  • 21
    • 55949107533 scopus 로고    scopus 로고
    • Physiology of cell volume regulation in vertebrates
    • Hoffmann, E.K., et al. Physiology of cell volume regulation in vertebrates. Physiol. Rev. 89 (2009), 193–277.
    • (2009) Physiol. Rev. , vol.89 , pp. 193-277
    • Hoffmann, E.K.1
  • 22
    • 20344402550 scopus 로고    scopus 로고
    • An emergency response team for membrane repair
    • McNeil, P.L., Kirchhausen, T., An emergency response team for membrane repair. Nat. Rev. Mol. Cell Biol. 6 (2005), 499–505.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 499-505
    • McNeil, P.L.1    Kirchhausen, T.2
  • 23
    • 84897624850 scopus 로고    scopus 로고
    • ESCRT machinery is required for plasma membrane repair
    • 1247136–1247136
    • Jimenez, A.J., et al. ESCRT machinery is required for plasma membrane repair. Science, 343, 2014 1247136–1247136.
    • (2014) Science , vol.343
    • Jimenez, A.J.1
  • 24
    • 85017108918 scopus 로고    scopus 로고
    • ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences
    • 286–300.e16
    • Gong, Y.-N., et al. ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences. Cell, 169, 2017 286–300.e16.
    • (2017) Cell , vol.169
    • Gong, Y.-N.1
  • 25
    • 85017405855 scopus 로고    scopus 로고
    • NAIP–NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of caspase-1 and -8
    • Rauch, I., et al. NAIP–NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of caspase-1 and -8. Immunity 46 (2017), 649–659.
    • (2017) Immunity , vol.46 , pp. 649-659
    • Rauch, I.1
  • 26
    • 84957922975 scopus 로고    scopus 로고
    • Inflammasome-dependent IL-1β release depends upon membrane permeabilisation
    • Martín-Sánchez, F., et al. Inflammasome-dependent IL-1β release depends upon membrane permeabilisation. Cell Death Differ. 23 (2016), 1219–1231.
    • (2016) Cell Death Differ. , vol.23 , pp. 1219-1231
    • Martín-Sánchez, F.1
  • 27
    • 34047179487 scopus 로고    scopus 로고
    • Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death
    • Brough, D., Rothwell, N.J., Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death. J. Cell Sci. 120 (2007), 772–781.
    • (2007) J. Cell Sci. , vol.120 , pp. 772-781
    • Brough, D.1    Rothwell, N.J.2
  • 28
    • 84983776563 scopus 로고    scopus 로고
    • Active caspase-1 induces plasma membrane pores that precede pyroptotic lysis and are blocked by lanthanides
    • Russo, H.M., et al. Active caspase-1 induces plasma membrane pores that precede pyroptotic lysis and are blocked by lanthanides. J. Immunol. 197 (2016), 1353–1367.
    • (2016) J. Immunol. , vol.197 , pp. 1353-1367
    • Russo, H.M.1
  • 29
    • 84904792729 scopus 로고    scopus 로고
    • The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge
    • Chen, K.W., et al. The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge. Cell Rep. 8 (2014), 570–582.
    • (2014) Cell Rep. , vol.8 , pp. 570-582
    • Chen, K.W.1
  • 30
    • 84962219519 scopus 로고    scopus 로고
    • Human monocytes engage an alternative inflammasome pathway
    • Gaidt, M.M., et al. Human monocytes engage an alternative inflammasome pathway. Immunity 44 (2016), 833–846.
    • (2016) Immunity , vol.44 , pp. 833-846
    • Gaidt, M.M.1
  • 31
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    • Shi, C.-S., et al. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol. 13 (2012), 255–263.
    • (2012) Nat. Immunol. , vol.13 , pp. 255-263
    • Shi, C.-S.1
  • 32
    • 80052178985 scopus 로고    scopus 로고
    • Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner
    • Wang, J.-G., et al. Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. Blood 118 (2011), 2366–2374.
    • (2011) Blood , vol.118 , pp. 2366-2374
    • Wang, J.-G.1
  • 33
    • 0035655395 scopus 로고    scopus 로고
    • Rapid secretion of interleukin-1beta by microvesicle shedding
    • MacKenzie, A., et al. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15 (2001), 825–835.
    • (2001) Immunity , vol.15 , pp. 825-835
    • MacKenzie, A.1
  • 34
    • 78449269290 scopus 로고    scopus 로고
    • Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    • Miao, E.A., et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 11 (2010), 1136–1142.
    • (2010) Nat. Immunol. , vol.11 , pp. 1136-1142
    • Miao, E.A.1
  • 35
    • 84908544666 scopus 로고    scopus 로고
    • Inflammasome activation leads to caspase-1-dependent mitochondrial damage and block of mitophagy
    • Yu, J., et al. Inflammasome activation leads to caspase-1-dependent mitochondrial damage and block of mitophagy. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 15514–15519.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 15514-15519
    • Yu, J.1
  • 36
    • 80052687210 scopus 로고    scopus 로고
    • Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation
    • Bergsbaken, T., et al. Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation. J. Immunol. 187 (2011), 2748–2754.
    • (2011) J. Immunol. , vol.187 , pp. 2748-2754
    • Bergsbaken, T.1
  • 37
    • 76249090489 scopus 로고    scopus 로고
    • BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources
    • Wu, C., et al. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol., 10, 2009, R130.
    • (2009) Genome Biol. , vol.10 , pp. R130
    • Wu, C.1
  • 38
    • 84885813096 scopus 로고    scopus 로고
    • Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome
    • Tanaka, S., et al. Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. G3 (Bethesda) 3 (2013), 1843–1850.
    • (2013) G3 (Bethesda) , vol.3 , pp. 1843-1850
    • Tanaka, S.1
  • 39
    • 0033851634 scopus 로고    scopus 로고
    • Gasdermin (Gsdm) localizing to mouse chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells
    • Saeki, N., et al. Gasdermin (Gsdm) localizing to mouse chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mamm. Genome 11 (2000), 718–724.
    • (2000) Mamm. Genome , vol.11 , pp. 718-724
    • Saeki, N.1
  • 40
    • 4744369159 scopus 로고    scopus 로고
    • The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3
    • Runkel, F., et al. The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. Genomics 84 (2004), 824–835.
    • (2004) Genomics , vol.84 , pp. 824-835
    • Runkel, F.1
  • 41
    • 15044344065 scopus 로고    scopus 로고
    • Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland
    • Lunny, D.P., et al. Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland. J. Invest. Dermatol. 124 (2005), 615–621.
    • (2005) J. Invest. Dermatol. , vol.124 , pp. 615-621
    • Lunny, D.P.1
  • 42
    • 34250753983 scopus 로고    scopus 로고
    • A new Gsdma3 mutation affecting anagen phase of first hair cycle
    • Tanaka, S., et al. A new Gsdma3 mutation affecting anagen phase of first hair cycle. Biochem. Biophys. Res. Commun. 359 (2007), 902–907.
    • (2007) Biochem. Biophys. Res. Commun. , vol.359 , pp. 902-907
    • Tanaka, S.1
  • 43
    • 78649710010 scopus 로고    scopus 로고
    • Gsdma3 is required for hair follicle differentiation in mice
    • Li, J., et al. Gsdma3 is required for hair follicle differentiation in mice. Biochem. Biophys. Res. Commun. 403 (2010), 18–23.
    • (2010) Biochem. Biophys. Res. Commun. , vol.403 , pp. 18-23
    • Li, J.1
  • 44
    • 84862916670 scopus 로고    scopus 로고
    • Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation
    • Zhou, Y., et al. Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation. Am. J. Pathol. 180 (2012), 763–774.
    • (2012) Am. J. Pathol. , vol.180 , pp. 763-774
    • Zhou, Y.1
  • 45
    • 84864317759 scopus 로고    scopus 로고
    • Gsdma3(I359N) is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis
    • Kumar, S., et al. Gsdma3(I359N) is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis. J. Dermatol. Sci. 67 (2012), 190–192.
    • (2012) J. Dermatol. Sci. , vol.67 , pp. 190-192
    • Kumar, S.1
  • 46
    • 84934938651 scopus 로고    scopus 로고
    • Loss of conserved Gsdma3 self-regulation causes autophagy and cell death
    • Shi, P., et al. Loss of conserved Gsdma3 self-regulation causes autophagy and cell death. Biochem. J. 468 (2015), 325–336.
    • (2015) Biochem. J. , vol.468 , pp. 325-336
    • Shi, P.1
  • 47
    • 85030439325 scopus 로고    scopus 로고
    • Gsdma3 is required for mammary gland development in mice
    • Guo, H., et al. Gsdma3 is required for mammary gland development in mice. Histochem. Cell Biol. 135 (2017), 2162–2169.
    • (2017) Histochem. Cell Biol. , vol.135 , pp. 2162-2169
    • Guo, H.1
  • 48
    • 79959815406 scopus 로고    scopus 로고
    • Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR
    • Yu, J., et al. Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR. Pediatr. Pulmonol. 46 (2011), 701–708.
    • (2011) Pediatr. Pulmonol. , vol.46 , pp. 701-708
    • Yu, J.1
  • 49
    • 84870713668 scopus 로고    scopus 로고
    • Lung eQTLs to help reveal the molecular underpinnings of asthma
    • Hao, K., et al. Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genet., 8, 2012, e1003029.
    • (2012) PLoS Genet. , vol.8 , pp. e1003029
    • Hao, K.1
  • 50
    • 62449114842 scopus 로고    scopus 로고
    • Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma
    • Wu, H., et al. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy 64 (2009), 629–635.
    • (2009) Allergy , vol.64 , pp. 629-635
    • Wu, H.1
  • 51
    • 34547216747 scopus 로고    scopus 로고
    • Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    • Moffatt, M.F., et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448 (2007), 470–473.
    • (2007) Nature , vol.448 , pp. 470-473
    • Moffatt, M.F.1
  • 52
    • 77957113600 scopus 로고    scopus 로고
    • A large-scale, consortium-based genomewide association study of asthma
    • Moffatt, M.F., et al. A large-scale, consortium-based genomewide association study of asthma. N. Engl. J. Med. 363 (2010), 1211–1221.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1211-1221
    • Moffatt, M.F.1
  • 53
    • 84994813356 scopus 로고    scopus 로고
    • GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
    • Das, S., et al. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), 13132–13137.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , pp. 13132-13137
    • Das, S.1
  • 54
    • 85012964576 scopus 로고    scopus 로고
    • Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein
    • Chao, K.L., et al. Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein. Proc. Natl. Acad. Sci. U. S. A. 114 (2017), E1128–E1137.
    • (2017) Proc. Natl. Acad. Sci. U. S. A. , vol.114 , pp. E1128-E1137
    • Chao, K.L.1
  • 55
    • 84887954625 scopus 로고    scopus 로고
    • Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population
    • Qiu, R., et al. Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population. Scand. J. Rheumatol. 42 (2013), 469–472.
    • (2013) Scand. J. Rheumatol. , vol.42 , pp. 469-472
    • Qiu, R.1
  • 56
    • 85002253431 scopus 로고    scopus 로고
    • Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
    • Chu, A.Y., et al. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat. Genet. 49 (2017), 125–130.
    • (2017) Nat. Genet. , vol.49 , pp. 125-130
    • Chu, A.Y.1
  • 57
    • 84937759517 scopus 로고    scopus 로고
    • Genetic link of type 1 diabetes susceptibility loci with rheumatoid arthritis in Pakistani patients
    • Kiani, A.K., et al. Genetic link of type 1 diabetes susceptibility loci with rheumatoid arthritis in Pakistani patients. Immunogenetics 67 (2015), 277–282.
    • (2015) Immunogenetics , vol.67 , pp. 277-282
    • Kiani, A.K.1
  • 58
    • 84869116213 scopus 로고    scopus 로고
    • Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases
    • 861–8.e7
    • Li, X., et al. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J. Allergy Clin. Immunol., 130, 2012 861–8.e7.
    • (2012) J. Allergy Clin. Immunol. , vol.130
    • Li, X.1
  • 59
    • 77955087537 scopus 로고    scopus 로고
    • Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis
    • Hirschfield, G.M., et al. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat. Genet. 42 (2010), 655–657.
    • (2010) Nat. Genet. , vol.42 , pp. 655-657
    • Hirschfield, G.M.1
  • 60
    • 84862790007 scopus 로고    scopus 로고
    • Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12
    • Kurreeman, F.A.S., et al. Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12. Am. J. Hum. Genet. 90 (2012), 524–532.
    • (2012) Am. J. Hum. Genet. , vol.90 , pp. 524-532
    • Kurreeman, F.A.S.1
  • 61
    • 84949643400 scopus 로고    scopus 로고
    • Genetic determinants of enterovirus infections: polymorphisms in type 1 diabetes and innate immune genes in the MIDIA Study
    • Witsø, E., et al. Genetic determinants of enterovirus infections: polymorphisms in type 1 diabetes and innate immune genes in the MIDIA Study. Viral Immunol. 28 (2015), 556–563.
    • (2015) Viral Immunol. , vol.28 , pp. 556-563
    • Witsø, E.1
  • 62
    • 84860874813 scopus 로고    scopus 로고
    • Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
    • Crosslin, D.R., et al. Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Hum. Genet. 131 (2012), 639–652.
    • (2012) Hum. Genet. , vol.131 , pp. 639-652
    • Crosslin, D.R.1
  • 63
    • 0035076476 scopus 로고    scopus 로고
    • Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells
    • Watabe, K., et al. Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells. Jpn. J. Cancer Res. 92 (2001), 140–151.
    • (2001) Jpn. J. Cancer Res. , vol.92 , pp. 140-151
    • Watabe, K.1
  • 64
    • 10744221846 scopus 로고    scopus 로고
    • A novel mutation identified in the DFNA5 gene in a Dutch family: a clinical and genetic evaluation
    • Bischoff, A.M.L.C., et al. A novel mutation identified in the DFNA5 gene in a Dutch family: a clinical and genetic evaluation. Audiol. Neurootol. 9 (2004), 34–46.
    • (2004) Audiol. Neurootol. , vol.9 , pp. 34-46
    • Bischoff, A.M.L.C.1
  • 65
    • 0141957280 scopus 로고    scopus 로고
    • A 3-nucleotide deletion in the polypyrimidine tract of intron 7 of the DFNA5 gene causes nonsyndromic hearing impairment in a Chinese family
    • Yu, C., et al. A 3-nucleotide deletion in the polypyrimidine tract of intron 7 of the DFNA5 gene causes nonsyndromic hearing impairment in a Chinese family. Genomics 82 (2003), 575–579.
    • (2003) Genomics , vol.82 , pp. 575-579
    • Yu, C.1
  • 66
    • 17344371515 scopus 로고    scopus 로고
    • Nonsyndromic hearing impairment is associated with a mutation in DFNA5
    • Van Laer, L., et al. Nonsyndromic hearing impairment is associated with a mutation in DFNA5. Nat. Genet. 20 (1998), 194–197.
    • (1998) Nat. Genet. , vol.20 , pp. 194-197
    • Van Laer, L.1
  • 67
    • 84858201121 scopus 로고    scopus 로고
    • DFNA5, a gene involved in hearing loss and cancer: a review
    • de Beeck, K.O., et al. DFNA5, a gene involved in hearing loss and cancer: a review. Ann. Otol. Rhinol. Laryngol. 121 (2012), 197–207.
    • (2012) Ann. Otol. Rhinol. Laryngol. , vol.121 , pp. 197-207
    • de Beeck, K.O.1
  • 68
    • 22044436394 scopus 로고    scopus 로고
    • Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells
    • Van Laer, L., et al. Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells. Neurobiol. Dis. 19 (2005), 386–399.
    • (2005) Neurobiol. Dis. , vol.19 , pp. 386-399
    • Van Laer, L.1
  • 69
    • 33745577619 scopus 로고    scopus 로고
    • Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy
    • Delmaghani, S., et al. Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy. Nat. Genet. 38 (2006), 770–778.
    • (2006) Nat. Genet. , vol.38 , pp. 770-778
    • Delmaghani, S.1
  • 70
    • 33847407503 scopus 로고    scopus 로고
    • A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function
    • Schwander, M., et al. A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J. Neurosci. 27 (2007), 2163–2175.
    • (2007) J. Neurosci. , vol.27 , pp. 2163-2175
    • Schwander, M.1
  • 71
    • 84946234112 scopus 로고    scopus 로고
    • Hypervulnerability to sound exposure through impaired adaptive proliferation of peroxisomes
    • Delmaghani, S., et al. Hypervulnerability to sound exposure through impaired adaptive proliferation of peroxisomes. Cell 163 (2015), 894–906.
    • (2015) Cell , vol.163 , pp. 894-906
    • Delmaghani, S.1
  • 72
    • 84897059479 scopus 로고    scopus 로고
    • Evolving models for peroxisome biogenesis
    • Hettema, E.H., et al. Evolving models for peroxisome biogenesis. Curr. Opin. Cell Biol. 29 (2014), 25–30.
    • (2014) Curr. Opin. Cell Biol. , vol.29 , pp. 25-30
    • Hettema, E.H.1
  • 73
    • 85009946922 scopus 로고    scopus 로고
    • Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice
    • Harris, S.L., et al. Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice. Neuroscience 344 (2017), 380–393.
    • (2017) Neuroscience , vol.344 , pp. 380-393
    • Harris, S.L.1
  • 74
    • 84927745897 scopus 로고    scopus 로고
    • Pyroptotic cell death defends against intracellular pathogens
    • Jorgensen, I., Miao, E.A., Pyroptotic cell death defends against intracellular pathogens. Immunol. Rev. 265 (2015), 130–142.
    • (2015) Immunol. Rev. , vol.265 , pp. 130-142
    • Jorgensen, I.1    Miao, E.A.2
  • 75
    • 84962821778 scopus 로고    scopus 로고
    • The role of glycine in regulated cell death
    • Weinberg, J.M., et al. The role of glycine in regulated cell death. Cell Mol. Life Sci. 73 (2016), 2285–2308.
    • (2016) Cell Mol. Life Sci. , vol.73 , pp. 2285-2308
    • Weinberg, J.M.1
  • 76
    • 84858266819 scopus 로고    scopus 로고
    • Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia–reperfusion injury: current knowledge
    • Petrat, F., et al. Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia–reperfusion injury: current knowledge. Br. J. Pharmacol. 165 (2012), 2059–2072.
    • (2012) Br. J. Pharmacol. , vol.165 , pp. 2059-2072
    • Petrat, F.1
  • 77
    • 11144267737 scopus 로고    scopus 로고
    • Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein
    • Shaner, N.C., et al. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22 (2004), 1567–1572.
    • (2004) Nat. Biotechnol. , vol.22 , pp. 1567-1572
    • Shaner, N.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.