Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 7, 2017, Pages E1128-E1137

  Chao, Kinlin L ^a   Kulakova, Liudmila ^a   Herzberg, Osnat ^a,b  

^a UNIVERSITY OF MARYLAND   (United States)

^b Bldg 142   (United States)

Author keywords

Complex trait inflammatory disease; Disease risk polymorphism; GSDMB; Lipid binding; X ray crystallography

Indexed keywords

CASPASE 3; CASPASE 6; CASPASE 7; CARDIOLIPIN; CARRIER PROTEIN; CASPASE; GSDMB PROTEIN, HUMAN; IMMOBILIZED PROTEIN; ISOPROTEIN; LIPOSOME; PHOSPHATIDYLINOSITOL; PROTEIN BINDING; RECOMBINANT PROTEIN; TUMOR PROTEIN;

ARTICLE; ASTHMA; CARBOXY TERMINAL SEQUENCE; GASDERMIN B GENE; GENE; GENE STRUCTURE; GENETIC RISK; HUMAN; INFLAMMATORY BOWEL DISEASE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; AMINO ACID SEQUENCE; ARTIFICIAL MEMBRANE; CHEMISTRY; COMPARATIVE STUDY; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ASTHMA; CARDIOLIPINS; CARRIER PROTEINS; CASPASES; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMOBILIZED PROTEINS; INFLAMMATORY BOWEL DISEASES; LIPOSOMES; MEMBRANES, ARTIFICIAL; MODELS, MOLECULAR; NEOPLASM PROTEINS; PHOSPHATIDYLINOSITOLS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85012964576     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1616783114     Document Type: Article

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