DNA methylation profiling of human prefrontal cortex neurons in heroin users shows significant difference between genomic contexts of hyper- and hypomethylation and a younger epigenetic age

Genes

Volumn 8, Issue 6, 2017, Pages 2-15

  Kozlenkov, Alexey ^a,b   Jaffe, Andrew E ^c,d,e   Timashpolsky, Alisa ^a   Apontes, Pasha ^a   Rudchenko, Sergei ^f   Barbu, Mihaela ^f   Byne, William ^a,b   Hurd, Yasmin L ^b   Horvath, Steve ^g,h   Dracheva, Stella ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e Johns Hopkins University   (United States)

^f HOSPITAL FOR SPECIAL SURGERY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain; DNA methylation; Drug addiction; Heroin; Human; Neurons; Suicide

Indexed keywords

4 AMINOBUTYRIC ACID; DIAMORPHINE; DNA; GLUTAMIC ACID;

ADULT; ARTICLE; AXON; COHORT ANALYSIS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENHANCER REGION; EPIGENETIC AGE; EXON; GENE EXPRESSION REGULATION; GENE ONTOLOGY; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; MOLECULAR CLOCK; NERVE CELL; ORBITAL CORTEX; PROMOTER REGION; SYNAPSE;

EID: 85020398478     PISSN: None     EISSN: 20734425     Source Type: Journal    
DOI: 10.3390/genes8060152     Document Type: Article

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