A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions

Journal of Neuroscience

Volumn 34, Issue 33, 2014, Pages 11048-11066

  Xu, Jin ^a   Lu, Zhigang ^a   Xu, Mingming ^a   Pan, Ling ^a   Deng, Yi ^a   Xie, Xiaohu ^c   Liu, Huifen ^c   Ding, Shixiong ^d   Hurd, Yasmin L ^e   Pasternak, Xgavril W ^a   Klein, Robert J ^b,e   Cartegni, Luca ^f   Zhou, Xwenhua ^c   Pan, Ying Xian ^a  

^a Department of Neurology and the Molecular Pharmacology ^*  (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NINGBO UNIVERSITY   (China)

^d Yinzhou No2 Hospital   (China)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f RUTGERS UNIVERSITY   (United States)

Author keywords

Addiction; Heroin; HnRNPH; Opioid receptor; SNP; Splicing

Indexed keywords

CHAPERONE; GENOMIC DNA; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H; MESSENGER RNA; MU OPIATE RECEPTOR; RIBONUCLEOPROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; OPRM1 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DISEASE SEVERITY; DNA CROSS LINKING; EXON SKIPPING; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRANSFECTION; GENOTYPE; GENOTYPING TECHNIQUE; HEROIN DEPENDENCE; HUMAN; MAJOR CLINICAL STUDY; MALE; OPRM1 GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; RNA PROCESSING; RNA SPLICING; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ALLELE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; INTRON; METABOLISM; SEVERITY OF ILLNESS INDEX;

ALLELES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HEROIN DEPENDENCE; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP F-H; HUMANS; INTRONS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID, MU; RNA SPLICING; SEVERITY OF ILLNESS INDEX;

EID: 84905833596     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3986-13.2014     Document Type: Article

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