메뉴 건너뛰기




Volumn 8, Issue 1, 2016, Pages 1-8

Frailty is associated with the epigenetic clock but not with telomere length in a German cohort

Author keywords

CpG methylation; Cross sectional study; Epigenetic age acceleration; Frailty index; General population; Telomere length

Indexed keywords

ADULT; AGE ACCELERATION; AGE DISTRIBUTION; ARTICLE; CELLULAR DISTRIBUTION; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA METHYLATION; EPIGENETICS; FEMALE; FRAIL ELDERLY; GERMANY; HUMAN; HUMAN CELL; LEUKOCYTE; MALE; OBSERVATIONAL STUDY; PHENOTYPE; PRIORITY JOURNAL; TELOMERE HOMEOSTASIS; AGED; AGING; EPIDEMIOLOGY; GENETIC EPIGENESIS; GENETICS; MIDDLE AGED; PREMATURE AGING; STATISTICS AND NUMERICAL DATA; TELOMERE SHORTENING;

EID: 85001610245     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-016-0186-5     Document Type: Article
Times cited : (242)

References (28)
  • 1
    • 84894088246 scopus 로고    scopus 로고
    • Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites
    • COI: 1:CAS:528:DC%2BC2cXitFWiuro%3D, PID: 24163245
    • Florath I, Butterbach K, Müller H, Bewerunge-Hudler M, Brenner H. Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites. Hum Mol Genet. 2014;23:1186.
    • (2014) Hum Mol Genet , vol.23 , pp. 1186
    • Florath, I.1    Butterbach, K.2    Müller, H.3    Bewerunge-Hudler, M.4    Brenner, H.5
  • 2
    • 84886111619 scopus 로고    scopus 로고
    • DNA methylation age of human tissues and cell types
    • PID: 24138928
    • Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14:R115.
    • (2013) Genome Biol , vol.14 , pp. R115
    • Horvath, S.1
  • 3
    • 84900316278 scopus 로고    scopus 로고
    • Frailty prevalence and 10-year survival in community-dwelling older adults: results from the ESTHER cohort study
    • PID: 24671603
    • Saum KU, Dieffenbach AK, Müller H, Holleczek B, Hauer H, Brenner H. Frailty prevalence and 10-year survival in community-dwelling older adults: results from the ESTHER cohort study. Eur J Epidemiol. 2014;29:171–9.
    • (2014) Eur J Epidemiol , vol.29 , pp. 171-179
    • Saum, K.U.1    Dieffenbach, A.K.2    Müller, H.3    Holleczek, B.4    Hauer, H.5    Brenner, H.6
  • 4
    • 84942837378 scopus 로고    scopus 로고
    • Quantitative measures of healthy aging and biological age
    • Kim S, Jazwinski SM. Quantitative measures of healthy aging and biological age. Healthy Aging Res. 2015;4
    • (2015) Healthy Aging Res , pp. 4
    • Kim, S.1    Jazwinski, S.M.2
  • 5
    • 85016035785 scopus 로고    scopus 로고
    • Frailty and the prediction of dependence and mortality in low- and middle-income countries: a 10/66 population-based cohort study
    • Jotheeswaran AT, Bryce R, Prina M, Acosta D, Ferri CP, Guerra M, et al. Frailty and the prediction of dependence and mortality in low- and middle-income countries: a 10/66 population-based cohort study. BMC Med. 2015;13:138.
    • (2015) BMC Med , vol.13 , pp. 138
    • Jotheeswaran, A.T.1    Bryce, R.2    Prina, M.3    Acosta, D.4    Ferri, C.P.5    Guerra, M.6
  • 6
    • 84955374817 scopus 로고    scopus 로고
    • The rate of aging: the rate of deficit accumulation does not change over the adult life span
    • PID: 25972341
    • Mitnitski A, Rockwood K. The rate of aging: the rate of deficit accumulation does not change over the adult life span. Biogerontology. 2016;17:199–204.
    • (2016) Biogerontology , vol.17 , pp. 199-204
    • Mitnitski, A.1    Rockwood, K.2
  • 8
    • 84906237777 scopus 로고    scopus 로고
    • Shorter telomeres in peripheral blood mononuclear cells from older persons with sarcopenia: results from an exploratory study
    • PID: 25221511
    • Marzetti E, Lorenzi M, Antocicco M, Bonassi S, Celi M, Mastropaolo S, et al. Shorter telomeres in peripheral blood mononuclear cells from older persons with sarcopenia: results from an exploratory study. Front Aging Neurosci. 2014;6:233.
    • (2014) Front Aging Neurosci , vol.6 , pp. 233
    • Marzetti, E.1    Lorenzi, M.2    Antocicco, M.3    Bonassi, S.4    Celi, M.5    Mastropaolo, S.6
  • 10
    • 84930738510 scopus 로고    scopus 로고
    • The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
    • PID: 25617346
    • Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, et al. The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936. Int J Epidemiol. 2015;44:1388–96.
    • (2015) Int J Epidemiol , vol.44 , pp. 1388-1396
    • Marioni, R.E.1    Shah, S.2    McRae, A.F.3    Ritchie, S.J.4    Muniz-Terrera, G.5    Harris, S.E.6
  • 11
    • 84920700104 scopus 로고    scopus 로고
    • Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder
    • COI: 1:CAS:528:DC%2BC2cXhtlSru7rO
    • Boks MP, van Mierlo HC, Rutten BPF, Radstake TR, De Witte L, Geuze E, et al. Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder. Psychoneuroendocrinol. 2015;51:506–12.
    • (2015) Psychoneuroendocrinol , vol.51 , pp. 506-512
    • Boks, M.P.1    van Mierlo, H.C.2    Rutten, B.P.F.3    Radstake, T.R.4    De Witte, L.5    Geuze, E.6
  • 12
    • 84907941367 scopus 로고    scopus 로고
    • Frailty and telomere length: cross-sectional analysis in 3537 older adults from the ESTHER cohort
    • COI: 1:CAS:528:DC%2BC2cXhsVyhsLnN, PID: 25150678
    • Saum KU, Dieffenbach AK, Müezzinler A, Müller H, Holleczek B, Stegmaier C, et al. Frailty and telomere length: cross-sectional analysis in 3537 older adults from the ESTHER cohort. Exp Gerontol. 2014;58:250.
    • (2014) Exp Gerontol , vol.58 , pp. 250
    • Saum, K.U.1    Dieffenbach, A.K.2    Müezzinler, A.3    Müller, H.4    Holleczek, B.5    Stegmaier, C.6
  • 14
    • 84904327454 scopus 로고    scopus 로고
    • Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study
    • COI: 1:CAS:528:DC%2BC2cXntlOjur4%3D, PID: 24770842
    • Collerton J, Gautrey HE, van Otterdijk SD, Davies K, Martin-Ruiz C, von Zglinicki T, et al. Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study. Biogerontology. 2014;15:317–28.
    • (2014) Biogerontology , vol.15 , pp. 317-328
    • Collerton, J.1    Gautrey, H.E.2    van Otterdijk, S.D.3    Davies, K.4    Martin-Ruiz, C.5    von Zglinicki, T.6
  • 15
    • 84954379553 scopus 로고    scopus 로고
    • DNA methylation and healthy human aging
    • COI: 1:CAS:528:DC%2BC2MXntFWht7Y%3D, PID: 25913071
    • Jones MJ, Goodman SJ, Kobor MS. DNA methylation and healthy human aging. Aging Cell. 2015;14:924–32.
    • (2015) Aging Cell , vol.14 , pp. 924-932
    • Jones, M.J.1    Goodman, S.J.2    Kobor, M.S.3
  • 16
    • 84895929689 scopus 로고    scopus 로고
    • The association between global DNA methylation and telomere length in a longitudinal study of boilermakers
    • PID: 24616077
    • Wong JY, De Vivo I, Lin X, Grashow R, Cavallari J, Christiani DC. The association between global DNA methylation and telomere length in a longitudinal study of boilermakers. Genet Epidemiol. 2014;38:254–64.
    • (2014) Genet Epidemiol , vol.38 , pp. 254-264
    • Wong, J.Y.1    De Vivo, I.2    Lin, X.3    Grashow, R.4    Cavallari, J.5    Christiani, D.C.6
  • 17
    • 84900848092 scopus 로고    scopus 로고
    • Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci
    • COI: 1:CAS:528:DC%2BC2MXktlOmtbc%3D, PID: 24828261
    • Buxton JL, Suderman M, Pappas JJ, Borghol N, McArdle W, Blakemore AIF, et al. Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci. Sci Rep. 2014;4:4954.
    • (2014) Sci Rep , vol.4 , pp. 4954
    • Buxton, J.L.1    Suderman, M.2    Pappas, J.J.3    Borghol, N.4    McArdle, W.5    Blakemore, A.I.F.6
  • 18
    • 64849092436 scopus 로고    scopus 로고
    • Age-related changes in subtelomeric methylation in the normal Japanese population
    • PID: 19223605
    • Maeda T, Guan JZ, Oyama J, Higuchi Y, Makino N. Age-related changes in subtelomeric methylation in the normal Japanese population. J Gerontol A Biol Sci Med Sci. 2009;64:426–34.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 426-434
    • Maeda, T.1    Guan, J.Z.2    Oyama, J.3    Higuchi, Y.4    Makino, N.5
  • 19
  • 21
    • 84928728856 scopus 로고    scopus 로고
    • Aging and DNA methylation
    • PID: 25637097
    • Jung M, Pfeifer GP. Aging and DNA methylation. BMC Biol. 2015;13:7.
    • (2015) BMC Biol , vol.13 , pp. 7
    • Jung, M.1    Pfeifer, G.P.2
  • 24
    • 84858648623 scopus 로고    scopus 로고
    • Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease
    • PID: 22422451
    • Relton CL, Davey SG. Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol. 2012;41:161–76.
    • (2012) Int J Epidemiol , vol.41 , pp. 161-176
    • Relton, C.L.1    Davey, S.G.2
  • 25
    • 36649011630 scopus 로고    scopus 로고
    • Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach
    • PID: 18043304
    • Raum E, Rothenbacher D, Löw M, Stegmaier C, Ziegler H, Brenner H. Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach. Eur J Cardiovasc Prev Rehabil. 2007;14:809–14.
    • (2007) Eur J Cardiovasc Prev Rehabil , vol.14 , pp. 809-814
    • Raum, E.1    Rothenbacher, D.2    Löw, M.3    Stegmaier, C.4    Ziegler, H.5    Brenner, H.6
  • 26
    • 2342419515 scopus 로고    scopus 로고
    • Telomere measurement by quantitative PCR
    • PID: 12000852
    • Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30:e47.
    • (2002) Nucleic Acids Res , vol.30 , pp. e47
    • Cawthon, R.M.1
  • 28
    • 84900824657 scopus 로고    scopus 로고
    • Reference-free cell mixture adjustments in analysis of DNA methylation data
    • COI: 1:CAS:528:DC%2BC2cXnslOitL4%3D, PID: 24451622
    • Houseman EA, Molitor J, Marsit CJ. Reference-free cell mixture adjustments in analysis of DNA methylation data. Bioinformatics. 2014;30:1431–9.
    • (2014) Bioinformatics , vol.30 , pp. 1431-1439
    • Houseman, E.A.1    Molitor, J.2    Marsit, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.