DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative

Aging

Volumn 7, Issue 9, 2015, Pages 690-700

  Levine, Morgan E ^a,b   Hosgood, H Dean ^c   Chen, Brian ^d   Absher, Devin ^e   Assimes, Themistocles ^f   Horvath, Steve ^a,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biological age; Epigenetic clock; Lung cancer

Indexed keywords

DNA; TUMOR MARKER;

ADVERSE EFFECTS; AGED; AGING; BLOOD; COHORT ANALYSIS; DISEASE PREDISPOSITION; DNA METHYLATION; FEMALE; FOLLOW UP; GENETIC EPIGENESIS; GENETICS; HUMAN; INCIDENCE; LUNG NEOPLASMS; MIDDLE AGED; PATHOLOGY; PREDICTIVE VALUE; RISK ASSESSMENT; SMOKING; SURVIVAL ANALYSIS; WOMEN'S HEALTH;

AGED; AGING; BIOMARKERS, TUMOR; COHORT STUDIES; DISEASE SUSCEPTIBILITY; DNA; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; LUNG NEOPLASMS; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; SMOKING; SURVIVAL ANALYSIS; WOMEN'S HEALTH;

EID: 84943372238     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100809     Document Type: Article

References (38)

1. Howlader N, Noone A, Krapcho M, Garshell J, Neyman N, Altekruse S, Kosary C, Yu M, Ruhl J and Tatalovich Z. SEER Cancer Statistics Review, 1975-2010.[Based on the November 2012 SEER data submission, posted to the SEER web site, April 2013.]. Bethesda, MD: National Cancer Institute. 2013.
2. Group UCSW. United States Cancer Statistics: 1999-2011 incidence and mortality web-based report. Atlanta (GA): Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute. 2014.
3. Bender E. Epidemiology: The dominant malignancy. Nature. 2014; 513:S2-3.
4. Warren GW, Alberg AJ, Kraft AS and Cummings KM. The 2014 Surgeon General's report: "The health consequences of smoking--50 years of progress": a paradigm shift in cancer care. Cancer. 2014; 120:1914-1916.
5. Hecht SS. Lung carcinogenesis by tobacco smoke. Int J Cancer. 2012; 131:2724-2732.
6. National Lung Screening Trial Research T, Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM and Sicks JD. Reduced lung-cancer mortality with low-dose computed tomographic screening. The New England journal of medicine. 2011; 365:395-409.
7. Lopez-Otin C, Blasco MA, Partridge L, Serrano M and Kroemer G. The hallmarks of aging. Cell. 2013; 153:1194-1217.
8. Derhovanessian E, Solana R, Larbi A and Pawelec G. Immunity, ageing and cancer. Immun Ageing. 2008; 5:11.
9. Rodier F and Campisi J. Four faces of cellular senescence. J Cell Biol. 2011; 192:547-556.
10. Horvath S, Zhang Y, Langfelder P, Kahn RS, Boks MP, van Eijk K, van den Berg LH and OphoffRA. Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol. 2012; 13:R97.
11. Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013; 14:R115.
12. Cassidy A, Duffy SW, Myles JP, Liloglou T and Field JK. Lung cancer risk prediction: a tool for early detection. Int J Cancer. 2007; 120:1-6.
13. Yin D and Chen K. The essential mechanisms of aging: Irreparable damage accumulation of biochemical side-reactions. Experimental gerontology. 2005; 40:455-465.
14. Campisi J. Aging, cellular senescence, and cancer. Annu Rev Physiol. 2013; 75:685-705.
15. Akgun KM, Crothers K and Pisani M. Epidemiology and management of common pulmonary diseases in older persons. The journals of gerontology Series A, Biological sciences and medical sciences. 2012; 67:276-291.
16. Longo VD and Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci. 2010; 31:89-98.
17. Chang MY, Boulden J, Katz JB, Wang L, Meyer TJ, Soler AP, Muller AJ and Prendergast GC. Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer. Cancer research. 2007; 67:7605-7612.
18. Anisimov VN, Zhukovskaya NV, Loktionov AS, Vasilyeva IA, Kaminskaya EV and Vakhtin YB. Influence of host age on lung colony forming capacity of injected rat rhabdomyosarcoma cells. Cancer Lett. 1988; 40:77-82.
19. Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, Rotunno M, Mirabello L, Jacobs K, Wheeler W, Yeager M, Bergen AW, Li Q, Consonni D, et al. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet. 2009; 85:679-691.
20. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, et al. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nature genetics. 2008; 40:616-622.
21. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008; 452:633-637.
22. Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, Matakidou A, Qureshi M, Dong Q, Gu X, Chen WV, Spitz MR, Eisen T, Amos CI, et al. Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nature genetics. 2008; 40:1407-1409.
23. Wu C, Hu Z, Yu D, Huang L, Jin G, Liang J, Guo H, Tan W, Zhang M, Qian J, Lu D, Wu T, Lin D, et al. Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Cancer research. 2009; 69:5065-5072.
24. Truong T, Hung RJ, Amos CI, Wu X, Bickeboller H, Rosenberger A, Sauter W, Illig T, Wichmann HE, Risch A, Dienemann H, Kaaks R, Yang P, et al. Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst. 2010; 102:959-971.
25. Marioni RE, Shah S, McRae AF, Chen BH, Colicino E, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, et al. DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol. 2015; 16:25.
26. Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, Gibson J, Redmond P, Cox SR and Pattie A. The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936. Int J Epidemiol. 2015:dyu277.
27. Horvath S, Garagnani P, Bacalini MG, Pirazzini C, Salvioli S, Gentilini D, Di Blasio AM, Giuliani C, Tung S, Vinters HV and Franceschi C. Accelerated epigenetic aging in Down syndrome. Aging cell. 2015; 14:491-495.
28. Horvath S, Mah V, Lu AT, Woo JS, Choi OW, Jasinska AJ, Riancho JA, Tung S, Coles NS, Braun J, Vinters HV and Coles LS. The cerebellum ages slowly according to the epigenetic clock. Aging (Albany NY). 2015; 7:294-306.
29. Walker RF, Liu JS, Peters BA, Ritz BR, Wu T, OphoffRA and Horvath S. Epigenetic age analysis of children who seem to evade aging. Aging (Albany NY). 2015; 7:334-339.
30. Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group. Control Clin Trials. 1998; 19:61-109.
31. Curb JD, McTiernan A, Heckbert SR, Kooperberg C, Stanford J, Nevitt M, Johnson KC, Proulx-Burns L, Pastore L, Criqui M, Daugherty S, Morbidity WHI and Mortality C. Outcomes ascertainment and adjudication methods in the Women's Health Initiative. Annals of epidemiology. 2003; 13:S122-128.
32. Cunningham J. The SEER program code manual: Cancer Statistics Branch, National Cancer Institute, National Institutes of Health. 1994.
33. Friedman J, Hastie T and Tibshirani R. Regularization paths for generalized linear models via coordinate descent. Journal of statistical software. 2010; 33:1.
34. Fagnoni F, Vescovini R, Mazzola M, Bologna G, Nigro E, Lavagetto G, Franceschi C, Passeri M and Sansoni P. Expansion of cytotoxic CD8+ CD28-T cells in healthy ageing people, including centenarians. Immunology. 1996; 88:501.
35. Fagnoni FF, Vescovini R, Passeri G, Bologna G, Pedrazzoni M, Lavagetto G, Casti A, Franceschi C, Passeri M and Sansoni P. Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging. Blood. 2000; 95:2860-2868.
36. Gruver A, Hudson L and Sempowski G. Immunosenescence of ageing. The Journal of pathology. 2007; 211:144-156.
37. Effros RB, Boucher N, Porter V, Zhu X, Spaulding C, Walford RL, Kronenberg M, Cohen D and Schächter F. Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Experimental gerontology. 1994; 29: 601-609.
38. Horvath S and Levine AJ. HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis. 2015.