-
1
-
-
0033614446
-
Chronic myeloid leukemia
-
Sawyers C.L. Chronic myeloid leukemia. N Engl J Med 1999, 340(17):1330-1340.
-
(1999)
N Engl J Med
, vol.340
, Issue.17
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
2
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker B.J., Guilhot F., O'Brien S.G., et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006, 355(23):2408-2417.
-
(2006)
N Engl J Med
, vol.355
, Issue.23
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
-
3
-
-
67049087117
-
Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study
-
Noens L., van Lierde M.A., De Bock R., et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study. Blood 2009, 113(22):5401-5411.
-
(2009)
Blood
, vol.113
, Issue.22
, pp. 5401-5411
-
-
Noens, L.1
van Lierde, M.A.2
De Bock, R.3
-
4
-
-
77952467377
-
Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
-
Marin D., Bazeos A., Mahon F.X., et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 2010, 28(14):2381-2388.
-
(2010)
J Clin Oncol
, vol.28
, Issue.14
, pp. 2381-2388
-
-
Marin, D.1
Bazeos, A.2
Mahon, F.X.3
-
5
-
-
14644425319
-
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
-
Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 2005, 5(3):172-183.
-
(2005)
Nat Rev Cancer
, vol.5
, Issue.3
, pp. 172-183
-
-
Ren, R.1
-
6
-
-
21744462100
-
Dynamics of chronic myeloid leukaemia
-
Michor F., Hughes T.P., Iwasa Y., et al. Dynamics of chronic myeloid leukaemia. Nature 2005, 435(7046):1267-1270.
-
(2005)
Nature
, vol.435
, Issue.7046
, pp. 1267-1270
-
-
Michor, F.1
Hughes, T.P.2
Iwasa, Y.3
-
7
-
-
38149089514
-
Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia-insights from mathematical model analyses
-
Roeder I., Glauche I. Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia-insights from mathematical model analyses. J Mol Med 2008, 86(1):17-27.
-
(2008)
J Mol Med
, vol.86
, Issue.1
, pp. 17-27
-
-
Roeder, I.1
Glauche, I.2
-
8
-
-
58149380742
-
Stem cell concepts renew cancer research
-
Dick J.E. Stem cell concepts renew cancer research. Blood 2008, 112(13):4793-4807.
-
(2008)
Blood
, vol.112
, Issue.13
, pp. 4793-4807
-
-
Dick, J.E.1
-
9
-
-
0000062301
-
Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells
-
Becker A.J., McCulloch E.A., Till J.E. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963, 197:452-454.
-
(1963)
Nature
, vol.197
, pp. 452-454
-
-
Becker, A.J.1
McCulloch, E.A.2
Till, J.E.3
-
10
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
Nowell P.C. The clonal evolution of tumor cell populations. Science 1976, 194(4260):23-28.
-
(1976)
Science
, vol.194
, Issue.4260
, pp. 23-28
-
-
Nowell, P.C.1
-
11
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T., Sirard C., Vormoor J., et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994, 367(6464):645-648.
-
(1994)
Nature
, vol.367
, Issue.6464
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
-
12
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997, 3(7):730-737.
-
(1997)
Nat Med
, vol.3
, Issue.7
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
13
-
-
33750313208
-
Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells
-
Clarke M.F., Dick J.E., Dirks P.B., et al. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006, 66(19):9339-9344.
-
(2006)
Cancer Res
, vol.66
, Issue.19
, pp. 9339-9344
-
-
Clarke, M.F.1
Dick, J.E.2
Dirks, P.B.3
-
14
-
-
58249105984
-
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy
-
Misaghian N., Ligresti G., Steelman L.S., et al. Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Leukemia 2009, 23(1):25-42.
-
(2009)
Leukemia
, vol.23
, Issue.1
, pp. 25-42
-
-
Misaghian, N.1
Ligresti, G.2
Steelman, L.S.3
-
15
-
-
69849104865
-
The leukemic stem cell niche: current concepts and therapeutic opportunities
-
Lane S.W., Scadden D.T., Gilliland D.G. The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood 2009, 114(6):1150-1157.
-
(2009)
Blood
, vol.114
, Issue.6
, pp. 1150-1157
-
-
Lane, S.W.1
Scadden, D.T.2
Gilliland, D.G.3
-
16
-
-
70349547152
-
Identification and targeting of cancer stem cells
-
Schatton T., Frank N.Y., Frank M.H. Identification and targeting of cancer stem cells. Bioessays 2009, 31(10):1038-1049.
-
(2009)
Bioessays
, vol.31
, Issue.10
, pp. 1038-1049
-
-
Schatton, T.1
Frank, N.Y.2
Frank, M.H.3
-
17
-
-
74949090309
-
The therapeutic promise of the cancer stem cell concept
-
Frank N.Y., Schatton T., Frank M.H. The therapeutic promise of the cancer stem cell concept. J Clin Invest 2010, 120(1):41-50.
-
(2010)
J Clin Invest
, vol.120
, Issue.1
, pp. 41-50
-
-
Frank, N.Y.1
Schatton, T.2
Frank, M.H.3
-
18
-
-
38349183668
-
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia
-
Hong D., Gupta R., Ancliff P., et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008, 319(5861):336-339.
-
(2008)
Science
, vol.319
, Issue.5861
, pp. 336-339
-
-
Hong, D.1
Gupta, R.2
Ancliff, P.3
-
19
-
-
57349143739
-
Efficient tumour formation by single human melanoma cells
-
Quintana E., Shackleton M., Sabel M.S., et al. Efficient tumour formation by single human melanoma cells. Nature 2008, 456(7222):593-598.
-
(2008)
Nature
, vol.456
, Issue.7222
, pp. 593-598
-
-
Quintana, E.1
Shackleton, M.2
Sabel, M.S.3
-
20
-
-
69449096005
-
Heterogeneity in cancer: cancer stem cells versus clonal evolution
-
Shackleton M., Quintana E., Fearon E.R., et al. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009, 138(5):822-829.
-
(2009)
Cell
, vol.138
, Issue.5
, pp. 822-829
-
-
Shackleton, M.1
Quintana, E.2
Fearon, E.R.3
-
21
-
-
60149109533
-
Looking ahead in cancer stem cell research
-
Dick J.E. Looking ahead in cancer stem cell research. Nat Biotechnol 2009, 27(1):44-46.
-
(2009)
Nat Biotechnol
, vol.27
, Issue.1
, pp. 44-46
-
-
Dick, J.E.1
-
22
-
-
54249143589
-
Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines
-
Jaksch M., Munera J., Bajpai R., et al. Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines. Cancer Res 2008, 68(19):7882-7886.
-
(2008)
Cancer Res
, vol.68
, Issue.19
, pp. 7882-7886
-
-
Jaksch, M.1
Munera, J.2
Bajpai, R.3
-
23
-
-
34547113747
-
Tumor growth need not be driven by rare cancer stem cells
-
Kelly P.N., Dakic A., Adams J.M., et al. Tumor growth need not be driven by rare cancer stem cells. Science 2007, 317(5836):337.
-
(2007)
Science
, vol.317
, Issue.5836
, pp. 337
-
-
Kelly, P.N.1
Dakic, A.2
Adams, J.M.3
-
24
-
-
37249044166
-
Comment on "Tumor growth need not be driven by rare cancer stem cells"
-
[author reply: 1722]
-
Kennedy J.A., Barabe F., Poeppl A.G., et al. Comment on "Tumor growth need not be driven by rare cancer stem cells" Science 2007, 318(5857):1722. [author reply: 1722].
-
(2007)
Science
, vol.318
, Issue.5857
, pp. 1722
-
-
Kennedy, J.A.1
Barabe, F.2
Poeppl, A.G.3
-
25
-
-
38349165576
-
Identification of cells initiating human melanomas
-
Schatton T., Murphy G.F., Frank N.Y., et al. Identification of cells initiating human melanomas. Nature 2008, 451(7176):345-349.
-
(2008)
Nature
, vol.451
, Issue.7176
, pp. 345-349
-
-
Schatton, T.1
Murphy, G.F.2
Frank, N.Y.3
-
26
-
-
75749090051
-
Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase
-
Cortes J.E., Jones D., O'Brien S., et al. Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase. J Clin Oncol 2010, 28(3):392-397.
-
(2010)
J Clin Oncol
, vol.28
, Issue.3
, pp. 392-397
-
-
Cortes, J.E.1
Jones, D.2
O'Brien, S.3
-
27
-
-
75749129911
-
Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia
-
Cortes J.E., Jones D., O'Brien S., et al. Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia. J Clin Oncol 2010, 28(3):398-404.
-
(2010)
J Clin Oncol
, vol.28
, Issue.3
, pp. 398-404
-
-
Cortes, J.E.1
Jones, D.2
O'Brien, S.3
-
28
-
-
0033568250
-
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia
-
Holyoake T., Jiang X., Eaves C., et al. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood 1999, 94(6):2056-2064.
-
(1999)
Blood
, vol.94
, Issue.6
, pp. 2056-2064
-
-
Holyoake, T.1
Jiang, X.2
Eaves, C.3
-
29
-
-
34247329753
-
Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells
-
Jorgensen H.G., Allan E.K., Jordanides N.E., et al. Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. Blood 2007, 109(9):4016-4019.
-
(2007)
Blood
, vol.109
, Issue.9
, pp. 4016-4019
-
-
Jorgensen, H.G.1
Allan, E.K.2
Jordanides, N.E.3
-
30
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Copland M., Hamilton A., Elrick L.J., et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006, 107(11):4532-4539.
-
(2006)
Blood
, vol.107
, Issue.11
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
-
31
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham S.M., Jorgensen H.G., Allan E., et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002, 99(1):319-325.
-
(2002)
Blood
, vol.99
, Issue.1
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
-
32
-
-
42349116071
-
Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors
-
Konig H., Holtz M., Modi H., et al. Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors. Leukemia 2008, 22(4):748-755.
-
(2008)
Leukemia
, vol.22
, Issue.4
, pp. 748-755
-
-
Konig, H.1
Holtz, M.2
Modi, H.3
-
33
-
-
41349083561
-
Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606
-
Konig H., Holyoake T.L., Bhatia R. Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606. Blood 2008, 111(4):2329-2338.
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 2329-2338
-
-
Konig, H.1
Holyoake, T.L.2
Bhatia, R.3
-
34
-
-
70350114792
-
Persistence of leukemia stem cells in chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib treatment for 5 years
-
Chu S., Lin A., McDonald T., et al. Persistence of leukemia stem cells in chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib treatment for 5 years. Blood 2008, 112(11):79.
-
(2008)
Blood
, vol.112
, Issue.11
, pp. 79
-
-
Chu, S.1
Lin, A.2
McDonald, T.3
-
35
-
-
77949704880
-
Discontinuation of imatinib therapy after achieving a molecular response in chronic myeloid leukemia patients
-
[abstract: 859]
-
Mahon F., Rea F., Guilhot F., et al. Discontinuation of imatinib therapy after achieving a molecular response in chronic myeloid leukemia patients. Blood 2009, 114(22). [abstract: 859].
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Mahon, F.1
Rea, F.2
Guilhot, F.3
-
36
-
-
44849093562
-
Oncogene addiction
-
[discussion: 3080]
-
Weinstein I.B., Joe A. Oncogene addiction. Cancer Res 2008, 68(9):3077-3080. [discussion: 3080].
-
(2008)
Cancer Res
, vol.68
, Issue.9
, pp. 3077-3080
-
-
Weinstein, I.B.1
Joe, A.2
-
37
-
-
48249105193
-
Responses and disease progression in CML-CP patients treated with nilotinib after imatinib failure appear to be affected by the BCR-ABL mutation status and types
-
Hughes T., Saglio G., Martinelli G., et al. Responses and disease progression in CML-CP patients treated with nilotinib after imatinib failure appear to be affected by the BCR-ABL mutation status and types. Blood 2007, 110(11):101a.
-
(2007)
Blood
, vol.110
, Issue.11
, pp. 101
-
-
Hughes, T.1
Saglio, G.2
Martinelli, G.3
-
38
-
-
34247555482
-
Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
-
Jiang X., Zhao Y., Smith C., et al. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 2007, 21(5):926-935.
-
(2007)
Leukemia
, vol.21
, Issue.5
, pp. 926-935
-
-
Jiang, X.1
Zhao, Y.2
Smith, C.3
-
39
-
-
0037443754
-
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
-
Mahon F.X., Belloc F., Lagarde V., et al. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood 2003, 101(6):2368-2373.
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2368-2373
-
-
Mahon, F.X.1
Belloc, F.2
Lagarde, V.3
-
40
-
-
77950959714
-
Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity
-
Engler J.R., Frede A., Saunders V.A., et al. Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity. Leukemia 2010, 24(4):765-770.
-
(2010)
Leukemia
, vol.24
, Issue.4
, pp. 765-770
-
-
Engler, J.R.1
Frede, A.2
Saunders, V.A.3
-
41
-
-
33747155024
-
Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate
-
Jordanides N.E., Jorgensen H.G., Holyoake T.L., et al. Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate. Blood 2006, 108(4):1370-1373.
-
(2006)
Blood
, vol.108
, Issue.4
, pp. 1370-1373
-
-
Jordanides, N.E.1
Jorgensen, H.G.2
Holyoake, T.L.3
-
42
-
-
1942506722
-
Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro
-
Houghton P.J., Germain G.S., Harwood F.C., et al. Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer Res 2004, 64(7):2333-2337.
-
(2004)
Cancer Res
, vol.64
, Issue.7
, pp. 2333-2337
-
-
Houghton, P.J.1
Germain, G.S.2
Harwood, F.C.3
-
43
-
-
7244232706
-
Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
-
Burger H., van Tol H., Boersma A.W., et al. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood 2004, 104(9):2940-2942.
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2940-2942
-
-
Burger, H.1
van Tol, H.2
Boersma, A.W.3
-
44
-
-
67349280901
-
Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib
-
Hatziieremia S., Jordanides N.E., Holyoake T.L., et al. Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib. Exp Hematol 2009, 37(6):692-700.
-
(2009)
Exp Hematol
, vol.37
, Issue.6
, pp. 692-700
-
-
Hatziieremia, S.1
Jordanides, N.E.2
Holyoake, T.L.3
-
45
-
-
37049028176
-
Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity
-
White D.L., Saunders V.A., Dang P., et al. Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood 2007, 110(12):4064-4072.
-
(2007)
Blood
, vol.110
, Issue.12
, pp. 4064-4072
-
-
White, D.L.1
Saunders, V.A.2
Dang, P.3
-
46
-
-
70450255111
-
Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters
-
Davies A., Jordanides N.E., Giannoudis A., et al. Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. Leukemia 2009, 23(11):1999-2006.
-
(2009)
Leukemia
, vol.23
, Issue.11
, pp. 1999-2006
-
-
Davies, A.1
Jordanides, N.E.2
Giannoudis, A.3
-
47
-
-
0032533620
-
Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia
-
Zhang X., Ren R. Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia. Blood 1998, 92(10):3829-3840.
-
(1998)
Blood
, vol.92
, Issue.10
, pp. 3829-3840
-
-
Zhang, X.1
Ren, R.2
-
48
-
-
0032827603
-
Bcr-Abl with an SH3 deletion retains the ability To induce a myeloproliferative disease in mice, yet c-Abl activated by an SH3 deletion induces only lymphoid malignancy
-
Gross A.W., Zhang X., Ren R. Bcr-Abl with an SH3 deletion retains the ability To induce a myeloproliferative disease in mice, yet c-Abl activated by an SH3 deletion induces only lymphoid malignancy. Mol Cell Biol 1999, 19(10):6918-6928.
-
(1999)
Mol Cell Biol
, vol.19
, Issue.10
, pp. 6918-6928
-
-
Gross, A.W.1
Zhang, X.2
Ren, R.3
-
49
-
-
77949327323
-
A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice
-
Johnson K.J., Griswold I.J., O'Hare T., et al. A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice. PLoS One 2009, 4(10):e7439.
-
(2009)
PLoS One
, vol.4
, Issue.10
, pp. 7439
-
-
Johnson, K.J.1
Griswold, I.J.2
O'Hare, T.3
-
50
-
-
19944385935
-
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
-
Huntly B.J., Shigematsu H., Deguchi K., et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 2004, 6(6):587-596.
-
(2004)
Cancer Cell
, vol.6
, Issue.6
, pp. 587-596
-
-
Huntly, B.J.1
Shigematsu, H.2
Deguchi, K.3
-
51
-
-
77951446379
-
BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells
-
Schemionek M., Elling C., Steidl U., et al. BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells. Blood 2010, 115(16):3185-3195.
-
(2010)
Blood
, vol.115
, Issue.16
, pp. 3185-3195
-
-
Schemionek, M.1
Elling, C.2
Steidl, U.3
-
52
-
-
33746388176
-
"Oncogenic shock": explaining oncogene addiction through differential signal attenuation
-
Sharma S.V., Fischbach M.A., Haber D.A., et al. "Oncogenic shock": explaining oncogene addiction through differential signal attenuation. Clin Cancer Res 2006, 12(14 Pt 2):4392s-4395s.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.14 PART 2
, pp. 4392-4395
-
-
Sharma, S.V.1
Fischbach, M.A.2
Haber, D.A.3
-
53
-
-
33750627972
-
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes
-
Sharma S.V., Gajowniczek P., Way I.P., et al. A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell 2006, 10(5):425-435.
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 425-435
-
-
Sharma, S.V.1
Gajowniczek, P.2
Way, I.P.3
-
54
-
-
33750937577
-
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
-
Hu Y., Swerdlow S., Duffy T.M., et al. Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A 2006, 103(45):16870-16875.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.45
, pp. 16870-16875
-
-
Hu, Y.1
Swerdlow, S.2
Duffy, T.M.3
-
55
-
-
9144234689
-
Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia
-
Donato N.J., Wu J.Y., Stapley J., et al. Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia. Cancer Res 2004, 64(2):672-677.
-
(2004)
Cancer Res
, vol.64
, Issue.2
, pp. 672-677
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
-
56
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao C., Chen A., Jamieson C.H., et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009, 458(7239):776-779.
-
(2009)
Nature
, vol.458
, Issue.7239
, pp. 776-779
-
-
Zhao, C.1
Chen, A.2
Jamieson, C.H.3
-
57
-
-
50649118068
-
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
-
Dierks C., Beigi R., Guo G.R., et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008, 14(3):238-249.
-
(2008)
Cancer Cell
, vol.14
, Issue.3
, pp. 238-249
-
-
Dierks, C.1
Beigi, R.2
Guo, G.R.3
-
58
-
-
79953907017
-
Combination of the hedgehog pathway inhibitor LDE225 and nilotinib eliminates chronic myeloid leukemia stem and progenitor cells
-
[abstract: 1428]
-
Irvine D., Zhang B., Allan E., et al. Combination of the hedgehog pathway inhibitor LDE225 and nilotinib eliminates chronic myeloid leukemia stem and progenitor cells. Blood 2009, 114(22). [abstract: 1428].
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Irvine, D.1
Zhang, B.2
Allan, E.3
-
59
-
-
43049144313
-
Wnt signaling and stem cell control
-
Nusse R. Wnt signaling and stem cell control. Cell Res 2008, 18(5):523-527.
-
(2008)
Cell Res
, vol.18
, Issue.5
, pp. 523-527
-
-
Nusse, R.1
-
60
-
-
58249120738
-
Beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia
-
Hu Y., Chen Y., Douglas L., et al. beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia. Leukemia 2009, 23(1):109-116.
-
(2009)
Leukemia
, vol.23
, Issue.1
, pp. 109-116
-
-
Hu, Y.1
Chen, Y.2
Douglas, L.3
-
61
-
-
79953846892
-
Wnt-pathway directed compound targets blast crisis and chronic phase CML leukemia stem progenitors
-
[abstract: 2168]
-
Peterson L., Turbiak A., Giannola D., et al. Wnt-pathway directed compound targets blast crisis and chronic phase CML leukemia stem progenitors. Blood 2009, 114(22). [abstract: 2168].
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Peterson, L.1
Turbiak, A.2
Giannola, D.3
-
62
-
-
27644569730
-
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
-
Neviani P., Santhanam R., Trotta R., et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 2005, 8(5):355-368.
-
(2005)
Cancer Cell
, vol.8
, Issue.5
, pp. 355-368
-
-
Neviani, P.1
Santhanam, R.2
Trotta, R.3
-
63
-
-
76749127647
-
Activation of PP2A by FTY720 inhibits survival and self-renewal of the Ph(+) chronic myelogenous leukemia (CML) CD34+/CD38- stem cell through the simultaneous suppression of BCR/ABL and BCR/ABL- independent signals
-
[abstract: 189]
-
Neviani P., Santhanam R., Ma Y., et al. Activation of PP2A by FTY720 inhibits survival and self-renewal of the Ph(+) chronic myelogenous leukemia (CML) CD34+/CD38- stem cell through the simultaneous suppression of BCR/ABL and BCR/ABL- independent signals. Blood 2008, 112(11). [abstract: 189].
-
(2008)
Blood
, vol.112
, Issue.11
-
-
Neviani, P.1
Santhanam, R.2
Ma, Y.3
-
64
-
-
76249087423
-
TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
-
Naka K., Hoshii T., Muraguchi T., et al. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 2010, 463(7281):676-680.
-
(2010)
Nature
, vol.463
, Issue.7281
, pp. 676-680
-
-
Naka, K.1
Hoshii, T.2
Muraguchi, T.3
-
65
-
-
80755185527
-
Investigation of the role of FOXO in TKI-induced G1 arrest as potential targets in CML stem/progenitor cell eradication
-
Abstract presented at ESH-EHA Scientific Workshop Leukemic and Cancer Stem Cells. Mandelieu (France), April 3-5
-
Pellicano F, Huntly BJ, Holyoake TL. Investigation of the role of FOXO in TKI-induced G1 arrest as potential targets in CML stem/progenitor cell eradication. Abstract presented at ESH-EHA Scientific Workshop Leukemic and Cancer Stem Cells. Mandelieu (France), April 3-5, 2009.
-
(2009)
-
-
Pellicano, F.1
Huntly, B.J.2
Holyoake, T.L.3
-
66
-
-
31544451592
-
Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate
-
Jorgensen H.G., Copland M., Allan E.K., et al. Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clin Cancer Res 2006, 12(2):626-633.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.2
, pp. 626-633
-
-
Jorgensen, H.G.1
Copland, M.2
Allan, E.K.3
-
67
-
-
33847049119
-
Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment
-
Holtz M., Forman S.J., Bhatia R. Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment. Cancer Res 2007, 67(3):1113-1120.
-
(2007)
Cancer Res
, vol.67
, Issue.3
, pp. 1113-1120
-
-
Holtz, M.1
Forman, S.J.2
Bhatia, R.3
-
68
-
-
67349105601
-
A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response
-
Drummond M.W., Heaney N., Kaeda J., et al. A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response. Leukemia 2009, 23(6):1199-1201.
-
(2009)
Leukemia
, vol.23
, Issue.6
, pp. 1199-1201
-
-
Drummond, M.W.1
Heaney, N.2
Kaeda, J.3
-
69
-
-
0037169341
-
The role of PML in tumor suppression
-
Salomoni P., Pandolfi P.P. The role of PML in tumor suppression. Cell 2002, 108(2):165-170.
-
(2002)
Cell
, vol.108
, Issue.2
, pp. 165-170
-
-
Salomoni, P.1
Pandolfi, P.P.2
-
70
-
-
44349166602
-
PML targeting eradicates quiescent leukaemia-initiating cells
-
Ito K., Bernardi R., Morotti A., et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008, 453(7198):1072-1078.
-
(2008)
Nature
, vol.453
, Issue.7198
, pp. 1072-1078
-
-
Ito, K.1
Bernardi, R.2
Morotti, A.3
-
71
-
-
30744446226
-
Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy
-
Borthakur G., Kantarjian H., Daley G., et al. Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy. Cancer 2006, 106(2):346-352.
-
(2006)
Cancer
, vol.106
, Issue.2
, pp. 346-352
-
-
Borthakur, G.1
Kantarjian, H.2
Daley, G.3
-
72
-
-
21744457612
-
Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro
-
Jorgensen H.G., Allan E.K., Graham S.M., et al. Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro. Leukemia 2005, 19(7):1184-1191.
-
(2005)
Leukemia
, vol.19
, Issue.7
, pp. 1184-1191
-
-
Jorgensen, H.G.1
Allan, E.K.2
Graham, S.M.3
-
73
-
-
58149261815
-
The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation
-
Copland D.A., Wertheim M.S., Armitage W.J., et al. The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation. Invest Ophthalmol Vis Sci 2008, 49(12):5458-5465.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, Issue.12
, pp. 5458-5465
-
-
Copland, D.A.1
Wertheim, M.S.2
Armitage, W.J.3
-
74
-
-
77950536837
-
BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta
-
Pellicano F., Copland M., Jorgensen H.G., et al. BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta. Blood 2009, 114(19):4186-4196.
-
(2009)
Blood
, vol.114
, Issue.19
, pp. 4186-4196
-
-
Pellicano, F.1
Copland, M.2
Jorgensen, H.G.3
-
75
-
-
0033607274
-
Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia
-
Jiang X., Lopez A., Holyoake T., et al. Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proc Natl Acad Sci U S A 1999, 96(22):12804-12809.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.22
, pp. 12804-12809
-
-
Jiang, X.1
Lopez, A.2
Holyoake, T.3
-
76
-
-
77950949255
-
Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors
-
Hiwase D.K., White D.L., Powell J.A., et al. Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors. Leukemia 2010, 24(4):771-778.
-
(2010)
Leukemia
, vol.24
, Issue.4
, pp. 771-778
-
-
Hiwase, D.K.1
White, D.L.2
Powell, J.A.3
-
77
-
-
33847407174
-
Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation
-
Wang Y., Cai D., Brendel C., et al. Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation. Blood 2007, 109(5):2147-2155.
-
(2007)
Blood
, vol.109
, Issue.5
, pp. 2147-2155
-
-
Wang, Y.1
Cai, D.2
Brendel, C.3
-
78
-
-
79953872404
-
Jak2 phosphorylates Tyr 177 of Bcr-Abl activating the Ras and PI-3 kinase pathways and maintains functional levels of Bcr-Abl in chronic myelogenous leukemia
-
[abstract: 39]
-
Samanta A., Chakraborty S., Sun X., et al. Jak2 phosphorylates Tyr 177 of Bcr-Abl activating the Ras and PI-3 kinase pathways and maintains functional levels of Bcr-Abl in chronic myelogenous leukemia. Blood 2009, 114(22). [abstract: 39].
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Samanta, A.1
Chakraborty, S.2
Sun, X.3
-
79
-
-
77952853306
-
Histone deacetylases and epigenetic therapies of hematological malignancies
-
Mercurio C., Minucci S., Pelicci P.G. Histone deacetylases and epigenetic therapies of hematological malignancies. Pharm Res 2010, 62(1):18-34.
-
(2010)
Pharm Res
, vol.62
, Issue.1
, pp. 18-34
-
-
Mercurio, C.1
Minucci, S.2
Pelicci, P.G.3
-
80
-
-
78651461961
-
Effective targeting of quiescent CML stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
-
[abstract: 190]
-
Zhang B., Campbell Strauss A., Chu S., et al. Effective targeting of quiescent CML stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Blood 2009, 114(22). [abstract: 190].
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Zhang, B.1
Campbell Strauss, A.2
Chu, S.3
-
81
-
-
78651333339
-
A phase I study of the HDAC inhibitor LBH589 in combination with imatinib for patients with CML in cytogenetic remission with residual disease detectable by Q-PCR
-
[abstract: 2194]
-
Bhatia R., Snyder D., Lin A., et al. A phase I study of the HDAC inhibitor LBH589 in combination with imatinib for patients with CML in cytogenetic remission with residual disease detectable by Q-PCR. Blood 2009, 114(22). [abstract: 2194].
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Bhatia, R.1
Snyder, D.2
Lin, A.3
-
82
-
-
77950432694
-
Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells
-
Heaney N.B., Pellicano F., Zhang B., et al. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 2010, 115(11):2241-2250.
-
(2010)
Blood
, vol.115
, Issue.11
, pp. 2241-2250
-
-
Heaney, N.B.1
Pellicano, F.2
Zhang, B.3
-
83
-
-
35448981935
-
Autophagy: from phenomenology to molecular understanding in less than a decade
-
Klionsky D.J. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007, 8(11):931-937.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.11
, pp. 931-937
-
-
Klionsky, D.J.1
-
84
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
Lum J.J., Bauer D.E., Kong M., et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005, 120(2):237-248.
-
(2005)
Cell
, vol.120
, Issue.2
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
-
85
-
-
66449122303
-
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
-
Bellodi C., Lidonnici M.R., Hamilton A., et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009, 119(5):1109-1123.
-
(2009)
J Clin Invest
, vol.119
, Issue.5
, pp. 1109-1123
-
-
Bellodi, C.1
Lidonnici, M.R.2
Hamilton, A.3
-
86
-
-
0029100438
-
Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients
-
Kolb H.J., Schattenberg A., Goldman J.M., et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 1995, 86(5):2041-2050.
-
(1995)
Blood
, vol.86
, Issue.5
, pp. 2041-2050
-
-
Kolb, H.J.1
Schattenberg, A.2
Goldman, J.M.3
-
87
-
-
0025678601
-
Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients
-
Kolb H.J., Mittermuller J., Clemm C., et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 1990, 76(12):2462-2465.
-
(1990)
Blood
, vol.76
, Issue.12
, pp. 2462-2465
-
-
Kolb, H.J.1
Mittermuller, J.2
Clemm, C.3
-
88
-
-
35449008469
-
Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study
-
Rojas J.M., Knight K., Wang L., et al. Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study. Leukemia 2007, 21(11):2287-2295.
-
(2007)
Leukemia
, vol.21
, Issue.11
, pp. 2287-2295
-
-
Rojas, J.M.1
Knight, K.2
Wang, L.3
-
89
-
-
69249097885
-
Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: a phase 2 trial
-
Jain N., Reuben J.M., Kantarjian H., et al. Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: a phase 2 trial. Cancer 2009, 115(17):3924-3934.
-
(2009)
Cancer
, vol.115
, Issue.17
, pp. 3924-3934
-
-
Jain, N.1
Reuben, J.M.2
Kantarjian, H.3
-
90
-
-
75149121612
-
K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate
-
Smith B.D., Kasamon Y.L., Kowalski J., et al. K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate. Clin Cancer Res 2010, 16(1):338-347.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.1
, pp. 338-347
-
-
Smith, B.D.1
Kasamon, Y.L.2
Kowalski, J.3
-
91
-
-
49449115889
-
A pilot vaccination trial of synthetic analog peptides derived from the BCR-ABL breakpoints in CML patients with minimal disease
-
Maslak P.G., Dao T., Gomez M., et al. A pilot vaccination trial of synthetic analog peptides derived from the BCR-ABL breakpoints in CML patients with minimal disease. Leukemia 2008, 22(8):1613-1616.
-
(2008)
Leukemia
, vol.22
, Issue.8
, pp. 1613-1616
-
-
Maslak, P.G.1
Dao, T.2
Gomez, M.3
-
92
-
-
20444448873
-
Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia
-
Li Z., Qiao Y., Liu B., et al. Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia. Clin Cancer Res 2005, 11(12):4460-4468.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.12
, pp. 4460-4468
-
-
Li, Z.1
Qiao, Y.2
Liu, B.3
-
93
-
-
0037441629
-
Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis
-
Kantarjian H.M., O'Brien S., Cortes J.E., et al. Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis. Cancer 2003, 97(4):1033-1041.
-
(2003)
Cancer
, vol.97
, Issue.4
, pp. 1033-1041
-
-
Kantarjian, H.M.1
O'Brien, S.2
Cortes, J.E.3
-
94
-
-
0033826799
-
Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
-
Molldrem J.J., Lee P.P., Wang C., et al. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat Med 2000, 6(9):1018-1023.
-
(2000)
Nat Med
, vol.6
, Issue.9
, pp. 1018-1023
-
-
Molldrem, J.J.1
Lee, P.P.2
Wang, C.3
-
95
-
-
77950496740
-
Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia
-
Burchert A., Muller M.C., Kostrewa P., et al. Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia. J Clin Oncol 2010, 28(8):1429-1435.
-
(2010)
J Clin Oncol
, vol.28
, Issue.8
, pp. 1429-1435
-
-
Burchert, A.1
Muller, M.C.2
Kostrewa, P.3
|