메뉴 건너뛰기




Volumn 25, Issue 5, 2011, Pages 951-966

Hurdles Toward a Cure for CML: The CML Stem Cell

Author keywords

Chronic myeloid leukemia; Cure; Stem cell; Targeted therapy

Indexed keywords

3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; BORTEZOMIB; ERISMODEGIB; FINGOLIMOD; HYDROXYCHLOROQUINE; IMATINIB; LONAFARNIB; LY 364947; PANOBINOSTAT; UNCLASSIFIED DRUG;

EID: 80755125628     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2011.09.001     Document Type: Review
Times cited : (22)

References (95)
  • 1
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers C.L. Chronic myeloid leukemia. N Engl J Med 1999, 340(17):1330-1340.
    • (1999) N Engl J Med , vol.340 , Issue.17 , pp. 1330-1340
    • Sawyers, C.L.1
  • 2
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker B.J., Guilhot F., O'Brien S.G., et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006, 355(23):2408-2417.
    • (2006) N Engl J Med , vol.355 , Issue.23 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 3
    • 67049087117 scopus 로고    scopus 로고
    • Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study
    • Noens L., van Lierde M.A., De Bock R., et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study. Blood 2009, 113(22):5401-5411.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5401-5411
    • Noens, L.1    van Lierde, M.A.2    De Bock, R.3
  • 4
    • 77952467377 scopus 로고    scopus 로고
    • Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
    • Marin D., Bazeos A., Mahon F.X., et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 2010, 28(14):2381-2388.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2381-2388
    • Marin, D.1    Bazeos, A.2    Mahon, F.X.3
  • 5
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 2005, 5(3):172-183.
    • (2005) Nat Rev Cancer , vol.5 , Issue.3 , pp. 172-183
    • Ren, R.1
  • 6
    • 21744462100 scopus 로고    scopus 로고
    • Dynamics of chronic myeloid leukaemia
    • Michor F., Hughes T.P., Iwasa Y., et al. Dynamics of chronic myeloid leukaemia. Nature 2005, 435(7046):1267-1270.
    • (2005) Nature , vol.435 , Issue.7046 , pp. 1267-1270
    • Michor, F.1    Hughes, T.P.2    Iwasa, Y.3
  • 7
    • 38149089514 scopus 로고    scopus 로고
    • Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia-insights from mathematical model analyses
    • Roeder I., Glauche I. Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia-insights from mathematical model analyses. J Mol Med 2008, 86(1):17-27.
    • (2008) J Mol Med , vol.86 , Issue.1 , pp. 17-27
    • Roeder, I.1    Glauche, I.2
  • 8
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick J.E. Stem cell concepts renew cancer research. Blood 2008, 112(13):4793-4807.
    • (2008) Blood , vol.112 , Issue.13 , pp. 4793-4807
    • Dick, J.E.1
  • 9
    • 0000062301 scopus 로고
    • Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells
    • Becker A.J., McCulloch E.A., Till J.E. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963, 197:452-454.
    • (1963) Nature , vol.197 , pp. 452-454
    • Becker, A.J.1    McCulloch, E.A.2    Till, J.E.3
  • 10
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell P.C. The clonal evolution of tumor cell populations. Science 1976, 194(4260):23-28.
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 11
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T., Sirard C., Vormoor J., et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994, 367(6464):645-648.
    • (1994) Nature , vol.367 , Issue.6464 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 12
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997, 3(7):730-737.
    • (1997) Nat Med , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 13
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke M.F., Dick J.E., Dirks P.B., et al. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006, 66(19):9339-9344.
    • (2006) Cancer Res , vol.66 , Issue.19 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 14
    • 58249105984 scopus 로고    scopus 로고
    • Targeting the leukemic stem cell: the Holy Grail of leukemia therapy
    • Misaghian N., Ligresti G., Steelman L.S., et al. Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Leukemia 2009, 23(1):25-42.
    • (2009) Leukemia , vol.23 , Issue.1 , pp. 25-42
    • Misaghian, N.1    Ligresti, G.2    Steelman, L.S.3
  • 15
    • 69849104865 scopus 로고    scopus 로고
    • The leukemic stem cell niche: current concepts and therapeutic opportunities
    • Lane S.W., Scadden D.T., Gilliland D.G. The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood 2009, 114(6):1150-1157.
    • (2009) Blood , vol.114 , Issue.6 , pp. 1150-1157
    • Lane, S.W.1    Scadden, D.T.2    Gilliland, D.G.3
  • 16
    • 70349547152 scopus 로고    scopus 로고
    • Identification and targeting of cancer stem cells
    • Schatton T., Frank N.Y., Frank M.H. Identification and targeting of cancer stem cells. Bioessays 2009, 31(10):1038-1049.
    • (2009) Bioessays , vol.31 , Issue.10 , pp. 1038-1049
    • Schatton, T.1    Frank, N.Y.2    Frank, M.H.3
  • 17
    • 74949090309 scopus 로고    scopus 로고
    • The therapeutic promise of the cancer stem cell concept
    • Frank N.Y., Schatton T., Frank M.H. The therapeutic promise of the cancer stem cell concept. J Clin Invest 2010, 120(1):41-50.
    • (2010) J Clin Invest , vol.120 , Issue.1 , pp. 41-50
    • Frank, N.Y.1    Schatton, T.2    Frank, M.H.3
  • 18
    • 38349183668 scopus 로고    scopus 로고
    • Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia
    • Hong D., Gupta R., Ancliff P., et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008, 319(5861):336-339.
    • (2008) Science , vol.319 , Issue.5861 , pp. 336-339
    • Hong, D.1    Gupta, R.2    Ancliff, P.3
  • 19
    • 57349143739 scopus 로고    scopus 로고
    • Efficient tumour formation by single human melanoma cells
    • Quintana E., Shackleton M., Sabel M.S., et al. Efficient tumour formation by single human melanoma cells. Nature 2008, 456(7222):593-598.
    • (2008) Nature , vol.456 , Issue.7222 , pp. 593-598
    • Quintana, E.1    Shackleton, M.2    Sabel, M.S.3
  • 20
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: cancer stem cells versus clonal evolution
    • Shackleton M., Quintana E., Fearon E.R., et al. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009, 138(5):822-829.
    • (2009) Cell , vol.138 , Issue.5 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3
  • 21
    • 60149109533 scopus 로고    scopus 로고
    • Looking ahead in cancer stem cell research
    • Dick J.E. Looking ahead in cancer stem cell research. Nat Biotechnol 2009, 27(1):44-46.
    • (2009) Nat Biotechnol , vol.27 , Issue.1 , pp. 44-46
    • Dick, J.E.1
  • 22
    • 54249143589 scopus 로고    scopus 로고
    • Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines
    • Jaksch M., Munera J., Bajpai R., et al. Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines. Cancer Res 2008, 68(19):7882-7886.
    • (2008) Cancer Res , vol.68 , Issue.19 , pp. 7882-7886
    • Jaksch, M.1    Munera, J.2    Bajpai, R.3
  • 23
    • 34547113747 scopus 로고    scopus 로고
    • Tumor growth need not be driven by rare cancer stem cells
    • Kelly P.N., Dakic A., Adams J.M., et al. Tumor growth need not be driven by rare cancer stem cells. Science 2007, 317(5836):337.
    • (2007) Science , vol.317 , Issue.5836 , pp. 337
    • Kelly, P.N.1    Dakic, A.2    Adams, J.M.3
  • 24
    • 37249044166 scopus 로고    scopus 로고
    • Comment on "Tumor growth need not be driven by rare cancer stem cells"
    • [author reply: 1722]
    • Kennedy J.A., Barabe F., Poeppl A.G., et al. Comment on "Tumor growth need not be driven by rare cancer stem cells" Science 2007, 318(5857):1722. [author reply: 1722].
    • (2007) Science , vol.318 , Issue.5857 , pp. 1722
    • Kennedy, J.A.1    Barabe, F.2    Poeppl, A.G.3
  • 25
    • 38349165576 scopus 로고    scopus 로고
    • Identification of cells initiating human melanomas
    • Schatton T., Murphy G.F., Frank N.Y., et al. Identification of cells initiating human melanomas. Nature 2008, 451(7176):345-349.
    • (2008) Nature , vol.451 , Issue.7176 , pp. 345-349
    • Schatton, T.1    Murphy, G.F.2    Frank, N.Y.3
  • 26
    • 75749090051 scopus 로고    scopus 로고
    • Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase
    • Cortes J.E., Jones D., O'Brien S., et al. Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase. J Clin Oncol 2010, 28(3):392-397.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 392-397
    • Cortes, J.E.1    Jones, D.2    O'Brien, S.3
  • 27
    • 75749129911 scopus 로고    scopus 로고
    • Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia
    • Cortes J.E., Jones D., O'Brien S., et al. Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia. J Clin Oncol 2010, 28(3):398-404.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 398-404
    • Cortes, J.E.1    Jones, D.2    O'Brien, S.3
  • 28
    • 0033568250 scopus 로고    scopus 로고
    • Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia
    • Holyoake T., Jiang X., Eaves C., et al. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood 1999, 94(6):2056-2064.
    • (1999) Blood , vol.94 , Issue.6 , pp. 2056-2064
    • Holyoake, T.1    Jiang, X.2    Eaves, C.3
  • 29
    • 34247329753 scopus 로고    scopus 로고
    • Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells
    • Jorgensen H.G., Allan E.K., Jordanides N.E., et al. Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. Blood 2007, 109(9):4016-4019.
    • (2007) Blood , vol.109 , Issue.9 , pp. 4016-4019
    • Jorgensen, H.G.1    Allan, E.K.2    Jordanides, N.E.3
  • 30
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • Copland M., Hamilton A., Elrick L.J., et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006, 107(11):4532-4539.
    • (2006) Blood , vol.107 , Issue.11 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3
  • 31
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham S.M., Jorgensen H.G., Allan E., et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002, 99(1):319-325.
    • (2002) Blood , vol.99 , Issue.1 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3
  • 32
    • 42349116071 scopus 로고    scopus 로고
    • Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors
    • Konig H., Holtz M., Modi H., et al. Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors. Leukemia 2008, 22(4):748-755.
    • (2008) Leukemia , vol.22 , Issue.4 , pp. 748-755
    • Konig, H.1    Holtz, M.2    Modi, H.3
  • 33
    • 41349083561 scopus 로고    scopus 로고
    • Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606
    • Konig H., Holyoake T.L., Bhatia R. Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606. Blood 2008, 111(4):2329-2338.
    • (2008) Blood , vol.111 , Issue.4 , pp. 2329-2338
    • Konig, H.1    Holyoake, T.L.2    Bhatia, R.3
  • 34
    • 70350114792 scopus 로고    scopus 로고
    • Persistence of leukemia stem cells in chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib treatment for 5 years
    • Chu S., Lin A., McDonald T., et al. Persistence of leukemia stem cells in chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib treatment for 5 years. Blood 2008, 112(11):79.
    • (2008) Blood , vol.112 , Issue.11 , pp. 79
    • Chu, S.1    Lin, A.2    McDonald, T.3
  • 35
    • 77949704880 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response in chronic myeloid leukemia patients
    • [abstract: 859]
    • Mahon F., Rea F., Guilhot F., et al. Discontinuation of imatinib therapy after achieving a molecular response in chronic myeloid leukemia patients. Blood 2009, 114(22). [abstract: 859].
    • (2009) Blood , vol.114 , Issue.22
    • Mahon, F.1    Rea, F.2    Guilhot, F.3
  • 36
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • [discussion: 3080]
    • Weinstein I.B., Joe A. Oncogene addiction. Cancer Res 2008, 68(9):3077-3080. [discussion: 3080].
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 37
    • 48249105193 scopus 로고    scopus 로고
    • Responses and disease progression in CML-CP patients treated with nilotinib after imatinib failure appear to be affected by the BCR-ABL mutation status and types
    • Hughes T., Saglio G., Martinelli G., et al. Responses and disease progression in CML-CP patients treated with nilotinib after imatinib failure appear to be affected by the BCR-ABL mutation status and types. Blood 2007, 110(11):101a.
    • (2007) Blood , vol.110 , Issue.11 , pp. 101
    • Hughes, T.1    Saglio, G.2    Martinelli, G.3
  • 38
    • 34247555482 scopus 로고    scopus 로고
    • Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
    • Jiang X., Zhao Y., Smith C., et al. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 2007, 21(5):926-935.
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 926-935
    • Jiang, X.1    Zhao, Y.2    Smith, C.3
  • 39
    • 0037443754 scopus 로고    scopus 로고
    • MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
    • Mahon F.X., Belloc F., Lagarde V., et al. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood 2003, 101(6):2368-2373.
    • (2003) Blood , vol.101 , Issue.6 , pp. 2368-2373
    • Mahon, F.X.1    Belloc, F.2    Lagarde, V.3
  • 40
    • 77950959714 scopus 로고    scopus 로고
    • Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity
    • Engler J.R., Frede A., Saunders V.A., et al. Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity. Leukemia 2010, 24(4):765-770.
    • (2010) Leukemia , vol.24 , Issue.4 , pp. 765-770
    • Engler, J.R.1    Frede, A.2    Saunders, V.A.3
  • 41
    • 33747155024 scopus 로고    scopus 로고
    • Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate
    • Jordanides N.E., Jorgensen H.G., Holyoake T.L., et al. Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate. Blood 2006, 108(4):1370-1373.
    • (2006) Blood , vol.108 , Issue.4 , pp. 1370-1373
    • Jordanides, N.E.1    Jorgensen, H.G.2    Holyoake, T.L.3
  • 42
    • 1942506722 scopus 로고    scopus 로고
    • Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro
    • Houghton P.J., Germain G.S., Harwood F.C., et al. Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer Res 2004, 64(7):2333-2337.
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2333-2337
    • Houghton, P.J.1    Germain, G.S.2    Harwood, F.C.3
  • 43
    • 7244232706 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
    • Burger H., van Tol H., Boersma A.W., et al. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood 2004, 104(9):2940-2942.
    • (2004) Blood , vol.104 , Issue.9 , pp. 2940-2942
    • Burger, H.1    van Tol, H.2    Boersma, A.W.3
  • 44
    • 67349280901 scopus 로고    scopus 로고
    • Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib
    • Hatziieremia S., Jordanides N.E., Holyoake T.L., et al. Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib. Exp Hematol 2009, 37(6):692-700.
    • (2009) Exp Hematol , vol.37 , Issue.6 , pp. 692-700
    • Hatziieremia, S.1    Jordanides, N.E.2    Holyoake, T.L.3
  • 45
    • 37049028176 scopus 로고    scopus 로고
    • Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity
    • White D.L., Saunders V.A., Dang P., et al. Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood 2007, 110(12):4064-4072.
    • (2007) Blood , vol.110 , Issue.12 , pp. 4064-4072
    • White, D.L.1    Saunders, V.A.2    Dang, P.3
  • 46
    • 70450255111 scopus 로고    scopus 로고
    • Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters
    • Davies A., Jordanides N.E., Giannoudis A., et al. Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. Leukemia 2009, 23(11):1999-2006.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 1999-2006
    • Davies, A.1    Jordanides, N.E.2    Giannoudis, A.3
  • 47
    • 0032533620 scopus 로고    scopus 로고
    • Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia
    • Zhang X., Ren R. Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia. Blood 1998, 92(10):3829-3840.
    • (1998) Blood , vol.92 , Issue.10 , pp. 3829-3840
    • Zhang, X.1    Ren, R.2
  • 48
    • 0032827603 scopus 로고    scopus 로고
    • Bcr-Abl with an SH3 deletion retains the ability To induce a myeloproliferative disease in mice, yet c-Abl activated by an SH3 deletion induces only lymphoid malignancy
    • Gross A.W., Zhang X., Ren R. Bcr-Abl with an SH3 deletion retains the ability To induce a myeloproliferative disease in mice, yet c-Abl activated by an SH3 deletion induces only lymphoid malignancy. Mol Cell Biol 1999, 19(10):6918-6928.
    • (1999) Mol Cell Biol , vol.19 , Issue.10 , pp. 6918-6928
    • Gross, A.W.1    Zhang, X.2    Ren, R.3
  • 49
    • 77949327323 scopus 로고    scopus 로고
    • A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice
    • Johnson K.J., Griswold I.J., O'Hare T., et al. A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice. PLoS One 2009, 4(10):e7439.
    • (2009) PLoS One , vol.4 , Issue.10 , pp. 7439
    • Johnson, K.J.1    Griswold, I.J.2    O'Hare, T.3
  • 50
    • 19944385935 scopus 로고    scopus 로고
    • MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
    • Huntly B.J., Shigematsu H., Deguchi K., et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 2004, 6(6):587-596.
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 587-596
    • Huntly, B.J.1    Shigematsu, H.2    Deguchi, K.3
  • 51
    • 77951446379 scopus 로고    scopus 로고
    • BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells
    • Schemionek M., Elling C., Steidl U., et al. BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells. Blood 2010, 115(16):3185-3195.
    • (2010) Blood , vol.115 , Issue.16 , pp. 3185-3195
    • Schemionek, M.1    Elling, C.2    Steidl, U.3
  • 52
    • 33746388176 scopus 로고    scopus 로고
    • "Oncogenic shock": explaining oncogene addiction through differential signal attenuation
    • Sharma S.V., Fischbach M.A., Haber D.A., et al. "Oncogenic shock": explaining oncogene addiction through differential signal attenuation. Clin Cancer Res 2006, 12(14 Pt 2):4392s-4395s.
    • (2006) Clin Cancer Res , vol.12 , Issue.14 PART 2 , pp. 4392-4395
    • Sharma, S.V.1    Fischbach, M.A.2    Haber, D.A.3
  • 53
    • 33750627972 scopus 로고    scopus 로고
    • A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes
    • Sharma S.V., Gajowniczek P., Way I.P., et al. A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell 2006, 10(5):425-435.
    • (2006) Cancer Cell , vol.10 , Issue.5 , pp. 425-435
    • Sharma, S.V.1    Gajowniczek, P.2    Way, I.P.3
  • 54
    • 33750937577 scopus 로고    scopus 로고
    • Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
    • Hu Y., Swerdlow S., Duffy T.M., et al. Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A 2006, 103(45):16870-16875.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.45 , pp. 16870-16875
    • Hu, Y.1    Swerdlow, S.2    Duffy, T.M.3
  • 55
    • 9144234689 scopus 로고    scopus 로고
    • Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia
    • Donato N.J., Wu J.Y., Stapley J., et al. Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia. Cancer Res 2004, 64(2):672-677.
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 672-677
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3
  • 56
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Zhao C., Chen A., Jamieson C.H., et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009, 458(7239):776-779.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3
  • 57
    • 50649118068 scopus 로고    scopus 로고
    • Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
    • Dierks C., Beigi R., Guo G.R., et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008, 14(3):238-249.
    • (2008) Cancer Cell , vol.14 , Issue.3 , pp. 238-249
    • Dierks, C.1    Beigi, R.2    Guo, G.R.3
  • 58
    • 79953907017 scopus 로고    scopus 로고
    • Combination of the hedgehog pathway inhibitor LDE225 and nilotinib eliminates chronic myeloid leukemia stem and progenitor cells
    • [abstract: 1428]
    • Irvine D., Zhang B., Allan E., et al. Combination of the hedgehog pathway inhibitor LDE225 and nilotinib eliminates chronic myeloid leukemia stem and progenitor cells. Blood 2009, 114(22). [abstract: 1428].
    • (2009) Blood , vol.114 , Issue.22
    • Irvine, D.1    Zhang, B.2    Allan, E.3
  • 59
    • 43049144313 scopus 로고    scopus 로고
    • Wnt signaling and stem cell control
    • Nusse R. Wnt signaling and stem cell control. Cell Res 2008, 18(5):523-527.
    • (2008) Cell Res , vol.18 , Issue.5 , pp. 523-527
    • Nusse, R.1
  • 60
    • 58249120738 scopus 로고    scopus 로고
    • Beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia
    • Hu Y., Chen Y., Douglas L., et al. beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia. Leukemia 2009, 23(1):109-116.
    • (2009) Leukemia , vol.23 , Issue.1 , pp. 109-116
    • Hu, Y.1    Chen, Y.2    Douglas, L.3
  • 61
    • 79953846892 scopus 로고    scopus 로고
    • Wnt-pathway directed compound targets blast crisis and chronic phase CML leukemia stem progenitors
    • [abstract: 2168]
    • Peterson L., Turbiak A., Giannola D., et al. Wnt-pathway directed compound targets blast crisis and chronic phase CML leukemia stem progenitors. Blood 2009, 114(22). [abstract: 2168].
    • (2009) Blood , vol.114 , Issue.22
    • Peterson, L.1    Turbiak, A.2    Giannola, D.3
  • 62
    • 27644569730 scopus 로고    scopus 로고
    • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
    • Neviani P., Santhanam R., Trotta R., et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 2005, 8(5):355-368.
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 355-368
    • Neviani, P.1    Santhanam, R.2    Trotta, R.3
  • 63
    • 76749127647 scopus 로고    scopus 로고
    • Activation of PP2A by FTY720 inhibits survival and self-renewal of the Ph(+) chronic myelogenous leukemia (CML) CD34+/CD38- stem cell through the simultaneous suppression of BCR/ABL and BCR/ABL- independent signals
    • [abstract: 189]
    • Neviani P., Santhanam R., Ma Y., et al. Activation of PP2A by FTY720 inhibits survival and self-renewal of the Ph(+) chronic myelogenous leukemia (CML) CD34+/CD38- stem cell through the simultaneous suppression of BCR/ABL and BCR/ABL- independent signals. Blood 2008, 112(11). [abstract: 189].
    • (2008) Blood , vol.112 , Issue.11
    • Neviani, P.1    Santhanam, R.2    Ma, Y.3
  • 64
    • 76249087423 scopus 로고    scopus 로고
    • TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    • Naka K., Hoshii T., Muraguchi T., et al. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 2010, 463(7281):676-680.
    • (2010) Nature , vol.463 , Issue.7281 , pp. 676-680
    • Naka, K.1    Hoshii, T.2    Muraguchi, T.3
  • 65
    • 80755185527 scopus 로고    scopus 로고
    • Investigation of the role of FOXO in TKI-induced G1 arrest as potential targets in CML stem/progenitor cell eradication
    • Abstract presented at ESH-EHA Scientific Workshop Leukemic and Cancer Stem Cells. Mandelieu (France), April 3-5
    • Pellicano F, Huntly BJ, Holyoake TL. Investigation of the role of FOXO in TKI-induced G1 arrest as potential targets in CML stem/progenitor cell eradication. Abstract presented at ESH-EHA Scientific Workshop Leukemic and Cancer Stem Cells. Mandelieu (France), April 3-5, 2009.
    • (2009)
    • Pellicano, F.1    Huntly, B.J.2    Holyoake, T.L.3
  • 66
    • 31544451592 scopus 로고    scopus 로고
    • Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate
    • Jorgensen H.G., Copland M., Allan E.K., et al. Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clin Cancer Res 2006, 12(2):626-633.
    • (2006) Clin Cancer Res , vol.12 , Issue.2 , pp. 626-633
    • Jorgensen, H.G.1    Copland, M.2    Allan, E.K.3
  • 67
    • 33847049119 scopus 로고    scopus 로고
    • Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment
    • Holtz M., Forman S.J., Bhatia R. Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment. Cancer Res 2007, 67(3):1113-1120.
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 1113-1120
    • Holtz, M.1    Forman, S.J.2    Bhatia, R.3
  • 68
    • 67349105601 scopus 로고    scopus 로고
    • A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response
    • Drummond M.W., Heaney N., Kaeda J., et al. A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response. Leukemia 2009, 23(6):1199-1201.
    • (2009) Leukemia , vol.23 , Issue.6 , pp. 1199-1201
    • Drummond, M.W.1    Heaney, N.2    Kaeda, J.3
  • 69
    • 0037169341 scopus 로고    scopus 로고
    • The role of PML in tumor suppression
    • Salomoni P., Pandolfi P.P. The role of PML in tumor suppression. Cell 2002, 108(2):165-170.
    • (2002) Cell , vol.108 , Issue.2 , pp. 165-170
    • Salomoni, P.1    Pandolfi, P.P.2
  • 70
    • 44349166602 scopus 로고    scopus 로고
    • PML targeting eradicates quiescent leukaemia-initiating cells
    • Ito K., Bernardi R., Morotti A., et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008, 453(7198):1072-1078.
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1072-1078
    • Ito, K.1    Bernardi, R.2    Morotti, A.3
  • 71
    • 30744446226 scopus 로고    scopus 로고
    • Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy
    • Borthakur G., Kantarjian H., Daley G., et al. Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy. Cancer 2006, 106(2):346-352.
    • (2006) Cancer , vol.106 , Issue.2 , pp. 346-352
    • Borthakur, G.1    Kantarjian, H.2    Daley, G.3
  • 72
    • 21744457612 scopus 로고    scopus 로고
    • Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro
    • Jorgensen H.G., Allan E.K., Graham S.M., et al. Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro. Leukemia 2005, 19(7):1184-1191.
    • (2005) Leukemia , vol.19 , Issue.7 , pp. 1184-1191
    • Jorgensen, H.G.1    Allan, E.K.2    Graham, S.M.3
  • 73
    • 58149261815 scopus 로고    scopus 로고
    • The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation
    • Copland D.A., Wertheim M.S., Armitage W.J., et al. The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation. Invest Ophthalmol Vis Sci 2008, 49(12):5458-5465.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.12 , pp. 5458-5465
    • Copland, D.A.1    Wertheim, M.S.2    Armitage, W.J.3
  • 74
    • 77950536837 scopus 로고    scopus 로고
    • BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta
    • Pellicano F., Copland M., Jorgensen H.G., et al. BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta. Blood 2009, 114(19):4186-4196.
    • (2009) Blood , vol.114 , Issue.19 , pp. 4186-4196
    • Pellicano, F.1    Copland, M.2    Jorgensen, H.G.3
  • 75
    • 0033607274 scopus 로고    scopus 로고
    • Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia
    • Jiang X., Lopez A., Holyoake T., et al. Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proc Natl Acad Sci U S A 1999, 96(22):12804-12809.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.22 , pp. 12804-12809
    • Jiang, X.1    Lopez, A.2    Holyoake, T.3
  • 76
    • 77950949255 scopus 로고    scopus 로고
    • Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors
    • Hiwase D.K., White D.L., Powell J.A., et al. Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors. Leukemia 2010, 24(4):771-778.
    • (2010) Leukemia , vol.24 , Issue.4 , pp. 771-778
    • Hiwase, D.K.1    White, D.L.2    Powell, J.A.3
  • 77
    • 33847407174 scopus 로고    scopus 로고
    • Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation
    • Wang Y., Cai D., Brendel C., et al. Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation. Blood 2007, 109(5):2147-2155.
    • (2007) Blood , vol.109 , Issue.5 , pp. 2147-2155
    • Wang, Y.1    Cai, D.2    Brendel, C.3
  • 78
    • 79953872404 scopus 로고    scopus 로고
    • Jak2 phosphorylates Tyr 177 of Bcr-Abl activating the Ras and PI-3 kinase pathways and maintains functional levels of Bcr-Abl in chronic myelogenous leukemia
    • [abstract: 39]
    • Samanta A., Chakraborty S., Sun X., et al. Jak2 phosphorylates Tyr 177 of Bcr-Abl activating the Ras and PI-3 kinase pathways and maintains functional levels of Bcr-Abl in chronic myelogenous leukemia. Blood 2009, 114(22). [abstract: 39].
    • (2009) Blood , vol.114 , Issue.22
    • Samanta, A.1    Chakraborty, S.2    Sun, X.3
  • 79
    • 77952853306 scopus 로고    scopus 로고
    • Histone deacetylases and epigenetic therapies of hematological malignancies
    • Mercurio C., Minucci S., Pelicci P.G. Histone deacetylases and epigenetic therapies of hematological malignancies. Pharm Res 2010, 62(1):18-34.
    • (2010) Pharm Res , vol.62 , Issue.1 , pp. 18-34
    • Mercurio, C.1    Minucci, S.2    Pelicci, P.G.3
  • 80
    • 78651461961 scopus 로고    scopus 로고
    • Effective targeting of quiescent CML stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
    • [abstract: 190]
    • Zhang B., Campbell Strauss A., Chu S., et al. Effective targeting of quiescent CML stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Blood 2009, 114(22). [abstract: 190].
    • (2009) Blood , vol.114 , Issue.22
    • Zhang, B.1    Campbell Strauss, A.2    Chu, S.3
  • 81
    • 78651333339 scopus 로고    scopus 로고
    • A phase I study of the HDAC inhibitor LBH589 in combination with imatinib for patients with CML in cytogenetic remission with residual disease detectable by Q-PCR
    • [abstract: 2194]
    • Bhatia R., Snyder D., Lin A., et al. A phase I study of the HDAC inhibitor LBH589 in combination with imatinib for patients with CML in cytogenetic remission with residual disease detectable by Q-PCR. Blood 2009, 114(22). [abstract: 2194].
    • (2009) Blood , vol.114 , Issue.22
    • Bhatia, R.1    Snyder, D.2    Lin, A.3
  • 82
    • 77950432694 scopus 로고    scopus 로고
    • Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells
    • Heaney N.B., Pellicano F., Zhang B., et al. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 2010, 115(11):2241-2250.
    • (2010) Blood , vol.115 , Issue.11 , pp. 2241-2250
    • Heaney, N.B.1    Pellicano, F.2    Zhang, B.3
  • 83
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: from phenomenology to molecular understanding in less than a decade
    • Klionsky D.J. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007, 8(11):931-937.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.11 , pp. 931-937
    • Klionsky, D.J.1
  • 84
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum J.J., Bauer D.E., Kong M., et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005, 120(2):237-248.
    • (2005) Cell , vol.120 , Issue.2 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3
  • 85
    • 66449122303 scopus 로고    scopus 로고
    • Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
    • Bellodi C., Lidonnici M.R., Hamilton A., et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009, 119(5):1109-1123.
    • (2009) J Clin Invest , vol.119 , Issue.5 , pp. 1109-1123
    • Bellodi, C.1    Lidonnici, M.R.2    Hamilton, A.3
  • 86
    • 0029100438 scopus 로고
    • Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients
    • Kolb H.J., Schattenberg A., Goldman J.M., et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 1995, 86(5):2041-2050.
    • (1995) Blood , vol.86 , Issue.5 , pp. 2041-2050
    • Kolb, H.J.1    Schattenberg, A.2    Goldman, J.M.3
  • 87
    • 0025678601 scopus 로고
    • Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients
    • Kolb H.J., Mittermuller J., Clemm C., et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 1990, 76(12):2462-2465.
    • (1990) Blood , vol.76 , Issue.12 , pp. 2462-2465
    • Kolb, H.J.1    Mittermuller, J.2    Clemm, C.3
  • 88
    • 35449008469 scopus 로고    scopus 로고
    • Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study
    • Rojas J.M., Knight K., Wang L., et al. Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study. Leukemia 2007, 21(11):2287-2295.
    • (2007) Leukemia , vol.21 , Issue.11 , pp. 2287-2295
    • Rojas, J.M.1    Knight, K.2    Wang, L.3
  • 89
    • 69249097885 scopus 로고    scopus 로고
    • Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: a phase 2 trial
    • Jain N., Reuben J.M., Kantarjian H., et al. Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: a phase 2 trial. Cancer 2009, 115(17):3924-3934.
    • (2009) Cancer , vol.115 , Issue.17 , pp. 3924-3934
    • Jain, N.1    Reuben, J.M.2    Kantarjian, H.3
  • 90
    • 75149121612 scopus 로고    scopus 로고
    • K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate
    • Smith B.D., Kasamon Y.L., Kowalski J., et al. K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate. Clin Cancer Res 2010, 16(1):338-347.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 338-347
    • Smith, B.D.1    Kasamon, Y.L.2    Kowalski, J.3
  • 91
    • 49449115889 scopus 로고    scopus 로고
    • A pilot vaccination trial of synthetic analog peptides derived from the BCR-ABL breakpoints in CML patients with minimal disease
    • Maslak P.G., Dao T., Gomez M., et al. A pilot vaccination trial of synthetic analog peptides derived from the BCR-ABL breakpoints in CML patients with minimal disease. Leukemia 2008, 22(8):1613-1616.
    • (2008) Leukemia , vol.22 , Issue.8 , pp. 1613-1616
    • Maslak, P.G.1    Dao, T.2    Gomez, M.3
  • 92
    • 20444448873 scopus 로고    scopus 로고
    • Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia
    • Li Z., Qiao Y., Liu B., et al. Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia. Clin Cancer Res 2005, 11(12):4460-4468.
    • (2005) Clin Cancer Res , vol.11 , Issue.12 , pp. 4460-4468
    • Li, Z.1    Qiao, Y.2    Liu, B.3
  • 93
    • 0037441629 scopus 로고    scopus 로고
    • Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis
    • Kantarjian H.M., O'Brien S., Cortes J.E., et al. Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis. Cancer 2003, 97(4):1033-1041.
    • (2003) Cancer , vol.97 , Issue.4 , pp. 1033-1041
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.E.3
  • 94
    • 0033826799 scopus 로고    scopus 로고
    • Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
    • Molldrem J.J., Lee P.P., Wang C., et al. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat Med 2000, 6(9):1018-1023.
    • (2000) Nat Med , vol.6 , Issue.9 , pp. 1018-1023
    • Molldrem, J.J.1    Lee, P.P.2    Wang, C.3
  • 95
    • 77950496740 scopus 로고    scopus 로고
    • Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia
    • Burchert A., Muller M.C., Kostrewa P., et al. Sustained molecular response with interferon alfa maintenance after induction therapy with imatinib plus interferon alfa in patients with chronic myeloid leukemia. J Clin Oncol 2010, 28(8):1429-1435.
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1429-1435
    • Burchert, A.1    Muller, M.C.2    Kostrewa, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.