Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells

Science

Volumn 322, Issue 5909, 2008, Pages 1861-1865

  Colmone, Angela ^a   Amorim, Maria ^a   Pontier, Andrea L ^a   Wang, Sheng ^a   Jablonski, Elizabeth ^a   Sipkins, Dorothy A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CHEMOATTRACTANT; GRANULOCYTE COLONY STIMULATING FACTOR; HOMING RECEPTOR; PLERIXAFOR; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1;

BLOOD SYSTEM DISORDER; CANCER; HOMINID; HORMONE; INHIBITION; PROTEIN; RODENT; TUMOR;

ARTICLE; BONE MARROW; CANCER CELL; CELL FUNCTION; CELL GROWTH; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSPLANTATION; CYTOKINE PRODUCTION; DOWN REGULATION; ENGRAFTMENT; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; IN VIVO STUDY; LEUKEMIA CELL; METASTASIS; NONOBESE DIABETIC MOUSE; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANTIGENS, CD34; BONE MARROW; CELL COUNT; CELL LINE, TUMOR; CELL MOVEMENT; CHEMOKINE CXCL12; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HETEROCYCLIC COMPOUNDS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; STEM CELL FACTOR; STEM CELL NICHE; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

MUS;

EID: 57849108116     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1164390     Document Type: Article

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28. + purification; V. Bindokas for imaging expertise; and S. Gurbuxani for assistance with histopathology interpretation. Supported by a grant from the Illinois Regenerative Medicine Institute (IRMI), an NIH (National Cancer Institute) K08 award (5K08CA112126-02), and an NIH Director's DP2 award (1DP2OD002160-01). A patent application related to this work has been filed by the University of Chicago.