-
1
-
-
0032418092
-
Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria
-
Tsujimoto, Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells 3, 697-707, doi:10.1046/j.1365-2443.1998.00223.x (1998).
-
(1998)
Genes Cells
, vol.3
, pp. 697-707
-
-
Tsujimoto, Y.1
-
2
-
-
0036729911
-
BAX and BAK mediate p53-independent suppression of tumorigenesis
-
Degenhardt, K., Chen, G. H., Lindsten, T. &White, E. BAX and BAK mediate p53-independent suppression of tumorigenesis. Cancer Cell 2, 193-203, doi:10.1016/S1535-6108(02)00126-5 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 193-203
-
-
Degenhardt, K.1
Chen, G.H.2
Lindsten, T.3
White, E.4
-
3
-
-
0033713002
-
Structure of Bax: Coregulation of dimer formation and intracellular localization
-
Suzuki, M., Youle, R. J. &Tjandra, N. Structure of Bax: Coregulation of dimer formation and intracellular localization. Cell 103, 645-654, doi:10.1016/S0092-8674(00)00167-7 (2000).
-
(2000)
Cell
, vol.103
, pp. 645-654
-
-
Suzuki, M.1
Youle, R.J.2
Tjandra, N.3
-
4
-
-
84876852297
-
Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming
-
Schellenberg, B. et al. Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming. Mol Cell 49, 959-971, doi:10.1016/j.molcel.2012.12.022 (2013).
-
(2013)
Mol Cell
, vol.49
, pp. 959-971
-
-
Schellenberg, B.1
-
5
-
-
84873307384
-
Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
-
Czabotar, P. E. et al. Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis. Cell 152, 519-531, doi:10.1016/j.cell.2012.12.031 (2013).
-
(2013)
Cell
, vol.152
, pp. 519-531
-
-
Czabotar, P.E.1
-
6
-
-
84892412571
-
Building blocks of the apoptotic pore: How Bax and Bak are activated and oligomerize during apoptosis
-
Westphal, D., Kluck, R. M. &Dewson, G. Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis. Cell Death Differ 21, 196-205, doi:10.1038/cdd.2013.139 (2014).
-
(2014)
Cell Death Differ
, vol.21
, pp. 196-205
-
-
Westphal, D.1
Kluck, R.M.2
Dewson, G.3
-
7
-
-
84875989395
-
Mechanisms of Action of Bcl-2 Family Proteins
-
Shamas-Din, A., Kale, J., Leber, B. &Andrews, D. W. Mechanisms of Action of Bcl-2 Family Proteins. Csh Perspect Biol 5, doi:ARTN a008714 10.1101/cshperspect.a008714 (2013).
-
(2013)
Csh Perspect Biol
, vol.5
-
-
Shamas-Din, A.1
Kale, J.2
Leber, B.3
Andrews, D.W.4
-
8
-
-
78650390233
-
Heterodimerization of BAK and MCL-1 Activated by Detergent Micelles
-
Liu, Q. A. &Gehring, K. Heterodimerization of BAK and MCL-1 Activated by Detergent Micelles. J Biol Chem 285, 41202-41210, doi:10.1074/jbc.M110.144857 (2010).
-
(2010)
J Biol Chem
, vol.285
, pp. 41202-41210
-
-
Liu, Q.A.1
Gehring, K.2
-
9
-
-
43049105074
-
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3: Groove interactions
-
Dewson, G. et al. To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3: Groove interactions. Mol Cell 30, 369-380, doi:10.1016/j.molcel.2008.04.005 (2008).
-
(2008)
Mol Cell
, vol.30
, pp. 369-380
-
-
Dewson, G.1
-
10
-
-
33646354381
-
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
-
Certo, M. et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9, 351-365, doi:10.1016/j.ccr.2006.03.027 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 351-365
-
-
Certo, M.1
-
11
-
-
60249089101
-
Putative partners in Bax mediated cytochrome-c release: ANT, CypD, VDAC or none of them
-
Kumarswamy, R. &Chandna, S. Putative partners in Bax mediated cytochrome-c release: ANT, CypD, VDAC or none of them? Mitochondrion 9, 1-8, doi:10.1016/j.mito.2008.10.003 (2009).
-
(2009)
Mitochondrion
, vol.9
, pp. 1-8
-
-
Kumarswamy, R.1
Chandna, S.2
-
12
-
-
85020224228
-
Involvement of Bcl-2 family proteins in Gleevec's mechanism of action
-
Strasser, A. et al. Involvement of Bcl-2 family proteins in Gleevec's mechanism of action. Ejc Suppl 4, 3-3, doi:10.1016/S1359-6349(06)70010-6 (2006).
-
(2006)
Ejc Suppl
, vol.4
, pp. 3
-
-
Strasser, A.1
-
13
-
-
77949897877
-
Molecular details of bax activation, oligomerization, and membrane insertion
-
Bleicken, S. et al. Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion. J Biol Chem 285, 6636-6647, doi:10.1074/jbc.M109.081539 (2010).
-
(2010)
J Biol Chem
, vol.285
, pp. 6636-6647
-
-
Bleicken, S.1
-
14
-
-
70350025502
-
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis
-
Dewson, G. &Kluck, R. M. Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. J Cell Sci 122, 2801-2808, doi:10.1242/jcs.038166 (2009).
-
(2009)
J Cell Sci
, vol.122
, pp. 2801-2808
-
-
Dewson, G.1
Kluck, R.M.2
-
15
-
-
84866650630
-
Bax activation initiates the assembly of a multimeric catalyst that facilitates bax pore formation in mitochondrial outer membranes
-
Kushnareva, Y., Andreyev, A. Y., Kuwana, T. &Newmeyer, D. D. Bax Activation Initiates the Assembly of a Multimeric Catalyst that Facilitates Bax Pore Formation in Mitochondrial Outer Membranes. Plos Biol 10, doi:ARTN e1001394 10.1371/journal.pbio.1001394 (2012).
-
(2012)
Plos Biol
, vol.10
-
-
Kushnareva, Y.1
Andreyev, A.Y.2
Kuwana, T.3
Newmeyer, D.D.4
-
16
-
-
0032570577
-
Cytochrome c in the apoptotic and antioxidant cascades
-
Skulachev, V. P. Cytochrome c in the apoptotic and antioxidant cascades. Febs Lett 423, 275-280, doi:10.1016/S0014-5793(98)00061-1 (1998).
-
(1998)
Febs Lett
, vol.423
, pp. 275-280
-
-
Skulachev, V.P.1
-
17
-
-
84874462899
-
Cytochrome c assembly
-
Mavridou, D. A., Ferguson, S. J. &Stevens, J. M. Cytochrome c assembly. IUBMB life 65, 209-216, doi:10.1002/iub.1123 (2013).
-
(2013)
IUBMB Life
, vol.65
, pp. 209-216
-
-
Mavridou, D.A.1
Ferguson, S.J.2
Stevens, J.M.3
-
18
-
-
0033694734
-
Redox reactions of heme-containing metalloproteins: Dynamic effects of self-assembled monolayers on thermodynamics and kinetics of cytochrome c electron-transfer reactions
-
Fedurco, M. Redox reactions of heme-containing metalloproteins: dynamic effects of self-assembled monolayers on thermodynamics and kinetics of cytochrome c electron-transfer reactions. Coordin Chem Rev 209, 263-331, doi:10.1016/S0010-8545(00)00292-7 (2000).
-
(2000)
Coordin Chem Rev
, vol.209
, pp. 263-331
-
-
Fedurco, M.1
-
19
-
-
84973248006
-
Electron transfer between cytochrome C and P66SHC generates reactive oxygen species that trigger mitochondrial apoptosis
-
Pelicci, P. G. Electron transfer between cytochrome C and P66SHC generates reactive oxygen species that trigger mitochondrial apoptosis. Febs J 272, 319-320 (2005).
-
(2005)
Febs J
, vol.272
, pp. 319-320
-
-
Pelicci, P.G.1
-
20
-
-
0037952979
-
High-resolution crystal structures and spectroscopy of native and compound i cytochrome c peroxidase
-
Bonagura, C. A. et al. High-resolution crystal structures and spectroscopy of native and compound I cytochrome c peroxidase. Biochemistry-Us 42, 5600-5608, doi:10.1021/bi034058c (2003).
-
(2003)
Biochemistry-Us
, vol.42
, pp. 5600-5608
-
-
Bonagura, C.A.1
-
21
-
-
36549033797
-
A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1
-
Dabir, D. V. et al. A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1. Embo J 26, 4801-4811, doi:10.1038/sj.emboj.7601909 (2007).
-
(2007)
Embo J
, vol.26
, pp. 4801-4811
-
-
Dabir, D.V.1
-
22
-
-
0037022787
-
Structure and spectroscopy of the periplasmic cytochrome c nitrite reductase from Escherichia coli
-
Bamford, V. A. et al. Structure and spectroscopy of the periplasmic cytochrome c nitrite reductase from Escherichia coli. Biochemistry-Us 41, 2921-2931, doi:10.1021/bi015765d (2002).
-
(2002)
Biochemistry-Us
, vol.41
, pp. 2921-2931
-
-
Bamford, V.A.1
-
23
-
-
0037010002
-
Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase
-
Einsle, O., Messerschmidt, A., Huber, R., Kroneck, P. M. H. &Neese, F. Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase. J Am Chem Soc 124, 11737-11745, doi:10.1021/ja0206487 (2002).
-
(2002)
J Am Chem Soc
, vol.124
, pp. 11737-11745
-
-
Einsle, O.1
Messerschmidt, A.2
Huber, R.3
Kroneck, P.M.H.4
Neese, F.5
-
24
-
-
77950890499
-
Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia
-
Taylor, C. T. &Moncada, S. Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia. Arterioscl Throm Vas 30, 643-647, doi:10.1161/Atvbaha.108.181628 (2010).
-
(2010)
Arterioscl Throm Vas
, vol.30
, pp. 643-647
-
-
Taylor, C.T.1
Moncada, S.2
-
25
-
-
0037417334
-
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
-
Breckenridge, D. G., Stojanovic, M., Marcellus, R. C. &Shore, G. C. Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. The Journal of cell biology 160, 1115-1127, doi:10.1083/jcb.200212059 (2003).
-
(2003)
The Journal of Cell Biology
, vol.160
, pp. 1115-1127
-
-
Breckenridge, D.G.1
Stojanovic, M.2
Marcellus, R.C.3
Shore, G.C.4
-
26
-
-
0344825875
-
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis
-
Boehning, D. et al. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol 5, 1051-1061, doi:10.1038/ncb1063 (2003).
-
(2003)
Nat Cell Biol
, vol.5
, pp. 1051-1061
-
-
Boehning, D.1
-
27
-
-
3943071150
-
Cytochrome C-mediated apoptosis
-
Jiang, X. J. &Wang, X. D. Cytochrome C-mediated apoptosis. Annu Rev Biochem 73, 87-106, doi:10.1146/annurev. biochem.73.011303.073706 (2004).
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 87-106
-
-
Jiang, X.J.1
Wang, X.D.2
-
28
-
-
0034956140
-
Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells
-
Nakagawa, I., Nakata, M., Kawabata, S. &Hamada, S. Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells. Cell Microbiol 3, 395-405, doi:10.1046/j.1462-5822.2001.00122.x (2001).
-
(2001)
Cell Microbiol
, vol.3
, pp. 395-405
-
-
Nakagawa, I.1
Nakata, M.2
Kawabata, S.3
Hamada, S.4
-
29
-
-
0034523818
-
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
-
Korsmeyer, S. J. et al. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 7, 1166-1173, doi:10.1038/sj.cdd.4400783 (2000).
-
(2000)
Cell Death Differ
, vol.7
, pp. 1166-1173
-
-
Korsmeyer, S.J.1
-
30
-
-
0034253592
-
BAX-dependent transport of cytochrome c reconstituted in pure liposomes
-
Saito, M., Korsmeyer, S. J. &Schlesinger, P. H. BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol 2, 553-555, doi:10.1038/35019596 (2000).
-
(2000)
Nat Cell Biol
, vol.2
, pp. 553-555
-
-
Saito, M.1
Korsmeyer, S.J.2
Schlesinger, P.H.3
-
32
-
-
56249132688
-
Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores
-
Qian, S., Wang, W. C., Yang, L. &Huang, H. W. Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores. Proceedings of the National Academy of Sciences of the United States of America 105, 17379-17383, doi:10.1073/ pnas.0807764105 (2008).
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, pp. 17379-17383
-
-
Qian, S.1
Wang, W.C.2
Yang, L.3
Huang, H.W.4
-
33
-
-
33745933456
-
The Bax pore in liposomes, biophysics
-
Schlesinger, P. H. &Saito, M. The Bax pore in liposomes, biophysics. Cell Death Differ 13, 1403-1408, doi:10.1038/sj.cdd.4401991 (2006).
-
(2006)
Cell Death Differ
, vol.13
, pp. 1403-1408
-
-
Schlesinger, P.H.1
Saito, M.2
-
34
-
-
84879679314
-
Three-dimensional structure of Bax-mediated pores in membrane bilayers
-
Xu, X. P. et al. Three-dimensional structure of Bax-mediated pores in membrane bilayers. Cell Death Dis 4, doi:ARTN e683 10.1038/ cddis.2013.210 (2013).
-
(2013)
Cell Death Dis
, vol.4
-
-
Xu, X.P.1
-
35
-
-
0034697365
-
Electrophysiological study of a novel large pore formed by Bax and the voltagedependent anion channel that is permeable to cytochrome c
-
Shimizu, S., Ide, T., Yanagida, T. &Tsujimoto, Y. Electrophysiological study of a novel large pore formed by Bax and the voltagedependent anion channel that is permeable to cytochrome c. J Biol Chem 275, 12321-12325, doi:10.1074/jbc.275.16.12321 (2000).
-
(2000)
J Biol Chem
, vol.275
, pp. 12321-12325
-
-
Shimizu, S.1
Ide, T.2
Yanagida, T.3
Tsujimoto, Y.4
-
36
-
-
0036435610
-
Direct evidence for membrane pore formation by the apoptotic protein Bax
-
Epand, R. F., Martinou, J. C., Montessuit, S., Epand, R. M. &Yip, C. M. Direct evidence for membrane pore formation by the apoptotic protein Bax. Biochem Bioph Res Co 298, 744-749, doi:Pii S0006-291x(02)02544-5, doi:10.1016/S0006-291x(02)02544-5 (2002).
-
(2002)
Biochem Bioph Res Co
, vol.298
, pp. 744-749
-
-
Epand, R.F.1
Martinou, J.C.2
Montessuit, S.3
Epand, R.M.4
Yip, C.M.5
-
37
-
-
34447255173
-
Pore formation by a Bax-derived peptide: Effect on the line tension of the membrane probed by AFM
-
Garcia-Saez, A. J., Chiantia, S., Salgado, J. &Schwille, P. Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM. Biophysical journal 93, 103-112, doi:10.1529/biophysj.106.100370 (2007).
-
(2007)
Biophysical Journal
, vol.93
, pp. 103-112
-
-
Garcia-Saez, A.J.1
Chiantia, S.2
Salgado, J.3
Schwille, P.4
-
38
-
-
0036850312
-
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
-
Kuwana, T. et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111, 331-342 (2002).
-
(2002)
Cell
, vol.111
, pp. 331-342
-
-
Kuwana, T.1
-
39
-
-
3142746012
-
Lipidic pore formation by the concerted action of proapoptotic BAX and tBID
-
Terrones, O. et al. Lipidic pore formation by the concerted action of proapoptotic BAX and tBID. J Biol Chem 279, 30081-30091, doi:10.1074/jbc.M313420200 (2004).
-
(2004)
J Biol Chem
, vol.279
, pp. 30081-30091
-
-
Terrones, O.1
-
40
-
-
21844464054
-
Rax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
-
Annis, M. G. et al. Rax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. Embo J 24, 2096-2103, doi:10.1038/sj.emboj.7600675 (2005).
-
(2005)
Embo J
, vol.24
, pp. 2096-2103
-
-
Annis, M.G.1
-
41
-
-
0034650523
-
Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
-
Antonsson, B., Montessuit, S., Lauper, S., Eskes, R. &Martinou, J. C. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. The Biochemical journal 345(Pt 2), 271-278 (2000).
-
(2000)
The Biochemical Journal
, vol.345
, pp. 271-278
-
-
Antonsson, B.1
Montessuit, S.2
Lauper, S.3
Eskes, R.4
Martinou, J.C.5
-
42
-
-
84907573467
-
Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane
-
Westphal, D. et al. Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane. Proceedings of the National Academy of Sciences of the United States of America 111, E4076-4085, doi:10.1073/ pnas.1415142111 (2014).
-
(2014)
Proceedings of the National Academy of Sciences of the United States of America
, vol.111
, pp. E4076-4085
-
-
Westphal, D.1
-
43
-
-
84887840021
-
Proapoptotic Bax and Bak proteins form stable proteinpermeable pores of tunable size
-
Bleicken, S., Landeta, O., Landajuela, A. &Basanez, G. &Garcia-Saez, A. J. Proapoptotic Bax and Bak proteins form stable proteinpermeable pores of tunable size. J Biol Chem 288, 33241-33252, doi:10.1074/jbc.M113.512087 (2013).
-
(2013)
J Biol Chem
, vol.288
, pp. 33241-33252
-
-
Bleicken, S.1
Landeta, O.2
Landajuela, A.3
Basanez, G.4
Garcia-Saez, A.J.5
-
44
-
-
84912095121
-
Structural Model of Active Bax at the Membrane
-
Bleicken, S. et al. Structural Model of Active Bax at the Membrane. Mol Cell 56, 496-505, doi:10.1016/j.molcel.2014.09.022 (2014).
-
(2014)
Mol Cell
, vol.56
, pp. 496-505
-
-
Bleicken, S.1
-
45
-
-
84893480044
-
Organization of the mitochondrial apoptotic BAK pore: Oligomerization of the BAK homodimers
-
Aluvila, S. et al. Organization of the mitochondrial apoptotic BAK pore: oligomerization of the BAK homodimers. J Biol Chem 289, 2537-2551, doi:10.1074/jbc.M113.526806 (2014).
-
(2014)
J Biol Chem
, vol.289
, pp. 2537-2551
-
-
Aluvila, S.1
-
46
-
-
84987923366
-
Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane
-
Zhang, M., Zheng, J., Nussinov, R. &Ma, B. Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane. Sci Rep 6, 33340, doi:10.1038/srep33340 (2016).
-
(2016)
Sci Rep
, vol.6
, pp. 33340
-
-
Zhang, M.1
Zheng, J.2
Nussinov, R.3
Ma, B.4
-
47
-
-
33745591102
-
Multiple pathways of cytochrome c release from mitochondria in apoptosis
-
Gogvadze, V., Orrenius, S. &Zhivotovsky, B. Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim Biophys Acta 1757, 639-647, doi:10.1016/j.bbabio.2006.03.016 (2006).
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 639-647
-
-
Gogvadze, V.1
Orrenius, S.2
Zhivotovsky, B.3
-
48
-
-
0035229427
-
The mitochondrion in apoptosis: How Pandora's box opens
-
Zamzami, N. &Kroemer, G. The mitochondrion in apoptosis: how Pandora's box opens. Nature reviews. Molecular cell biology 2, 67-71, doi:10.1038/35048073 (2001).
-
(2001)
Nature Reviews. Molecular Cell Biology
, vol.2
, pp. 67-71
-
-
Zamzami, N.1
Kroemer, G.2
-
49
-
-
84883411678
-
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice
-
Karch, J. et al. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. eLife 2, e00772, doi:10.7554/eLife.00772 (2013).
-
(2013)
ELife
, vol.2
, pp. e00772
-
-
Karch, J.1
-
50
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei, M. C. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730, doi:10.1126/science.1059108 (2001).
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
-
51
-
-
84885583662
-
Bax induces cytochrome c release by multiple mechanisms in mitochondria from MCF7 cells
-
Gomez-Crisostomo, N. P., Lopez-Marure, R., Zapata, E., Zazueta, C. &Martinez-Abundis, E. Bax induces cytochrome c release by multiple mechanisms in mitochondria from MCF7 cells. J Bioenerg Biomembr 45, 441-448, doi:10.1007/s10863-013-9508-x (2013).
-
(2013)
J Bioenerg Biomembr
, vol.45
, pp. 441-448
-
-
Gomez-Crisostomo, N.P.1
Lopez-Marure, R.2
Zapata, E.3
Zazueta, C.4
Martinez-Abundis, E.5
-
52
-
-
84944463400
-
The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization
-
Zhou, H. et al. The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization. Oncotarget 6, 26599-26614, doi:10.18632/oncotarget.5613 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 26599-26614
-
-
Zhou, H.1
-
53
-
-
84923370451
-
Small-molecule Bax agonists for cancer therapy
-
Xin, M. et al. Small-molecule Bax agonists for cancer therapy. Nature communications 5, 4935, doi:10.1038/ncomms5935 (2014).
-
(2014)
Nature Communications
, vol.5
, pp. 4935
-
-
Xin, M.1
-
54
-
-
22244432513
-
Killing cancer cells by flipping the Bcl-2/Bax switch
-
Cory, S. &Adams, J. M. Killing cancer cells by flipping the Bcl-2/Bax switch. Cancer Cell 8, 5-6, doi:10.1016/j.ccr.2005.06.012 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 5-6
-
-
Cory, S.1
Adams, J.M.2
-
55
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
Yang, J. et al. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 275, 1129-1132, doi:10.1126/science.275.5303.1129 (1997).
-
(1997)
Science
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
-
56
-
-
84888426235
-
MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX
-
Hamada, S., Masamune, A., Miura, S., Satoh, K. &Shimosegawa, T. MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX. Cellular signalling 26, 179-185, doi:10.1016/j. cellsig.2013.11.003 (2014).
-
(2014)
Cellular Signalling
, vol.26
, pp. 179-185
-
-
Hamada, S.1
Masamune, A.2
Miura, S.3
Satoh, K.4
Shimosegawa, T.5
-
57
-
-
84970004345
-
Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
-
Iyer, S. et al. Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies. Nat Commun 7, 11734, doi:10.1038/ncomms11734 (2016).
-
(2016)
Nat Commun
, vol.7
, pp. 11734
-
-
Iyer, S.1
-
58
-
-
84958900764
-
Direct Activation of Bax Protein for Cancer Therapy
-
Liu, Z. et al. Direct Activation of Bax Protein for Cancer Therapy. Med Res Rev 36, 313-341, doi:10.1002/med.21379 (2016).
-
(2016)
Med Res Rev
, vol.36
, pp. 313-341
-
-
Liu, Z.1
-
59
-
-
84958604397
-
Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis
-
Grosse, L. et al. Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis. EMBO J 35, 402-413, doi:10.15252/embj.201592789 (2016).
-
(2016)
EMBO J
, vol.35
, pp. 402-413
-
-
Grosse, L.1
-
60
-
-
84958632050
-
Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores
-
Salvador-Gallego, R. et al. Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores. EMBO J 35, 389-401, doi:10.15252/embj.201593384 (2016).
-
(2016)
EMBO J
, vol.35
, pp. 389-401
-
-
Salvador-Gallego, R.1
-
61
-
-
0033758751
-
N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death
-
Gao, G. &Dou, Q. P. N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death. Journal of cellular biochemistry 80, 53-72 (2000).
-
(2000)
Journal of Cellular Biochemistry
, vol.80
, pp. 53-72
-
-
Gao, G.1
Dou, Q.P.2
-
62
-
-
0037469097
-
Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax
-
Toyota, H. et al. Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax. Cancer letters 189, 221-230 (2003).
-
(2003)
Cancer Letters
, vol.189
, pp. 221-230
-
-
Toyota, H.1
-
63
-
-
0035795725
-
Bilayer thickness and lipid interface area in unilamellar extruded 1,2-diacylphosphatidylcholine liposomes: A smallangle neutron scattering study
-
Balgavy, P. et al. Bilayer thickness and lipid interface area in unilamellar extruded 1,2-diacylphosphatidylcholine liposomes: a smallangle neutron scattering study. Biochim Biophys Acta 1512, 40-52 (2001).
-
(2001)
Biochim Biophys Acta
, vol.1512
, pp. 40-52
-
-
Balgavy, P.1
-
64
-
-
0021444491
-
Study of the orientational ordering of carotenoids in lipid bilayers by resonance-Raman spectroscopy
-
van de Ven, M., Kattenberg, M., van Ginkel, G. &Levine, Y. K. Study of the orientational ordering of carotenoids in lipid bilayers by resonance-Raman spectroscopy. Biophysical journal 45, 1203-1209, doi:10.1016/S0006-3495(84)84269-1 (1984).
-
(1984)
Biophysical Journal
, vol.45
, pp. 1203-1209
-
-
Van De Ven, M.1
Kattenberg, M.2
Van Ginkel, G.3
Levine, Y.K.4
-
65
-
-
85015192488
-
Molecular understanding of abeta-hiapp cross-seeding assemblies on lipid membranes
-
Zhang, M. et al. Molecular Understanding of Abeta-hIAPP Cross-Seeding Assemblies on Lipid Membranes. ACS chemical neuroscience 8, 524-537, doi:10.1021/acschemneuro.6b00247 (2017).
-
(2017)
ACS Chemical Neuroscience
, vol.8
, pp. 524-537
-
-
Zhang, M.1
-
66
-
-
38049155818
-
Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis
-
Deniaud, A. et al. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 27, 285-299, doi:10.1038/sj.onc.1210638 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 285-299
-
-
Deniaud, A.1
-
67
-
-
0038464650
-
Regulation of cell death: The calcium-apoptosis link
-
Orrenius, S., Zhivotovsky, B. &Nicotera, P. Regulation of cell death: the calcium-apoptosis link. Nature reviews. Molecular cell biology 4, 552-565, doi:10.1038/nrm1150 (2003).
-
(2003)
Nature Reviews. Molecular Cell Biology
, vol.4
, pp. 552-565
-
-
Orrenius, S.1
Zhivotovsky, B.2
Nicotera, P.3
-
68
-
-
0037418843
-
BAX and BAK regulation of endoplasmic reticulum Ca2+: A control point for apoptosis
-
Scorrano, L. et al. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 300, 135-139, doi:10.1126/science.1081208 (2003).
-
(2003)
Science
, vol.300
, pp. 135-139
-
-
Scorrano, L.1
-
70
-
-
66449087483
-
Assembly of the Mitochondrial Apoptosis-induced Channel, MAC
-
Martinez-Caballero, S. et al. Assembly of the Mitochondrial Apoptosis-induced Channel, MAC. J Biol Chem 284, 12235-12245, doi:10.1074/jbc.M806610200 (2009).
-
(2009)
J Biol Chem
, vol.284
, pp. 12235-12245
-
-
Martinez-Caballero, S.1
-
71
-
-
0041977046
-
Spatial and temporal changes in Bax subcellular localization during anoikis
-
Valentijn, A. J., Metcalfe, A. D., Kott, J., Streuli, C. H. &Gilmore, A. P. Spatial and temporal changes in Bax subcellular localization during anoikis. J Cell Biol 162, 599-612, doi:10.1083/jcb.200302154 (2003).
-
(2003)
J Cell Biol
, vol.162
, pp. 599-612
-
-
Valentijn, A.J.1
Metcalfe, A.D.2
Kott, J.3
Streuli, C.H.4
Gilmore, A.P.5
-
72
-
-
84982690266
-
Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases
-
Duncan, A. L., Robinson, A. J. &Walker, J. E. Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases. Proceedings of the National Academy of Sciences 113, 8687-8692, doi:10.1073/pnas.1608396113 (2016).
-
(2016)
Proceedings of the National Academy of Sciences
, vol.113
, pp. 8687-8692
-
-
Duncan, A.L.1
Robinson, A.J.2
Walker, J.E.3
-
73
-
-
78650543009
-
Release of content through mechano-sensitive gates in pressurized liposomes
-
Louhivuori, M., Risselada, H. J., van der Giessen, E. &Marrink, S. J. Release of content through mechano-sensitive gates in pressurized liposomes. Proceedings of the National Academy of Sciences 107, 19856-19860, doi:10.1073/pnas.1001316107 (2010).
-
(2010)
Proceedings of the National Academy of Sciences
, vol.107
, pp. 19856-19860
-
-
Louhivuori, M.1
Risselada, H.J.2
Van Der Giessen, E.3
Marrink, S.J.4
-
74
-
-
84948845292
-
Organization and dynamics of receptor proteins in a plasma membrane
-
Koldso, H. &Sansom, M. S. P. Organization and Dynamics of Receptor Proteins in a Plasma Membrane. Journal of the American Chemical Society 137, 14694-14704, doi:10.1021/jacs.5b08048 (2015).
-
(2015)
Journal of the American Chemical Society
, vol.137
, pp. 14694-14704
-
-
Koldso, H.1
Sansom, M.S.P.2
-
75
-
-
84957539705
-
Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins
-
Stetz, G. &Verkhivker, G. M. Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins. PLoS One 10, e0143752, doi:10.1371/journal.pone.0143752 (2015).
-
(2015)
PLoS One
, vol.10
, pp. e0143752
-
-
Stetz, G.1
Verkhivker, G.M.2
-
76
-
-
84974578261
-
Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? the Diverse Functional Roles of Conformational Ensembles in the Cell
-
Wei, G., Xi, W., Nussinov, R. &Ma, B. Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? The Diverse Functional Roles of Conformational Ensembles in the Cell. Chem Rev 116, 6516-6551, doi:10.1021/acs.chemrev.5b00562 (2016).
-
(2016)
Chem Rev
, vol.116
, pp. 6516-6551
-
-
Wei, G.1
Xi, W.2
Nussinov, R.3
Ma, B.4
-
77
-
-
84883690023
-
Assembly of the Bak apoptotic pore: A critical role for the Bak protein alpha6 helix in the multimerization of homodimers during apoptosis
-
Ma, S. et al. Assembly of the Bak apoptotic pore: a critical role for the Bak protein alpha6 helix in the multimerization of homodimers during apoptosis. J Biol Chem 288, 26027-26038, doi:10.1074/jbc.M113.490094 (2013).
-
(2013)
J Biol Chem
, vol.288
, pp. 26027-26038
-
-
Ma, S.1
-
78
-
-
84941191862
-
Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains
-
Iyer, S. et al. Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains. Cell Death Differ 22, 1665-1675, doi:10.1038/cdd.2015.15 (2015).
-
(2015)
Cell Death Differ
, vol.22
, pp. 1665-1675
-
-
Iyer, S.1
-
79
-
-
34547629939
-
A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax
-
George, N. M., Evans, J. J. &Luo, X. A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax. Genes Dev 21, 1937-1948, doi:10.1101/gad.1553607 (2007).
-
(2007)
Genes Dev
, vol.21
, pp. 1937-1948
-
-
George, N.M.1
Evans, J.J.2
Luo, X.3
-
80
-
-
84884965580
-
Lipids of mitochondria
-
Horvath, S. E. &Daum, G. Lipids of mitochondria. Progress in lipid research 52, 590-614, doi:10.1016/j.plipres.2013.07.002 (2013).
-
(2013)
Progress in Lipid Research
, vol.52
, pp. 590-614
-
-
Horvath, S.E.1
Daum, G.2
-
81
-
-
84888402530
-
The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: Implications for the enhanced pro-apoptotic activity of the G41S mutant
-
Rajagopal, B. S. et al. The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant. The Biochemical journal 456, 441-452, doi:10.1042/ BJ20130758 (2013).
-
(2013)
The Biochemical Journal
, vol.456
, pp. 441-452
-
-
Rajagopal, B.S.1
-
82
-
-
47149096704
-
CHARMM-GUI: A web-based graphical user interface for CHARMM
-
Jo, S., Kim, T., Iyer, V. G. &Im, W. CHARMM-GUI: a web-based graphical user interface for CHARMM. Journal of computational chemistry 29, 1859-1865, doi:10.1002/jcc.20945 (2008).
-
(2008)
Journal of Computational Chemistry
, vol.29
, pp. 1859-1865
-
-
Jo, S.1
Kim, T.2
Iyer, V.G.3
Im, W.4
-
83
-
-
27344436659
-
Scalable molecular dynamics with NAMD
-
Phillips, J. C. et al. Scalable molecular dynamics with NAMD. Journal of computational chemistry 26, 1781-1802, doi:10.1002/ jcc.20289 (2005).
-
(2005)
Journal of Computational Chemistry
, vol.26
, pp. 1781-1802
-
-
Phillips, J.C.1
|