Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 39, 2014, Pages E4076-E4085

  Westphal, Dana ^a,b   Dewson, Grant ^a,b   Menard, Marie ^a,d   Frederick, Paul ^a   Iyer, Sweta ^a,b   Bartolo, Ray ^a   Gibson, Leonie ^a   Czabotar, Peter E ^a,b   Smith, Brian J ^c   Adams, Jerry M ^a,b   Kluck, Ruth M ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c LA TROBE UNIVERSITY   (Australia)

^d UNIVERSITÉ DE LYON   (France)

Author keywords

Cell death; Cysteine scanning mutagenesis; Membrane pores; Mitochondrial permeabilization; Protein membrane topology

Indexed keywords

4-ACETAMIDO-4'-((IODOACETYL)AMINO)STILBENE-2,2'-DISULFONATE; BAK1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; CYSTEINE; PROTEIN BAK; PROTEIN BAX; RECOMBINANT PROTEIN; STILBENE DERIVATIVE; THIOL REAGENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; APOPTOSIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; CYSTEINE; HUMANS; MICE; MITOCHONDRIAL MEMBRANES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STILBENES; SULFHYDRYL REAGENTS;

EID: 84907573467     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415142111     Document Type: Article

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