Sirtuin 3 deregulation promotes pulmonary fibrosis

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 72, Issue 5, 2017, Pages 595-602

  Sosulski, Meredith L ^a   Gongora, Rafael ^a   Feghali Bostwick, Carol ^b   Lasky, Joseph A ^a   Sanchez, Cecilia G ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Age related pathology; Lungs pulmonary; Mitochondria; Reactive oxygen species; SIRT3

Indexed keywords

ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, MOUSE; RESVERATROL; SIRTUIN 3; SMAD3 PROTEIN; STILBENE DERIVATIVE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

AGING; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; DISEASE MODEL; DOWN REGULATION; FIBROBLAST; HUMAN; LUNG FIBROSIS; MALE; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY;

AGING; ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FIBROBLASTS; HUMANS; ISOCITRATE DEHYDROGENASE; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PULMONARY FIBROSIS; SIRTUIN 3; SMAD3 PROTEIN; STILBENES; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85020044768     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glw151     Document Type: Review

References (50)

1. Roberts AB, Sporn MB, Assoian RK, et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA. 1986;83:4167-4171. doi:10.1073/pnas.83.12.4167
2. Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M. Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol. 1998;110:47-51. doi:10.1046/j.1523-1747.1998.00073.x
3. Bhattacharyya S, Wei J, Varga J. Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol. 2012;8:42-54. doi:10.1038/nrrheum.2011.149
4. Vij R, Strek ME. Diagnosis and treatment of connective tissue disease-associated interstitial lung disease. Chest. 2013;143:814-824. doi:10.1378/chest.12-0741
5. Raghu G, Chen SY, Hou Q, Yeh WS, Collard HR. Incidence and prevalence of idiopathic pulmonary fibrosis in US adults 18-64 years old. Eur Respir J. 2016;48:179-186. doi:10.1183/13993003.01653-2015
6. Sosulski ML, Gongora R, Danchuk S, Dong C, Luo F, Sanchez CG. Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1. Aging Cell. 2015;14:774-783. doi:10.1111/acel.12357
7. Yao Y, Yang Y, Zhu WG. Sirtuins: nodes connecting aging, metabolism and tumorigenesis. Curr Pharm Des. 2014;20:1614-1624. doi:10.2174/13816 128113199990513
8. Chakraborty C, Doss CG. Sirtuins family-recent development as a drug target for aging, metabolism, and age related diseases. Curr Drug Targets. 2013;14:666-675. doi:10.2174/1389450111314060008
9. Guarente L. Sirtuins, aging, and metabolism. Cold Spring Harb Symp Quant Biol. 2011;76:81-90. doi:10.1101/sqb.2011.76.010629
10. Kincaid B, Bossy-Wetzel E. Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci. 2013;5:48. doi:10.3389/fnagi.2013.00048
11. Sadoshima J. Sirt3 targets mPTP and prevents aging in the heart. Aging (Albany NY). 2011;3:12-13. doi:10.18632/aging.100266
12. Hebert SL, Marquet-de Rougé P, Lanza IR, et al. Mitochondrial aging and physical decline: insights from three generations of women. J Gerontol A Biol Sci Med Sci. 2015;70:1409-1417. doi:10.1093/gerona/glv086
13. Jacobs KM, Pennington JD, Bisht KS, et al. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci. 2008;4:291-299. doi:10.7150/ijbs.4.291
14. Yu W, Dittenhafer-Reed KE, Denu JM. SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem. 2012;287:14078-14086. doi:10.1074/jbc. M112.355206
15. Zhu Y, Park SH, Ozden O, et al. Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radic Biol Med. 2012;53:828-833. doi:10.1016/j.freeradbiomed.2012.06.020
16. Schumacker PT. SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF. Cancer Cell. 2011;19:299-300. doi:10.1016/j.ccr.2011.03.001
17. McDonnell E, Peterson BS, Bomze HM, Hirschey MD. SIRT3 regulates progression and development of diseases of aging. Trends Endocrinol Metab. 2015;26:486-492. doi:10.1016/j.tem.2015.06.001
18. Yamane K, Ihn H, Kubo M, Tamaki K. Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts. Arthritis Rheum. 2002;46:2421-2428. doi:10.1002/art.10477
19. Zhou X, Chen M, Zeng X, et al. Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells. Cell Death Dis. 2014;5:e1576. doi:10.1038/cddis.2014.530
20. Chen T, Li J, Liu J, et al. Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-beta/Smad3 pathway. Am J Physiol Heart Circ Physiol. 2015;308:H424-434. doi:10.1152/ajpheart.00454.2014
21. Olson ER, Naugle JE, Zhang X, Bomser JA, Meszaros JG. Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol. Am J Physiol Heart Circ Physiol. 2005;288:H1131-H1138. doi:10.1152/ajpheart.00763.2004
22. Hübner RH, Gitter W, El Mokhtari NE, et al. Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques. 2008;44:507-511, 514. doi:10.2144/000112729
23. Shim JJ, Dabbagh K, Ueki IF, et al. IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol. 2001;280:L134-L140.
24. Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol. 2000;164:1546-1552. doi:10.4049/jimmunol.164.3.1546
25. Lou YP, Takeyama K, Grattan KM, et al. Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. Am J Respir Crit Care Med. 1998;157(6 Pt 1):1927-1934. doi:10.1164/ajrccm.157.6.9709113
26. Mata M, Ruíz A, Cerdá M, et al. Oral N-acetylcysteine reduces bleomycininduced lung damage and mucin Muc5ac expression in rats. Eur Respir J. 2003;22:900-905. doi:10.1183/09031936.03.00018003
27. Zhang Y, Handley D, Kaplan T, et al. High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells. PLoS One. 2011;6:e20319. doi:10.1371/journal.pone.0020319
28. Calabresi C, Arosio B, Galimberti L, et al. Natural aging, expression of fibrosis-related genes and collagen deposition in rat lung. Exp Gerontol. 2007;42:1003-1011. doi:10.1016/j.exger.2007.06.016
29. Sueblinvong V, Neujahr DC, Mills ST, et al. Predisposition for disrepair in the aged lung. Am J Med Sci. 2012;344:41-51. doi:10.1097/MAJ.0b013e318234c132
30. Chilosi M, Carloni A, Rossi A, Poletti V. Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema. Transl Res. 2013;162:156-173. doi:10.1016/j.trsl.2013.06.004
31. Homer RJ, Herzog EL. Recent advances in pulmonary fibrosis: implications for scleroderma. Curr Opin Rheumatol. 2010;22:683-689. doi:10.1097/BOR.0b013e32833ddcc9
32. Hirose T, Nakano Y, Nagamatsu Y, Misumi T, Ohta H, Ohshima Y. Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans. Development. 2003;130:1089-1099. doi:10.1242/dev.00330
33. Carrieri G, Marzi E, Olivieri F, et al. The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell. 2004;3:443-448. doi:10.1111/j.1474-9728.2004.00129.x
34. Bellizzi D, Dato S, Cavalcante P, et al. Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13. Genomics. 2007;89:143-150. doi:10.1016/j.ygeno.2006.09.004
35. Liu Y, Zhang D, Chen D. SIRT3: striking at the heart of aging. Aging (Albany NY). 2011;3:1-2. doi:10.18632/aging.100256
36. Zeng H, Vaka VR, He X, Booz GW, Chen JX. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J Cell Mol Med. 2015;19:1847-1856. doi:10.1111/jcmm.12556
37. Albani D, Ateri E, Mazzuco S, et al. Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)". Age (Dordr). 2014;36:469-478. doi:10.1007/s11357-013-9559-2
38. Zhao J, Shi W, Wang YL, et al. Smad3 deficiency attenuates bleomycininduced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 2002;282:L585-L593. doi:10.1152/ajplung.00151.2001
39. Bonniaud P, Margetts PJ, Ask K, Flanders K, Gauldie J, Kolb M. TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis. J Immunol. 2005;175:5390-5395. doi:10.4049/jimmunol.175.8.5390
40. Inazaki K, Kanamaru Y, Kojima Y, et al. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int. 2004;66:597-604. doi:10.1111/j.1523-1755.2004.00779.x
41. Sundaresan NR, Bindu S, Pillai VB, et al. SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3 beta. Mol Cell Biol. 2015;36:678-692. doi:10.1128/mcb.00586-15
42. Amara N, Goven D, Prost F, Muloway R, Crestani B, Boczkowski J. NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts. Thorax. 2010;65:733-738. doi:10.1136/thx.2009.113456
43. Kim HS, Patel K, Muldoon-Jacobs K, et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 2010;17:41-52. doi:10.1016/j.ccr.2009.11.023
44. Tao R, Coleman MC, Pennington JD, et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell. 2010;40:893-904. doi:10.1016/j.molcel. 2010.12.013
45. Ozden O, Park SH, Kim HS, et al. Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging. 2011;3:102-107. doi:10.18632/aging.100291
46. Johnson ML, Irving BA, Lanza IR, et al. Differential effect of endurance training on mitochondrial protein damage, degradation, and acetylation in the context of aging. J Gerontol A Biol Sci Med Sci. 2015;70:1386-1393. doi:10.1093/gerona/glu221
47. Scheurmann J, Treiber N, Weber C, et al. Mice with heterozygous deficiency of manganese superoxide dismutase (SOD2) have a skin immune system with features of "inflamm-aging". Arch Dermatol Res. 2014;306:143-155. doi:10.1007/s00403-013-1389-7
48. Weyemi U, Parekh PR, Redon CE, Bonner WM. SOD2 deficiency promotes aging phenotypes in mouse skin. Aging. 2012;4:116-118. doi:10.18632/aging.100433
49. Luckhardt TR, Thannickal VJ. Systemic sclerosis-associated fibrosis: an accelerated aging phenotype? Curr Opin Rheumatol. 2015;27:571-576. doi:10.1097/bor.0000000000000219
50. Im J, Hergert P, Nho RS. Reduced FoxO3a expression causes low autophagy in idiopathic pulmonary fibrosis fibroblasts on collagen matrices. Am J Physiol Lung Cell Mol Physiol. 2015;309:L552-L561. doi:10.1152/ajplung.00079.2015