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Volumn 27, Issue 6, 2015, Pages 571-576

Systemic sclerosis-associated fibrosis: An accelerated aging phenotype?

Author keywords

Aging; Fibrosis; Systemic sclerosis

Indexed keywords

BETA CATENIN; MITOCHONDRIAL DNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SIRTUIN 1; WNT PROTEIN;

EID: 84942511812     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000219     Document Type: Review
Times cited : (36)

References (54)
  • 1
    • 0043074631 scopus 로고    scopus 로고
    • Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population
    • Mayes MD, Lacey JV Jr, Beebe-Dimmer J, et al. Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population. Arthritis Rheum 2003; 48:2246-2255.
    • (2003) Arthritis Rheum , vol.48 , pp. 2246-2255
    • Mayes, M.D.1    Lacey, J.V.2    Beebe-Dimmer, J.3
  • 3
    • 84859464725 scopus 로고    scopus 로고
    • Epidemiology of systemic sclerosis in a large US managed care population
    • Furst DE, Fernandes AW, Iorga SR, et al. Epidemiology of systemic sclerosis in a large US managed care population. J Rheumatol 2012; 39:784-786.
    • (2012) J Rheumatol , vol.39 , pp. 784-786
    • Furst, D.E.1    Fernandes, A.W.2    Iorga, S.R.3
  • 4
    • 84908126065 scopus 로고    scopus 로고
    • Systemic sclerosis evolution of disease pathomorphosis and survival. Our experience on Italian patients' population and review of the literature
    • Ferri C, Sebastiani M, Lo Monaco A, et al. Systemic sclerosis evolution of disease pathomorphosis and survival. Our experience on Italian patients' population and review of the literature. Autoimmun Rev 2014; 13:1026-1034.
    • (2014) Autoimmun Rev , vol.13 , pp. 1026-1034
    • Ferri, C.1    Sebastiani, M.2    Lo Monaco, A.3
  • 5
    • 84885309893 scopus 로고    scopus 로고
    • Mortality in systemic sclerosis-A single centre study from the UK
    • Strickland G, Pauling J, Cavill C, et al. Mortality in systemic sclerosis-a single centre study from the UK. Clin Rheumatol 2013; 32:1533-1539.
    • (2013) Clin Rheumatol , vol.32 , pp. 1533-1539
    • Strickland, G.1    Pauling, J.2    Cavill, C.3
  • 7
    • 77953514787 scopus 로고    scopus 로고
    • Age-related survival and clinical features in systemic sclerosis patients older or younger than 65 at diagnosis
    • Perez-Bocanegra C, Solans-Laque R, Simeon-Aznar CP, et al. Age-related survival and clinical features in systemic sclerosis patients older or younger than 65 at diagnosis. Rheumatology 2010; 49:1112-1117.
    • (2010) Rheumatology , vol.49 , pp. 1112-1117
    • Perez-Bocanegra, C.1    Solans-Laque, R.2    Simeon-Aznar, C.P.3
  • 8
    • 79952717349 scopus 로고    scopus 로고
    • An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management
    • Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 2011; 183:788-824.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 788-824
    • Raghu, G.1    Collard, H.R.2    Egan, J.J.3
  • 9
    • 84926176338 scopus 로고    scopus 로고
    • Histopathology of lung disease in the connective tissue diseases
    • Vivero M, Padera RF. Histopathology of lung disease in the connective tissue diseases. Rheum Dis Clin North Am 2015; 41:197-211.
    • (2015) Rheum Dis Clin North Am , vol.41 , pp. 197-211
    • Vivero, M.1    Padera, R.F.2
  • 10
    • 84905040885 scopus 로고    scopus 로고
    • Review: Interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: How similar and distinct?
    • Herzog EL, Mathur A, Tager AM, et al. Review: interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct? Arthritis Rheumatol 2014; 66:1967-1978.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1967-1978
    • Herzog, E.L.1    Mathur, A.2    Tager, A.M.3
  • 11
    • 84890558367 scopus 로고    scopus 로고
    • Mechanistic links between aging and lung fibrosis
    • Thannickal VJ. Mechanistic links between aging and lung fibrosis. Biogerontology 2013; 14:609-615.
    • (2013) Biogerontology , vol.14 , pp. 609-615
    • Thannickal, V.J.1
  • 13
    • 84910029849 scopus 로고    scopus 로고
    • Geroscience: Linking aging to chronic disease
    • Kennedy BK, Berger SL, Brunet A, et al. Geroscience: linking aging to chronic disease. Cell 2014; 159:709-713.
    • (2014) Cell , vol.159 , pp. 709-713
    • Kennedy, B.K.1    Berger, S.L.2    Brunet, A.3
  • 14
    • 80054852150 scopus 로고    scopus 로고
    • Oxidative stress, inflamm-aging and immunosenescence
    • Cannizzo ES, Clement CC, Sahu R, et al. Oxidative stress, inflamm-aging and immunosenescence. J Proteomics 2011; 74:2313-2323.
    • (2011) J Proteomics , vol.74 , pp. 2313-2323
    • Cannizzo, E.S.1    Clement, C.C.2    Sahu, R.3
  • 15
    • 84902273600 scopus 로고    scopus 로고
    • Cellular signaling in the aging immune system
    • Fulop T, Le Page A, Fortin C, et al. Cellular signaling in the aging immune system. Curr Opin Immunol 2014; 29:105-111.
    • (2014) Curr Opin Immunol , vol.29 , pp. 105-111
    • Fulop, T.1    Le Page, A.2    Fortin, C.3
  • 16
    • 84865121012 scopus 로고    scopus 로고
    • Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
    • Faner R, Rojas M, Macnee W, Agusti A. Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2012; 186:306-313.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 306-313
    • Faner, R.1    Rojas, M.2    Macnee, W.3    Agusti, A.4
  • 17
    • 34247108103 scopus 로고    scopus 로고
    • Analyses of immunosenescent markers in patients with autoimmune disease
    • Thewissen M, Somers V, Venken K, et al. Analyses of immunosenescent markers in patients with autoimmune disease. Clin Immunol 2007; 123:209-218.
    • (2007) Clin Immunol , vol.123 , pp. 209-218
    • Thewissen, M.1    Somers, V.2    Venken, K.3
  • 18
    • 84918777207 scopus 로고    scopus 로고
    • TNFalpha polymorphismas marker of immunosenescence for rheumatoid arthritis patients
    • Rodriguez-Carrio J, Alperi-Lopez M, Lopez P, et al. TNFalpha polymorphismas marker of immunosenescence for rheumatoid arthritis patients. Exp Gerontol 2015; 61:123-129.
    • (2015) Exp Gerontol , vol.61 , pp. 123-129
    • Rodriguez-Carrio, J.1    Alperi-Lopez, M.2    Lopez, P.3
  • 19
    • 77952489797 scopus 로고    scopus 로고
    • CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis
    • Gilani SR, Vuga LJ, Lindell KO, et al. CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis. PLoS One 2010; 5:e8959.
    • (2010) PLoS One , vol.5 , pp. e8959
    • Gilani, S.R.1    Vuga, L.J.2    Lindell, K.O.3
  • 20
    • 84936869900 scopus 로고    scopus 로고
    • Circulating naive and memory CD4+ T-cells and metabolic syndrome in patients with systemic lupus erythematosus: Data from a primarily Mestizo population
    • Ugarte-Gil MF, Sanchez-Zuniga C, Gamboa-Cardenas RV, et al. Circulating naive and memory CD4+ T-cells and metabolic syndrome in patients with systemic lupus erythematosus: data from a primarily Mestizo population. Rheumatology 2015; 54:1302-1307.
    • (2015) Rheumatology , vol.54 , pp. 1302-1307
    • Ugarte-Gil, M.F.1    Sanchez-Zuniga, C.2    Gamboa-Cardenas, R.V.3
  • 21
    • 84901748297 scopus 로고    scopus 로고
    • Age-related changes in tissue macrophages precede cardiac functional impairment
    • Pinto AR, Godwin JW, Chandran A, et al. Age-related changes in tissue macrophages precede cardiac functional impairment. Aging 2014; 6:399-413.
    • (2014) Aging , vol.6 , pp. 399-413
    • Pinto, A.R.1    Godwin, J.W.2    Chandran, A.3
  • 22
    • 84901033375 scopus 로고    scopus 로고
    • Epigenetics of aging and aging-related disease
    • Brunet A, Berger SL. Epigenetics of aging and aging-related disease. J Gerontol A Biol Sci Med Sci 2014; 69 (Suppl 1):S17-S20.
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. S17-S20
    • Brunet, A.1    Berger, S.L.2
  • 23
    • 84923338418 scopus 로고    scopus 로고
    • Epigenetics, the holy grail in the pathogenesis of systemic sclerosis
    • [Epub ahead of print]
    • Altorok N, Almeshal N, Wang Y, Kahaleh B. Epigenetics, the holy grail in the pathogenesis of systemic sclerosis. Rheumatology 2014. [Epub ahead of print]
    • (2014) Rheumatology
    • Altorok, N.1    Almeshal, N.2    Wang, Y.3    Kahaleh, B.4
  • 24
    • 85027906306 scopus 로고    scopus 로고
    • Sirt1 regulates canonical TGF-beta signalling to control fibroblast activation and tissue fibrosis
    • [Epub ahead of print]
    • Zerr P, Palumbo-Zerr K, Huang J, et al. Sirt1 regulates canonical TGF-beta signalling to control fibroblast activation and tissue fibrosis. Ann Rheum Dis 2014. [Epub ahead of print]
    • (2014) Ann Rheum Dis
    • Zerr, P.1    Palumbo-Zerr, K.2    Huang, J.3
  • 25
    • 84928641974 scopus 로고    scopus 로고
    • The histone deacetylase sirtuin 1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting transforming growth factor beta signaling
    • Wei J, Ghosh AK, Chu H, et al. The histone deacetylase sirtuin 1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting transforming growth factor beta signaling. Arthritis Rheumatol 2015; 67:1323-1334.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 1323-1334
    • Wei, J.1    Ghosh, A.K.2    Chu, H.3
  • 26
    • 84869058572 scopus 로고    scopus 로고
    • Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease
    • Sampson N, Berger P, Zenzmaier C. Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease. Oxid Med Cell Longev 2012; 2012:458276.
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 458276
    • Sampson, N.1    Berger, P.2    Zenzmaier, C.3
  • 27
    • 84893415235 scopus 로고    scopus 로고
    • NADPH oxidase-dependent redox signaling in TGF-beta-mediated fibrotic responses
    • Jiang F, Liu GS, Dusting GJ, Chan EC. NADPH oxidase-dependent redox signaling in TGF-beta-mediated fibrotic responses. Redox Biol 2014; 2:267-272.
    • (2014) Redox Biol , vol.2 , pp. 267-272
    • Jiang, F.1    Liu, G.S.2    Dusting, G.J.3    Chan, E.C.4
  • 28
    • 84929902758 scopus 로고    scopus 로고
    • A reactive oxygen speciesmediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis
    • Spadoni T, Svegliati Baroni S, Amico D, et al. A reactive oxygen speciesmediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis. Arthritis Rheumatol 2015; 67:1611-1622.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 1611-1622
    • Spadoni, T.1    Svegliati Baroni, S.2    Amico, D.3
  • 29
    • 69949114515 scopus 로고    scopus 로고
    • NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
    • Hecker L, Vittal R, Jones T, et al. NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med 2009; 15:1077-1081.
    • (2009) Nat Med , vol.15 , pp. 1077-1081
    • Hecker, L.1    Vittal, R.2    Jones, T.3
  • 30
    • 84899103689 scopus 로고    scopus 로고
    • Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance
    • Hecker L, Logsdon NJ, Kurundkar D, et al. Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med 2014; 6:231ra47.
    • (2014) Sci Transl Med , vol.6 , pp. 231ra47
    • Hecker, L.1    Logsdon, N.J.2    Kurundkar, D.3
  • 31
    • 84920742368 scopus 로고    scopus 로고
    • Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence
    • Sanders YY, Liu H, Liu G, Thannickal VJ. Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence. Free Radic Biol Med 2015; 79:197-205.
    • (2015) Free Radic Biol Med , vol.79 , pp. 197-205
    • Sanders, Y.Y.1    Liu, H.2    Liu, G.3    Thannickal, V.J.4
  • 32
    • 84899785349 scopus 로고    scopus 로고
    • Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice
    • Sanders YY, Hagood JS, Liu H, et al. Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice. Eur Respir J 2014; 43:1448-1458.
    • (2014) Eur Respir J , vol.43 , pp. 1448-1458
    • Sanders, Y.Y.1    Hagood, J.S.2    Liu, H.3
  • 33
    • 84886769903 scopus 로고    scopus 로고
    • Canonical Wnt signalling as a key regulator of fibrogenesis: Implications for targeted therapies?
    • Dees C, Distler JH. Canonical Wnt signalling as a key regulator of fibrogenesis: implications for targeted therapies? Exp Dermatol 2013; 22:710-713.
    • (2013) Exp Dermatol , vol.22 , pp. 710-713
    • Dees, C.1    Distler, J.H.2
  • 34
    • 84899914231 scopus 로고    scopus 로고
    • The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis
    • Dees C, Schlottmann I, Funke R, et al. The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis. Ann Rheum Dis 2014; 73:1232-1239.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1232-1239
    • Dees, C.1    Schlottmann, I.2    Funke, R.3
  • 35
    • 84873638532 scopus 로고    scopus 로고
    • Aging, cellular senescence, and cancer
    • Campisi J. Aging, cellular senescence, and cancer. Annu Rev Physiol 2013; 75:685-705.
    • (2013) Annu Rev Physiol , vol.75 , pp. 685-705
    • Campisi, J.1
  • 36
    • 49749145668 scopus 로고    scopus 로고
    • Senescence of activated stellate cells limits liver fibrosis
    • Krizhanovsky V, Yon M, Dickins RA, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008; 134:657-667.
    • (2008) Cell , vol.134 , pp. 657-667
    • Krizhanovsky, V.1    Yon, M.2    Dickins, R.A.3
  • 37
    • 84904702784 scopus 로고    scopus 로고
    • Cellular senescence: From physiology to pathology
    • Munoz-Espin D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol 2014; 15:482-496.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 482-496
    • Munoz-Espin, D.1    Serrano, M.2
  • 38
    • 84919904439 scopus 로고    scopus 로고
    • Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis
    • Piera-Velazquez S, Jimenez SA. Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis. Curr Rheumatol Rep 2015; 17:473.
    • (2015) Curr Rheumatol Rep , vol.17 , pp. 473
    • Piera-Velazquez, S.1    Jimenez, S.A.2
  • 39
    • 84874591240 scopus 로고    scopus 로고
    • The role of mitochondria in aging
    • Bratic A, Larsson NG. The role of mitochondria in aging. J Clin Invest 2013; 123:951-957.
    • (2013) J Clin Invest , vol.123 , pp. 951-957
    • Bratic, A.1    Larsson, N.G.2
  • 40
    • 84922287355 scopus 로고    scopus 로고
    • Blue journal conference. Aging and susceptibility to lung disease
    • Thannickal VJ, Murthy M, Balch WE, et al. Blue journal conference. Aging and susceptibility to lung disease. Am J Respir Crit Care Med 2015; 191:261-269.
    • (2015) Am J Respir Crit Care Med , vol.191 , pp. 261-269
    • Thannickal, V.J.1    Murthy, M.2    Balch, W.E.3
  • 41
    • 84941944128 scopus 로고    scopus 로고
    • Mitochondria autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay
    • [Epub ahead of print]
    • Lionaki E, Markaki M, Palikaras K, Tavernarakis N. Mitochondria autophagy and age-associated neurodegenerative diseases: new insights into a complex interplay. Biochim Biophys Acta 2015. [Epub ahead of print]
    • (2015) Biochim Biophys Acta
    • Lionaki, E.1    Markaki, M.2    Palikaras, K.3    Tavernarakis, N.4
  • 42
    • 84961290427 scopus 로고    scopus 로고
    • PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis
    • Bueno M, Lai YC, Romero Y, et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest 2015; 125:521-538.
    • (2015) J Clin Invest , vol.125 , pp. 521-538
    • Bueno, M.1    Lai, Y.C.2    Romero, Y.3
  • 43
    • 84925433501 scopus 로고    scopus 로고
    • Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis
    • Patel AS, Song JW, Chu SG, et al. Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis. PLoS One 2015; 10:e0121246.
    • (2015) PLoS One , vol.10 , pp. e0121246
    • Patel, A.S.1    Song, J.W.2    Chu, S.G.3
  • 44
    • 84902795026 scopus 로고    scopus 로고
    • Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis
    • Gazdhar A, Lebrecht D, Roth M, et al. Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis. Sci Rep 2014; 4:5336.
    • (2014) Sci Rep , vol.4 , pp. 5336
    • Gazdhar, A.1    Lebrecht, D.2    Roth, M.3
  • 45
    • 84911165025 scopus 로고    scopus 로고
    • Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway
    • Song X, Wang B, Lin S, et al. Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway. J Cell Mol Med 2014; 18:2198-2212.
    • (2014) J Cell Mol Med , vol.18 , pp. 2198-2212
    • Song, X.1    Wang, B.2    Lin, S.3
  • 46
    • 84871916907 scopus 로고    scopus 로고
    • Regulation and functional significance of autophagy in respiratory cell biology and disease
    • Patel AS, Morse D, Choi AM. Regulation and functional significance of autophagy in respiratory cell biology and disease. Am J Respir Cell Mol Biol 2013; 48:1-9.
    • (2013) Am J Respir Cell Mol Biol , vol.48 , pp. 1-9
    • Patel, A.S.1    Morse, D.2    Choi, A.M.3
  • 48
    • 83455203536 scopus 로고    scopus 로고
    • Defective autophagy in fibroblasts may contribute to fibrogenesis in autoimmune processes
    • Del Principe D, Vona R, Giordani L, et al. Defective autophagy in fibroblasts may contribute to fibrogenesis in autoimmune processes. Curr Pharm Des 2011; 17:3878-3887.
    • (2011) Curr Pharm des , vol.17 , pp. 3878-3887
    • Del Principe, D.1    Vona, R.2    Giordani, L.3
  • 49
    • 84877298036 scopus 로고    scopus 로고
    • Self-eating: Friend or foe? The emerging role of autophagy in idiopathic pulmonary fibrosis
    • Margaritopoulos GA, Tsitoura E, Tzanakis N, et al. Self-eating: friend or foe? The emerging role of autophagy in idiopathic pulmonary fibrosis. Biomed Res Int 2013; 2013:420497.
    • (2013) Biomed Res Int , vol.2013 , pp. 420497
    • Margaritopoulos, G.A.1    Tsitoura, E.2    Tzanakis, N.3
  • 51
    • 84942511008 scopus 로고    scopus 로고
    • Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis
    • Cabrera S, Maciel M, Herrera I, et al. Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis. Autophagy 2015; 11:670-684.
    • (2015) Autophagy , vol.11 , pp. 670-684
    • Cabrera, S.1    Maciel, M.2    Herrera, I.3
  • 52
    • 84899639570 scopus 로고    scopus 로고
    • IPF fibroblasts are desensitized to type I collagen matrixinduced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases
    • Nho RS, Hergert P. IPF fibroblasts are desensitized to type I collagen matrixinduced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases. PLoS One 2014; 9:e94616.
    • (2014) PLoS One , vol.9 , pp. e94616
    • Nho, R.S.1    Hergert, P.2
  • 53
    • 84896731487 scopus 로고    scopus 로고
    • Autophagy is a key feature in the pathogenesis of systemic sclerosis
    • Frech T, De Domenico I, Murtaugh MA, et al. Autophagy is a key feature in the pathogenesis of systemic sclerosis. Rheumatol Int 2014; 34:435-439.
    • (2014) Rheumatol Int , vol.34 , pp. 435-439
    • Frech, T.1    De Domenico, I.2    Murtaugh, M.A.3
  • 54
    • 84906322037 scopus 로고    scopus 로고
    • Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts
    • Dumit VI, Kuttner V, Kappler J, et al. Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts. J Invest Dermatol 2014; 134:2321-2330.
    • (2014) J Invest Dermatol , vol.134 , pp. 2321-2330
    • Dumit, V.I.1    Kuttner, V.2    Kappler, J.3


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