-
1
-
-
0037470488
-
Evolutionary medicine: from dwarf model systems to healthy centenarians
-
Longo V.D., and Finch C.E. Evolutionary medicine: from dwarf model systems to healthy centenarians. Science 299 (2003) 1342-1346
-
(2003)
Science
, vol.299
, pp. 1342-1346
-
-
Longo, V.D.1
Finch, C.E.2
-
2
-
-
0036245337
-
Mechanisms of ageing: public or private?
-
Partridge L., and Gems D. Mechanisms of ageing: public or private?. Nat. Rev. Genet. 3 (2002) 165-175
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 165-175
-
-
Partridge, L.1
Gems, D.2
-
3
-
-
19944432549
-
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?
-
Leroi A.M., et al. What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?. Mech. Ageing Dev. 126 (2005) 421-429
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 421-429
-
-
Leroi, A.M.1
-
4
-
-
13844249825
-
Is aging programmed?
-
Austad S.N. Is aging programmed?. Aging Cells 3 (2004) 249-251
-
(2004)
Aging Cells
, vol.3
, pp. 249-251
-
-
Austad, S.N.1
-
6
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M., McVey M., and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 (1999) 2570-2580
-
(1999)
Genes Dev.
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
7
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (2001) 227-230
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
8
-
-
5644279201
-
Role of sirtuin proteins in life extension by caloric restriction
-
Masoro E.J. Role of sirtuin proteins in life extension by caloric restriction. Mech. Ageing Dev. 125 (2004) 591-594
-
(2004)
Mech. Ageing Dev.
, vol.125
, pp. 591-594
-
-
Masoro, E.J.1
-
9
-
-
2942564591
-
Sirtuins: Sir2-related NAD-dependent protein deacetylases
-
North B.J., and Verdin E. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol. 5 (2004) 224
-
(2004)
Genome Biol.
, vol.5
, pp. 224
-
-
North, B.J.1
Verdin, E.2
-
10
-
-
0033600176
-
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
-
Frye R.A. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260 (1999) 273-279
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.260
, pp. 273-279
-
-
Frye, R.A.1
-
11
-
-
0037108799
-
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
-
Onyango P., Celic I., McCaffery J.M., Boeke J.D., and Feinberg A.P. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc. Natl. Acad. Sci. USA 99 (2002) 13653-13658
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13653-13658
-
-
Onyango, P.1
Celic, I.2
McCaffery, J.M.3
Boeke, J.D.4
Feinberg, A.P.5
-
12
-
-
0037135972
-
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
-
Schwer B., North B.J., Frye R.A., Ott M., and Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J. Cell. Biol. 158 (2002) 647-657
-
(2002)
J. Cell. Biol.
, vol.158
, pp. 647-657
-
-
Schwer, B.1
North, B.J.2
Frye, R.A.3
Ott, M.4
Verdin, E.5
-
13
-
-
26244436281
-
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
-
Michishita E., Park J.Y., Burneskis J.M., Barrett J.C., and Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 16 (2005) 4623-4635
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4623-4635
-
-
Michishita, E.1
Park, J.Y.2
Burneskis, J.M.3
Barrett, J.C.4
Horikawa, I.5
-
14
-
-
17144424946
-
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
-
Shi T., Wang F., Stieren E., and Tong Q. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J. Biol. Chem. 280 (2005) 13560-13567
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 13560-13567
-
-
Shi, T.1
Wang, F.2
Stieren, E.3
Tong, Q.4
-
15
-
-
33748979744
-
Mitochondrial DNA involvement in human longevity
-
(Electronic publication ahead of print)
-
Santoro A., et al. Mitochondrial DNA involvement in human longevity. Biochim. Biophys. Acta (2006) (Electronic publication ahead of print)
-
(2006)
Biochim. Biophys. Acta
-
-
Santoro, A.1
-
16
-
-
33646251112
-
Lipoprotein genotype and conserved pathway for exceptional longevity in humans
-
Atzmon G., et al. Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol. 4 (2006) e113
-
(2006)
PLoS Biol.
, vol.4
-
-
Atzmon, G.1
-
17
-
-
28044445460
-
Targeted disruption of cytosolic SIR2 deacetylase discloses its essential role in Leishmania survival and proliferation
-
Vergnes B., et al. Targeted disruption of cytosolic SIR2 deacetylase discloses its essential role in Leishmania survival and proliferation. Gene 19 (2005) 85-96
-
(2005)
Gene
, vol.19
, pp. 85-96
-
-
Vergnes, B.1
-
18
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B., and Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101 (2004) 15998-16003
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
19
-
-
10744232772
-
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
-
Rose G., et al. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp. Gerontol. 38 (2003) 1065-1070
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 1065-1070
-
-
Rose, G.1
-
20
-
-
19944433088
-
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
-
Bellizzi D., et al. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85 (2005) 258-263
-
(2005)
Genomics
, vol.85
, pp. 258-263
-
-
Bellizzi, D.1
-
21
-
-
33644662970
-
Proteasome function in aging and oxidative stress: implications in protein maintenance failure
-
Farout L., and Friguet B. Proteasome function in aging and oxidative stress: implications in protein maintenance failure. Antioxid. Redox Signaling 8 (2006) 205-216
-
(2006)
Antioxid. Redox Signaling
, vol.8
, pp. 205-216
-
-
Farout, L.1
Friguet, B.2
-
22
-
-
27944510125
-
Proteasome dysfunction in mammalian aging: steps and factors involved
-
Chondrogianni N., and Gonos E.S. Proteasome dysfunction in mammalian aging: steps and factors involved. Exp. Gerontol. 40 (2005) 931-938
-
(2005)
Exp. Gerontol.
, vol.40
, pp. 931-938
-
-
Chondrogianni, N.1
Gonos, E.S.2
-
23
-
-
21744443068
-
Comparative genomics of bidirectional gene pairs and its implications for the evolution of a transcriptional regulation system
-
Koyanagi K.O., Hagiwara M., Itoh T., Gojobori T., and Imanishi T. Comparative genomics of bidirectional gene pairs and its implications for the evolution of a transcriptional regulation system. Gene 353 (2005) 169-176
-
(2005)
Gene
, vol.353
, pp. 169-176
-
-
Koyanagi, K.O.1
Hagiwara, M.2
Itoh, T.3
Gojobori, T.4
Imanishi, T.5
-
24
-
-
0037188910
-
Bidirectional gene organization: a common architectural feature of the human genome
-
Adachi N., and Lieber M.R. Bidirectional gene organization: a common architectural feature of the human genome. Cell 109 (2002) 807-809
-
(2002)
Cell
, vol.109
, pp. 807-809
-
-
Adachi, N.1
Lieber, M.R.2
-
25
-
-
1542719907
-
Origins of bidirectional promoters: computational analyses of intergenic distance in the human genome
-
Takai D., and Jones P.A. Origins of bidirectional promoters: computational analyses of intergenic distance in the human genome. Mol. Biol. Evol. 21 (2004) 463-467
-
(2004)
Mol. Biol. Evol.
, vol.21
, pp. 463-467
-
-
Takai, D.1
Jones, P.A.2
-
26
-
-
0347135948
-
An abundance of bidirectional promoters in human genome
-
Trinklein N.D., et al. An abundance of bidirectional promoters in human genome. Genome Res. 14 (2004) 62-66
-
(2004)
Genome Res.
, vol.14
, pp. 62-66
-
-
Trinklein, N.D.1
-
28
-
-
0032866999
-
The Sp-family of transcription factors
-
Suske G. The Sp-family of transcription factors. Gene 238 (1999) 291-300
-
(1999)
Gene
, vol.238
, pp. 291-300
-
-
Suske, G.1
-
29
-
-
0027428745
-
Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference
-
Fischer K.D., Haese A., and Nowock J. Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference. J. Biol. Chem. 268 (1993) 23915-23923
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 23915-23923
-
-
Fischer, K.D.1
Haese, A.2
Nowock, J.3
-
31
-
-
1842427830
-
The evolutionary dynamics of eukaryotic gene order
-
Hurst L.D., Pal C., and Lercher M.J. The evolutionary dynamics of eukaryotic gene order. Nat. Rev. Genet. 5 (2004) 299-310
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 299-310
-
-
Hurst, L.D.1
Pal, C.2
Lercher, M.J.3
-
32
-
-
0035895502
-
The human transcriptome map: clustering of highly expressed genes in chromosomal domains
-
Caron H., et al. The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Science 291 (2001) 1289-1292
-
(2001)
Science
, vol.291
, pp. 1289-1292
-
-
Caron, H.1
-
33
-
-
0036890388
-
Natural selection promotes the conservation of linkage of co-expressed genes
-
Hurst L.D., Williams E.J.B., and Pal C. Natural selection promotes the conservation of linkage of co-expressed genes. Trends Genet. 18 (2002) 604-606
-
(2002)
Trends Genet.
, vol.18
, pp. 604-606
-
-
Hurst, L.D.1
Williams, E.J.B.2
Pal, C.3
-
34
-
-
14544301584
-
Clusters of co-expressed genes in mammalian genomes are conserved by natural selection
-
Singer G.A.C., Lloyd A.T., Huminiecki L.B., and Wolfe K.H. Clusters of co-expressed genes in mammalian genomes are conserved by natural selection. Mol. Biol. Evol. 22 (2004) 767-775
-
(2004)
Mol. Biol. Evol.
, vol.22
, pp. 767-775
-
-
Singer, G.A.C.1
Lloyd, A.T.2
Huminiecki, L.B.3
Wolfe, K.H.4
-
35
-
-
0037371689
-
Evidence for co-evolution of gene order and recombination rate
-
Pal C., and Hurst L.D. Evidence for co-evolution of gene order and recombination rate. Nat. Genet. 33 (2003) 392-395
-
(2003)
Nat. Genet.
, vol.33
, pp. 392-395
-
-
Pal, C.1
Hurst, L.D.2
-
36
-
-
33746657720
-
Systematic analysis of head-to-head gene organization: evolutionary conservation and potential biological relevance
-
Li Y.Y., et al. Systematic analysis of head-to-head gene organization: evolutionary conservation and potential biological relevance. PLoS Comput. Biol. 2 (2006) e74
-
(2006)
PLoS Comput. Biol.
, vol.2
-
-
Li, Y.Y.1
-
37
-
-
0034044042
-
Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE)
-
Franceschi C., et al. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging Clin. Exp. Res. 12 (2000) 77-84
-
(2000)
Aging Clin. Exp. Res.
, vol.12
, pp. 77-84
-
-
Franceschi, C.1
-
38
-
-
0003752712
-
-
Sinauer, Sunderland, MA
-
Weir B.S. Genetic Data Analysis, II, Methods for Discrete Population Genetic Data (1996), Sinauer, Sunderland, MA
-
(1996)
Genetic Data Analysis, II, Methods for Discrete Population Genetic Data
-
-
Weir, B.S.1
-
39
-
-
0030131165
-
Testing for linkage disequilibrium in genotypic data using the expectation-maximization algorithm
-
Slatkin M., and Excoffier L. Testing for linkage disequilibrium in genotypic data using the expectation-maximization algorithm. Heredity 76 (1996) 377-383
-
(1996)
Heredity
, vol.76
, pp. 377-383
-
-
Slatkin, M.1
Excoffier, L.2
-
40
-
-
0029130796
-
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
-
Excoffier L., and Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol. 12 (1995) 921-927
-
(1995)
Mol. Biol. Evol.
, vol.12
, pp. 921-927
-
-
Excoffier, L.1
Slatkin, M.2
-
41
-
-
0029048325
-
Testing heterozygote excess and deficiency
-
Rousset F., and Raymond M. Testing heterozygote excess and deficiency. Genetics 140 (1995) 1413-1419
-
(1995)
Genetics
, vol.140
, pp. 1413-1419
-
-
Rousset, F.1
Raymond, M.2
|