High-quality fish oil has a more favourable effect than oxidised fish oil on intermediate-density lipoprotein and LDL subclasses: A randomised controlled trial

British Journal of Nutrition

Volumn 117, Issue 9, 2017, Pages 1291-1298

  Rundblad, Amanda ^a   Holven, Kirsten B ^b,c   Ottestad, Inger ^b   Myhrstad, Mari C ^a   Ulven, Stine M ^b  

^a OSLO METROPOLITAN UNIVERSITY   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Fish oil: Oxidised fish oil: Lipoprotein subclasses: LDL

Indexed keywords

CHOLESTEROL ESTER; FISH OIL; INTERMEDIATE DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN EXPERIMENT; INTERVENTION STUDY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUTRITIONAL STATUS; NUTRITIONAL VALUE; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; ADOLESCENT; BLOOD; CHEMISTRY; MIDDLE AGED; OXIDATION REDUCTION REACTION; YOUNG ADULT;

ADOLESCENT; ADULT; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; FEMALE; FISH OILS; HUMANS; LIPOPROTEINS, IDL; MALE; MIDDLE AGED; OXIDATION-REDUCTION; YOUNG ADULT;

EID: 85019717567     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114517001167     Document Type: Article

References (49)

1. Mozaffarian D, Benjamin EJ, Go AS, et al. (2016) Heart disease and stroke statistics-2016 update: A report from the American Heart Association. Circulation 133, e38-e360.
2. Tavazzi L, Maggioni AP, Marchioli R, et al. (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial. Lancet 372, 1223-1230.
3. Gruppo Italiano Per Lo Studio Della Sopravvivenza Nell'Infarto Miocardio - Heart Failure (GISSI-HF) Investigators (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSIPrevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 354, 447-455.
4. Yokoyama M, Origasa H, Matsuzaki M, et al. (2007) Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis. Lancet 369, 1090-1098.
5. Harris WS (1997) n-3 fatty acids and serum lipoproteins: Human studies. Am J Clin Nutr 65, 1645s-1654s.
6. Morris MC, Sacks F, Rosner B (1993) Does fish oil lower blood pressure?. A meta-analysis of controlled trials. Circulation 88, 523-533.
7. Knapp HR (1997) Dietary fatty acids in human thrombosis and hemostasis. Am J Clin Nutr 65, 1687s-1698s.
8. Cheng JW, Santoni F (2008) Omega-3 fatty acid: A role in the management of cardiac arrhythmias?. J Altern Complement Med 14, 965-974.
9. Goodnight SH Jr, Harris WS, Connor WE, et al. (1982) Polyunsaturated fatty acids, hyperlipidemia, and thrombosis. Arteriosclerosis 2, 87-113.
10. Balk EM, Lichtenstein AH, Chung M, et al. (2006) Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review. Atherosclerosis 189, 19-30.
11. Olano-Martin E, Anil E, Caslake MJ, et al. (2010) Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDLcholesterol response to fish oil. Atherosclerosis 209, 104-110.
12. Minihane AM, Khan S, Leigh-Firbank EC, et al. (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler Thromb Vasc Biol 20, 1990-1997.
13. Shahidi F, Zhong Y (2010) Lipid oxidation and improving the oxidative stability. Chem Soc Rev 39, 4067-4079.
14. Albert BB, Derraik JG, Cameron-Smith D, et al. (2015) Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA. Sci Rep 5, 7928.
15. Jackowski SA, Alvi AZ, Mirajkar A, et al. (2015) Oxidation levels of North American over-the-counter n-3 (omega-3) supplements and the influence of supplement formulation and delivery form on evaluating oxidative safety. J Nutr Sci 4, e30.
16. Opperman M, Benade S (2013) Analysis of the omega-3 fatty acid content of South African fish oil supplements: A follow-up study. Cardiovasc J Afr 24, 297-302.
17. Halvorsen BL, Blomhoff R (2011) Determination of lipid oxidation products in vegetable oils and marine omega-3 supplements. Food Nutr Res 55, 10.3402/fnr.v55i0.5792.
18. European Food Safety Authority (2010) Scientific opinion on fish oil for human consumption. Food hygiene, including rancidity. EFSA J 8, 1874.
19. Health Canada (2013) Monograph: Fish oil. http://webprod.hcsc. gc.ca/nhpid-bdipsn/monoReq.do?id=88 (accessed February 2017).
20. Ismail A, Bannenberg G, Rice HB, et al. (2016) Oxidation in EPA- and DHA-rich oils: An overview. Lipid Technol 28, 55-59.
21. Mason RP, Sherratt SC (2017) Omega-3 fatty acid fish oil dietary supplements contain saturated fats and oxidized lipids that may interfere with their intended biological benefits. Biochem Biophys Res Commun 483, 425-429.
22. Nichols PD, Dogan L, Sinclair A (2016) Australian and New Zealand fish oil products in 2016 meet label omega-3 claims and are not oxidized. Nutrients 8, 703.
23. Ottestad I, Vogt G, Retterstol K, et al. (2012) Oxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: A randomised controlled trial. Br J Nutr 108, 315-326.
24. Ottestad I, Retterstol K, Myhrstad MC, et al. (2013) Intake of oxidised fish oil does not affect circulating levels of oxidized LDL or inflammatory markers in healthy subjects. Nutr Metab Cardiovasc Dis 23, e3-e4.
25. Garcia-Hernandez VM, Gallar M, Sanchez-Soriano J, et al. (2013) Effect of omega-3 dietary supplements with different oxidation levels in the lipidic profile of women: A randomized controlled trial. Int J Food Sci Nutr 64, 993-1000.
26. Mallol R, Rodriguez MA, Brezmes J, et al. (2013) Human serum/plasma lipoprotein analysis by NMR: Application to the study of diabetic dyslipidemia. Prog Nucl Magn Reson Spectrosc 70, 1-24.
27. Soininen P, Kangas AJ, Wurtz P, et al. (2009) High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst 134, 1781-1785.
28. Krauss RM (2010) Lipoprotein subfractions and cardiovascular disease risk. Curr Opin Lipidol 21, 305-311.
29. Mostad IL, Bjerve KS, Lydersen S, et al. (2008) Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes. Eur J Clin Nutr 62, 419-429.
30. Erkkila AT, Schwab US, Lehto S, et al. (2014) Effect of fatty and lean fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial. J Clin Lipidol 8, 126-133.
31. Lankinen M, Kolehmainen M, Jaaskelainen T, et al. (2014) Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: A randomized trial (Sysdimet). PLOS ONE 9, e90352.
32. Packard CJ (2006) Small dense low-density lipoprotein and its role as an independent predictor of cardiovascular disease. Curr Opin Lipidol 17, 412-417.
33. Davidson MH, Benes LB (2016) The future of n-3 polyunsaturated fatty acid therapy. Curr Opin Lipidol 27, 570-578.
34. Myhrstad MC, Ottestad I, Gunther CC, et al. (2016) The PBMC transcriptome profile after intake of oxidized versus highquality fish oil: An explorative study in healthy subjects. Genes Nutr 11, 16.
35. Soininen P, Kangas AJ, Wurtz P, et al. (2015) Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ Cardiovasc Genet 8, 192-206.
36. Myhrstad MC, Ulven SM, Gunther CC, et al. (2014) Fish oil supplementation induces expression of genes related to cell cycle, endoplasmic reticulum stress and apoptosis in peripheral blood mononuclear cells: A transcriptomic approach. J Intern Med 276, 498-511.
37. de Mello VD, Kolehmanien M, Schwab U, et al. (2012) Gene expression of peripheral blood mononuclear cells as a tool in dietary intervention studies: What do we know so far?. Mol Nutr Food Res 56, 1160-1172.
38. Albert BB, Cameron-Smith D, Hofman PL, et al. (2013) Oxidation of marine omega-3 supplements and human health. Biomed Res Int 2013, 464921.
39. Turner R, McLean CH, Silvers KM (2006) Are the health benefits of fish oils limited by products of oxidation?. Nutr Res Rev 19, 53-62.
40. Parks JS, Bullock BC (1987) Effect of fish oil versus lard diets on the chemical and physical properties of low density lipoproteins of nonhuman primates. J Lipid Res 28, 173-182.
41. Taylor F, Huffman MD, Macedo AF, et al. (2013) Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev, issue 1, CD004816.
42. Ridker PM (2014) LDL cholesterol: Controversies and future therapeutic directions. Lancet 384, 607-617.
43. Law MR, Wald NJ, Thompson SG (1994) By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?. BMJ 308, 367-372.
44. Yeang C, Witztum JL, Tsimikas S (2015) 'LDL-C' = LDL-C + Lp(a)-C: Implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol 26, 169-178.
45. Baumstark MW, Frey I, Berg A, et al. (1992) Influence of n-3 fatty acids from fish oils on concentration of high- and lowdensity lipoprotein subfractions and their lipid and apolipoprotein composition. Clin Biochem 25, 338-340.
46. Kasbi Chadli F, Nazih H, Krempf M, et al. (2013) Omega 3 fatty acids promote macrophage reverse cholesterol transport in hamster fed high fat diet. PLOS ONE 8, e61109.
47. Bagdade JD, Ritter M, Subbaiah PV (1996) Marine lipids normalize cholesteryl ester transfer in IDDM. Diabetologia 39, 487-491.
48. Khan-Merchant N, Penumetcha M, Meilhac O, et al. (2002) Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. J Nutr 132, 3256-3262.
49. Penumetcha M, Khan-Merchant N, Parthasarathy S (2002) Enhanced solubilization and intestinal absorption of cholesterol by oxidized linoleic acid. J Lipid Res 43, 895-903.