Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice

Journal of Nutrition

Volumn 132, Issue 11, 2002, Pages 3256-3262

  Khan Merchant, Nadya ^a   Penumetcha, Meera ^a   Meilhac, Olivier ^a   Parthasarathy, Sampath ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerotic lesions; Autoantibodies; Lipid hydroxide; Oxidized lipoproteins; Plasma cholesterol

Indexed keywords

AUTOANTIBODY; CORIOLIC ACID; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LINOLEIC ACID; LIPOXYGENASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; FAT INTAKE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; SOYBEAN;

ANIMALIA; GLYCINE MAX;

EID: 0036845143     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.11.3256     Document Type: Article

References (36)

1. Wolff, S. P. & Nourooz-Zadeh, J. (1996) Hypothesis: UK consumption of dietary lipid hydroperoxides: A possible contributory factor to atherosclerosis. Atherosclerosis 119: 261-263.
2. Frankel, E., Smith, L., Hamblin, C., Creveling, R. & Clifford, A. (1984) Occurance of cyclic fatty acid monomers in frying oils used for fast foods. J. Am. Oil Chem. Soc. 61: 87-90.
3. Yagi, K., Kiuchi, K., Saito, Y., Miike, A., Kayahara, N., Tatano, T. & Ohishi, N. (1986) Use of a new methylene blue derivative for determination of lipid peroxides in foods. Biochem. Int. 12: 367-371.
4. Staprans, I., Pan, X. M., Miller, M. & Rapp, J. H. (1993) Effect of dietary lipid peroxides on metabolism of serum chylomicrons in rats. Am. J. Physiol. 264: G561-G568.
5. Staprans, I., Rapp, J. H., Pan, X. M., Kim, K. Y. & Feingold, K. R. (1994) Oxidized lipids in the diet are a source of oxidized lipid in chylomicrons of human serum. Arterioscler. Thromb. 14: 1900-1905.
6. Staprans, I., Rapp, J. H., Pan, X. M. & Feingold, K. R. (1996) Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. J. Lipid Res. 37: 420-430.
7. Penumetcha, M., Khan, N. & Parthasarathy, S. (2000) Dietary oxidized fatty acids: An atherogenic risk? J. Lipid Res. 41: 1473-1480.
8. Quinn, M. T., Parthasarathy, S., Fong, L. G. & Steinberg, D. (1987) Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc. Natl. Acad. Sci. USA 84: 2995-2998.
9. Parthasarathy, S., Khan-Merchant, N., Penumetcha, M., Khan, B. V. & Santanam, N. (2001) Did the antioxidant trials fail to validate the oxidation hypothesis? Curr. Atheroscler. Rep. 3: 392-398.
10. Kaunitz, H., Johnson, R. & Pegus, L. (1965) A long-term nutritional study with fresh and mildly oxidized vegetable and animal fats. J. Am. Oil Chem. Soc. 42: 770-774.
11. Kritchevsky, D. & Tepper, S. A. (1967) Cholesterol vehicle in experimental atherosclerosis. 9. Comparison of heated corn oil and heated olive oil. J. Atheroscler. Res. 7: 647-651.
12. Staprans, I., Rapp, J. H., Pan, X. M., Hardman, D. A. & Feingold, K. R. (1996) Oxidized lipids in the diet accelerate the development of fatty streaks in cholesterol-fed rabbits. Arterioscler. Thromb. Vasc. Biol. 16: 533-538.
13. Greco, A. V. & Mingrone, G. (1990) Serum and biliary lipid pattern in rabbits feeding a diet enriched with unsaturated fatty acids. Exp. Pathol. 40: 19-33.
14. Fruebis, J., Parthasarathy, S. & Steinberg, D. (1992) Evidence for a concerted reaction between lipid hydroperoxides and polypeptides. Proc. Natl. Acad. Sci. USA 89: 10588-10592.
15. Auerbach, B. J., Kiely, J. S. & Cornicelli, J. A. (1992) A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. Anal. Biochem. 201: 375-380.
16. Palinski, W., Ord, V. A., Plump, A. S., Breslow, J. L., Steinberg, D. & Witztum, J. L. (1994) ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis: Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler. Thromb. 14:605-616.
17. Innis-Whitehouse, W., Li, X., Brown, W. V. & Le, N. A. (1998) An efficient chromatographic system for lipoprotein fractionation using whole plasma. J. Lipid Res. 39: 679-690.
18. Regnstrom, J., Strom, K., Moldeus, P. & Nilsson, J. (1993) Analysis of lipoprotein diene formation in human serum exposed to copper. Free Radical Res. Commun. 19: 267-278.
19. Kim, J. G., Sabbagh, F., Santanam, N., Wilcox, J. N., Medford, R. M. & Parthasarathy, S. (1997) Generation of a polyclonal antibody against lipid peroxide-modified proteins. Free Radic. Biol. Med. 23: 251-259.
20. Narasimhamurthy, K. & Raina, P. L. (1999) Long term feeding effects of heated and fried oils on lipids and lipoproteins in rats. Mol. Cell Biochem. 195: 143-153.
21. Liu, J. F. & Lee, Y. W. (1998) Vitamin C supplementation restores the impaired vitamin E status of guinea pigs fed oxidized frying oil. J. Nutr. 128: 116-122.
22. Meilhac, O., Zhou, M., Santanam, N. & Parthasarathy, S. (2000) Lipid peroxides induce expression of catalase in cultured vascular cells. J. Lipid Res. 41: 1205-1213.
23. Agarwal, A., Shiraishi, F., Visner, G. A. & Nick, H. S. (1998) Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells. J. Am. Soc. Nephrol. 9: 1990-1997.
24. Ramasamy, S., Parthasarathy, S. & Harrison, D. G. (1998) Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid. J. Lipid Res. 39: 268-276.
25. Kinscherf, R., Deigner, H. P., Usinger, C., Pill, J., Wagner, M., Kamencic, H., Hou, D., Chen, M., Schmiedt, W., Schrader, M., Kovacs, G., Kato, K. & Metz, J. (1997) Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: Its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits. FASEB J. 11: 1317-1328.
26. Darley-Usmar, V. M., Severn, A., O'Leary, V. J. & Rogers, M. (1991) Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content. Biochem. J. 278: 429-434.
27. Naruszewicz, M., Wozny, E., Mirkiewicz, E., Nowicka, G. & Szostak, W. B. (1987) The effect of thermally oxidized soya bean oil on metabolism of chylomicrons: Increased uptake and degradation of oxidized chylomicrons in cultured mouse macrophages. Atherosclerosis 66: 45-53.
28. Sheehy, P. J., Morrissey, P. A. & Flynn, A. (1994) Consumption of thermally-oxidized sunflower oil by chicks reduces α-tocopherol status and increases susceptibility of tissues to lipid oxidation. Br. J. Nutr. 71: 53-65.
29. Penumetcha, M., Khan-Merchant, N. & Parthasarathy, S. (2002) Oxidized Linoleic Acid, by Mimicking Bile Acids Might Enhance Cholesterol Absorption and Promote Atherosclerosis. In press.
30. Anonymous. (1993) Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). J. Am. Med. Assoc. 269: 3015-3023.
31. Keys, A., Menotti, A., Karvonen, M. J., Aravanis, C., Blackburn, H., Buzina, R., Djordjevic, B. S., Dontas, A. S., Fidanza, F., Keys, M. H. et al. (1986) The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol. 124: 903-915.
32. Shekelle, R. B., Shryock, A. M., Paul, O., Lepper, M., Stamler, J., Liu, S. & Raynor, W. J., Jr. (1981) Diet, serum cholesterol, and death from coronary heart disease: The Western Electric study, N. Engl. J. Med. 304: 65-70.
33. Kanazawa, K. & Ashida, H. (1998) Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. Biochim. Biophys. Acta 1393: 349-361.
34. Kanazawa, K. & Ashida, H. (1998) Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines. Biochim. Biophys. Acta 1393: 336-348.
35. Mensink, R. P. & Katan, M. B. (1992) Effect of dietary fatty acids on serum lipids and lipoproteins: A meta-analysis of 27 trials. Arterioscler. Thromb. 12: 911-919.
36. Thompson, L. & Aust, R. (1983) Lipid changes in french fries and heated oils during commercial deep frying and their nutritional and toxicological implications. Can. Inst. Sci. Technol. J. 16: 246-253.