Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil

Atherosclerosis

Volumn 209, Issue 1, 2010, Pages 104-110

  Olano Martin, Estibaliz ^a   Anil, Eliz ^a   Caslake, Muriel J ^b   Packard, Chris J ^b   Bedford, Dorothy ^b   Stewart, Grace ^b   Peiris, Dammika ^a   Williams, Christine M ^a   Minihane, Anne M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

ApoE genotype; Docosahexaenoic acid (DHA); Eicosapentaenoic acid (EPA); Fish oils; LDL cholesterol; Nutrigenetics

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CHOLESTEROL; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DISEASE PREDISPOSITION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; DRUG MEGADOSE; EX VIVO STUDY; FRACTIONATION; GENOTYPE; HEART PROTECTION; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INTERVENTION STUDY; LIPID COMPOSITION; LIPOPROTEIN BLOOD LEVEL; MALE; NORMAL HUMAN; NUTRIGENOMICS; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; APOLIPOPROTEINS E; CELL LINE; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FISH OILS; GENOTYPE; HUMANS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 77049108658     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.08.024     Document Type: Article

References (36)

1. Bucher H.C., Hengstler P., Schindler C., and Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 112 (2002) 298-304
2. GISSI. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 354 (1999) 447-455
3. Hu F., Bronner L., Willett W., et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. J Am Med Assoc 287 (2002) 1815-1821
4. Kris-Etherton P., Harris W., and Appel L. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler Thromb Vasc Biol 23 (2003) E31-E42
5. Balk E.M., Lichtenstein A.H., Chung M., et al. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 189 (2006) 19-30
6. Harris W. n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 65 Suppl. (1997) 1645S-1654S
7. Minihane A.M., Khan S., Leigh-Firbank E.C., et al. ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler Thromb Vasc Biol 20 (2000) 1990-1997
8. Minihane A.M., Jofre-Monseny L., Olano-Martin E., and Rimbach G.H. Apolipoprotein E genotype, cardiovascular risk and responsiveness to dietary fat manipulation. Proc Nutr Soc 66 (2007) 183-197
9. Sarkkinen E., Korhonen M., Erkkila A., Ebeling T., and Uusitupa M. Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol. Am J Clin Nutr 68 (1998) 1215-1222
10. Leigh-Firbank E.C., Minihane A.M., Leake D.S., et al. Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. Br J Nutr 87 (2002) 435-445
11. Jeon H., and Blacklow S.C. Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem 74 (2005) 535-562
12. Jackson K.G., Maitin V., Leake D.S., Yaqoob P., and Williams C.M. Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells. J Lipid Res 47 (2006) 393-403
13. Henderson L., Gregory J., Irving K., and Swan G. The National Diet & Nutrition Survey: adults aged 19 to 64 years (2003), HMSO, London
14. Hixson J.E., and Vernier D.T. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 31 (1990) 545-548
15. Lipid Research Clinics Program Manual of Laboratory Operations (1975), DHEW Publications
16. Lindgren F.T., Jensen L.C., and Hatch F.T. The isolation and quantitative analysis of serum lipoproteins. Blood Lipids and Lipoproteins: Quantitation, Composition and Metabolism (1972) 181-274
17. Griffin B.A., Caslake M.J., Yip B., et al. Rapid isolation of low density lipoprotein (LDL) subfractions from plasma by density gradient ultracentrifugation. Atherosclerosis 83 (1990) 59-67
18. Havel R.J., Eder H.A., and Bragdon J.H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34 (1955) 1345-1353
19. Folch J., Lees M., and Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226 (1957) 497-509
20. Hamilton J.G., and Comai K. Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica Sep-Pak columns. Lipids 23 (1988) 1146-1149
21. Leake D.S., and Rankin S.M. The oxidative modification of low-density lipoproteins by macrophages. Biochem J 270 (1990) 741-748
22. NCEP. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III): final report. Circulation 106 (2002) 3143-3421
23. Buckley R., Shewring B., Turner R., Yaqoob P., and Minihane A.M. Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects. Br J Nutr 92 (2004) 477-483
24. Grimsgaard S., Bonaa K.H., Hansen J.B., and Nordoy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr 66 (1997) 649-659
25. Mori T., Watts G., Burke V., et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 102 (2000) 1264-1269
26. Woodman R.J., Mori T.A., Burke V., et al. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr 76 (2002) 1007-1015
27. Nestel P.J. Fish oil and cardiovascular disease: lipids and arterial function. Am J Clin Nutr 71 (2000) 228S-231S
28. Mori T., and Woodman R. The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk in humans. Curr Opin Clin Nutr Metab Care 9 (2006) 95-104
29. Harris W.S., and Bulchandani D. Why do omega-3 fatty acids lower serum triglycerides?. Curr Opin Lipidol 17 (2006) 387-393
30. Khan S., Minihane A.M., Talmud P.J., et al. Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype. J Lipid Res 43 (2002) 979-985
31. Chan D.C., Watts G.F., Mori T.A., et al. Randomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity. Am J Clin Nutr 77 (2003) 300-307
32. Harris W.S., Connor W.E., Illingworth D.R., Rothrock D.W., and Foster D.M. Effects of fish oil on VLDL triglyceride kinetics in humans. J Lipid Res 31 (1990) 1549-1558
33. Mori T.A., Burke V., Puddey I.B., et al. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr 71 (2000) 1085-1094
34. Huff M.W., and Telford D.E. Dietary fish oil increases conversion of very low density lipoprotein apoprotein B to low density lipoprotein. Arteriosclerosis 9 (1989) 58-66
35. Demant T., Bedford D., Packard C.J., and Shepherd J. Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. J Clin Invest 88 (1991) 1490-1501
36. Welty F.K., Lichtenstein A.H., Barrett P.H., et al. Effects of ApoE genotype on ApoB-48 and ApoB-100 kinetics with stable isotopes in humans. Arterioscler Thromb Vasc Biol 20 (2000) 1807-1810