Oxidation levels of North American over-the-counter n-3 (omega-3) supplements and the influence of supplement formulation and delivery form on evaluating oxidative safety

Journal of Nutritional Science

Volumn 4, Issue , 2015, Pages

  Jackowski, Stefan A ^a,b   Alvi, Azhar Z ^b   Mirajkar, Abdur ^b   Imani, Zahabia ^b   Gamalevych, Yuliya ^b   Shaikh, Nisar A ^c   Jackowski, George ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b Pivotal Therapeutics Inc   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Anisidine; n 3 Supplements; Omega 3 supplements; Peroxides; PUFA; Total oxidation

Indexed keywords

FLAVORING AGENT; NON PRESCRIPTION DRUG; OMEGA 3 FATTY ACID;

ARTICLE; CANADA; DIETARY SUPPLEMENT; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DOSAGE FORM; DRUG EFFICACY; DRUG FORMULATION; DRUG LABELING; DRUG OXIDATION; DRUG SAFETY; DRUG SCREENING; FLAVOR; HUMAN; NORTH AMERICAN; PRIMARY AND SECONDARY OXIDATION AND TOTAL OXIDATION; PRIORITY JOURNAL;

EID: 84994666044     PISSN: 20486790     EISSN: None     Source Type: Journal    
DOI: 10.1017/jns.2015.21     Document Type: Article

References (34)

1. Health Canada (2011) Eating well with Canada's Food Guide. http://www.hc-sc.gc.ca/fn-an/food-guide-aliment/index-eng.php (accessed August 2015).
2. Canadian Aquaculture Industry Alliance (2013) Farmer seafood and Canadian health: how higher seafood consumption can save lives. http://www.aquaculture.ca/files/documents/2013-11-19FarmedSeafoodandCanadianHealth-Paper.pdf (accessed August 2015).
3. Barns P, Bloom B & Nahin R (2008) Complementary and alternative medicine use among adults and children. CDC National Health Statistics Report no. 12. http://www.cdc.gov/nchs/data/nhsr/nhsr012.pdf (accessed August 2015).
4. Millen AE, Dodd KW & Subar AF (2004) Use of vitamin, mineral, nonvitamin, and nonmineral supplements in the United States: the 1987, 1992, and 2000 National Health Interview Survey results. J Am Diet Assoc 104, 942-950.
5. Guo X, Willows N, Kuhle S, et al. (2009) Use of vitamin and mineral supplements among Canadian adults. Can J Public Health Rev Can Santé Publique 100, 357-360.
6. Albert CM, Campos H, Stampfer MJ, et al. (2002) Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med 346, 1113-1118.
7. Calder PC (2015) Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta 1851, 469-484.
8. Daiello LA, Gongvatana A, Dunsiger S, et al. (2015) Association of fish oil supplement use with preservation of brain volume and cognitive function. Alzheimers Dement 11, 226-235.
9. Harris WS (2010) The omega-3 index: clinical utility for therapeutic intervention. Curr Cardiol Rep 12, 503-508.
10. Khorsan R, Crawford C, Ives JA, et al. (2014) The effect of omega-3 fatty acids on biomarkers of inflammation: a rapid evidence assessment of the literature. Mil Med 179, 11 Suppl., 2-60.
11. Janssen CI & Kiliaan AJ (2014) Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: the influence of LCPUFA on neural development, aging, and neurodegeneration. Prog Lipid Res 53, 1-17.
12. Shaikh NA, Yantha J, Shaikh S, et al. (2014) Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN((R)) REVEAL trial. Mol Cell Biochem 396, 9-22.
13. Shaikh U, Byrd RS & Auinger P (2009) Vitamin and mineral supplement use by children and adolescents in the 1999-2004 National Health and Nutrition Examination Survey: relationship with nutrition, food security, physical activity, and health care access. Arch Pediatr Adolesc Med 163, 150-157.
14. Albert BB, Cameron-Smith D, Hofman PL, et al. (2013) Oxidation of marine omega-3 supplements and human health. Biomed Res Int 2013, article ID 464921.
15. Shahidi F & Zhong Y (2010) Lipid oxidation and improving the oxidative stability. Chem Soc Rev 39, 4067-4079.
16. Garcia-Hernandez VM, Gallar M, Sanchez-Soriano J, et al. (2013) Effect of omega-3 dietary supplements with different oxidation levels in the lipidic profile of women: a randomized controlled trial. Int J Food Sci Nutr 64, 993-1000.
17. Esterbauer H (1993) Cytotoxicity and genotoxicity of lipidoxidation products. Am J Clin Nutr 57, 5 Suppl., 779S-785S.
18. Bartsch H & Nair J (2006) Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch Surg 391, 499-510.
19. Health Canada (2013) Monograph: fish oil. http://webprod.hc-sc. gc.ca/nhpid-bdipsn/monoReq.do?id=88 (accessed August 2015).
20. Global Organization for EPA and DHA and Omega 3s (2012) GOED voluntary monograph (v.4). www.goedomega3.com/index.php/files/download/243 (accessed August 2015).
21. Global Organization for EPA and DHA & Nutrasource Diagnostics (2013) Whitepaper: measurement of environmental contaminants in a globally-representative sample of fish oil supplements. http://info.nutrasource.ca/download-ndi-goed-whitepaperifos (accessed August 2015).
22. Council for Responsible Nutrition (2006) Voluntary monograph: Omega-3 DHA & EPA. http://www.crnusa.org/pdfs/O3FINA LMONOGRAPHdoc.pdf (accessed August 2015).
23. Ritter JC & Budge SM (2012) Key lipid oxidation products can be used to predict sensory quality of fish oils with different levels of EPA and DHA. Lipids 47, 1169-1179.
24. Fierens C, Corthout J (2007) Omega-3 fatty acid preparations - a comparative study. J Pharm Belg 62, 115-119.
25. Kolanowski W (2010) Omega-3 LC PUFA contents and oxidative stability of encapsulated fish oil dietary supplements. Int J Food Prop 13, 498-511.
26. Opperman M, Marais de W & Spinnler Benade AJ (2011) Analysis of omega-3 fatty acid content of South African fish oil supplements. Cardiovasc J Afr 22, 324-329.
27. Opperman M & Benade S (2013) Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. Cardiovasc J Afr 24, 297-302.
28. Albert BB, Derraik JG, Cameron-Smith D, et al. (2015) Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA. Sci Rep 5, 7928.
29. Fantoni C, Cuccio A & Barrera-Arellano D (1996) Brazilian encapsulated fish oils: oxidative stability and fatty acid composition. J Am Oil Chem Soc 73, 251-253.
30. American Oil Chemists' Society (2003) AOCS Official Method CD 8-53. Official Methods and Recommended Practises of the American Oil Chemists' Society. Champaign, IL: AOCS.
31. American Oil Chemists' Society (2003) AOCS Official Method CD 18-90. Official Methods and Recommended Practises of the American Oil Chemists' Society. Champaign, IL: AOCS.
32. Ballantyne CM, Bays HE, Kastelein JJ, et al. (2012) Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). Am J Cardiol 110, 984-992.
33. Braeckman RA, Manku MS, Bays HE, et al. (2013) Icosapent ethyl, a pure EPA omega-3 fatty acid: effects on plasma and red blood cell fatty acids in patients with very high triglyceride levels (results from the MARINE study). Prostaglandins Leukot Essent Fatty Acids 89, 195-201.
34. Nelson SD & Munger MA (2013) Icosapent ethyl for treatment of elevated triglyceride levels. Ann Pharmacother 47, 1517-1523.