Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 21, 2017, Pages E4251-E4260

  Deng, Xufang ^a   Hackbart, Matthew ^a   Mettelman, Robert C ^a   O'Brien, Amornrat ^a   Mielech, Anna M ^a   Yi, Guanghui ^b   Kao, C Cheng ^b   Baker, Susan C ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Coronavirus; DsRNA; Endoribonuclease; Interferon; Nsp15

Indexed keywords

CASPASE 3; CASPASE 7; DOUBLE STRANDED RNA; INTERFERON; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 15; PROTEIN KINASE R; RIBONUCLEASE L; RNA 18S; UNCLASSIFIED DRUG; VIRAL PROTEIN; VIRUS VACCINE; 2-5A-DEPENDENT RIBONUCLEASE; IFIH1 PROTEIN, MOUSE; NONSTRUCTURAL PROTEIN, CORONAVIRUS; RIBONUCLEASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BHK CELL LINE; BONE MARROW DERIVED MACROPHAGE; CELL DEATH; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORONAVIRIDAE; CORONAVIRUS INFECTION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; FIBROBLAST CELL LINE; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; L929 CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; RNA CLEAVAGE; RNA DEGRADATION; VIRUS MUTANT; VIRUS REPLICATION; WEIGHT REDUCTION; ANIMAL; CELL LINE; CORONAVIRINAE; GENETICS; HAMSTER; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; METABOLISM; PATHOLOGY; VIROLOGY;

ANIMALS; APOPTOSIS; CELL LINE; CORONAVIRUS; CORONAVIRUS INFECTIONS; CRICETINAE; ENDORIBONUCLEASES; ENZYME ACTIVATION; IMMUNITY, INNATE; INTERFERON TYPE I; INTERFERON-INDUCED HELICASE, IFIH1; MACROPHAGES; MICE; RNA, DOUBLE-STRANDED; VIRAL NONSTRUCTURAL PROTEINS;

EID: 85019620345     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1618310114     Document Type: Article

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