Nonstructural protein 11 of porcine reproductive and respiratory syndrome virus suppresses both MAVS and RIG-I expression as one of the mechanisms to antagonize Type I interferon production

PLoS ONE

Volumn 11, Issue 12, 2016, Pages

  Sun, Yan ^a,c   Ke, Hanzhong ^a   Han, Mingyuan ^a,d   Chen, Ning ^a,e   Fang, Weihuan ^b   Yoo, Dongwan ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e Department of Oncology Roche R and D Center   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; COMPLEMENTARY DNA; DOUBLE STRANDED RNA; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; MAVS PROTEIN; MESSENGER RNA; NONSTRUCTURAL PROTEIN 11; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; RETINOIC ACID INDUCIBLE PROTEIN I; RIBONUCLEASE; RLR PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VIRAL PROTEIN; ENDONUCLEASE; INTERFERON; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CLONING; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME SPECIFICITY; FRAMESHIFT MUTATION; GENE OVEREXPRESSION; GENE REPRESSION; GENOTYPE; IMMUNOMODULATION; NONHUMAN; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PROGENY; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; VIRUS INFECTION; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS REPLICATION; VIRUS VIABILITY; ANIMAL; BIOSYNTHESIS; CELL LINE; CHLOROCEBUS AETHIOPS; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PIG;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CRICETINAE; DEAD BOX PROTEIN 58; ENDONUCLEASES; GENE EXPRESSION REGULATION; INTERFERON TYPE I; MUTATION, MISSENSE; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SWINE; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 85006913794     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0168314     Document Type: Article

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