Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology

Cell Host and Microbe

Volumn 11, Issue 6, 2012, Pages 607-616

  Zhao, Ling ^a   Jha, Babal K ^b   Wu, Ashley ^a   Elliott, Ruth ^a   Ziebuhr, John ^c   Gorbalenya, Alexander E ^d   Silverman, Robert H ^b   Weiss, Susan R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' PHOSPHODIESTERASE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; INTERFERON; NONSTRUCTURAL PROTEIN 2; PHOSPHODIESTERASE; RIBONUCLEASE L; UNCLASSIFIED DRUG; VIRUS RNA;

ACUTE HEPATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER CELL; MOUSE; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RNA DEGRADATION; SIGNAL TRANSDUCTION; VIRUS CELL INTERACTION; VIRUS REPLICATION;

2',5'-OLIGOADENYLATE SYNTHETASE; ADENINE NUCLEOTIDES; ANIMALS; ENDORIBONUCLEASES; INTERFERONS; LIVER; MICE; MURINE HEPATITIS VIRUS; OLIGORIBONUCLEOTIDES; RNA STABILITY; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE FACTORS; VIRUS REPLICATION;

EID: 84862297105     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2012.04.011     Document Type: Article

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