A dimerization-dependent mechanism drives the endoribonuclease function of porcine reproductive and respiratory syndrome virus nsp11

Journal of Virology

Volumn 90, Issue 9, 2016, Pages 4579-4592

  Shi, Yuejun ^a   Li, Youwen ^a   Lei, Yingying ^a   Ye, Gang ^a   Shen, Zhou ^a   Sun, Limeng ^a   Luo, Rui ^a   Wang, Dang ^a   Fu, Zhen F ^a,b   Xiao, Shaobo ^a   Peng, Guiqing ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ANTIVIRUS AGENT; ARGININE; DIMER; GLYCINE; HISTAMINE; LEUCINE; LYSINE; NSP11 PROTEIN; PHENYLALANINE; PROLINE; RIBONUCLEASE; SERINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG; VALINE; PROTEIN BINDING; RECOMBINANT PROTEIN; VIRAL PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTERIVIRUS; ARTICLE; CONTROLLED STUDY; CORONAVIRIDAE; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE MUTATION; HEK293 CELL LINE; MOLECULAR INTERACTION; MUTAGENESIS; NIDOVIRALES; NONHUMAN; PHYLOGENY; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PRIORITY JOURNAL; RIBOSOME SUBUNIT; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS; VIRUS GENE; WILD TYPE; ANIMAL; BINDING SITE; CELL LINE; CHEMISTRY; CLASSIFICATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MOLECULAR MODEL; MUTATION; PHYSIOLOGY; PIG; PROMOTER REGION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; REPORTER GENE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENDORIBONUCLEASES; ENZYME ACTIVATION; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84964955849     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03065-15     Document Type: Article

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