Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia

Brain

Volumn 140, Issue 5, 2017, Pages 1447-1465

  Arrant, Andrew E ^a   Filiano, Anthony J ^a   Unger, Daniel E ^a   Young, Allen H ^a   Roberson, Erik D ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

dementia; experimental models; FTD; gene therapy; progranulin

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; NESTIN; PROGRANULIN; GRN PROTEIN, MOUSE; SIGNAL PEPTIDE;

ADENO ASSOCIATED VIRUS; ALLELE; AMYGDALA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NUCLEUS (AMYGDALA); CONFOCAL MICROSCOPY; CONTROLLED STUDY; FOREBRAIN; FRONTOTEMPORAL DEMENTIA; IMMUNOREACTIVITY; MALE; MEDIAL PREFRONTAL CORTEX; MOUSE; NESTING; NONHUMAN; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOCIAL BEHAVIOR; SOCIAL DOMINANCE; SOCIAL ENVIRONMENT; VIRAL GENE DELIVERY SYSTEM; Y-MAZE TEST; ANIMAL; CONDITIONING; DEFICIENCY; DEPENDOPARVOVIRUS; DISEASE MODEL; FEMALE; GENE VECTOR; GENETICS; KNOCKOUT MOUSE; MAZE TEST; METABOLISM; NERVE CELL; TRANSGENIC MOUSE;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CONDITIONING (PSYCHOLOGY); DEPENDOVIRUS; DISEASE MODELS, ANIMAL; FEMALE; FRONTOTEMPORAL DEMENTIA; GENETIC VECTORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAZE LEARNING; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NESTIN; NEURONS; PREFRONTAL CORTEX; SOCIAL BEHAVIOR; SOCIAL DOMINANCE;

EID: 85019611196     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awx060     Document Type: Article

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