Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice

Neuroscience

Volumn 250, Issue , 2013, Pages 8-19

  Tanaka, Y ^a   Matsuwaki, T ^a   Yamanouchi, K ^a   Nishihara, M ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Lysosome; Microglia; Progranulin; Traumatic brain injury

Indexed keywords

LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROGRANULIN; S6 KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL ACTIVATION; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; KNOCKOUT MOUSE; LYSOSOME; MALE; MICROGLIA; MOUSE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRAUMATIC BRAIN INJURY; WILD TYPE;

AD; ALS; ALZHEIMER'S DISEASE; AMYLOID Β; AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANOVA; AΒ; BASIC HELIX-LOOP-HELIX; BETA-GLUCOCEREBROSIDASE; BHLH; C4; CLEAR; COMPLEMENT C4; COORDINATED LYSOSOMAL EXPRESSION AND REGULATION; CYBA; CYTOCHROME B-245 LIGHT CHAIN; DISTILLED WATER; DW; EDTA; ETHYLENEDIAMINETETRAACETIC ACID; FJB; FLUORO-JADE B; FRONTOTEMPORAL LOBAR DEGENERATION; FTLD; GBA; GRANULIN; GRN; GRN-DEFICIENT; HPRT; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IBA1; IMMUNOREACTIVE; IONIZED CALCIUM-BINDING ADAPTOR MOLECULE 1; IR; KO; LAMP1; LSD; LYSOSOMAL STORAGE DISEASE; LYSOSOME; LYSOSOME-ASSOCIATED MEMBRANE PROTEIN 1; MACROPHAGE EXPRESSED GENE 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICROGLIA; MPEG1; MTORC1; NCL; NEURONAL CEROID LIPOFUSCINOSIS; P-NITROPHENYL PHOSPHATE; PBS CONTAINING TRITON X-100; PBST; PGRN; PHENYLMETHYLSULFONYL FLUORIDE; PMSF; PNPP; POLYVINYLIDENE FLUORIDE; PROGRANULIN; PVDF; RIBOSOMAL S6 KINASE 1; ROOM TEMPERATURE; RT; S6K1; SEM; STANDARD ERROR OF THE MEAN; TAR DNA-BINDING PROTEIN-43; TBI; TBS CONTAINING TWEEN 20; TBST; TDP-43; TFEB; TRANSCRIPTION FACTOR EB; TRAUMATIC BRAIN INJURY; V-ATPASE; VACUOLAR H(+)-ATPASE; WILD-TYPE; WT;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BLOTTING, WESTERN; BRAIN INJURIES; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; NEURONS; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; TOR SERINE-THREONINE KINASES;

EID: 84881220459     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.06.049     Document Type: Article

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