Microphysiological Human Brain and Neural Systems-on-a-Chip: Potential Alternatives to Small Animal Models and Emerging Platforms for Drug Discovery and Personalized Medicine

Stem Cell Reviews and Reports

Volumn 13, Issue 3, 2017, Pages 381-406

  Haring, Alexander P ^a,b   Sontheimer, Harald ^b,c   Johnson, Blake N ^a,b  

^a Virginia Polytechnic Institute and State University   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c VIRGINIA TECH CARILION SCHOOL OF MEDICINE   (United States)

Author keywords

3D bioprinting; 3D cell culture; Brain on a chip; Microfluidics; Nervous system on a chip; Organ on a chip

Indexed keywords

AGAROSE; DIMETICONE; HYALURONIC ACID; MATRIGEL; POLITEF; POLYCAPROLACTONE; POLYCARBONATE; SILICON;

ARTICLE; BIOMIMETICS; DRUG DESIGN; EXTRACELLULAR MATRIX; HUMAN; INDUCED PLURIPOTENT STEM CELL; LASER PATTERNING; MICROELECTRODE; MICROFLUIDICS; MICROTECHNOLOGY; NERVOUS SYSTEM; NEURAL SYSTEM ON A CHIP; NEUROANATOMY; NEUROLOGIC DISEASE; NEUROPHYSIOLOGY; PATHOPHYSIOLOGY; PERSONALIZED MEDICINE; PHOTOLITHOGRAPHY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SPINOTHALAMIC NERVE CELL; THREE DIMENSIONAL PRINTING; TISSUE SCAFFOLD; TWO-DIMENSIONAL IMAGING; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; BRAIN; DEVICES; DRUG DEVELOPMENT; LAB ON A CHIP; METABOLISM; PATHOLOGY; PROCEDURES;

ANIMALS; BRAIN; DRUG DISCOVERY; HUMANS; LAB-ON-A-CHIP DEVICES; NERVOUS SYSTEM DISEASES;

EID: 85019133056     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-017-9738-0     Document Type: Article

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