A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons

Journal of Neuroscience Methods

Volumn 209, Issue 1, 2012, Pages 35-39

  Lu, Xi ^a   Kim Han, Jeong S ^b   O'Malley, Karen L ^b   Sakiyama Elbert, Shelly E ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axonal transport; Parkinson's disease; Soft lithography

Indexed keywords

DIMETICONE;

ANALYZER; ARTICLE; CELL CULTURE; CELL TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; IMAGE ANALYSIS; MICROFLUIDICS; MITOCHONDRIAL TRANSPORT; PARKINSON DISEASE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; AXONAL TRANSPORT; CELL CULTURE TECHNIQUES; DOPAMINERGIC NEURONS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MICE, TRANSGENIC; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROSCOPY, CONFOCAL; MITOCHONDRIA;

EID: 84862244535     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2012.05.021     Document Type: Article

References (11)

1. Araki T., Sasaki Y., Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 2004, 305(5686):1010-1013.
2. Blum D., Torch S., Lambeng N., Nissou M., Benabid A.L., Sadoul R., Verna J.M. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 2001, 65(2):135-172.
3. Campenot R.B. Local control of neurite development by nerve growth factor. Proc Natl Acad Sci U S A 1977, 74(10):4516-4519.
4. Cheng H.C., Ulane C.M., Burke R.E. Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol 2010, 67(6):715-725.
5. Ivins K.J., Bui E.T., Cotman C.W. Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis. Neurobiol Dis 1998, 5(5):365-378.
6. +, specifically impairs mitochondrial transport in dopamine axons. J Neurosci 2011, 31(19):7212-7221.
7. Kim Y.T., Karthikeyan K., Chirvi S., Dave D.P. Neuro-optical microfluidic platform to study injury and regeneration of single axons. Lab Chip 2009, 9(17):2576-2581.
8. Mayeux R. Epidemiology of neurodegeneration. Annu Rev Neurosci 2003, 26:81-104.
9. Taylor A.M., Blurton-Jones M., Rhee S.W., Cribbs D.H., Cotman C.W., Jeon N.L. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods 2005, 2(8):599-605.
10. Taylor A.M., Rhee S.W., Jeon N.L. Microfluidic chambers for cell migration and neuroscience research. Methods Mol Biol 2006, 321:167-177.
11. Yu W., Sun Y., Guo S., Lu B. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet 2011, 20(16):3227-3240.