A disease-associated mutant of NLRC4 shows enhanced interaction with SUG1 leading to constitutive fadddependent caspase-8 activation and cell death

Journal of Biological Chemistry

Volumn 292, Issue 4, 2017, Pages 1218-1230

  Raghawan, Akhouri Kishore ^a   Sripada, Anand ^a   Gopinath, Gayathri ^a   Pushpanjali, Pendyala ^a   Kumar, Yatender ^a,b   Radha, Vegesna ^a   Swarup, Ghanshyam ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b NETAJI SUBHAS INSTITUTE OF TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; CYTOLOGY; ENZYME ACTIVITY; PHOSPHORYLATION; PROTEINS;

ADAPTOR PROTEINS; APOPTOTIC CELL DEATH; CELLULAR PROTEINS; INNATE IMMUNE RESPONSE; NOD-LIKE RECEPTORS; PATHOGEN-ASSOCIATED MOLECULAR PATTERNS; POINT MUTATIONS; UBIQUITINATED PROTEINS;

CELLS;

ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATASE; CASPASE 8; CYTOPLASMIC RECEPTOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; MUTANT PROTEIN; NOD LIKE RECEPTOR FAMILY CARD CONTAINING 4; SERINE; SUG1 PROTEIN; UNCLASSIFIED DRUG; AAA PROTEIN; CALCIUM BINDING PROTEIN; CASP8 PROTEIN, HUMAN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; FADD PROTEIN, HUMAN; LIM PROTEIN; NLRC4 PROTEIN, HUMAN; PROTEASOME; PSMC5 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; AUTOINFLAMMATORY DISEASE; CELL DEATH; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LUNG EPITHELIUM; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; A-549 CELL LINE; AMINO ACID SUBSTITUTION; GENETICS; HEREDITARY PERIODIC FEVER; METABOLISM; MISSENSE MUTATION;

A549 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SUBSTITUTION; ATPASES ASSOCIATED WITH DIVERSE CELLULAR ACTIVITIES; CALCIUM-BINDING PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; CASPASE 8; CELL DEATH; ENZYME ACTIVATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HEREDITARY AUTOINFLAMMATORY DISEASES; HUMANS; LIM DOMAIN PROTEINS; MUTATION, MISSENSE; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 85019005737     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.763979     Document Type: Article

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