메뉴 건너뛰기




Volumn 21, Issue 5, 2011, Pages 862-873

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6

Author keywords

[No Author keywords available]

Indexed keywords

DICKKOPF 1 PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; WNT PROTEIN;

EID: 80755186529     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2011.09.003     Document Type: Article
Times cited : (151)

References (62)
  • 2
    • 20344398197 scopus 로고    scopus 로고
    • Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling
    • Ai M., Holmen S.L., Van Hul W., Williams B.O., Warman M.L. Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Mol. Cell. Biol. 2005, 25:4946-4955.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 4946-4955
    • Ai, M.1    Holmen, S.L.2    Van Hul, W.3    Williams, B.O.4    Warman, M.L.5
  • 3
    • 0034933057 scopus 로고    scopus 로고
    • Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
    • Bafico A., Liu G., Yaniv A., Gazit A., Aaronson S.A. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. 2001, 3:683-686.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 683-686
    • Bafico, A.1    Liu, G.2    Yaniv, A.3    Gazit, A.4    Aaronson, S.A.5
  • 4
    • 34447526757 scopus 로고    scopus 로고
    • Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling
    • Balemans W., Devogelaer J.P., Cleiren E., Piters E., Caussin E., Van Hul W. Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling. J. Bone Miner. Res. 2007, 22:708-716.
    • (2007) J. Bone Miner. Res. , vol.22 , pp. 708-716
    • Balemans, W.1    Devogelaer, J.P.2    Cleiren, E.3    Piters, E.4    Caussin, E.5    Van Hul, W.6
  • 8
    • 0036337388 scopus 로고    scopus 로고
    • Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins
    • Brott B.K., Sokol S.Y. Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol. Cell. Biol. 2002, 22:6100-6110.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6100-6110
    • Brott, B.K.1    Sokol, S.Y.2
  • 10
    • 53149105939 scopus 로고    scopus 로고
    • Structural insight into the mechanisms of Wnt signaling antagonism by Dkk
    • Chen L., Wang K., Shao Y., Huang J., Li X., Shan J., Wu D., Zheng J.J. Structural insight into the mechanisms of Wnt signaling antagonism by Dkk. J. Biol. Chem. 2008, 283:23364-23370.
    • (2008) J. Biol. Chem. , vol.283 , pp. 23364-23370
    • Chen, L.1    Wang, K.2    Shao, Y.3    Huang, J.4    Li, X.5    Shan, J.6    Wu, D.7    Zheng, J.J.8
  • 12
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease
    • Clevers H. Wnt/β-catenin signaling in development and disease. Cell 2006, 127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 13
    • 0013623497 scopus 로고
    • Determination of the partial specific volume of conjugated proteins
    • Durschlag H. Determination of the partial specific volume of conjugated proteins. Colloid Polym. Sci. 1989, 267:1139-1150.
    • (1989) Colloid Polym. Sci. , vol.267 , pp. 1139-1150
    • Durschlag, H.1
  • 16
    • 62649139615 scopus 로고    scopus 로고
    • DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering
    • Franke D., Svergun D.I. DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering. J. Appl. Crystallogr. 2009, 42:342-346.
    • (2009) J. Appl. Crystallogr. , vol.42 , pp. 342-346
    • Franke, D.1    Svergun, D.I.2
  • 17
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Osteoporosis-Pseudoglioma Syndrome Collaborative Group
    • Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., Wang H., Cundy T., Glorieux F.H., Lev D., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001, 107:513-523. Osteoporosis-Pseudoglioma Syndrome Collaborative Group.
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3    Rawadi, G.4    Roman-Roman, S.5    Reginato, A.M.6    Wang, H.7    Cundy, T.8    Glorieux, F.H.9    Lev, D.10
  • 20
    • 33748742271 scopus 로고    scopus 로고
    • Protein N-glycosylation in the baculovirus-insect cell expression system and engineering of insect cells to produce "mammalianized" recombinant glycoproteins
    • Harrison R.L., Jarvis D.L. Protein N-glycosylation in the baculovirus-insect cell expression system and engineering of insect cells to produce "mammalianized" recombinant glycoproteins. Adv. Virus Res. 2006, 68:159-191.
    • (2006) Adv. Virus Res. , vol.68 , pp. 159-191
    • Harrison, R.L.1    Jarvis, D.L.2
  • 21
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way
    • He X., Semenov M., Tamai K., Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development 2004, 131:1663-1677.
    • (2004) Development , vol.131 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 23
    • 0035013711 scopus 로고    scopus 로고
    • Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair
    • Jeon H., Meng W., Takagi J., Eck M.J., Springer T.A., Blacklow S.C. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat. Struct. Biol. 2001, 8:499-504.
    • (2001) Nat. Struct. Biol. , vol.8 , pp. 499-504
    • Jeon, H.1    Meng, W.2    Takagi, J.3    Eck, M.J.4    Springer, T.A.5    Blacklow, S.C.6
  • 24
    • 6344241957 scopus 로고    scopus 로고
    • Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5
    • Jiao X., Ventruto V., Trese M.T., Shastry B.S., Hejtmancik J.F. Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5. Am. J. Hum. Genet. 2004, 75:878-884.
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 878-884
    • Jiao, X.1    Ventruto, V.2    Trese, M.T.3    Shastry, B.S.4    Hejtmancik, J.F.5
  • 25
    • 0037092049 scopus 로고    scopus 로고
    • Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    • Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass D.A., Hartmann C., Li L., Hwang T.H., Brayton C.F., et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 2002, 157:303-314.
    • (2002) J. Cell Biol. , vol.157 , pp. 303-314
    • Kato, M.1    Patel, M.S.2    Levasseur, R.3    Lobov, I.4    Chang, B.H.5    Glass, D.A.6    Hartmann, C.7    Li, L.8    Hwang, T.H.9    Brayton, C.F.10
  • 26
    • 2342441840 scopus 로고    scopus 로고
    • The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
    • Kelly O.G., Pinson K.I., Skarnes W.C. The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development 2004, 131:2803-2815.
    • (2004) Development , vol.131 , pp. 2803-2815
    • Kelly, O.G.1    Pinson, K.I.2    Skarnes, W.C.3
  • 27
    • 0345169163 scopus 로고    scopus 로고
    • Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution
    • Koch M.H.J., Vachette P., Svergun D.I. Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution. Q. Rev. Biophys. 2003, 36:147-227.
    • (2003) Q. Rev. Biophys. , vol.36 , pp. 147-227
    • Koch, M.H.J.1    Vachette, P.2    Svergun, D.I.3
  • 29
    • 0035124442 scopus 로고    scopus 로고
    • Automated matching of high- and low-resolution structural models
    • Kozin M.B., Svergun D.I. Automated matching of high- and low-resolution structural models. J. Appl. Crystallogr. 2001, 34:33-41.
    • (2001) J. Appl. Crystallogr. , vol.34 , pp. 33-41
    • Kozin, M.B.1    Svergun, D.I.2
  • 31
    • 0037155185 scopus 로고    scopus 로고
    • Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled
    • Li L., Mao J., Sun L., Liu W., Wu D. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J. Biol. Chem. 2002, 277:5977-5981.
    • (2002) J. Biol. Chem. , vol.277 , pp. 5977-5981
    • Li, L.1    Mao, J.2    Sun, L.3    Liu, W.4    Wu, D.5
  • 34
    • 67649386522 scopus 로고    scopus 로고
    • Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains
    • Liu C.C., Pearson C., Bu G. Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains. J. Biol. Chem. 2009, 284:15299-15307.
    • (2009) J. Biol. Chem. , vol.284 , pp. 15299-15307
    • Liu, C.C.1    Pearson, C.2    Bu, G.3
  • 35
    • 0042131956 scopus 로고    scopus 로고
    • A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor
    • Liu G., Bafico A., Harris V.K., Aaronson S.A. A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol. Cell. Biol. 2003, 23:5825-5835.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5825-5835
    • Liu, G.1    Bafico, A.2    Harris, V.K.3    Aaronson, S.A.4
  • 36
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 2004, 20:781-810.
    • (2004) Annu. Rev. Cell Dev. Biol. , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 37
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: components, mechanisms, and diseases
    • MacDonald B.T., Tamai K., He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 2009, 17:9-26.
    • (2009) Dev. Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 39
    • 0037413696 scopus 로고    scopus 로고
    • Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling
    • Mao B., Niehrs C. Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene 2003, 302:179-183.
    • (2003) Gene , vol.302 , pp. 179-183
    • Mao, B.1    Niehrs, C.2
  • 41
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 2001, 411:321-325.
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 42
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
    • Mao J., Wang J., Liu B., Pan W., Farr G.H., Flynn C., Yuan H., Takada S., Kimelman D., Li L., Wu D. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 2001, 7:801-809.
    • (2001) Mol. Cell , vol.7 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3    Pan, W.4    Farr, G.H.5    Flynn, C.6    Yuan, H.7    Takada, S.8    Kimelman, D.9    Li, L.10    Wu, D.11
  • 46
    • 33845359084 scopus 로고    scopus 로고
    • Function and biological roles of the Dickkopf family of Wnt modulators
    • Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006, 25:7469-7481.
    • (2006) Oncogene , vol.25 , pp. 7469-7481
    • Niehrs, C.1
  • 47
    • 0034484513 scopus 로고    scopus 로고
    • SAXS experiments on absolute scale with Kratky systems using water as a secondary standard
    • Orthaber D., Bergmann A., Glatter O. SAXS experiments on absolute scale with Kratky systems using water as a secondary standard. J. Appl. Crystallogr. 2000, 33:218-225.
    • (2000) J. Appl. Crystallogr. , vol.33 , pp. 218-225
    • Orthaber, D.1    Bergmann, A.2    Glatter, O.3
  • 48
    • 0031059866 scopus 로고    scopus 로고
    • Processing of x-ray diffraction data collected in oscillation mode
    • Otwinowski Z., Minor W. Processing of x-ray diffraction data collected in oscillation mode. Methods Enzymol. 1997, 276:307-326.
    • (1997) Methods Enzymol. , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 49
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • Pinson K.I., Brennan J., Monkley S., Avery B.J., Skarnes W.C. An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 2000, 407:535-538.
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 50
    • 22844443861 scopus 로고    scopus 로고
    • Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes
    • Qin M., Hayashi H., Oshima K., Tahira T., Hayashi K., Kondo H. Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes. Hum. Mutat. 2005, 26:104-112.
    • (2005) Hum. Mutat. , vol.26 , pp. 104-112
    • Qin, M.1    Hayashi, H.2    Oshima, K.3    Tahira, T.4    Hayashi, K.5    Kondo, H.6
  • 51
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T., Clevers H. Wnt signalling in stem cells and cancer. Nature 2005, 434:843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 53
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali A., Blundell T.L. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 1993, 234:779-815.
    • (1993) J. Mol. Biol. , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 54
    • 52049099892 scopus 로고    scopus 로고
    • DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation
    • Semënov M.V., Zhang X., He X. DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation. J. Biol. Chem. 2008, 283:21427-21432.
    • (2008) J. Biol. Chem. , vol.283 , pp. 21427-21432
    • Semënov, M.V.1    Zhang, X.2    He, X.3
  • 55
    • 0029185933 scopus 로고
    • CRYSOL: a program to evaluate x-ray solution scattering of biological macromolecules from atomic coordinates
    • Svergun D., Barberato C., Koch M.H.J. CRYSOL: a program to evaluate x-ray solution scattering of biological macromolecules from atomic coordinates. J. Appl. Crystallogr. 1995, 28:768-773.
    • (1995) J. Appl. Crystallogr. , vol.28 , pp. 768-773
    • Svergun, D.1    Barberato, C.2    Koch, M.H.J.3
  • 56
    • 0041858013 scopus 로고    scopus 로고
    • Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface
    • Takagi J., Yang Y., Liu J.H., Wang J.H., Springer T.A. Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface. Nature 2003, 424:969-974.
    • (2003) Nature , vol.424 , pp. 969-974
    • Takagi, J.1    Yang, Y.2    Liu, J.H.3    Wang, J.H.4    Springer, T.A.5
  • 58
    • 0037701585 scopus 로고    scopus 로고
    • Uniqueness of ab initio shape determination in small-angle scattering
    • Volkov V.V., Svergun D.I. Uniqueness of ab initio shape determination in small-angle scattering. J. Appl. Crystallogr. 2003, 36:860-864.
    • (2003) J. Appl. Crystallogr. , vol.36 , pp. 860-864
    • Volkov, V.V.1    Svergun, D.I.2
  • 59
    • 53149087478 scopus 로고    scopus 로고
    • Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism
    • Wang K., Zhang Y., Li X., Chen L., Wang H., Wu J., Zheng J., Wu D. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J. Biol. Chem. 2008, 283:23371-23375.
    • (2008) J. Biol. Chem. , vol.283 , pp. 23371-23375
    • Wang, K.1    Zhang, Y.2    Li, X.3    Chen, L.4    Wang, H.5    Wu, J.6    Zheng, J.7    Wu, D.8
  • 61
    • 71749096157 scopus 로고    scopus 로고
    • Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation
    • Yasui N., Mihara E., Nampo M., Tamura-Kawakami K., Unno H., Matsumoto K., Takagi J. Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation. J. Immunol. Methods 2010, 352:153-160.
    • (2010) J. Immunol. Methods , vol.352 , pp. 153-160
    • Yasui, N.1    Mihara, E.2    Nampo, M.3    Tamura-Kawakami, K.4    Unno, H.5    Matsumoto, K.6    Takagi, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.