Impact of cytosine methylation on DNA binding specificities of human transcription factors

Science

Volumn 356, Issue 6337, 2017, Pages

  Yin, Yimeng ^a   Morgunova, Ekaterina ^a   Jolma, Arttu ^a   Kaasinen, Eevi ^a   Sahu, Biswajyoti ^b   Khund Sayeed, Syed ^c   Das, Pratyush K ^b   Kivioja, Teemu ^b   Dave, Kashyap ^a   Zhong, Fan ^a   Nitta, Kazuhiro R ^a   Taipale, Minna ^a   Popov, Alexander ^d   Ginno, Paul A ^e   Domcke, Silvia ^e,f   Yan, Jian ^a   Schübeler, Dirk ^e,f   Vinson, Charles ^c   Taipale, Jussi ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL CANCER INSTITUTE   (United States)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^e FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^f UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; CYTOSINE; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; LIGAND; METHYL GROUP; TRANSCRIPTION FACTOR; CYTIDYLYL-3'-5'-GUANOSINE; DINUCLEOSIDE PHOSPHATE; DNA; PROTEIN BINDING;

CHEMICAL BINDING; DNA; GENE EXPRESSION; GENOME; HYDROPHOBICITY; METHYLATION; PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DNA FLANKING REGION; DNA METHYLATION; DNA MODIFICATION; DNA SEQUENCE; DNA STRUCTURE; EPIGENETICS; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; STEREOSPECIFICITY; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT APTAMER TECHNIQUE; CHEMISTRY; CLASSIFICATION; CPG ISLAND; GENETIC EPIGENESIS; HUMAN GENOME;

CPG ISLANDS; CYTOSINE; DINUCLEOSIDE PHOSPHATES; DNA; DNA METHYLATION; EPIGENESIS, GENETIC; GENOME, HUMAN; HUMANS; PROTEIN BINDING; PROTEIN DOMAINS; SELEX APTAMER TECHNIQUE; TRANSCRIPTION FACTORS;

EID: 85018754019     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaj2239     Document Type: Article

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