메뉴 건너뛰기




Volumn 7, Issue 1, 2017, Pages

Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; AGRP PROTEIN, MOUSE; ESTROGEN RECEPTOR ALPHA;

EID: 85018741899     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-01393-0     Document Type: Article
Times cited : (10)

References (83)
  • 1
    • 84874376748 scopus 로고    scopus 로고
    • Cross-talk between metabolism and reproduction: The role of POMC and SF1 neurons
    • 10.3389/fendo.2011.00098 22649394
    • Xu, Y., Faulkner, L. D. & Hill, J. W. Cross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 Neurons. Frontiers in Endocrinology 2, 98, doi: 10.3389/fendo.2011.00098 (2011).
    • (2011) Frontiers in Endocrinology , vol.2 , pp. 98
    • Xu, Y.1    Faulkner, L.D.2    Hill, J.W.3
  • 2
    • 78649502664 scopus 로고    scopus 로고
    • Kisspeptins: Bridging energy homeostasis and reproduction
    • 10.1016/j.brainres.2010.08.057 1:CAS:528:DC%2BC3cXhsVyht7%2FP 20800054
    • Castellano, J. M., Bentsen, A. H., Mikkelsen, J. D. & Tena-Sempere, M. Kisspeptins: bridging energy homeostasis and reproduction. Brain Research 1364, 129-138, doi: 10.1016/j.brainres.2010.08.057 (2010).
    • (2010) Brain Research , vol.1364 , pp. 129-138
    • Castellano, J.M.1    Bentsen, A.H.2    Mikkelsen, J.D.3    Tena-Sempere, M.4
  • 3
    • 45549104270 scopus 로고    scopus 로고
    • Hypothalamic pathways linking energy balance and reproduction
    • 10.1152/ajpendo.00670.2007 1:CAS:528:DC%2BD1cXlvFCjurk%3D 18285524
    • Hill, J. W., Elmquist, J. K. & Elias, C. F. Hypothalamic pathways linking energy balance and reproduction. American Journal of Physiology. Endocrinology and Metabolism 294, E827-832, doi: 10.1152/ajpendo.00670.2007 (2008).
    • (2008) American Journal of Physiology. Endocrinology and Metabolism , vol.294 , pp. E827-E832
    • Hill, J.W.1    Elmquist, J.K.2    Elias, C.F.3
  • 4
    • 4344561363 scopus 로고    scopus 로고
    • A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    • 10.1210/en.2004-0431 1:CAS:528:DC%2BD2cXnt1CisbY%3D 15217982
    • Gottsch, M. L. et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145, 4073-4077, doi: 10.1210/en.2004-0431 (2004).
    • (2004) Endocrinology , vol.145 , pp. 4073-4077
    • Gottsch, M.L.1
  • 5
    • 80053899725 scopus 로고    scopus 로고
    • Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction
    • 10.1016/j.cmet.2011.08.009 1:CAS:528:DC%2BC3MXht12rtLrN 21982706 3235745
    • Xu, Y. et al. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metabolism 14, 453-465, doi: 10.1016/j.cmet.2011.08.009 (2011).
    • (2011) Cell Metabolism , vol.14 , pp. 453-465
    • Xu, Y.1
  • 6
    • 84871683410 scopus 로고    scopus 로고
    • Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice
    • 10.1210/en.2012-2007 1:CAS:528:DC%2BC3sXlt1Cjsw%3D%3D 23211707
    • Zhu, L. et al. Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology 154, 150-158, doi: 10.1210/en.2012-2007 (2013).
    • (2013) Endocrinology , vol.154 , pp. 150-158
    • Zhu, L.1
  • 7
    • 70349452304 scopus 로고    scopus 로고
    • Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake
    • 10.1073/pnas.0904747106 2009PNAS.10615932O 1:CAS:528:DC%2BD1MXhtFOqtrnJ 19805233 2747221
    • Olofsson, L. E., Pierce, A. A. & Xu, A. W. Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proceedings of the National Academy of Sciences of the United States of America 106, 15932-15937, doi: 10.1073/pnas.0904747106 (2009).
    • (2009) Proceedings of the National Academy of Sciences of the United States of America , vol.106 , pp. 15932-15937
    • Olofsson, L.E.1    Pierce, A.A.2    Xu, A.W.3
  • 8
    • 85047688692 scopus 로고    scopus 로고
    • Energy metabolism and fertility: A balance preserved for female health
    • 10.1038/nrendo.2013.203 24146033
    • Della Torre, S., Benedusi, V., Fontana, R. & Maggi, A. Energy metabolism and fertility: a balance preserved for female health. Nature Reviews. Endocrinology 10, 13-23, doi: 10.1038/nrendo.2013.203 (2014).
    • (2014) Nature Reviews. Endocrinology , vol.10 , pp. 13-23
    • Della Torre, S.1    Benedusi, V.2    Fontana, R.3    Maggi, A.4
  • 9
    • 79551519965 scopus 로고    scopus 로고
    • Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1
    • 10.1016/j.cmet.2011.01.002 21284987
    • Della Torre, S. et al. Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1. Cell Metabolism 13, 205-214, doi: 10.1016/j.cmet.2011.01.002 (2011).
    • (2011) Cell Metabolism , vol.13 , pp. 205-214
    • Della Torre, S.1
  • 10
    • 84863954467 scopus 로고    scopus 로고
    • Tetradian oscillation of estrogen receptor α is necessary to prevent liver lipid deposition
    • 10.1073/pnas.1205797109 2012PNAS.10911806V 1:CAS:528:DC%2BC38Xht1eqtr%2FE 22761311 3406808
    • Villa, A. et al. Tetradian oscillation of estrogen receptor α is necessary to prevent liver lipid deposition. Proceedings of the National Academy of Sciences of the United States of America 109, 11806-11811, doi: 10.1073/pnas.1205797109 (2012).
    • (2012) Proceedings of the National Academy of Sciences of the United States of America , vol.109 , pp. 11806-11811
    • Villa, A.1
  • 11
    • 84962081939 scopus 로고    scopus 로고
    • An essential role for liver ERalpha in coupling hepatic metabolism to the reproductive cycle
    • 10.1016/j.celrep.2016.03.019 27050513 4835581
    • Della Torre, S. et al. An Essential Role for Liver ERalpha in Coupling Hepatic Metabolism to the Reproductive Cycle. Cell Rep 15, 360-371, doi: 10.1016/j.celrep.2016.03.019 (2016).
    • (2016) Cell Rep , vol.15 , pp. 360-371
    • Della Torre, S.1
  • 12
    • 79958245908 scopus 로고    scopus 로고
    • Nuclear receptor-driven alterations in bile acid and lipid metabolic pathways during gestation
    • 10.1016/j.bbadis.2010.11.001 1:CAS:528:DC%2BC3MXnsVOktbY%3D 21073948
    • Papacleovoulou, G., Abu-Hayyeh, S. & Williamson, C. Nuclear receptor-driven alterations in bile acid and lipid metabolic pathways during gestation. Biochimica Et Biophysica Acta 1812, 879-887, doi: 10.1016/j.bbadis.2010.11.001 (2011).
    • (2011) Biochimica et Biophysica Acta , vol.1812 , pp. 879-887
    • Papacleovoulou, G.1    Abu-Hayyeh, S.2    Williamson, C.3
  • 13
    • 77957964750 scopus 로고    scopus 로고
    • Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function
    • 10.1002/hep.23849 1:CAS:528:DC%2BC3cXhtlejsrjE
    • Milona, A. et al. Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function. Hepatology (Baltimore, Md.) 52, 1341-1349, doi: 10.1002/hep.23849 (2010).
    • (2010) Hepatology (Baltimore, Md.) , vol.52 , pp. 1341-1349
    • Milona, A.1
  • 14
    • 84880502855 scopus 로고    scopus 로고
    • The dietary protein/carbohydrate ratio differentially modifies lipogenesis and protein synthesis in the mammary gland, liver and adipose tissue during gestation and lactation
    • 10.1371/journal.pone.0069338 2013PLoSO.869338V 23874950 3712928
    • Velázquez-Villegas, L. A., Tovar, A. R., López-Barradas, A. M. & Torres, N. The dietary protein/carbohydrate ratio differentially modifies lipogenesis and protein synthesis in the mammary gland, liver and adipose tissue during gestation and lactation. PloS One 8, e69338, doi: 10.1371/journal.pone.0069338 (2013).
    • (2013) PloS One , vol.8 , pp. e69338
    • Velázquez-Villegas, L.A.1    Tovar, A.R.2    López-Barradas, A.M.3    Torres, N.4
  • 15
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • 10.1126/science.286.5439.487 1:CAS:528:DyaK1MXmvVOhtL0%3D
    • Evans, W. E. & Relling, M. V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science (New York, NY) 286, 487-491, doi: 10.1126/science.286.5439.487 (1999).
    • (1999) Science (New York, NY) , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 16
    • 38049007472 scopus 로고    scopus 로고
    • Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver
    • 10.1210/me.2007-0121 1:CAS:528:DC%2BD1cXks1Sjsg%3D%3D
    • Gao, H., Fält, S., Sandelin, A., Gustafsson, J.-A. & Dahlman-Wright, K. Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver. Molecular Endocrinology (Baltimore, Md.) 22, 10-22, doi: 10.1210/me.2007-0121 (2008).
    • (2008) Molecular Endocrinology (Baltimore, Md.) , vol.22 , pp. 10-22
    • Gao, H.1    Fält, S.2    Sandelin, A.3    Gustafsson, J.-A.4    Dahlman-Wright, K.5
  • 17
    • 84869229985 scopus 로고    scopus 로고
    • Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning
    • 10.1038/emboj.2012.250 1:CAS:528:DC%2BC38XhtlGqtbbJ 22990237 3501217
    • Joly-Amado, A. et al. Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning. The EMBO journal 31, 4276-4288, doi: 10.1038/emboj.2012.250 (2012).
    • (2012) The EMBO Journal , vol.31 , pp. 4276-4288
    • Joly-Amado, A.1
  • 18
    • 84874391991 scopus 로고    scopus 로고
    • Arcuate AgRP neurons and the regulation of energy balance
    • 10.3389/fendo.2012.00169 1:CAS:528:DC%2BC3sXmvVCqtrs%3D 23293630 3530831
    • Cansell, C., Denis, R. G. P., Joly-Amado, A., Castel, J. & Luquet, S. Arcuate AgRP neurons and the regulation of energy balance. Frontiers in Endocrinology 3, 169, doi: 10.3389/fendo.2012.00169 (2012).
    • (2012) Frontiers in Endocrinology , vol.3 , pp. 169
    • Cansell, C.1    Denis, R.G.P.2    Joly-Amado, A.3    Castel, J.4    Luquet, S.5
  • 19
    • 84870624154 scopus 로고    scopus 로고
    • Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
    • 10.1038/embor.2012.174 1:CAS:528:DC%2BC38Xhs1GksbzL 23146889 3512417
    • Varela, L. & Horvath, T. L. Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO reports 13, 1079-1086, doi: 10.1038/embor.2012.174 (2012).
    • (2012) EMBO Reports , vol.13 , pp. 1079-1086
    • Varela, L.1    Horvath, T.L.2
  • 20
    • 34249651956 scopus 로고    scopus 로고
    • Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    • 10.1016/j.cmet.2007.05.004 17550779
    • Könner, A. C. et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metabolism 5, 438-449, doi: 10.1016/j.cmet.2007.05.004 (2007).
    • (2007) Cell Metabolism , vol.5 , pp. 438-449
    • Könner, A.C.1
  • 21
    • 12844278828 scopus 로고    scopus 로고
    • Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus
    • 10.1016/j.brainres.2004.11.008 1:CAS:528:DC%2BD2MXosVKisQ%3D%3D 15680952
    • Breen, T. L., Conwell, I. M. & Wardlaw, S. L. Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Brain Research 1032, 141-148, doi: 10.1016/j.brainres.2004.11.008 (2005).
    • (2005) Brain Research , vol.1032 , pp. 141-148
    • Breen, T.L.1    Conwell, I.M.2    Wardlaw, S.L.3
  • 22
    • 70649092451 scopus 로고    scopus 로고
    • Hormone and glucose signalling in POMC and AgRP neurons
    • 10.1113/jphysiol.2009.179192 1:CAS:528:DC%2BD1MXhsVyrtb7L 19770186 2793863
    • Belgardt, B. F., Okamura, T. & Brüning, J. C. Hormone and glucose signalling in POMC and AgRP neurons. The Journal of Physiology 587, 5305-5314, doi: 10.1113/jphysiol.2009.179192 (2009).
    • (2009) The Journal of Physiology , vol.587 , pp. 5305-5314
    • Belgardt, B.F.1    Okamura, T.2    Brüning, J.C.3
  • 23
    • 33745838578 scopus 로고    scopus 로고
    • Central insulin action in energy and glucose homeostasis
    • 10.1172/JCI29063 1:CAS:528:DC%2BD28XmvV2ltL4%3D 16823473 1483153
    • Plum, L., Belgardt, B. F. & Brüning, J. C. Central insulin action in energy and glucose homeostasis. The Journal of Clinical Investigation 116, 1761-1766, doi: 10.1172/JCI29063 (2006).
    • (2006) The Journal of Clinical Investigation , vol.116 , pp. 1761-1766
    • Plum, L.1    Belgardt, B.F.2    Brüning, J.C.3
  • 24
    • 84899486552 scopus 로고    scopus 로고
    • Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus
    • 10.1523/JNEUROSCI.4861-12.2014
    • Baver, S. B. et al. Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 34, 5486-5496, doi: 10.1523/JNEUROSCI.4861-12.2014 (2014).
    • (2014) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.34 , pp. 5486-5496
    • Baver, S.B.1
  • 25
    • 33644665508 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
    • 10.1152/ajpendo.00094.2005 1:CAS:528:DC%2BD28XlslKrug%3D%3D 16046456
    • Morrison, C. D., Morton, G. J., Niswender, K. D., Gelling, R. W. & Schwartz, M. W. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. American Journal of Physiology. Endocrinology and Metabolism 289, E1051-1057, doi: 10.1152/ajpendo.00094.2005 (2005).
    • (2005) American Journal of Physiology. Endocrinology and Metabolism , vol.289 , pp. E1051-E1057
    • Morrison, C.D.1    Morton, G.J.2    Niswender, K.D.3    Gelling, R.W.4    Schwartz, M.W.5
  • 26
    • 84895099544 scopus 로고    scopus 로고
    • Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin
    • 10.1016/j.molmet.2013.10.001 1:CAS:528:DC%2BC3sXhslGltr3F 24567905
    • Wang, Q. et al. Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin. Molecular Metabolism 3, 64-72, doi: 10.1016/j.molmet.2013.10.001 (2014).
    • (2014) Molecular Metabolism , vol.3 , pp. 64-72
    • Wang, Q.1
  • 27
    • 84901427559 scopus 로고    scopus 로고
    • Estrogen replacement therapy regulation of energy metabolism in female mouse hypothalamus
    • 10.1210/en.2013-1731 24635349
    • Fontana, R. et al. Estrogen replacement therapy regulation of energy metabolism in female mouse hypothalamus. Endocrinology 155, 2213-2221, doi: 10.1210/en.2013-1731 (2014).
    • (2014) Endocrinology , vol.155 , pp. 2213-2221
    • Fontana, R.1
  • 28
    • 84879554065 scopus 로고    scopus 로고
    • Kisspeptin as a link between metabolism and reproduction: Evidences from rodent and primate studies
    • 10.1016/j.metabol.2013.01.015 1:CAS:528:DC%2BC3sXisVyjs7w%3D
    • Wahab, F., Atika, B. & Shahab, M. Kisspeptin as a link between metabolism and reproduction: evidences from rodent and primate studies. Metabolism: Clinical and Experimental 62, 898-910, doi: 10.1016/j.metabol.2013.01.015 (2013).
    • (2013) Metabolism: Clinical and Experimental , vol.62 , pp. 898-910
    • Wahab, F.1    Atika, B.2    Shahab, M.3
  • 29
    • 37549000647 scopus 로고    scopus 로고
    • KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake
    • 10.1016/j.mce.2007.10.011 1:CAS:528:DC%2BD2sXhsVOltrfI 18069123
    • Brown, R. E., Imran, S. A., Ur, E. & Wilkinson, M. KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake. Molecular and Cellular Endocrinology 281, 64-72, doi: 10.1016/j.mce.2007.10.011 (2008).
    • (2008) Molecular and Cellular Endocrinology , vol.281 , pp. 64-72
    • Brown, R.E.1    Imran, S.A.2    Ur, E.3    Wilkinson, M.4
  • 30
    • 34748840772 scopus 로고    scopus 로고
    • Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: Analyses using mouse models and a cell line
    • 10.1210/en.2007-0500 1:CAS:528:DC%2BD2sXhtFWls7rP 17595226
    • Luque, R. M., Kineman, R. D. & Tena-Sempere, M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 148, 4601-4611, doi: 10.1210/en.2007-0500 (2007).
    • (2007) Endocrinology , vol.148 , pp. 4601-4611
    • Luque, R.M.1    Kineman, R.D.2    Tena-Sempere, M.3
  • 31
    • 0036288345 scopus 로고    scopus 로고
    • Neither agouti-related protein nor neuropeptide y is critically required for the regulation of energy homeostasis in mice
    • 10.1128/MCB.22.14.5027-5035.2002 1:CAS:528:DC%2BD38XltVOqsbY%3D 12077332 139785
    • Qian, S. et al. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Molecular and Cellular Biology 22, 5027-5035, doi: 10.1128/MCB.22.14.5027-5035.2002 (2002).
    • (2002) Molecular and Cellular Biology , vol.22 , pp. 5027-5035
    • Qian, S.1
  • 32
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • 10.1126/science.1115524 2005Sci.310.683L 1:CAS:528:DC%2BD2MXhtFChsLjI
    • Luquet, S., Perez, F. A., Hnasko, T. S. & Palmiter, R. D. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science (New York, NY) 310, 683-685, doi: 10.1126/science.1115524 (2005).
    • (2005) Science (New York, NY) , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 33
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • 10.1016/j.cell.2008.07.043 1:CAS:528:DC%2BD1cXht1Gkt7nP 18854155 2586330
    • Zhang, X. et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135, 61-73, doi: 10.1016/j.cell.2008.07.043 (2008).
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1
  • 34
    • 84922802034 scopus 로고    scopus 로고
    • Hypothalamic inflammation in the control of metabolic function
    • 10.1146/annurev-physiol-021014-071656 1:CAS:528:DC%2BC2MXls1Ckurg%3D 25668019
    • Valdearcos, M., Xu, A. W. & Koliwad, S. K. Hypothalamic inflammation in the control of metabolic function. Annual Review of Physiology 77, 131-160, doi: 10.1146/annurev-physiol-021014-071656 (2015).
    • (2015) Annual Review of Physiology , vol.77 , pp. 131-160
    • Valdearcos, M.1    Xu, A.W.2    Koliwad, S.K.3
  • 35
    • 84919674550 scopus 로고    scopus 로고
    • Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα
    • 10.1016/j.celrep.2014.09.025 1:CAS:528:DC%2BC2cXhslOrtL3N 25373903 4223650
    • Morselli, E. et al. Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα. Cell Reports 9, 633-645, doi: 10.1016/j.celrep.2014.09.025 (2014).
    • (2014) Cell Reports , vol.9 , pp. 633-645
    • Morselli, E.1
  • 36
    • 84860277644 scopus 로고    scopus 로고
    • Hypothalamic inflammation: A double-edged sword to nutritional diseases
    • 10.1111/j.1749-6632.2011.06388.x 2011NYASA1243E.1C 22417140 4389774
    • Cai, D. & Liu, T. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Annals of the New York Academy of Sciences 1243, E1-39, doi: 10.1111/j.1749-6632.2011.06388.x (2011).
    • (2011) Annals of the New York Academy of Sciences , vol.1243 , pp. E1-E39
    • Cai, D.1    Liu, T.2
  • 37
    • 53249125782 scopus 로고    scopus 로고
    • Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation
    • 10.1210/en.2007-1680 1:CAS:528:DC%2BD1cXhtF2gtbjF 18583425 2582916
    • Scarlett, J. M. et al. Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology 149, 4837-4845, doi: 10.1210/en.2007-1680 (2008).
    • (2008) Endocrinology , vol.149 , pp. 4837-4845
    • Scarlett, J.M.1
  • 38
    • 38949117050 scopus 로고    scopus 로고
    • Aberrant agouti-related protein system in the hypothalamus of the anx/anx mouse is associated with activation of microglia
    • 10.1002/cne.21599 1:CAS:528:DC%2BD1cXitFKntb8%3D 18098136
    • Nilsson, I., Lindfors, C., Fetissov, S. O., Hökfelt, T. & Johansen, J. E. Aberrant agouti-related protein system in the hypothalamus of the anx/anx mouse is associated with activation of microglia. The Journal of Comparative Neurology 507, 1128-1140, doi: 10.1002/cne.21599 (2008).
    • (2008) The Journal of Comparative Neurology , vol.507 , pp. 1128-1140
    • Nilsson, I.1    Lindfors, C.2    Fetissov, S.O.3    Hökfelt, T.4    Johansen, J.E.5
  • 39
    • 0036088134 scopus 로고    scopus 로고
    • Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression
    • 10.1152/ajpendo.00230.2001 1:CAS:528:DC%2BD38Xks12isr8%3D 12006366
    • Wang, H., Storlien, L. H. & Huang, X.-F. Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression. American Journal of Physiology. Endocrinology and Metabolism 282, E1352-1359, doi: 10.1152/ajpendo.00230.2001 (2002).
    • (2002) American Journal of Physiology. Endocrinology and Metabolism , vol.282 , pp. E1352-E1359
    • Wang, H.1    Storlien, L.H.2    Huang, X.-F.3
  • 40
    • 34547687830 scopus 로고    scopus 로고
    • Chronic consumption of a low-fat diet leads to increased hypothalamic agouti-related protein and reduced leptin
    • 10.1016/j.nut.2007.06.001 1:CAS:528:DC%2BD2sXosF2itL0%3D
    • Staszkiewicz, J., Horswell, R. & Argyropoulos, G. Chronic consumption of a low-fat diet leads to increased hypothalamic agouti-related protein and reduced leptin. Nutrition (Burbank, Los Angeles County, Calif.) 23, 665-671, doi: 10.1016/j.nut.2007.06.001 (2007).
    • (2007) Nutrition (Burbank, Los Angeles County, Calif.) , vol.23 , pp. 665-671
    • Staszkiewicz, J.1    Horswell, R.2    Argyropoulos, G.3
  • 41
    • 84856036647 scopus 로고    scopus 로고
    • Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity
    • 10.1371/journal.pone.0030485 2012PLoSO.730485G 1:CAS:528:DC%2BC38XitFeis7g%3D 22276206 3262822
    • Gamber, K. M. et al. Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity. PloS One 7, e30485, doi: 10.1371/journal.pone.0030485 (2012).
    • (2012) PloS One , vol.7 , pp. e30485
    • Gamber, K.M.1
  • 42
    • 83255185095 scopus 로고    scopus 로고
    • Effect of dietary fatty acid composition on food intake, triglycerides, and hypothalamic peptides
    • 10.1016/j.regpep.2011.08.012 1:CAS:528:DC%2BC3MXhs1Shur%2FP 21903140
    • Barson, J. R., Karatayev, O., Gaysinskaya, V., Chang, G.-Q. & Leibowitz, S. F. Effect of dietary fatty acid composition on food intake, triglycerides, and hypothalamic peptides. Regulatory Peptides 173, 13-20, doi: 10.1016/j.regpep.2011.08.012 (2012).
    • (2012) Regulatory Peptides , vol.173 , pp. 13-20
    • Barson, J.R.1    Karatayev, O.2    Gaysinskaya, V.3    Chang, G.-Q.4    Leibowitz, S.F.5
  • 43
    • 55249090498 scopus 로고    scopus 로고
    • Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions
    • 10.1523/JNEUROSCI.2449-08.2008 1:CAS:528:DC%2BD1cXht1Sns7jK
    • Wu, Q., Howell, M. P. & Palmiter, R. D. Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 28, 9218-9226, doi: 10.1523/JNEUROSCI.2449-08.2008 (2008).
    • (2008) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.28 , pp. 9218-9226
    • Wu, Q.1    Howell, M.P.2    Palmiter, R.D.3
  • 44
    • 84862928989 scopus 로고    scopus 로고
    • Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling
    • 10.1017/S0007114511002868 1:CAS:528:DC%2BC38XhtV2qsL4%3D 21733316
    • Wang, Z. et al. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling. The British Journal of Nutrition 107, 229-241, doi: 10.1017/S0007114511002868 (2012).
    • (2012) The British Journal of Nutrition , vol.107 , pp. 229-241
    • Wang, Z.1
  • 45
    • 84862928989 scopus 로고    scopus 로고
    • Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling
    • 10.1017/S0007114511002868 1:CAS:528:DC%2BC38XhtV2qsL4%3D 21733316
    • Wang, Z. et al. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling. Br J Nutr 107, 229-241, doi: 10.1017/S0007114511002868 (2012).
    • (2012) Br J Nutr , vol.107 , pp. 229-241
    • Wang, Z.1
  • 46
    • 34248204347 scopus 로고    scopus 로고
    • Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation
    • 10.1016/j.bbrc.2007.04.092 1:CAS:528:DC%2BD2sXlt1ersL8%3D 17467667
    • Laine, P. S. et al. Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation. Biochem Biophys Res Commun 358, 150-155, doi: 10.1016/j.bbrc.2007.04.092 (2007).
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 150-155
    • Laine, P.S.1
  • 47
    • 84947797161 scopus 로고    scopus 로고
    • GPER/GPR30 knockout mice: Effects of GPER on metabolism
    • 10.1007/978-1-4939-3127-9-38
    • Sharma, G. & Prossnitz, E. R. GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism. Methods in Molecular Biology (Clifton, NJ) 1366, 489-502, doi: 10.1007/978-1-4939-3127-9-38 (2016).
    • (2016) Methods in Molecular Biology (Clifton, NJ) , vol.1366 , pp. 489-502
    • Sharma, G.1    Prossnitz, E.R.2
  • 49
    • 0033047926 scopus 로고    scopus 로고
    • Cyclical variations in the abundance of leptin receptors, but not in circulating leptin, correlate with NPY expression during the oestrous cycle
    • 1:CAS:528:DyaK1MXktVajs7o%3D 10364693
    • Bennett, P. A. et al. Cyclical variations in the abundance of leptin receptors, but not in circulating leptin, correlate with NPY expression during the oestrous cycle. Neuroendocrinology 69, 417-423 (1999).
    • (1999) Neuroendocrinology , vol.69 , pp. 417-423
    • Bennett, P.A.1
  • 51
    • 0344406153 scopus 로고    scopus 로고
    • Differential sensitivity to central leptin and insulin in male and female rats
    • 10.2337/diabetes.52.3.682 1:CAS:528:DC%2BD3sXitFajtrw%3D 12606509
    • Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C. & Woods, S. C. Differential sensitivity to central leptin and insulin in male and female rats. Diabetes 52, 682-687, doi: 10.2337/diabetes.52.3.682 (2003).
    • (2003) Diabetes , vol.52 , pp. 682-687
    • Clegg, D.J.1    Riedy, C.A.2    Smith, K.A.B.3    Benoit, S.C.4    Woods, S.C.5
  • 52
    • 33745298324 scopus 로고    scopus 로고
    • Gonadal hormones determine sensitivity to central leptin and insulin
    • 10.2337/diabetes.55.04.06.db05-1339 1:CAS:528:DC%2BD28XjsVGmtL4%3D 16567519
    • Clegg, D. J., Brown, L. M., Woods, S. C. & Benoit, S. C. Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes 55, 978-987, doi: 10.2337/diabetes.55.04.06.db05-1339 (2006).
    • (2006) Diabetes , vol.55 , pp. 978-987
    • Clegg, D.J.1    Brown, L.M.2    Woods, S.C.3    Benoit, S.C.4
  • 53
    • 36349004794 scopus 로고    scopus 로고
    • Estradiol enhances cholecystokinin-dependent lipid-induced satiation and activates estrogen receptor-alpha-expressing cells in the nucleus tractus solitarius of ovariectomized rats
    • 10.1210/en.2007-0341 1:CAS:528:DC%2BD2sXhsVersrfL 17823256
    • Asarian, L. & Geary, N. Estradiol enhances cholecystokinin-dependent lipid-induced satiation and activates estrogen receptor-alpha-expressing cells in the nucleus tractus solitarius of ovariectomized rats. Endocrinology 148, 5656-5666, doi: 10.1210/en.2007-0341 (2007).
    • (2007) Endocrinology , vol.148 , pp. 5656-5666
    • Asarian, L.1    Geary, N.2
  • 54
    • 0032887181 scopus 로고    scopus 로고
    • Endogenous cholecystokinin's satiating action increases during estrus in female rats
    • 10.1016/S0196-9781(99)00025-X 1:CAS:528:DyaK1MXltFGnt7c%3D 10458514
    • Eckel, L. A. & Geary, N. Endogenous cholecystokinin's satiating action increases during estrus in female rats. Peptides 20, 451-456, doi: 10.1016/S0196-9781(99)00025-X (1999).
    • (1999) Peptides , vol.20 , pp. 451-456
    • Eckel, L.A.1    Geary, N.2
  • 55
    • 34047189195 scopus 로고    scopus 로고
    • Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats
    • 10.2337/db06-0015 1:CAS:528:DC%2BD2sXktFChur0%3D 17251274
    • Clegg, D. J. et al. Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes 56, 1051-1058, doi: 10.2337/db06-0015 (2007).
    • (2007) Diabetes , vol.56 , pp. 1051-1058
    • Clegg, D.J.1
  • 56
    • 84876407588 scopus 로고    scopus 로고
    • Effects of intracerebroventricular ghrelin on food intake and Fos expression in the arcuate nucleus of the hypothalamus in female rats vary with estrous cycle phase
    • 10.1016/j.neulet.2013.02.006 1:CAS:528:DC%2BC3sXjvVOnur4%3D 23435434
    • Sakurazawa, N., Mano-Otagiri, A., Nemoto, T. & Shibasaki, T. Effects of intracerebroventricular ghrelin on food intake and Fos expression in the arcuate nucleus of the hypothalamus in female rats vary with estrous cycle phase. Neuroscience Letters 541, 204-208, doi: 10.1016/j.neulet.2013.02.006 (2013).
    • (2013) Neuroscience Letters , vol.541 , pp. 204-208
    • Sakurazawa, N.1    Mano-Otagiri, A.2    Nemoto, T.3    Shibasaki, T.4
  • 57
    • 84876829711 scopus 로고    scopus 로고
    • Ovariectomy stimulates hepatic fat and cholesterol accumulation in high-fat diet-fed rats
    • 10.1055/s-0032-1329964 1:STN:280:DC%2BC3s3gtVWqtQ%3D%3D 23225241
    • Ngo Sock, E. T. et al. Ovariectomy stimulates hepatic fat and cholesterol accumulation in high-fat diet-fed rats. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme 45, 283-290, doi: 10.1055/s-0032-1329964 (2013).
    • (2013) Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme , vol.45 , pp. 283-290
    • Ngo Sock, E.T.1
  • 58
    • 34848915426 scopus 로고    scopus 로고
    • Time course of liver lipid infiltration in ovariectomized rats: Impact of a high-fat diet
    • 10.1016/j.maturitas.2007.08.002 1:CAS:528:DC%2BD2sXhtFekurfE 17889461
    • Paquette, A., Shinoda, M., Rabasa Lhoret, R., Prud'homme, D. & Lavoie, J.-M. Time course of liver lipid infiltration in ovariectomized rats: impact of a high-fat diet. Maturitas 58, 182-190, doi: 10.1016/j.maturitas.2007.08.002 (2007).
    • (2007) Maturitas , vol.58 , pp. 182-190
    • Paquette, A.1    Shinoda, M.2    Rabasa Lhoret, R.3    Prud'Homme, D.4    Lavoie, J.-M.5
  • 59
    • 84908506595 scopus 로고    scopus 로고
    • Physiological and pathophysiological implications of lipid sensing in the brain
    • 10.1111/dom.12335 1:CAS:528:DC%2BC2cXhsFarsrrJ
    • Picard, A. et al. Physiological and pathophysiological implications of lipid sensing in the brain. Diabetes, Obesity & Metabolism 16(Suppl 1), 49-55, doi: 10.1111/dom.12335 (2014).
    • (2014) Diabetes, Obesity & Metabolism , vol.16 , pp. 49-55
    • Picard, A.1
  • 60
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
    • 10.1523/JNEUROSCI.2760-08.2009 1:CAS:528:DC%2BD1MXhtVKrurw%3D
    • Milanski, M. et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 29, 359-370, doi: 10.1523/JNEUROSCI.2760-08.2009 (2009).
    • (2009) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.29 , pp. 359-370
    • Milanski, M.1
  • 61
    • 70350482557 scopus 로고    scopus 로고
    • Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner
    • 10.1074/jbc.M109.044065 1:CAS:528:DC%2BD1MXhtFyjs77M 19648648 2785667
    • Wong, S. W. et al. Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. The Journal of Biological Chemistry 284, 27384-27392, doi: 10.1074/jbc.M109.044065 (2009).
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 27384-27392
    • Wong, S.W.1
  • 62
    • 84964601654 scopus 로고    scopus 로고
    • Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid
    • 10.1016/j.ejphar.2016.04.024 1:CAS:528:DC%2BC28XntFCms7k%3D 27085899
    • Hwang, D. H., Kim, J.-A. & Lee, J. Y. Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid. European Journal of Pharmacology 785, 24-35, doi: 10.1016/j.ejphar.2016.04.024 (2016).
    • (2016) European Journal of Pharmacology , vol.785 , pp. 24-35
    • Hwang, D.H.1    Kim, J.-A.2    Lee, J.Y.3
  • 63
    • 84949883781 scopus 로고    scopus 로고
    • Saturated fatty acids trigger TLR4-mediated inflammatory response
    • 10.1016/j.atherosclerosis.2015.11.015 1:CAS:528:DC%2BC2MXitVSkt7rN 26687466
    • Rocha, D. M., Caldas, A. P., Oliveira, L. L., Bressan, J. & Hermsdorff, H. H. Saturated fatty acids trigger TLR4-mediated inflammatory response. Atherosclerosis 244, 211-215, doi: 10.1016/j.atherosclerosis.2015.11.015 (2016).
    • (2016) Atherosclerosis , vol.244 , pp. 211-215
    • Rocha, D.M.1    Caldas, A.P.2    Oliveira, L.L.3    Bressan, J.4    Hermsdorff, H.H.5
  • 64
    • 84862812857 scopus 로고    scopus 로고
    • Saturated long-chain fatty acids activate inflammatory signaling in astrocytes
    • 10.1111/j.1471-4159.2012.07660.x 1:CAS:528:DC%2BC38XksFCmsr4%3D 22248073 3296820
    • Gupta, S., Knight, A. G., Keller, J. N. & Bruce-Keller, A. J. Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J Neurochem 120, 1060-1071, doi: 10.1111/j.1471-4159.2012.07660.x (2012).
    • (2012) J Neurochem , vol.120 , pp. 1060-1071
    • Gupta, S.1    Knight, A.G.2    Keller, J.N.3    Bruce-Keller, A.J.4
  • 65
    • 84924217948 scopus 로고    scopus 로고
    • Docosahexaenoic acid (DHA): A modulator of microglia activity and dendritic spine morphology
    • 10.1186/s12974-015-0244-5 25889069 4344754
    • Chang, P. K., Khatchadourian, A., McKinney, R. A. & Maysinger, D. Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology. J Neuroinflammation 12, 34, doi: 10.1186/s12974-015-0244-5 (2015).
    • (2015) J Neuroinflammation , vol.12 , pp. 34
    • Chang, P.K.1    Khatchadourian, A.2    McKinney, R.A.3    Maysinger, D.4
  • 66
    • 84868600772 scopus 로고    scopus 로고
    • Very long-chain fatty acids: Elongation, physiology and related disorders
    • 10.1093/jb/mvs105 1:CAS:528:DC%2BC38Xhs1WqsL7L 22984005
    • Kihara, A. Very long-chain fatty acids: elongation, physiology and related disorders. J Biochem 152, 387-395, doi: 10.1093/jb/mvs105 (2012).
    • (2012) J Biochem , vol.152 , pp. 387-395
    • Kihara, A.1
  • 67
    • 0029589279 scopus 로고
    • Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids
    • 1:CAS:528:DyaK28Xlslygsg%3D%3D 8847474
    • Sprecher, H., Luthria, D. L., Mohammed, B. S. & Baykousheva, S. P. Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J Lipid Res 36, 2471-2477 (1995).
    • (1995) J Lipid Res , vol.36 , pp. 2471-2477
    • Sprecher, H.1    Luthria, D.L.2    Mohammed, B.S.3    Baykousheva, S.P.4
  • 68
    • 84919847348 scopus 로고    scopus 로고
    • Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function
    • 10.1016/j.celrep.2014.11.018 1:CAS:528:DC%2BC2cXitFKnurnN 25497089 4617309
    • Valdearcos, M. et al. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Reports 9, 2124-2138, doi: 10.1016/j.celrep.2014.11.018 (2014).
    • (2014) Cell Reports , vol.9 , pp. 2124-2138
    • Valdearcos, M.1
  • 69
    • 1842523084 scopus 로고    scopus 로고
    • Truncal and hepatic vagotomy reduce suppression of feeding by jejunal lipid infusions
    • 10.1016/j.physbeh.2003.12.012 1:CAS:528:DC%2BD2cXisl2ktb4%3D 15059681
    • Cox, J. E., Kelm, G. R., Meller, S. T., Spraggins, D. S. & Randich, A. Truncal and hepatic vagotomy reduce suppression of feeding by jejunal lipid infusions. Physiol Behav 81, 29-36, doi: 10.1016/j.physbeh.2003.12.012 (2004).
    • (2004) Physiol Behav , vol.81 , pp. 29-36
    • Cox, J.E.1    Kelm, G.R.2    Meller, S.T.3    Spraggins, D.S.4    Randich, A.5
  • 70
    • 0035829039 scopus 로고    scopus 로고
    • Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity
    • 10.1097/00001756-200110080-00024 1:CAS:528:DC%2BD3MXns1GqtLs%3D 11568645
    • Randich, A., Spraggins, D. S., Cox, J. E., Meller, S. T. & Kelm, G. R. Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity. Neuroreport 12, 3101-3105, doi: 10.1097/00001756-200110080-00024 (2001).
    • (2001) Neuroreport , vol.12 , pp. 3101-3105
    • Randich, A.1    Spraggins, D.S.2    Cox, J.E.3    Meller, S.T.4    Kelm, G.R.5
  • 72
    • 27344433932 scopus 로고    scopus 로고
    • Agouti-related peptide-expressing neurons are mandatory for feeding
    • 10.1038/nn1548 1:CAS:528:DC%2BD2MXhtVeqs7zI 16158063
    • Gropp, E. et al. Agouti-related peptide-expressing neurons are mandatory for feeding. Nature Neuroscience 8, 1289-1291, doi: 10.1038/nn1548 (2005).
    • (2005) Nature Neuroscience , vol.8 , pp. 1289-1291
    • Gropp, E.1
  • 73
    • 29144519352 scopus 로고    scopus 로고
    • Effects of hypothalamic neurodegeneration on energy balance
    • 10.1371/journal.pbio.0030415 16296893 1287504
    • Xu, A. W. et al. Effects of hypothalamic neurodegeneration on energy balance. PLoS biology 3, e415, doi: 10.1371/journal.pbio.0030415 (2005).
    • (2005) PLoS Biology , vol.3 , pp. e415
    • Xu, A.W.1
  • 74
    • 70350774226 scopus 로고    scopus 로고
    • Feeding signals and brain circuitry
    • 10.1111/j.1460-9568.2009.06963.x 19878280
    • Dietrich, M. O. & Horvath, T. L. Feeding signals and brain circuitry. The European Journal of Neuroscience 30, 1688-1696, doi: 10.1111/j.1460-9568.2009.06963.x (2009).
    • (2009) The European Journal of Neuroscience , vol.30 , pp. 1688-1696
    • Dietrich, M.O.1    Horvath, T.L.2
  • 75
    • 67549112681 scopus 로고    scopus 로고
    • Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    • 10.1016/j.cell.2009.04.022 19563755 2729323
    • Wu, Q., Boyle, M. P. & Palmiter, R. D. Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137, 1225-1234, doi: 10.1016/j.cell.2009.04.022 (2009).
    • (2009) Cell , vol.137 , pp. 1225-1234
    • Wu, Q.1    Boyle, M.P.2    Palmiter, R.D.3
  • 76
    • 79951999061 scopus 로고    scopus 로고
    • GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism
    • 10.1016/j.ejphar.2010.10.110 1:CAS:528:DC%2BC3MXmtFGju78%3D 21211531 3108334
    • Wu, Q. & Palmiter, R. D. GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism. European Journal of Pharmacology 660, 21-27, doi: 10.1016/j.ejphar.2010.10.110 (2011).
    • (2011) European Journal of Pharmacology , vol.660 , pp. 21-27
    • Wu, Q.1    Palmiter, R.D.2
  • 77
    • 1642349297 scopus 로고    scopus 로고
    • Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice
    • 10.1523/JNEUROSCI.5369-03.2004 1:CAS:528:DC%2BD2cXivF2guro%3D
    • Bouret, S. G., Draper, S. J. & Simerly, R. B. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 24, 2797-2805, doi: 10.1523/JNEUROSCI.5369-03.2004 (2004).
    • (2004) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.24 , pp. 2797-2805
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 78
    • 15544364590 scopus 로고    scopus 로고
    • Maturation of the hypothalamic arcuate agouti-related protein system during postnatal development in the mouse
    • 10.1016/j.devbrainres.2005.01.009 1:CAS:528:DC%2BD2MXivVSgsLk%3D 15804403
    • Nilsson, I., Johansen, J. E., Schalling, M., Hökfelt, T. & Fetissov, S. O. Maturation of the hypothalamic arcuate agouti-related protein system during postnatal development in the mouse. Brain Research. Developmental Brain Research 155, 147-154, doi: 10.1016/j.devbrainres.2005.01.009 (2005).
    • (2005) Brain Research. Developmental Brain Research , vol.155 , pp. 147-154
    • Nilsson, I.1    Johansen, J.E.2    Schalling, M.3    Hökfelt, T.4    Fetissov, S.O.5
  • 79
    • 73649108220 scopus 로고    scopus 로고
    • Cre activity in fetal albCre mouse hepatocytes: Utility for developmental studies
    • doi: 10.1002/dvg.20568
    • Weisend, C. M., Kundert, J. A., Suvorova, E. S., Prigge, J. R. & Schmidt, E. E. Cre activity in fetal albCre mouse hepatocytes: Utility for developmental studies. Genesis 47, 789-792, doi: 10.1002/dvg.20568 (2009).
    • (2009) Genesis , vol.47 , pp. 789-792
    • Weisend, C.M.1    Kundert, J.A.2    Suvorova, E.S.3    Prigge, J.R.4    Schmidt, E.E.5
  • 80
    • 84866172856 scopus 로고    scopus 로고
    • Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women's Health Across the Nation
    • 10.1210/jc.2012-1614 1:CAS:528:DC%2BC38Xhtlylsr3O 22723312 3431568
    • Wildman, R. P. et al. Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women's Health Across the Nation. The Journal of Clinical Endocrinology and Metabolism 97, E1695-1704, doi: 10.1210/jc.2012-1614 (2012).
    • (2012) The Journal of Clinical Endocrinology and Metabolism , vol.97 , pp. E1695-E1704
    • Wildman, R.P.1
  • 81
    • 84861312425 scopus 로고    scopus 로고
    • A lack of ovarian function increases neuroinflammation in aged mice
    • 10.1210/en.2011-1925 1:CAS:528:DC%2BC38Xns1eitbo%3D 22492304 3359599
    • Benedusi, V. et al. A lack of ovarian function increases neuroinflammation in aged mice. Endocrinology 153, 2777-2788, doi: 10.1210/en.2011-1925 (2012).
    • (2012) Endocrinology , vol.153 , pp. 2777-2788
    • Benedusi, V.1
  • 82
    • 0024464856 scopus 로고
    • Monokine production by microglial cell clones
    • 10.1002/eji.1830190815 1:CAS:528:DyaL1MXlslaiu78%3D 2789141
    • Righi, M. et al. Monokine production by microglial cell clones. European Journal of Immunology 19, 1443-1448, doi: 10.1002/eji.1830190815 (1989).
    • (1989) European Journal of Immunology , vol.19 , pp. 1443-1448
    • Righi, M.1
  • 83
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • 10.1016/0166-2236(96)10049-7 1:STN:280:DyaK2s%2FgtVGitg%3D%3D 8843599
    • Kreutzberg, G. W. Microglia: a sensor for pathological events in the CNS. Trends in Neurosciences 19, 312-318, doi: 10.1016/0166-2236(96)10049-7 (1996).
    • (1996) Trends in Neurosciences , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.