Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice

Journal of Biological Chemistry

Volumn 292, Issue 16, 2017, Pages 6786-6798

  Nikonorova, Inna A ^a   Al Baghdadi, Rana J T ^b   Mirek, Emily T ^a   Wang, Yongping ^a   Goudie, Michael P ^a   Wetstein, Berish B ^a   Dixon, Joseph L ^b,c   Hine, Christopher ^d   Mitchell, James R ^d   Adams, Christopher M ^e   Wek, X Ronald C ^f   Anthony, Tracy G ^a,b,c  

^a Department of Nutritional Sciences ^*  (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CHEMICAL ACTIVATION; ENZYMES; GENETIC ENGINEERING; HYDROGEN PRODUCTION; MAMMALS; NUTRITION; SIGNAL TRANSDUCTION; SULFUR COMPOUNDS; SULFUR DETERMINATION; TRANSCRIPTION;

ACTIVATING TRANSCRIPTION FACTOR; BIOCHEMICAL ANALYSIS; DIET-INDUCED OBESITY; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR; GENETIC DISRUPTION; INTEGRATED STRESS; TARGET OF RAPAMYCIN;

HYDROGEN SULFIDE;

ACTIVATING TRANSCRIPTION FACTOR 4; APOLIPOPROTEIN B100; ASPARAGINASE; HYDROGEN SULFIDE; INITIATION FACTOR 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; PROTEIN PERK; SESTRIN2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ACTIVATING TRANSCRIPTION FACTOR; ATF4 PROTEIN, MOUSE; ATF5 PROTEIN, MOUSE; CELL CYCLE PROTEIN; EIF2AK4 PROTEIN, MOUSE; GLUTATHIONE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PERK KINASE; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; SESTRIN 2 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TRB3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATF5 GENE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FATTY LIVER; FEMALE; GENE; GENE LOSS; GENE TARGETING; GLUCOSE TOLERANCE; IMMUNOBLOTTING; INTEGRATED STRESS RESPONSE; LIVER PROTECTION; MALE; MORBIDITY; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRESS; TRIACYLGLYCEROL BLOOD LEVEL; TRIB3 GENE; ANIMAL; C57BL MOUSE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENE DELETION; GENETICS; LIVER; METABOLISM; MOUSE MUTANT; PATHOLOGY; TRANSGENIC MOUSE;

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTORS; ANIMALS; APOLIPOPROTEIN B-100; ASPARAGINASE; CELL CYCLE PROTEINS; DISEASE MODELS, ANIMAL; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; FATTY LIVER; GENE DELETION; GLUTATHIONE; HYDROGEN SULFIDE; LIVER; MICE; MICE, INBRED C57BL; MICE, OBESE; MICE, TRANSGENIC; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; OBESITY; PROTEIN-SERINE-THREONINE KINASES; TOR SERINE-THREONINE KINASES;

EID: 85018576883     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.768408     Document Type: Article

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