The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment

American Journal of Physiology - Endocrinology and Metabolism

Volumn 305, Issue 9, 2013, Pages

  Wilson, Gabriel J ^a   Bunpo, Piyawan ^b   Cundiff, Judy K ^b   Wek, Ronald C ^c   Anthony, Tracy G ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b Indiana University School of Medicine Evansville   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amino acid stress response; Endoplasmic reticulum stress; Eukaryotic initiation factor 2; Liver; Steatosis

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALANINE; AMINO ACID; ARGININE; ASPARAGINASE; ASPARAGINE; ASPARTATE AMMONIA LIGASE; ASPARTIC ACID; CYSTINE; GENERAL CONTROL NONDEREPRESSIBLE KINASE 2; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE PEROXIDASE; GLYCINE; HISTIDINE; INITIATION FACTOR 2; ISOLEUCINE; LEUCINE; LYSINE; MAMMALIAN TARGET OF RAPAMYCIN; METHIONINE; PROLINE; PROTEIN KINASE R; SERINE; THREONINE; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VALINE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; FATTY LIVER; FEMALE; LIVER PROTECTION; LIVER TOXICITY; MALE; MICROSCOPY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STRESS; WILD TYPE;

AMINO ACID STRESS RESPONSE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR 2; LIVER; STEATOSIS;

AMINO ACIDS; ANIMALS; ANTINEOPLASTIC AGENTS; ASPARAGINASE; BLOTTING, WESTERN; BODY WEIGHT; DNA DAMAGE; DRUG-INDUCED LIVER INJURY; EATING; ENDOPLASMIC RETICULUM STRESS; FEMALE; INFLAMMATION; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; ORGAN SIZE; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; TOR SERINE-THREONINE KINASES; TRIGLYCERIDES; UNFOLDED PROTEIN RESPONSE;

EID: 84887008428     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00080.2013     Document Type: Article

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