메뉴 건너뛰기




Volumn 15, Issue 2, 2017, Pages 59-72

Circulating Tumor DNA as Biomarkers for Cancer Detection

Author keywords

Biomarker; Cell free nucleic acids; Circulating tumor DNA; Clinical diagnosis; Liquid biopsy; Precision medicine

Indexed keywords

BIOLOGICAL MARKER; CIRCULATING TUMOR DNA; DNA; UNCLASSIFIED DRUG; TUMOR MARKER;

EID: 85018551150     PISSN: 16720229     EISSN: 22103244     Source Type: Journal    
DOI: 10.1016/j.gpb.2016.12.004     Document Type: Review
Times cited : (191)

References (196)
  • 1
    • 84961644423 scopus 로고    scopus 로고
    • World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015
    • [1] McGuire, S., World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr 7 (2016), 418–419.
    • (2016) Adv Nutr , vol.7 , pp. 418-419
    • McGuire, S.1
  • 2
    • 84957095546 scopus 로고    scopus 로고
    • Inferences, risk modeling, and prediction of health effects of ionizing radiation
    • [2] Dainiak, N., Inferences, risk modeling, and prediction of health effects of ionizing radiation. Health Phys 110 (2016), 271–273.
    • (2016) Health Phys , vol.110 , pp. 271-273
    • Dainiak, N.1
  • 3
    • 84961763258 scopus 로고    scopus 로고
    • Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation
    • [3] Zhou, D.D., Hao, J.L., Guo, K.M., Lu, C.W., Liu, X.D., Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation. Genet Mol Res, 15, 2016, gmr8078.
    • (2016) Genet Mol Res , vol.15 , pp. gmr8078
    • Zhou, D.D.1    Hao, J.L.2    Guo, K.M.3    Lu, C.W.4    Liu, X.D.5
  • 4
    • 84941551429 scopus 로고    scopus 로고
    • Predicting radiotherapy responses and treatment outcomes through analysis of circulating tumor DNA
    • [4] Chaudhuri, A.A., Binkley, M.S., Osmundson, E.C., Alizadeh, A.A., Diehn, M., Predicting radiotherapy responses and treatment outcomes through analysis of circulating tumor DNA. Semin Radiat Oncol 25 (2015), 305–312.
    • (2015) Semin Radiat Oncol , vol.25 , pp. 305-312
    • Chaudhuri, A.A.1    Binkley, M.S.2    Osmundson, E.C.3    Alizadeh, A.A.4    Diehn, M.5
  • 5
    • 84910601938 scopus 로고    scopus 로고
    • Progress and controversies: radiation therapy for prostate cancer
    • [5] Martin, N.E., D'Amico, A.V., Progress and controversies: radiation therapy for prostate cancer. CA Cancer J Clin 64 (2014), 389–407.
    • (2014) CA Cancer J Clin , vol.64 , pp. 389-407
    • Martin, N.E.1    D'Amico, A.V.2
  • 6
    • 84908094995 scopus 로고    scopus 로고
    • Skin cancer: role of ultraviolet radiation in carcinogenesis
    • [6] Mancebo, S.E., Wang, S.Q., Skin cancer: role of ultraviolet radiation in carcinogenesis. Rev Environ Health 29 (2014), 265–273.
    • (2014) Rev Environ Health , vol.29 , pp. 265-273
    • Mancebo, S.E.1    Wang, S.Q.2
  • 7
    • 84947286516 scopus 로고    scopus 로고
    • Circulating tumor cells and circulating tumor DNA: challenges and opportunities on the path to clinical utility
    • [7] Ignatiadis, M., Lee, M., Jeffrey, S.S., Circulating tumor cells and circulating tumor DNA: challenges and opportunities on the path to clinical utility. Clin Cancer Res 21 (2015), 4786–4800.
    • (2015) Clin Cancer Res , vol.21 , pp. 4786-4800
    • Ignatiadis, M.1    Lee, M.2    Jeffrey, S.S.3
  • 8
    • 84906238686 scopus 로고    scopus 로고
    • Clonal evolution in breast cancer revealed by single nucleus genome sequencing
    • [8] Wang, Y., Waters, J., Leung, M.L., Unruh, A., Roh, W., Shi, X., et al. Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature 512 (2014), 155–160.
    • (2014) Nature , vol.512 , pp. 155-160
    • Wang, Y.1    Waters, J.2    Leung, M.L.3    Unruh, A.4    Roh, W.5    Shi, X.6
  • 9
    • 84922910667 scopus 로고    scopus 로고
    • Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
    • [9] Hiley, C., Bruin, E.C.D., Mcgranahan, N., Swanton, C., Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine. Genome Biol 15 (2014), 1–10.
    • (2014) Genome Biol , vol.15 , pp. 1-10
    • Hiley, C.1    Bruin, E.C.D.2    Mcgranahan, N.3    Swanton, C.4
  • 11
    • 84964700391 scopus 로고    scopus 로고
    • Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy
    • [11] Alix-Panabieres, C., Pantel, K., Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy. Cancer Discovery 6 (2016), 479–491.
    • (2016) Cancer Discovery , vol.6 , pp. 479-491
    • Alix-Panabieres, C.1    Pantel, K.2
  • 12
    • 84898542288 scopus 로고    scopus 로고
    • Liquid biopsies: genotyping circulating tumor DNA
    • [12] Diaz, L.A. Jr., Bardelli, A., Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol 32 (2014), 579–586.
    • (2014) J Clin Oncol , vol.32 , pp. 579-586
    • Diaz, L.A.1    Bardelli, A.2
  • 14
    • 84963971785 scopus 로고    scopus 로고
    • Methylated circulating tumor DNA in blood: power in cancer prognosis and response
    • [14] Warton, K., Mahon, K.L., Samimi, G., Methylated circulating tumor DNA in blood: power in cancer prognosis and response. Endocr Relat Cancer 23 (2016), R157–R171.
    • (2016) Endocr Relat Cancer , vol.23 , pp. R157-R171
    • Warton, K.1    Mahon, K.L.2    Samimi, G.3
  • 15
    • 77951039961 scopus 로고    scopus 로고
    • DNA methylation based biomarkers in non-invasive cancer screening
    • [15] Shivapurkar, N., Gazdar, A., DNA methylation based biomarkers in non-invasive cancer screening. Curr Mol Med 10 (2010), 123–132.
    • (2010) Curr Mol Med , vol.10 , pp. 123-132
    • Shivapurkar, N.1    Gazdar, A.2
  • 16
    • 34250802601 scopus 로고    scopus 로고
    • Gene methylation and early detection of genitourinary cancer: the road ahead
    • [16] Cairns, P., Gene methylation and early detection of genitourinary cancer: the road ahead. Nat Rev Cancer 7 (2007), 531–543.
    • (2007) Nat Rev Cancer , vol.7 , pp. 531-543
    • Cairns, P.1
  • 17
    • 79961093766 scopus 로고    scopus 로고
    • DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells
    • [17] Chimonidou, M., Strati, A., Tzitzira, A., Sotiropoulou, G., Malamos, N., Georgoulias, V., et al. DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells. Clin Chem 57 (2011), 1169–1177.
    • (2011) Clin Chem , vol.57 , pp. 1169-1177
    • Chimonidou, M.1    Strati, A.2    Tzitzira, A.3    Sotiropoulou, G.4    Malamos, N.5    Georgoulias, V.6
  • 18
    • 4644297522 scopus 로고    scopus 로고
    • Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients
    • [18] Dulaimi, E., Hillinck, J., Ibanez de Caceres, I., Al-Saleem, T., Cairns, P., Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients. Clin Cancer Res 10 (2004), 6189–6193.
    • (2004) Clin Cancer Res , vol.10 , pp. 6189-6193
    • Dulaimi, E.1    Hillinck, J.2    Ibanez de Caceres, I.3    Al-Saleem, T.4    Cairns, P.5
  • 19
    • 0032109535 scopus 로고    scopus 로고
    • Health effects of exposure to low-level ionizing radiation
    • [19] Hendee, W.R., Edwards, F.M., Health effects of exposure to low-level ionizing radiation. Acta Radiol 39 (1998), 453–454.
    • (1998) Acta Radiol , vol.39 , pp. 453-454
    • Hendee, W.R.1    Edwards, F.M.2
  • 20
    • 84912532399 scopus 로고    scopus 로고
    • Non-targeted effects induced by ionizing radiation: mechanisms and potential impact on radiation induced health effects
    • [20] Morgan, W.F., Sowa, M.B., Non-targeted effects induced by ionizing radiation: mechanisms and potential impact on radiation induced health effects. Cancer Lett 356 (2015), 17–21.
    • (2015) Cancer Lett , vol.356 , pp. 17-21
    • Morgan, W.F.1    Sowa, M.B.2
  • 21
    • 85052775519 scopus 로고    scopus 로고
    • Cancer nanotechnology: principles and applications in radiation oncology
    • CRC Press Boca Raton, FL
    • [21] Cho, S.H., Krishnan, S., Cancer nanotechnology: principles and applications in radiation oncology. 2013, CRC Press, Boca Raton, FL.
    • (2013)
    • Cho, S.H.1    Krishnan, S.2
  • 22
    • 0032822242 scopus 로고    scopus 로고
    • Prospective analysis of intraoperative frozen needle biopsy of solid renal masses in adults
    • [22] Dechet, C.B., Sebo, T., Farrow, G., Blute, M.L., Engen, D.E., Zincke, H., Prospective analysis of intraoperative frozen needle biopsy of solid renal masses in adults. J Urol 162 (1999), 1282–1284.
    • (1999) J Urol , vol.162 , pp. 1282-1284
    • Dechet, C.B.1    Sebo, T.2    Farrow, G.3    Blute, M.L.4    Engen, D.E.5    Zincke, H.6
  • 24
    • 84961212262 scopus 로고    scopus 로고
    • Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of pancreatic malignant lesions: a systematic review and meta-analysis
    • [24] Yang, Y., Li, L., Qu, C., Liang, S., Zeng, B., Luo, Z., Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of pancreatic malignant lesions: a systematic review and meta-analysis. Sci Rep, 6, 2016, 22978.
    • (2016) Sci Rep , vol.6 , pp. 22978
    • Yang, Y.1    Li, L.2    Qu, C.3    Liang, S.4    Zeng, B.5    Luo, Z.6
  • 25
    • 80051669505 scopus 로고    scopus 로고
    • Review: incidence and clinical significance of Bevacizumab-related non-surgical and surgical serious adverse events in metastatic colorectal cancer
    • [25] Hompes, D., Ruers, T., Review: incidence and clinical significance of Bevacizumab-related non-surgical and surgical serious adverse events in metastatic colorectal cancer. Eur J Surg Oncol 37 (2011), 737–746.
    • (2011) Eur J Surg Oncol , vol.37 , pp. 737-746
    • Hompes, D.1    Ruers, T.2
  • 27
    • 0026707677 scopus 로고
    • CEA serum levels in non-neoplastic disease
    • [27] Ruibal, Morell A., CEA serum levels in non-neoplastic disease. Int J Biol Markers 7 (1992), 160–166.
    • (1992) Int J Biol Markers , vol.7 , pp. 160-166
    • Ruibal, M.A.1
  • 28
    • 80052968454 scopus 로고    scopus 로고
    • CA125 – a test with a change of heart
    • [28] Sikaris, K.A., CA125 – a test with a change of heart. Heart Lung Circ 20 (2011), 634–640.
    • (2011) Heart Lung Circ , vol.20 , pp. 634-640
    • Sikaris, K.A.1
  • 30
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • [30] Schwarzenbach, H., Hoon, D.S., Pantel, K., Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 11 (2011), 426–437.
    • (2011) Nat Rev Cancer , vol.11 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.S.2    Pantel, K.3
  • 31
    • 84920508228 scopus 로고    scopus 로고
    • Circulating tumor DNA as a liquid biopsy for cancer
    • [31] Heitzer, E., Ulz, P., Geigl, J.B., Circulating tumor DNA as a liquid biopsy for cancer. Clin Chem 61 (2015), 112–123.
    • (2015) Clin Chem , vol.61 , pp. 112-123
    • Heitzer, E.1    Ulz, P.2    Geigl, J.B.3
  • 32
    • 79953301730 scopus 로고    scopus 로고
    • MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
    • [32] Vickers, K.C., Palmisano, B.T., Shoucri, B.M., Shamburek, R.D., Remaley, A.T., MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 13 (2011), 423–433.
    • (2011) Nat Cell Biol , vol.13 , pp. 423-433
    • Vickers, K.C.1    Palmisano, B.T.2    Shoucri, B.M.3    Shamburek, R.D.4    Remaley, A.T.5
  • 33
    • 84869112263 scopus 로고    scopus 로고
    • High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer
    • [33] Giovannetti, E., van der Velde, A., Funel, N., Vasile, E., Perrone, V., Leon, L.G., et al. High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer. PLoS One, 7, 2012, e49145.
    • (2012) PLoS One , vol.7 , pp. e49145
    • Giovannetti, E.1    van der Velde, A.2    Funel, N.3    Vasile, E.4    Perrone, V.5    Leon, L.G.6
  • 34
    • 84881398405 scopus 로고    scopus 로고
    • Pathway-based serum microRNA profiling and survival in patients with advanced stage non-small cell lung cancer
    • [34] Wang, Y., Gu, J., Roth, J.A., Hildebrandt, M.A., Lippman, S.M., Ye, Y., et al. Pathway-based serum microRNA profiling and survival in patients with advanced stage non-small cell lung cancer. Cancer Res 73 (2013), 4801–4809.
    • (2013) Cancer Res , vol.73 , pp. 4801-4809
    • Wang, Y.1    Gu, J.2    Roth, J.A.3    Hildebrandt, M.A.4    Lippman, S.M.5    Ye, Y.6
  • 35
    • 84865482681 scopus 로고    scopus 로고
    • Exosomes: new players in cell-cell communication
    • [35] Bang, C., Thum, T., Exosomes: new players in cell-cell communication. Int J Biochem Cell Biol 44 (2012), 2060–2064.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 2060-2064
    • Bang, C.1    Thum, T.2
  • 37
    • 84901842265 scopus 로고    scopus 로고
    • Double-stranded DNA in exosomes: a novel biomarker in cancer detection
    • [37] Thakur, B.K., Zhang, H., Becker, A., Matei, I., Huang, Y., Costa-Silva, B., et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res 24 (2014), 766–769.
    • (2014) Cell Res , vol.24 , pp. 766-769
    • Thakur, B.K.1    Zhang, H.2    Becker, A.3    Matei, I.4    Huang, Y.5    Costa-Silva, B.6
  • 38
    • 84928585501 scopus 로고    scopus 로고
    • Optimal design of trials to demonstrate the utility of genomically-guided therapy: putting precision cancer medicine to the test
    • [38] Dienstmann, R., Rodon, J., Tabernero, J., Optimal design of trials to demonstrate the utility of genomically-guided therapy: putting precision cancer medicine to the test. Mol Oncol 9 (2015), 940–950.
    • (2015) Mol Oncol , vol.9 , pp. 940-950
    • Dienstmann, R.1    Rodon, J.2    Tabernero, J.3
  • 39
  • 40
    • 84880270290 scopus 로고    scopus 로고
    • Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
    • [40] Baccelli, I., Schneeweiss, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol 31 (2013), 539–544.
    • (2013) Nat Biotechnol , vol.31 , pp. 539-544
    • Baccelli, I.1    Schneeweiss, A.2    Riethdorf, S.3    Stenzinger, A.4    Schillert, A.5    Vogel, V.6
  • 41
    • 84875824898 scopus 로고    scopus 로고
    • Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing
    • [41] Heitzer, E., Ulz, P., Belic, J., Gutschi, S., Quehenberger, F., Fischereder, K., et al. Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing. Genome Med, 5, 2013, 30.
    • (2013) Genome Med , vol.5 , pp. 30
    • Heitzer, E.1    Ulz, P.2    Belic, J.3    Gutschi, S.4    Quehenberger, F.5    Fischereder, K.6
  • 42
    • 84905819148 scopus 로고    scopus 로고
    • Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer
    • [42] Hodgkinson, C.L., Morrow, C.J., Li, Y., Metcalf, R.L., Rothwell, D.G., Trapani, F., et al. Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nat Med 20 (2014), 897–903.
    • (2014) Nat Med , vol.20 , pp. 897-903
    • Hodgkinson, C.L.1    Morrow, C.J.2    Li, Y.3    Metcalf, R.L.4    Rothwell, D.G.5    Trapani, F.6
  • 43
    • 84906731563 scopus 로고    scopus 로고
    • Challenges in circulating tumour cell research
    • [43] Alix-Panabieres, C., Pantel, K., Challenges in circulating tumour cell research. Nat Rev Cancer 14 (2014), 623–631.
    • (2014) Nat Rev Cancer , vol.14 , pp. 623-631
    • Alix-Panabieres, C.1    Pantel, K.2
  • 44
    • 0000110505 scopus 로고
    • A case of cancer in which cells similar to those in the tumors were seen in the blood after death
    • [44] Ashworth, T.R., A case of cancer in which cells similar to those in the tumors were seen in the blood after death. Aust Med J 14 (1869), 146–147.
    • (1869) Aust Med J , vol.14 , pp. 146-147
    • Ashworth, T.R.1
  • 45
    • 84865141520 scopus 로고    scopus 로고
    • The emerging role of circulating tumor cells in breast cancer
    • [45] Krishnamurthy, S., The emerging role of circulating tumor cells in breast cancer. Cancer Cytopathol 120 (2012), 161–166.
    • (2012) Cancer Cytopathol , vol.120 , pp. 161-166
    • Krishnamurthy, S.1
  • 46
    • 84889762593 scopus 로고    scopus 로고
    • Circulating tumor cells in prostate cancer
    • [46] Hu, B., Rochefort, H., Goldkorn, A., Circulating tumor cells in prostate cancer. Cancers (Basel) 5 (2013), 1676–1690.
    • (2013) Cancers (Basel) , vol.5 , pp. 1676-1690
    • Hu, B.1    Rochefort, H.2    Goldkorn, A.3
  • 48
    • 42649100970 scopus 로고    scopus 로고
    • Detection, clinical relevance and specific biological properties of disseminating tumour cells
    • [48] Pantel, K., Brakenhoff, R.H., Brandt, B., Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 8 (2008), 329–340.
    • (2008) Nat Rev Cancer , vol.8 , pp. 329-340
    • Pantel, K.1    Brakenhoff, R.H.2    Brandt, B.3
  • 49
    • 33847402612 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the cell search system
    • [49] Riethdorf, S., Fritsche, H., Muller, V., Rau, T., Schindlbeck, C., Rack, B., et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the cell search system. Clin Cancer Res 13 (2007), 920–928.
    • (2007) Clin Cancer Res , vol.13 , pp. 920-928
    • Riethdorf, S.1    Fritsche, H.2    Muller, V.3    Rau, T.4    Schindlbeck, C.5    Rack, B.6
  • 50
    • 37549002543 scopus 로고    scopus 로고
    • Isolation of rare circulating tumour cells in cancer patients by microchip technology
    • [50] Nagrath, S., Sequist, L.V., Maheswaran, S., Bell, D.W., Irimia, D., Ulkus, L., et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450 (2007), 1235–1239.
    • (2007) Nature , vol.450 , pp. 1235-1239
    • Nagrath, S.1    Sequist, L.V.2    Maheswaran, S.3    Bell, D.W.4    Irimia, D.5    Ulkus, L.6
  • 51
    • 84863587972 scopus 로고    scopus 로고
    • Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector
    • [51] Issadore, D., Chung, J., Shao, H., Liong, M., Ghazani, A.A., Castro, C.M., et al. Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med, 4, 2012, 141ra92.
    • (2012) Sci Transl Med , vol.4 , pp. 141ra92
    • Issadore, D.1    Chung, J.2    Shao, H.3    Liong, M.4    Ghazani, A.A.5    Castro, C.M.6
  • 52
    • 84895449750 scopus 로고    scopus 로고
    • Microfluidic, marker-free isolation of circulating tumor cells from blood samples
    • [52] Karabacak, N.M., Spuhler, P.S., Fachin, F., Lim, E.J., Pai, V., Ozkumur, E., et al. Microfluidic, marker-free isolation of circulating tumor cells from blood samples. Nat Protoc 9 (2014), 694–710.
    • (2014) Nat Protoc , vol.9 , pp. 694-710
    • Karabacak, N.M.1    Spuhler, P.S.2    Fachin, F.3    Lim, E.J.4    Pai, V.5    Ozkumur, E.6
  • 53
    • 84875520648 scopus 로고    scopus 로고
    • Analysis of circulating tumor DNA to monitor metastatic breast cancer
    • [53] Dawson, S.J., Tsui, D.W., Murtaza, M., Biggs, H., Rueda, O.M., Chin, S.F., et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med 368 (2013), 1199–1209.
    • (2013) N Engl J Med , vol.368 , pp. 1199-1209
    • Dawson, S.J.1    Tsui, D.W.2    Murtaza, M.3    Biggs, H.4    Rueda, O.M.5    Chin, S.F.6
  • 54
    • 84959178370 scopus 로고    scopus 로고
    • Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients
    • [54] Siravegna, G., Bardelli, A., Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients. Mol Oncol 10 (2016), 475–480.
    • (2016) Mol Oncol , vol.10 , pp. 475-480
    • Siravegna, G.1    Bardelli, A.2
  • 56
    • 84957852098 scopus 로고
    • Les acides nucleiques du plasma sanguin chez l'homme
    • [56] Mandel, P., Metais, P., Les acides nucleiques du plasma sanguin chez l'homme. CR Acad Sci Paris 142 (1948), 241–243.
    • (1948) CR Acad Sci Paris , vol.142 , pp. 241-243
    • Mandel, P.1    Metais, P.2
  • 57
    • 0017360626 scopus 로고
    • Free DNA in the serum of cancer patients and the effect of therapy
    • [57] Leon, S.A., Shapiro, B., Sklaroff, D.M., Yaros, M.J., Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 37 (1977), 646–650.
    • (1977) Cancer Res , vol.37 , pp. 646-650
    • Leon, S.A.1    Shapiro, B.2    Sklaroff, D.M.3    Yaros, M.J.4
  • 58
    • 0024420298 scopus 로고
    • Neoplastic characteristics of the DNA found in the plasma of cancer patients
    • [58] Stroun, M., Anker, P., Maurice, P., Lyautey, J., Lederrey, C., Beljanski, M., Neoplastic characteristics of the DNA found in the plasma of cancer patients. Oncology 46 (1989), 318–322.
    • (1989) Oncology , vol.46 , pp. 318-322
    • Stroun, M.1    Anker, P.2    Maurice, P.3    Lyautey, J.4    Lederrey, C.5    Beljanski, M.6
  • 59
    • 0028241030 scopus 로고
    • Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia
    • [59] Vasioukhin, V., Anker, P., Maurice, P., Lyautey, J., Lederrey, C., Stroun, M., Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. Br J Haematol 86 (1994), 774–779.
    • (1994) Br J Haematol , vol.86 , pp. 774-779
    • Vasioukhin, V.1    Anker, P.2    Maurice, P.3    Lyautey, J.4    Lederrey, C.5    Stroun, M.6
  • 60
    • 19944433956 scopus 로고    scopus 로고
    • Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer
    • [60] Fujiwara, K., Fujimoto, N., Tabata, M., Nishii, K., Matsuo, K., Hotta, K., et al. Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer. Clin Cancer Res 11 (2005), 1219–1225.
    • (2005) Clin Cancer Res , vol.11 , pp. 1219-1225
    • Fujiwara, K.1    Fujimoto, N.2    Tabata, M.3    Nishii, K.4    Matsuo, K.5    Hotta, K.6
  • 61
    • 85020106984 scopus 로고    scopus 로고
    • Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease
    • [61] Hardy, T., Zeybel, M., Day, C.P., Dipper, C., Masson, S., McPherson, S., et al. Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease. Gut, 2016 http://www.idf.org/gutjnl-2016-311526.
    • (2016) Gut
    • Hardy, T.1    Zeybel, M.2    Day, C.P.3    Dipper, C.4    Masson, S.5    McPherson, S.6
  • 62
    • 84975047629 scopus 로고    scopus 로고
    • Circulating cell-free tumor DNA analysis of 50 genes by next-generation sequencing in the prospective MOSCATO trial
    • [62] Jovelet, C., Ileana, E., Le Deley, M.C., Motte, N., Rosellini, S., Romero, A., et al. Circulating cell-free tumor DNA analysis of 50 genes by next-generation sequencing in the prospective MOSCATO trial. Clin Cancer Res 22 (2016), 2960–2968.
    • (2016) Clin Cancer Res , vol.22 , pp. 2960-2968
    • Jovelet, C.1    Ileana, E.2    Le Deley, M.C.3    Motte, N.4    Rosellini, S.5    Romero, A.6
  • 63
    • 84982782719 scopus 로고    scopus 로고
    • Circulating tumor DNA: a promising biomarker in the liquid biopsy of cancer
    • [63] Cheng, F., Su, L., Qian, C., Circulating tumor DNA: a promising biomarker in the liquid biopsy of cancer. Oncotarget 7 (2016), 48832–48841.
    • (2016) Oncotarget , vol.7 , pp. 48832-48841
    • Cheng, F.1    Su, L.2    Qian, C.3
  • 65
    • 84943375035 scopus 로고    scopus 로고
    • Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments
    • [65] Sun, K., Jiang, P., Chan, K.C., Wong, J., Cheng, Y.K., Liang, R.H., et al. Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proc Natl Acad Sci U S A 112 (2015), E5503–E5512.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E5503-E5512
    • Sun, K.1    Jiang, P.2    Chan, K.C.3    Wong, J.4    Cheng, Y.K.5    Liang, R.H.6
  • 66
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells
    • [66] Jahr, S., Hentze, H., Englisch, S., Hardt, D., Fackelmayer, F.O., Hesch, R.D., et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61 (2001), 1659–1665.
    • (2001) Cancer Res , vol.61 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3    Hardt, D.4    Fackelmayer, F.O.5    Hesch, R.D.6
  • 67
    • 33845476677 scopus 로고    scopus 로고
    • Circulating nucleic acids (CNAs) and cancer – a survey
    • [67] Fleischhacker, M., Schmidt, B., Circulating nucleic acids (CNAs) and cancer – a survey. Biochim Biophys Acta 1775 (2007), 181–232.
    • (2007) Biochim Biophys Acta , vol.1775 , pp. 181-232
    • Fleischhacker, M.1    Schmidt, B.2
  • 68
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early- and late-stage human malignancies
    • [68] Bettegowda, C., Sausen, M., Leary, R.J., Kinde, I., Wang, Y., Agrawal, N., et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med, 6, 2014, 224ra24.
    • (2014) Sci Transl Med , vol.6 , pp. 224ra24
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3    Kinde, I.4    Wang, Y.5    Agrawal, N.6
  • 69
    • 84928215966 scopus 로고    scopus 로고
    • Do circulating tumor cells, exosomes, and circulating tumor nucleic acids have clinical utility?
    • [69] Gold, B., Cankovic, M., Furtado, L.V., Meier, F., Gocke, C.D., Do circulating tumor cells, exosomes, and circulating tumor nucleic acids have clinical utility?. J Mol Diagn 17 (2015), 209–224.
    • (2015) J Mol Diagn , vol.17 , pp. 209-224
    • Gold, B.1    Cankovic, M.2    Furtado, L.V.3    Meier, F.4    Gocke, C.D.5
  • 70
    • 84925338452 scopus 로고    scopus 로고
    • Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
    • [70] Jiang, P., Chan, C.W., Chan, K.C., Cheng, S.H., Wong, J., Wong, V.W., et al. Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proc Natl Acad Sci U S A 112 (2015), E1317–E1325.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E1317-E1325
    • Jiang, P.1    Chan, C.W.2    Chan, K.C.3    Cheng, S.H.4    Wong, J.5    Wong, V.W.6
  • 71
    • 84863455602 scopus 로고    scopus 로고
    • Quantitation of plasma circulating DNA using quantitative PCR for the detection of hepatocellular carcinoma
    • [71] Huang, Z., Hua, D., Hu, Y., Cheng, Z., Zhou, X., Xie, Q., et al. Quantitation of plasma circulating DNA using quantitative PCR for the detection of hepatocellular carcinoma. Pathol Oncol Res 18 (2012), 271–276.
    • (2012) Pathol Oncol Res , vol.18 , pp. 271-276
    • Huang, Z.1    Hua, D.2    Hu, Y.3    Cheng, Z.4    Zhou, X.5    Xie, Q.6
  • 72
    • 33749024160 scopus 로고    scopus 로고
    • Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer
    • [72] Hoque, M.O., Feng, Q., Toure, P., Dem, A., Critchlow, C.W., Hawes, S.E., et al. Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer. J Clin Oncol 24 (2006), 4262–4269.
    • (2006) J Clin Oncol , vol.24 , pp. 4262-4269
    • Hoque, M.O.1    Feng, Q.2    Toure, P.3    Dem, A.4    Critchlow, C.W.5    Hawes, S.E.6
  • 73
    • 84994885645 scopus 로고    scopus 로고
    • The cancer bloodhounds
    • [73] Webb, S., The cancer bloodhounds. Nat Biotechnol 34 (2016), 1090–1094.
    • (2016) Nat Biotechnol , vol.34 , pp. 1090-1094
    • Webb, S.1
  • 74
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • [74] Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., Parkin, D.M., Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127 (2010), 2893–2917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, C.5    Parkin, D.M.6
  • 75
    • 84863011201 scopus 로고    scopus 로고
    • Genomic analysis of circulating cell-free DNA infers breast cancer dormancy
    • [75] Shaw, J.A., Page, K., Blighe, K., Hava, N., Guttery, D., Ward, B., et al. Genomic analysis of circulating cell-free DNA infers breast cancer dormancy. Genome Res 22 (2012), 220–231.
    • (2012) Genome Res , vol.22 , pp. 220-231
    • Shaw, J.A.1    Page, K.2    Blighe, K.3    Hava, N.4    Guttery, D.5    Ward, B.6
  • 76
    • 71049124846 scopus 로고    scopus 로고
    • Impact of American Society of Clinical Oncology/College of American Pathologists guideline recommendations on HER2 interpretation in breast cancer
    • [76] Shah, S.S., Ketterling, R.P., Goetz, M.P., Ingle, J.N., Reynolds, C.A., Perez, E.A., et al. Impact of American Society of Clinical Oncology/College of American Pathologists guideline recommendations on HER2 interpretation in breast cancer. Hum Pathol 41 (2010), 103–106.
    • (2010) Hum Pathol , vol.41 , pp. 103-106
    • Shah, S.S.1    Ketterling, R.P.2    Goetz, M.P.3    Ingle, J.N.4    Reynolds, C.A.5    Perez, E.A.6
  • 77
    • 84862537727 scopus 로고    scopus 로고
    • Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood
    • [77] Higgins, M.J., Jelovac, D., Barnathan, E., Blair, B., Slater, S., Powers, P., et al. Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood. Clin Cancer Res 18 (2012), 3462–3469.
    • (2012) Clin Cancer Res , vol.18 , pp. 3462-3469
    • Higgins, M.J.1    Jelovac, D.2    Barnathan, E.3    Blair, B.4    Slater, S.5    Powers, P.6
  • 80
    • 84964478541 scopus 로고    scopus 로고
    • ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients
    • [80] Chu, D., Paoletti, C., Gersch, C., VanDenBerg, D.A., Zabransky, D.J., Cochran, R.L., et al. ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients. Clin Cancer Res 22 (2016), 993–999.
    • (2016) Clin Cancer Res , vol.22 , pp. 993-999
    • Chu, D.1    Paoletti, C.2    Gersch, C.3    VanDenBerg, D.A.4    Zabransky, D.J.5    Cochran, R.L.6
  • 82
    • 84938414305 scopus 로고    scopus 로고
    • Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease
    • [82] Olsson, E., Winter, C., George, A., Chen, Y., Howlin, J., Tang, M.H., et al. Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease. EMBO Mol Med 7 (2015), 1034–1047.
    • (2015) EMBO Mol Med , vol.7 , pp. 1034-1047
    • Olsson, E.1    Winter, C.2    George, A.3    Chen, Y.4    Howlin, J.5    Tang, M.H.6
  • 83
    • 84950262715 scopus 로고    scopus 로고
    • Plasma DNA integrity index as a potential molecular diagnostic marker for breast cancer
    • [83] Kamel, A.M., Teama, S., Fawzy, A., El Deftar, M., Plasma DNA integrity index as a potential molecular diagnostic marker for breast cancer. Tumour Biol 37 (2016), 7565–7572.
    • (2016) Tumour Biol , vol.37 , pp. 7565-7572
    • Kamel, A.M.1    Teama, S.2    Fawzy, A.3    El Deftar, M.4
  • 84
    • 84923164411 scopus 로고    scopus 로고
    • Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients
    • [84] Madic, J., Kiialainen, A., Bidard, F.C., Birzele, F., Ramey, G., Leroy, Q., et al. Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients. Int J Cancer 136 (2015), 2158–2165.
    • (2015) Int J Cancer , vol.136 , pp. 2158-2165
    • Madic, J.1    Kiialainen, A.2    Bidard, F.C.3    Birzele, F.4    Ramey, G.5    Leroy, Q.6
  • 85
    • 78649622045 scopus 로고    scopus 로고
    • Methylation patterns in cell-free plasma DNA reflect removal of the primary tumor and drug treatment of breast cancer patients
    • [85] Liggett, T.E., Melnikov, A.A., Marks, J.R., Levenson, V.V., Methylation patterns in cell-free plasma DNA reflect removal of the primary tumor and drug treatment of breast cancer patients. Int J Cancer 128 (2011), 492–499.
    • (2011) Int J Cancer , vol.128 , pp. 492-499
    • Liggett, T.E.1    Melnikov, A.A.2    Marks, J.R.3    Levenson, V.V.4
  • 86
    • 13944250245 scopus 로고    scopus 로고
    • Circulating tumor-specific DNA: a marker for monitoring efficacy of adjuvant therapy in cancer patients
    • [86] Fiegl, H., Millinger, S., Mueller-Holzner, E., Marth, C., Ensinger, C., Berger, A., et al. Circulating tumor-specific DNA: a marker for monitoring efficacy of adjuvant therapy in cancer patients. Cancer Res 65 (2005), 1141–1145.
    • (2005) Cancer Res , vol.65 , pp. 1141-1145
    • Fiegl, H.1    Millinger, S.2    Mueller-Holzner, E.3    Marth, C.4    Ensinger, C.5    Berger, A.6
  • 87
    • 84929674483 scopus 로고    scopus 로고
    • Sox17 promoter methylation in plasma DNA is associated with poor survival and can be used as a prognostic factor in breast cancer
    • [87] Fu, D., Ren, C., Tan, H., Wei, J., Zhu, Y., He, C., et al. Sox17 promoter methylation in plasma DNA is associated with poor survival and can be used as a prognostic factor in breast cancer. Medicine (Baltimore), 94, 2015, e637.
    • (2015) Medicine (Baltimore) , vol.94 , pp. e637
    • Fu, D.1    Ren, C.2    Tan, H.3    Wei, J.4    Zhu, Y.5    He, C.6
  • 88
    • 84905814375 scopus 로고    scopus 로고
    • DNA methylation markers for early detection of women's cancer: promise and challenges
    • [88] Wittenberger, T., Sleigh, S., Reisel, D., Zikan, M., Wahl, B., Alunni-Fabbroni, M., et al. DNA methylation markers for early detection of women's cancer: promise and challenges. Epigenomics 6 (2014), 311–327.
    • (2014) Epigenomics , vol.6 , pp. 311-327
    • Wittenberger, T.1    Sleigh, S.2    Reisel, D.3    Zikan, M.4    Wahl, B.5    Alunni-Fabbroni, M.6
  • 89
    • 84864423461 scopus 로고    scopus 로고
    • Serum DNA methylation for monitoring response to neoadjuvant chemotherapy in breast cancer patients
    • [89] Avraham, A., Uhlmann, R., Shperber, A., Birnbaum, M., Sandbank, J., Sella, A., et al. Serum DNA methylation for monitoring response to neoadjuvant chemotherapy in breast cancer patients. Int J Cancer 131 (2012), E1166–E1672.
    • (2012) Int J Cancer , vol.131 , pp. E1166-E1672
    • Avraham, A.1    Uhlmann, R.2    Shperber, A.3    Birnbaum, M.4    Sandbank, J.5    Sella, A.6
  • 90
    • 84857911910 scopus 로고    scopus 로고
    • Detection of aberrant promoter methylation of GSTP1, RASSF1A, and RARbeta2 in serum DNA of patients with breast cancer by a newly established one-step methylation-specific PCR assay
    • [90] Yamamoto, N., Nakayama, T., Kajita, M., Miyake, T., Iwamoto, T., Kim, S.J., et al. Detection of aberrant promoter methylation of GSTP1, RASSF1A, and RARbeta2 in serum DNA of patients with breast cancer by a newly established one-step methylation-specific PCR assay. Breast Cancer Res Treat 132 (2012), 165–173.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 165-173
    • Yamamoto, N.1    Nakayama, T.2    Kajita, M.3    Miyake, T.4    Iwamoto, T.5    Kim, S.J.6
  • 91
    • 84867403293 scopus 로고    scopus 로고
    • Clinical significance of promoter hypermethylation of ERbeta and RARbeta2 in tumor and serum DNA in Indian breast cancer patients
    • [91] Mirza, S., Sharma, G., Parshad, R., Srivastava, A., Gupta, S.D., Ralhan, R., Clinical significance of promoter hypermethylation of ERbeta and RARbeta2 in tumor and serum DNA in Indian breast cancer patients. Ann Surg Oncol 19 (2012), 3107–3115.
    • (2012) Ann Surg Oncol , vol.19 , pp. 3107-3115
    • Mirza, S.1    Sharma, G.2    Parshad, R.3    Srivastava, A.4    Gupta, S.D.5    Ralhan, R.6
  • 92
    • 84979620819 scopus 로고    scopus 로고
    • Methylation analysis of plasma cell-free DNA for breast cancer early detection using bisulfite next-generation sequencing
    • [92] Li, Z., Guo, X.W., Tang, L.L., Peng, L.M., Chen, M., Luo, X.P., et al. Methylation analysis of plasma cell-free DNA for breast cancer early detection using bisulfite next-generation sequencing. Tumor Biol 37 (2016), 13111–13119.
    • (2016) Tumor Biol , vol.37 , pp. 13111-13119
    • Li, Z.1    Guo, X.W.2    Tang, L.L.3    Peng, L.M.4    Chen, M.5    Luo, X.P.6
  • 93
    • 84899438176 scopus 로고    scopus 로고
    • Colorectal cancer statistics, 2014
    • [93] Siegel, R., Desantis, C., Jemal, A., Colorectal cancer statistics, 2014. CA Cancer J Clin 64 (2014), 104–117.
    • (2014) CA Cancer J Clin , vol.64 , pp. 104-117
    • Siegel, R.1    Desantis, C.2    Jemal, A.3
  • 94
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • [94] Diaz, L.A. Jr., Williams, R.T., Wu, J., Kinde, I., Hecht, J.R., Berlin, J., et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486 (2012), 537–540.
    • (2012) Nature , vol.486 , pp. 537-540
    • Diaz, L.A.1    Williams, R.T.2    Wu, J.3    Kinde, I.4    Hecht, J.R.5    Berlin, J.6
  • 95
    • 84937205362 scopus 로고    scopus 로고
    • Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
    • [95] Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat Med, 21, 2015, 827.
    • (2015) Nat Med , vol.21 , pp. 827
    • Siravegna, G.1    Mussolin, B.2    Buscarino, M.3    Corti, G.4    Cassingena, A.5    Crisafulli, G.6
  • 96
    • 84857076207 scopus 로고    scopus 로고
    • Quantitative cell-free DNA, KRAS, and BRAF mutations in plasma from patients with metastatic colorectal cancer during treatment with cetuximab and irinotecan
    • [96] Spindler, K.L., Pallisgaard, N., Vogelius, I., Jakobsen, A., Quantitative cell-free DNA, KRAS, and BRAF mutations in plasma from patients with metastatic colorectal cancer during treatment with cetuximab and irinotecan. Clin Cancer Res 18 (2012), 1177–1185.
    • (2012) Clin Cancer Res , vol.18 , pp. 1177-1185
    • Spindler, K.L.1    Pallisgaard, N.2    Vogelius, I.3    Jakobsen, A.4
  • 97
    • 84877350259 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: outcome and results of KRAS mutational analysis in plasma
    • [97] Spindler, K.L., Sorensen, M.M., Pallisgaard, N., Andersen, R.F., Havelund, B.M., Ploen, J., et al. Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: outcome and results of KRAS mutational analysis in plasma. Acta Oncol 52 (2013), 963–970.
    • (2013) Acta Oncol , vol.52 , pp. 963-970
    • Spindler, K.L.1    Sorensen, M.M.2    Pallisgaard, N.3    Andersen, R.F.4    Havelund, B.M.5    Ploen, J.6
  • 98
    • 4143133293 scopus 로고    scopus 로고
    • Molecular detection of APC, K-ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers
    • [98] Wang, J.Y., Hsieh, J.S., Chang, M.Y., Huang, T.J., Chen, F.M., Cheng, T.L., et al. Molecular detection of APC, K-ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers. World J Surg 28 (2004), 721–726.
    • (2004) World J Surg , vol.28 , pp. 721-726
    • Wang, J.Y.1    Hsieh, J.S.2    Chang, M.Y.3    Huang, T.J.4    Chen, F.M.5    Cheng, T.L.6
  • 99
    • 84941630950 scopus 로고    scopus 로고
    • Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer
    • [99] Tie, J., Kinde, I., Wang, Y., Wong, H.L., Roebert, J., Christie, M., et al. Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer. Ann Oncol 26 (2015), 1715–1722.
    • (2015) Ann Oncol , vol.26 , pp. 1715-1722
    • Tie, J.1    Kinde, I.2    Wang, Y.3    Wong, H.L.4    Roebert, J.5    Christie, M.6
  • 100
    • 84923066128 scopus 로고    scopus 로고
    • Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform
    • [100] Kidess, E., Heirich, K., Wiggin, M., Vysotskaia, V., Visser, B.C., Marziali, A., et al. Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform. Oncotarget 6 (2015), 2549–2561.
    • (2015) Oncotarget , vol.6 , pp. 2549-2561
    • Kidess, E.1    Heirich, K.2    Wiggin, M.3    Vysotskaia, V.4    Visser, B.C.5    Marziali, A.6
  • 101
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
    • [101] Misale, S., Yaeger, R., Hobor, S., Scala, E., Janakiraman, M., Liska, D., et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486 (2012), 532–536.
    • (2012) Nature , vol.486 , pp. 532-536
    • Misale, S.1    Yaeger, R.2    Hobor, S.3    Scala, E.4    Janakiraman, M.5    Liska, D.6
  • 102
    • 84878862323 scopus 로고    scopus 로고
    • Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
    • [102] Bardelli, A., Corso, S., Bertotti, A., Hobor, S., Valtorta, E., Siravegna, G., et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discovery 3 (2013), 658–673.
    • (2013) Cancer Discovery , vol.3 , pp. 658-673
    • Bardelli, A.1    Corso, S.2    Bertotti, A.3    Hobor, S.4    Valtorta, E.5    Siravegna, G.6
  • 103
    • 84896078397 scopus 로고    scopus 로고
    • Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer
    • [103] Misale, S., Arena, S., Lamba, S., Siravegna, G., Lallo, A., Hobor, S., et al. Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer. Sci Transl Med, 6, 2014, 162ra54.
    • (2014) Sci Transl Med , vol.6 , pp. 162ra54
    • Misale, S.1    Arena, S.2    Lamba, S.3    Siravegna, G.4    Lallo, A.5    Hobor, S.6
  • 104
    • 84897389811 scopus 로고    scopus 로고
    • Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing
    • [104] Mohan, S., Heitzer, E., Ulz, P., Lafer, I., Lax, S., Auer, M., et al. Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing. PLoS Genet, 10, 2014, e1004271.
    • (2014) PLoS Genet , vol.10 , pp. e1004271
    • Mohan, S.1    Heitzer, E.2    Ulz, P.3    Lafer, I.4    Lax, S.5    Auer, M.6
  • 105
    • 19944432960 scopus 로고    scopus 로고
    • Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome
    • [105] Johnson, V., Volikos, E., Halford, S.E., Eftekhar Sadat, E.T., Popat, S., Talbot, I., et al. Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome. Gut 54 (2005), 264–267.
    • (2005) Gut , vol.54 , pp. 264-267
    • Johnson, V.1    Volikos, E.2    Halford, S.E.3    Eftekhar Sadat, E.T.4    Popat, S.5    Talbot, I.6
  • 107
    • 71049160060 scopus 로고    scopus 로고
    • Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling
    • [107] Guo, J., Cagatay, T., Zhou, G., Chan, C.C., Blythe, S., Suyama, K., et al. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One 4 (2009), 1493–1494.
    • (2009) PLoS One , vol.4 , pp. 1493-1494
    • Guo, J.1    Cagatay, T.2    Zhou, G.3    Chan, C.C.4    Blythe, S.5    Suyama, K.6
  • 108
    • 84898816773 scopus 로고    scopus 로고
    • Septin 9 promoter region methylation in free circulating DNA-potential role in noninvasive diagnosis of lung cancer: preliminary report
    • [108] Powrozek, T., Krawczyk, P., Kucharczyk, T., Milanowski, J., Septin 9 promoter region methylation in free circulating DNA-potential role in noninvasive diagnosis of lung cancer: preliminary report. Med Oncol, 31, 2014, 917.
    • (2014) Med Oncol , vol.31 , pp. 917
    • Powrozek, T.1    Krawczyk, P.2    Kucharczyk, T.3    Milanowski, J.4
  • 109
    • 84872598584 scopus 로고    scopus 로고
    • Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer
    • [109] Pack, S.C., Kim, H.R., Lim, S.W., Kim, H.Y., Ko, J.Y., Lee, K.S., et al. Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer. Int J Colorectal Dis 28 (2013), 139–147.
    • (2013) Int J Colorectal Dis , vol.28 , pp. 139-147
    • Pack, S.C.1    Kim, H.R.2    Lim, S.W.3    Kim, H.Y.4    Ko, J.Y.5    Lee, K.S.6
  • 110
    • 84938414806 scopus 로고    scopus 로고
    • Clinical utility of RASSF1A methylation in human malignancies
    • [110] Grawenda, A.M., O'Neill, E., Clinical utility of RASSF1A methylation in human malignancies. Br J Cancer 113 (2015), 372–381.
    • (2015) Br J Cancer , vol.113 , pp. 372-381
    • Grawenda, A.M.1    O'Neill, E.2
  • 111
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • [111] Zhang, Z., Lee, J.C., Lin, L., Olivas, V., Au, V., LaFramboise, T., et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet 44 (2012), 852–860.
    • (2012) Nat Genet , vol.44 , pp. 852-860
    • Zhang, Z.1    Lee, J.C.2    Lin, L.3    Olivas, V.4    Au, V.5    LaFramboise, T.6
  • 112
    • 84865442609 scopus 로고    scopus 로고
    • Influence of chemotherapy on EGFR mutation status among patients with non-small-cell lung cancer
    • [112] Bai, H., Wang, Z., Chen, K., Zhao, J., Lee, J.J., Wang, S., et al. Influence of chemotherapy on EGFR mutation status among patients with non-small-cell lung cancer. J Clin Oncol 30 (2012), 3077–3083.
    • (2012) J Clin Oncol , vol.30 , pp. 3077-3083
    • Bai, H.1    Wang, Z.2    Chen, K.3    Zhao, J.4    Lee, J.J.5    Wang, S.6
  • 113
    • 84875891467 scopus 로고    scopus 로고
    • Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non-small cell lung cancer
    • [113] Akca, H., Demiray, A., Yaren, A., Bir, F., Koseler, A., Iwakawa, R., et al. Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non-small cell lung cancer. Cancer Genet 206 (2013), 73–80.
    • (2013) Cancer Genet , vol.206 , pp. 73-80
    • Akca, H.1    Demiray, A.2    Yaren, A.3    Bir, F.4    Koseler, A.5    Iwakawa, R.6
  • 114
    • 84870312106 scopus 로고    scopus 로고
    • Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing
    • [114] Leary, R.J., Sausen, M., Kinde, I., Papadopoulos, N., Carpten, J.D., Craig, D., et al. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci Transl Med, 4, 2012, 162ra54.
    • (2012) Sci Transl Med , vol.4 , pp. 162ra54
    • Leary, R.J.1    Sausen, M.2    Kinde, I.3    Papadopoulos, N.4    Carpten, J.D.5    Craig, D.6
  • 115
    • 84863967346 scopus 로고    scopus 로고
    • Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing
    • [115] Narayan, A., Carriero, N.J., Gettinger, S.N., Kluytenaar, J., Kozak, K.R., Yock, T.I., et al. Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing. Cancer Res 72 (2012), 3492–3498.
    • (2012) Cancer Res , vol.72 , pp. 3492-3498
    • Narayan, A.1    Carriero, N.J.2    Gettinger, S.N.3    Kluytenaar, J.4    Kozak, K.R.5    Yock, T.I.6
  • 116
    • 80054924531 scopus 로고    scopus 로고
    • Epithelial-specific methylation marker: a potential plasma biomarker in advanced non-small cell lung cancer
    • [116] Vinayanuwattikun, C., Sriuranpong, V., Tanasanvimon, S., Chantranuwat, P., Mutirangura, A., Epithelial-specific methylation marker: a potential plasma biomarker in advanced non-small cell lung cancer. J Thorac Oncol 6 (2011), 1818–1825.
    • (2011) J Thorac Oncol , vol.6 , pp. 1818-1825
    • Vinayanuwattikun, C.1    Sriuranpong, V.2    Tanasanvimon, S.3    Chantranuwat, P.4    Mutirangura, A.5
  • 117
    • 33846017682 scopus 로고    scopus 로고
    • K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking
    • [117] Jiao, L., Zhu, J., Hassan, M.M., Evans, D.B., Abbruzzese, J.L., Li, D., K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking. Pancreas 34 (2007), 55–62.
    • (2007) Pancreas , vol.34 , pp. 55-62
    • Jiao, L.1    Zhu, J.2    Hassan, M.M.3    Evans, D.B.4    Abbruzzese, J.L.5    Li, D.6
  • 118
    • 84979247562 scopus 로고    scopus 로고
    • The potential use of cell-free-circulating-tumor DNA as a biomarker for prostate cancer
    • [118] He, W.S., Bishop, K.S., The potential use of cell-free-circulating-tumor DNA as a biomarker for prostate cancer. Expert Rev Mol Diagn 16 (2016), 839–852.
    • (2016) Expert Rev Mol Diagn , vol.16 , pp. 839-852
    • He, W.S.1    Bishop, K.S.2
  • 119
    • 52249104714 scopus 로고    scopus 로고
    • Deoxyribonuclease activity and circulating DNA concentration in blood plasma of patients with prostate tumors
    • [119] Cherepanova, A.V., Tamkovich, S.N., Bryzgunova, O.E., Vlassov, V.V., Laktionov, P.P., Deoxyribonuclease activity and circulating DNA concentration in blood plasma of patients with prostate tumors. Ann NY Acad Sci 1137 (2008), 218–221.
    • (2008) Ann NY Acad Sci , vol.1137 , pp. 218-221
    • Cherepanova, A.V.1    Tamkovich, S.N.2    Bryzgunova, O.E.3    Vlassov, V.V.4    Laktionov, P.P.5
  • 121
    • 84872329672 scopus 로고    scopus 로고
    • Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers
    • [121] Kinde, I., Bettegowda, C., Wang, Y., Wu, J., Agrawal, N., Shih Ie, M., et al. Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Sci Transl Med, 5, 2013, 167ra4.
    • (2013) Sci Transl Med , vol.5 , pp. 167ra4
    • Kinde, I.1    Bettegowda, C.2    Wang, Y.3    Wu, J.4    Agrawal, N.5    Shih Ie, M.6
  • 122
    • 84877579861 scopus 로고    scopus 로고
    • Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
    • [122] Murtaza, M., Dawson, S.J., Tsui, D.W., Gale, D., Forshew, T., Piskorz, A.M., et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 497 (2013), 108–112.
    • (2013) Nature , vol.497 , pp. 108-112
    • Murtaza, M.1    Dawson, S.J.2    Tsui, D.W.3    Gale, D.4    Forshew, T.5    Piskorz, A.M.6
  • 124
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • [124] Laird, P.W., The power and the promise of DNA methylation markers. Nat Rev Cancer 3 (2003), 253–266.
    • (2003) Nat Rev Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 125
    • 84901687247 scopus 로고    scopus 로고
    • DNA methylation in cancer: three decades of discovery
    • [125] Feinberg, A., DNA methylation in cancer: three decades of discovery. Genome Med 6 (2014), 1–4.
    • (2014) Genome Med , vol.6 , pp. 1-4
    • Feinberg, A.1
  • 126
    • 84917735735 scopus 로고    scopus 로고
    • Circulating methylated DNA as biomarkers for cancer detection. methylation-from DNA, RNA and histones to diseases and treatment
    • [126] Jin, H., Ma, Y., Shen, Q., Wang, X., Circulating methylated DNA as biomarkers for cancer detection. methylation-from DNA, RNA and histones to diseases and treatment. Intech, 2013, 137–152.
    • (2013) Intech , pp. 137-152
    • Jin, H.1    Ma, Y.2    Shen, Q.3    Wang, X.4
  • 127
    • 8544261148 scopus 로고    scopus 로고
    • Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer
    • [127] Miotto, E., Sabbioni, S., Veronese, A., Calin, G.A., Gullini, S., Liboni, A., et al. Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer. Cancer Res 64 (2004), 8156–8159.
    • (2004) Cancer Res , vol.64 , pp. 8156-8159
    • Miotto, E.1    Sabbioni, S.2    Veronese, A.3    Calin, G.A.4    Gullini, S.5    Liboni, A.6
  • 128
    • 0035117962 scopus 로고    scopus 로고
    • Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer
    • [128] Grady, W.M., Rajput, A., Lutterbaugh, J.D., Markowitz, S.D., Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Res 61 (2001), 900–902.
    • (2001) Cancer Res , vol.61 , pp. 900-902
    • Grady, W.M.1    Rajput, A.2    Lutterbaugh, J.D.3    Markowitz, S.D.4
  • 129
    • 0036152815 scopus 로고    scopus 로고
    • Detection of aberrant p16 methylation in the serum of colorectal cancer patients
    • [129] Zou, H.Z., Yu, B.M., Wang, Z.W., Sun, J.Y., Cai, H., Gao, F., et al. Detection of aberrant p16 methylation in the serum of colorectal cancer patients. Clin Cancer Res 8 (2002), 188–191.
    • (2002) Clin Cancer Res , vol.8 , pp. 188-191
    • Zou, H.Z.1    Yu, B.M.2    Wang, Z.W.3    Sun, J.Y.4    Cai, H.5    Gao, F.6
  • 130
    • 0037055554 scopus 로고    scopus 로고
    • Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis
    • [130] Lecomte, T., Berger, A., Zinzindohoue, F., Micard, S., Landi, B., Blons, H., et al. Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis. Int J Cancer 100 (2002), 542–548.
    • (2002) Int J Cancer , vol.100 , pp. 542-548
    • Lecomte, T.1    Berger, A.2    Zinzindohoue, F.3    Micard, S.4    Landi, B.5    Blons, H.6
  • 131
    • 33750701826 scopus 로고    scopus 로고
    • Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas
    • [131] Ebert, M.P., Model, F., Mooney, S., Hale, K., Lograsso, J., Tonnes-Priddy, L., et al. Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas. Gastroenterology 131 (2006), 1418–1430.
    • (2006) Gastroenterology , vol.131 , pp. 1418-1430
    • Ebert, M.P.1    Model, F.2    Mooney, S.3    Hale, K.4    Lograsso, J.5    Tonnes-Priddy, L.6
  • 132
    • 39749180354 scopus 로고    scopus 로고
    • DNA methylation biomarkers for blood-based colorectal cancer screening
    • [132] Lofton-Day, C., Model, F., Devos, T., Tetzner, R., Distler, J., Schuster, M., et al. DNA methylation biomarkers for blood-based colorectal cancer screening. Clin Chem 54 (2008), 414–423.
    • (2008) Clin Chem , vol.54 , pp. 414-423
    • Lofton-Day, C.1    Model, F.2    Devos, T.3    Tetzner, R.4    Distler, J.5    Schuster, M.6
  • 133
    • 83355163991 scopus 로고    scopus 로고
    • Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer
    • [133] Warren, J.D., Xiong, W., Bunker, A.M., Vaughn, C.P., Furtado, L.V., Roberts, W.L., et al. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med, 9, 2011, 133.
    • (2011) BMC Med , vol.9 , pp. 133
    • Warren, J.D.1    Xiong, W.2    Bunker, A.M.3    Vaughn, C.P.4    Furtado, L.V.5    Roberts, W.L.6
  • 134
    • 67650077151 scopus 로고    scopus 로고
    • Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer
    • [134] De Vos, T., Tetzner, R., Model, F., Weiss, G., Schuster, M., Distler, J., et al. Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem 55 (2009), 1337–1346.
    • (2009) Clin Chem , vol.55 , pp. 1337-1346
    • De Vos, T.1    Tetzner, R.2    Model, F.3    Weiss, G.4    Schuster, M.5    Distler, J.6
  • 135
    • 0033026117 scopus 로고    scopus 로고
    • Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients
    • [135] Silva, J., Dominguez, G., Gonzalez, R., Garcia, J., Corbacho, C., Provencio, M., et al. Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients. Br J Cancer 80 (1999), 1262–1264.
    • (1999) Br J Cancer , vol.80 , pp. 1262-1264
    • Silva, J.1    Dominguez, G.2    Gonzalez, R.3    Garcia, J.4    Corbacho, C.5    Provencio, M.6
  • 136
    • 0032894125 scopus 로고    scopus 로고
    • Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
    • [136] Esteller, M., Sanchez-Cespedes, M., Rosell, R., Sidransky, D., Baylin, S.B., Herman, J.G., Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 59 (1999), 67–70.
    • (1999) Cancer Res , vol.59 , pp. 67-70
    • Esteller, M.1    Sanchez-Cespedes, M.2    Rosell, R.3    Sidransky, D.4    Baylin, S.B.5    Herman, J.G.6
  • 137
    • 84880375472 scopus 로고    scopus 로고
    • Circulating cell free DNA: preanalytical considerations
    • [137] El Messaoudi, S., Rolet, F., Mouliere, F., Thierry, A.R., Circulating cell free DNA: preanalytical considerations. Clin Chim Acta 424 (2013), 222–230.
    • (2013) Clin Chim Acta , vol.424 , pp. 222-230
    • El Messaoudi, S.1    Rolet, F.2    Mouliere, F.3    Thierry, A.R.4
  • 138
    • 13144265739 scopus 로고    scopus 로고
    • Genome-wide association studies: theoretical and practical concerns
    • [138] Wang, W.Y., Barratt, B.J., Clayton, D.G., Todd, J.A., Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet 6 (2005), 109–118.
    • (2005) Nat Rev Genet , vol.6 , pp. 109-118
    • Wang, W.Y.1    Barratt, B.J.2    Clayton, D.G.3    Todd, J.A.4
  • 139
    • 84868206960 scopus 로고    scopus 로고
    • Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4
    • [139] Xu, J., Mo, Z., Ye, D., Wang, M., Liu, F., Jin, G., et al. Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nat Genet 44 (2012), 1231–1235.
    • (2012) Nat Genet , vol.44 , pp. 1231-1235
    • Xu, J.1    Mo, Z.2    Ye, D.3    Wang, M.4    Liu, F.5    Jin, G.6
  • 140
    • 84861746437 scopus 로고    scopus 로고
    • Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
    • [140] Forshew, T., Murtaza, M., Parkinson, C., Gale, D., Tsui, D.W.Y., Kaper, F., et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med, 4, 2012, 136ra68.
    • (2012) Sci Transl Med , vol.4 , pp. 136ra68
    • Forshew, T.1    Murtaza, M.2    Parkinson, C.3    Gale, D.4    Tsui, D.W.Y.5    Kaper, F.6
  • 141
    • 84962142349 scopus 로고    scopus 로고
    • Quantitative analysis of the BRAF mutation in circulating tumor-derived DNA in melanoma patients using competitive allele-specific TaqMan PCR
    • [141] Ashida, A., Sakaizawa, K., Mikoshiba, A., Uhara, H., Okuyama, R., Quantitative analysis of the BRAF mutation in circulating tumor-derived DNA in melanoma patients using competitive allele-specific TaqMan PCR. Int J Clin Oncol 21 (2016), 981–988.
    • (2016) Int J Clin Oncol , vol.21 , pp. 981-988
    • Ashida, A.1    Sakaizawa, K.2    Mikoshiba, A.3    Uhara, H.4    Okuyama, R.5
  • 143
    • 84903218109 scopus 로고    scopus 로고
    • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
    • [143] Newman, A.M., Bratman, S.V., To, J., Wynne, J.F., Eclov, N.C., Modlin, L.A., et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med 20 (2014), 548–554.
    • (2014) Nat Med , vol.20 , pp. 548-554
    • Newman, A.M.1    Bratman, S.V.2    To, J.3    Wynne, J.F.4    Eclov, N.C.5    Modlin, L.A.6
  • 144
    • 84929860892 scopus 로고    scopus 로고
    • Potential clinical utility of ultrasensitive circulating tumor DNA detection with CAPP-Seq
    • [144] Bratman, S.V., Newman, A.M., Alizadeh, A.A., Diehn, M., Potential clinical utility of ultrasensitive circulating tumor DNA detection with CAPP-Seq. Expert Rev Mol Diagn 15 (2015), 715–719.
    • (2015) Expert Rev Mol Diagn , vol.15 , pp. 715-719
    • Bratman, S.V.1    Newman, A.M.2    Alizadeh, A.A.3    Diehn, M.4
  • 145
    • 84966365311 scopus 로고    scopus 로고
    • Integrated digital error suppression for improved detection of circulating tumor DNA
    • [145] Newman, A.M., Lovejoy, A.F., Klass, D.M., Kurtz, D.M., Chabon, J.J., Scherer, F., et al. Integrated digital error suppression for improved detection of circulating tumor DNA. Nat Biotechnol 34 (2016), 547–555.
    • (2016) Nat Biotechnol , vol.34 , pp. 547-555
    • Newman, A.M.1    Lovejoy, A.F.2    Klass, D.M.3    Kurtz, D.M.4    Chabon, J.J.5    Scherer, F.6
  • 146
    • 84872020299 scopus 로고    scopus 로고
    • Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing
    • [146] Chan, K.C., Jiang, P., Zheng, Y.W., Liao, G.J., Sun, H., Wong, J., et al. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin Chem 59 (2013), 211–224.
    • (2013) Clin Chem , vol.59 , pp. 211-224
    • Chan, K.C.1    Jiang, P.2    Zheng, Y.W.3    Liao, G.J.4    Sun, H.5    Wong, J.6
  • 148
    • 84951757209 scopus 로고    scopus 로고
    • Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma
    • [148] Gray, E.S., Rizos, H., Reid, A.L., Boyd, S.C., Pereira, M.R., Lo, J., et al. Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma. Oncotarget 6 (2015), 42008–42018.
    • (2015) Oncotarget , vol.6 , pp. 42008-42018
    • Gray, E.S.1    Rizos, H.2    Reid, A.L.3    Boyd, S.C.4    Pereira, M.R.5    Lo, J.6
  • 149
    • 84934985499 scopus 로고    scopus 로고
    • Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations
    • [149] Tsao, S.C., Weiss, J., Hudson, C., Christophi, C., Cebon, J., Behren, A., et al. Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations. Sci Rep, 5, 2015, 11198.
    • (2015) Sci Rep , vol.5 , pp. 11198
    • Tsao, S.C.1    Weiss, J.2    Hudson, C.3    Christophi, C.4    Cebon, J.5    Behren, A.6
  • 150
    • 85003837114 scopus 로고    scopus 로고
    • Detecting circulating tumor DNA in hepatocellular carcinoma patients using droplet digital PCR is feasible and reflects intratumoral heterogeneity
    • [150] Huang, A., Zhang, X., Zhou, S.L., Cao, Y., Huang, X.W., Fan, J., et al. Detecting circulating tumor DNA in hepatocellular carcinoma patients using droplet digital PCR is feasible and reflects intratumoral heterogeneity. J Cancer 7 (2016), 1907–1914.
    • (2016) J Cancer , vol.7 , pp. 1907-1914
    • Huang, A.1    Zhang, X.2    Zhou, S.L.3    Cao, Y.4    Huang, X.W.5    Fan, J.6
  • 151
    • 84929463919 scopus 로고    scopus 로고
    • Clinical relevance of KRAS-mutated subclones detected with picodroplet digital PCR in advanced colorectal cancer treated with anti-EGFR therapy
    • [151] Laurent-Puig, P., Pekin, D., Normand, C., Kotsopoulos, S.K., Nizard, P., Perez-Toralla, K., et al. Clinical relevance of KRAS-mutated subclones detected with picodroplet digital PCR in advanced colorectal cancer treated with anti-EGFR therapy. Clin Cancer Res 21 (2015), 1087–1097.
    • (2015) Clin Cancer Res , vol.21 , pp. 1087-1097
    • Laurent-Puig, P.1    Pekin, D.2    Normand, C.3    Kotsopoulos, S.K.4    Nizard, P.5    Perez-Toralla, K.6
  • 152
    • 84993969514 scopus 로고    scopus 로고
    • Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery
    • [152] Denis, J.A., Patroni, A., Guillerm, E., Pépin, D., Benali-Furet, N., Wechsler, J., et al. Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery. Mol Oncol 10 (2016), 1221–1231.
    • (2016) Mol Oncol , vol.10 , pp. 1221-1231
    • Denis, J.A.1    Patroni, A.2    Guillerm, E.3    Pépin, D.4    Benali-Furet, N.5    Wechsler, J.6
  • 153
    • 84945126043 scopus 로고    scopus 로고
    • Promoter methylation of TRIM9 as a marker for detection of circulating tumor DNA in breast cancer patients
    • [153] Mishima, C., Kagara, N., Matsui, S., Tanei, T., Naoi, Y., Shimoda, M., et al. Promoter methylation of TRIM9 as a marker for detection of circulating tumor DNA in breast cancer patients. Springerplus, 4, 2015, 635.
    • (2015) Springerplus , vol.4 , pp. 635
    • Mishima, C.1    Kagara, N.2    Matsui, S.3    Tanei, T.4    Naoi, Y.5    Shimoda, M.6
  • 154
    • 84978431573 scopus 로고    scopus 로고
    • SOX17 promoter methylation in plasma circulating tumor DNA of patients with non-small cell lung cancer
    • [154] Balgkouranidou, I., Chimonidou, M., Milaki, G., Tsaroucha, E., Kakolyris, S., Georgoulias, V., et al. SOX17 promoter methylation in plasma circulating tumor DNA of patients with non-small cell lung cancer. Clin Chem Lab Med 54 (2016), 1385–1393.
    • (2016) Clin Chem Lab Med , vol.54 , pp. 1385-1393
    • Balgkouranidou, I.1    Chimonidou, M.2    Milaki, G.3    Tsaroucha, E.4    Kakolyris, S.5    Georgoulias, V.6
  • 155
    • 33646091508 scopus 로고    scopus 로고
    • Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients
    • [155] Wang, J., Qin, Y., Li, B., Sun, Z., Yang, B., Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients. Clin Biochem 39 (2006), 344–348.
    • (2006) Clin Biochem , vol.39 , pp. 344-348
    • Wang, J.1    Qin, Y.2    Li, B.3    Sun, Z.4    Yang, B.5
  • 156
    • 85018592984 scopus 로고    scopus 로고
    • Method for enriching methylated CpG sequences
    • US Patent Application 2013;US.
    • [156] Feehery GR, Pradhan S. Method for enriching methylated CpG sequences. US Patent Application 2013;US8367331.
    • Feehery, G.R.1    Pradhan, S.2
  • 157
  • 158
  • 159
    • 85018550821 scopus 로고    scopus 로고
    • Consistency of quantitative multiplexed – methylation specific PCR (QM-MSP) performed on breast epithelial cells acquired by random periareolar fine needle aspiration (RPFNA) of women at high risk for development of breast cancer
    • [159] Kimler, B., Fackler, M.J., Metheny, T., Phillips, T., Sukumar, S., Fabian, C., Consistency of quantitative multiplexed – methylation specific PCR (QM-MSP) performed on breast epithelial cells acquired by random periareolar fine needle aspiration (RPFNA) of women at high risk for development of breast cancer. Cancer Res, 67, 2007.
    • (2007) Cancer Res , vol.67
    • Kimler, B.1    Fackler, M.J.2    Metheny, T.3    Phillips, T.4    Sukumar, S.5    Fabian, C.6
  • 160
    • 77952966822 scopus 로고    scopus 로고
    • Single-tube analysis of DNA methylation with silica superparamagnetic beads
    • [160] Bailey, V.J., Zhang, Y., Keeley, B.P., Yin, C., Pelosky, K.L., Brock, M., et al. Single-tube analysis of DNA methylation with silica superparamagnetic beads. Clin Chem 56 (2010), 1022–1025.
    • (2010) Clin Chem , vol.56 , pp. 1022-1025
    • Bailey, V.J.1    Zhang, Y.2    Keeley, B.P.3    Yin, C.4    Pelosky, K.L.5    Brock, M.6
  • 161
    • 0032893755 scopus 로고    scopus 로고
    • Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients
    • [161] Wong, I.H., Lo, Y.M., Zhang, J., Liew, C.T., Ng, M.H., Wong, N., et al. Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res 59 (1999), 71–73.
    • (1999) Cancer Res , vol.59 , pp. 71-73
    • Wong, I.H.1    Lo, Y.M.2    Zhang, J.3    Liew, C.T.4    Ng, M.H.5    Wong, N.6
  • 163
    • 75649112663 scopus 로고    scopus 로고
    • Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection
    • [163] Bailey, V.J., Keeley, B.P., Zhang, Y., Ho, Y.P., Easwaran, H., Brock, M.V., et al. Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection. ChemBioChem 11 (2010), 71–74.
    • (2010) ChemBioChem , vol.11 , pp. 71-74
    • Bailey, V.J.1    Keeley, B.P.2    Zhang, Y.3    Ho, Y.P.4    Easwaran, H.5    Brock, M.V.6
  • 165
    • 84899550486 scopus 로고    scopus 로고
    • Novel methylated biomarkers and a robust assay to detect circulating tumor DNA in metastatic breast cancer
    • [165] Fackler, M.J., Lopez Bujanda, Z., Umbricht, C., Teo, W.W., Cho, S., Zhang, Z., et al. Novel methylated biomarkers and a robust assay to detect circulating tumor DNA in metastatic breast cancer. Cancer Res 74 (2014), 2160–2170.
    • (2014) Cancer Res , vol.74 , pp. 2160-2170
    • Fackler, M.J.1    Lopez Bujanda, Z.2    Umbricht, C.3    Teo, W.W.4    Cho, S.5    Zhang, Z.6
  • 166
    • 78649969065 scopus 로고    scopus 로고
    • The DNA methylome of human peripheral blood mononuclear cells
    • [166] Li, Y., Zhu, J., Geng, T., Ning, L., Li, Q., Ye, M., et al. The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol 8 (2010), 549–552.
    • (2010) PLoS Biol , vol.8 , pp. 549-552
    • Li, Y.1    Zhu, J.2    Geng, T.3    Ning, L.4    Li, Q.5    Ye, M.6
  • 167
    • 84923804522 scopus 로고    scopus 로고
    • MethylC-seq library preparation for base-resolution whole-genome bisulfite sequencing
    • [167] Urich, M.A., Nery, J.R., Lister, R., Schmitz, R.J., Ecker, J.R., MethylC-seq library preparation for base-resolution whole-genome bisulfite sequencing. Nat Protoc 10 (2015), 475–483.
    • (2015) Nat Protoc , vol.10 , pp. 475-483
    • Urich, M.A.1    Nery, J.R.2    Lister, R.3    Schmitz, R.J.4    Ecker, J.R.5
  • 168
    • 67649854923 scopus 로고    scopus 로고
    • High-throughput bisulfite sequencing in mammalian genomes
    • [168] Smith, Z.D., Gu, H.C., Bock, C., Gnirke, A., Meissner, A., High-throughput bisulfite sequencing in mammalian genomes. Methods 48 (2009), 226–232.
    • (2009) Methods , vol.48 , pp. 226-232
    • Smith, Z.D.1    Gu, H.C.2    Bock, C.3    Gnirke, A.4    Meissner, A.5
  • 169
    • 77449127799 scopus 로고    scopus 로고
    • MBD-isolated genome sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome
    • [169] Serre, D., Lee, B.H., Ting, A.H., MBD-isolated genome sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucl Acids Res 38 (2010), 391–399.
    • (2010) Nucl Acids Res , vol.38 , pp. 391-399
    • Serre, D.1    Lee, B.H.2    Ting, A.H.3
  • 170
    • 84870525593 scopus 로고    scopus 로고
    • A comparison of the whole genome approach of MeDIP-Seq to the targeted approach of the infinium humanmethylation450 BeadChip® for methylome profiling
    • [170] Clark, C., Palta, P., Joyce, C.J., Scott, C., Grundberg, E., Deloukas, P., et al. A comparison of the whole genome approach of MeDIP-Seq to the targeted approach of the infinium humanmethylation450 BeadChip® for methylome profiling. PLoS One, 7, 2012, e50233.
    • (2012) PLoS One , vol.7 , pp. e50233
    • Clark, C.1    Palta, P.2    Joyce, C.J.3    Scott, C.4    Grundberg, E.5    Deloukas, P.6
  • 172
    • 84888119068 scopus 로고    scopus 로고
    • Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing
    • [172] Chan, K.C., Jiang, P., Chan, C.W., Sun, K., Wong, J., Hui, E.P., et al. Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proc Natl Acad Sci U S A 110 (2013), 18761–18768.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 18761-18768
    • Chan, K.C.1    Jiang, P.2    Chan, C.W.3    Sun, K.4    Wong, J.5    Hui, E.P.6
  • 173
    • 84946488414 scopus 로고    scopus 로고
    • Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients
    • [173] Wen, L., Li, J., Guo, H., Liu, X., Zheng, S., Zhang, D., et al. Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients. Cell Res 25 (2015), 1250–1264.
    • (2015) Cell Res , vol.25 , pp. 1250-1264
    • Wen, L.1    Li, J.2    Guo, H.3    Liu, X.4    Zheng, S.5    Zhang, D.6
  • 174
    • 0036314222 scopus 로고    scopus 로고
    • Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives
    • [174] Rand, K., Qu, W., Ho, T., Clark, S.J., Molloy, P., Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives. Methods 27 (2002), 114–120.
    • (2002) Methods , vol.27 , pp. 114-120
    • Rand, K.1    Qu, W.2    Ho, T.3    Clark, S.J.4    Molloy, P.5
  • 175
    • 85015462482 scopus 로고    scopus 로고
    • Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?
    • [175] Ilie, M., Hofman, V., Long, E., Bordone, O., Selva, E., Washetine, K., et al. Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?. Ann Transl Med, 2, 2014, 107.
    • (2014) Ann Transl Med , vol.2 , pp. 107
    • Ilie, M.1    Hofman, V.2    Long, E.3    Bordone, O.4    Selva, E.5    Washetine, K.6
  • 176
    • 34248569300 scopus 로고    scopus 로고
    • Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance
    • [176] Gormally, E., Caboux, E., Vineis, P., Hainaut, P., Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance. Mutat Res 635 (2007), 105–117.
    • (2007) Mutat Res , vol.635 , pp. 105-117
    • Gormally, E.1    Caboux, E.2    Vineis, P.3    Hainaut, P.4
  • 177
    • 80052736273 scopus 로고    scopus 로고
    • Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease
    • [177] Schwarzenbach, H., Muller, V., Milde-Langosch, K., Steinbach, B., Pantel, K., Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease. Mol Biosyst 7 (2011), 2848–2854.
    • (2011) Mol Biosyst , vol.7 , pp. 2848-2854
    • Schwarzenbach, H.1    Muller, V.2    Milde-Langosch, K.3    Steinbach, B.4    Pantel, K.5
  • 178
    • 84863136284 scopus 로고    scopus 로고
    • Quantitative analysis of cell-free DNA in the plasma of gastric cancer patients
    • [178] Park, J.L., Kim, H.J., Choi, B.Y., Lee, H.C., Jang, H.R., Song, K.S., et al. Quantitative analysis of cell-free DNA in the plasma of gastric cancer patients. Oncol Lett 3 (2012), 921–926.
    • (2012) Oncol Lett , vol.3 , pp. 921-926
    • Park, J.L.1    Kim, H.J.2    Choi, B.Y.3    Lee, H.C.4    Jang, H.R.5    Song, K.S.6
  • 180
    • 80053928553 scopus 로고    scopus 로고
    • Elevated levels of cell-free circulating DNA in patients with acute dengue virus infection
    • [180] Ha, T.T., Huy, N.T., Murao, L.A., Lan, N.T., Thuy, T.T., Tuan, H.M., et al. Elevated levels of cell-free circulating DNA in patients with acute dengue virus infection. PLoS One, 6, 2011, e25969.
    • (2011) PLoS One , vol.6 , pp. e25969
    • Ha, T.T.1    Huy, N.T.2    Murao, L.A.3    Lan, N.T.4    Thuy, T.T.5    Tuan, H.M.6
  • 181
    • 84856509042 scopus 로고    scopus 로고
    • Circulating cell-free DNA levels correlate with postresuscitation survival rates in out-of-hospital cardiac arrest patients
    • [181] Huang, C.H., Tsai, M.S., Hsu, C.Y., Chen, H.W., Wang, T.D., Chang, W.T., et al. Circulating cell-free DNA levels correlate with postresuscitation survival rates in out-of-hospital cardiac arrest patients. Resuscitation 83 (2012), 213–218.
    • (2012) Resuscitation , vol.83 , pp. 213-218
    • Huang, C.H.1    Tsai, M.S.2    Hsu, C.Y.3    Chen, H.W.4    Wang, T.D.5    Chang, W.T.6
  • 182
    • 84858747507 scopus 로고    scopus 로고
    • Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome
    • [182] Iriyama, C., Tomita, A., Hoshino, H., Adachi-Shirahata, M., Furukawa-Hibi, Y., Yamada, K., et al. Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome. Biochem Biophys Res Commun 419 (2012), 662–669.
    • (2012) Biochem Biophys Res Commun , vol.419 , pp. 662-669
    • Iriyama, C.1    Tomita, A.2    Hoshino, H.3    Adachi-Shirahata, M.4    Furukawa-Hibi, Y.5    Yamada, K.6
  • 183
    • 84857647296 scopus 로고    scopus 로고
    • Measurement of circulating cell-free DNA in relation to 18F-fluorocholine PET/CT imaging in chemotherapy-treated advanced prostate cancer
    • [183] Kwee, S., Song, M.A., Cheng, I., Loo, L., Tiirikainen, M., Measurement of circulating cell-free DNA in relation to 18F-fluorocholine PET/CT imaging in chemotherapy-treated advanced prostate cancer. Clin Transl Sci 5 (2012), 65–70.
    • (2012) Clin Transl Sci , vol.5 , pp. 65-70
    • Kwee, S.1    Song, M.A.2    Cheng, I.3    Loo, L.4    Tiirikainen, M.5
  • 184
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • [184] Klein, C.A., Parallel progression of primary tumours and metastases. Nat Rev Cancer 9 (2009), 302–312.
    • (2009) Nat Rev Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 185
    • 85015493202 scopus 로고    scopus 로고
    • “Liquid biopsy”-ctDNA detection with great potential and challenges
    • [185] Ma, M., Zhu, H., Zhang, C., Sun, X., Gao, X., Chen, G., “Liquid biopsy”-ctDNA detection with great potential and challenges. Ann Transl Med, 3, 2015, 235.
    • (2015) Ann Transl Med , vol.3 , pp. 235
    • Ma, M.1    Zhu, H.2    Zhang, C.3    Sun, X.4    Gao, X.5    Chen, G.6
  • 186
    • 84867159872 scopus 로고    scopus 로고
    • Measuring the methylome in clinical samples: improved processing of the infinium human methylation450 beadchip array
    • [186] Pan, H., Chen, L., Dogra, S., Teh, A.L., Tan, J.H., Lim, Y.I., et al. Measuring the methylome in clinical samples: improved processing of the infinium human methylation450 beadchip array. Epigenetics 7 (2012), 1173–1187.
    • (2012) Epigenetics , vol.7 , pp. 1173-1187
    • Pan, H.1    Chen, L.2    Dogra, S.3    Teh, A.L.4    Tan, J.H.5    Lim, Y.I.6
  • 187
    • 84896739200 scopus 로고    scopus 로고
    • Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
    • [187] Mack, S.C., Witt, H., Piro, R.M., Gu, L., Zuyderduyn, S., Stutz, A.M., et al. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature 506 (2014), 445–450.
    • (2014) Nature , vol.506 , pp. 445-450
    • Mack, S.C.1    Witt, H.2    Piro, R.M.3    Gu, L.4    Zuyderduyn, S.5    Stutz, A.M.6
  • 188
    • 84943657622 scopus 로고    scopus 로고
    • Digital PCR analysis of circulating nucleic acids
    • [188] Hudecova, I., Digital PCR analysis of circulating nucleic acids. Clin Biochem 48 (2015), 948–956.
    • (2015) Clin Biochem , vol.48 , pp. 948-956
    • Hudecova, I.1
  • 189
    • 84978755588 scopus 로고    scopus 로고
    • Cell-free DNA mutations as biomarkers in breast cancer patients receiving tamoxifen
    • [189] Jansen, M., Martens, J., Helmijr, J., Beaufort, C., Van, M., Krol, N., et al. Cell-free DNA mutations as biomarkers in breast cancer patients receiving tamoxifen. Oncotarget 7 (2016), 43412–43418.
    • (2016) Oncotarget , vol.7 , pp. 43412-43418
    • Jansen, M.1    Martens, J.2    Helmijr, J.3    Beaufort, C.4    Van, M.5    Krol, N.6
  • 190
    • 84903878816 scopus 로고    scopus 로고
    • Multitarget stool DNA testing for colorectal-cancer screening
    • [190] Souverijn, J.H., Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med, 371, 2014, 187.
    • (2014) N Engl J Med , vol.371 , pp. 187
    • Souverijn, J.H.1
  • 191
    • 84891743167 scopus 로고    scopus 로고
    • Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer
    • [191] Church, T.R., Wandell, M., Lofton-Day, C., Mongin, S.J., Burger, M., Payne, S.R., et al. Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer. Gut 63 (2014), 317–325.
    • (2014) Gut , vol.63 , pp. 317-325
    • Church, T.R.1    Wandell, M.2    Lofton-Day, C.3    Mongin, S.J.4    Burger, M.5    Payne, S.R.6
  • 193
    • 84957684205 scopus 로고    scopus 로고
    • The Cobas(®) EGFR mutation test v2 assay
    • [193] Brown, P., The Cobas(®) EGFR mutation test v2 assay. Future Oncol 12 (2016), 451–452.
    • (2016) Future Oncol , vol.12 , pp. 451-452
    • Brown, P.1
  • 194
    • 0030724379 scopus 로고    scopus 로고
    • Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer
    • [194] Kopreski, M., Benko, F., Kwee, C., Leitzel, K., Eskander, E., Lipton, A., et al. Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer. Br J Cancer, 76, 1997, 1293.
    • (1997) Br J Cancer , vol.76 , pp. 1293
    • Kopreski, M.1    Benko, F.2    Kwee, C.3    Leitzel, K.4    Eskander, E.5    Lipton, A.6
  • 195
    • 17344377380 scopus 로고    scopus 로고
    • Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features
    • [195] Yamada, T., Nakamori, S., Ohzato, H., Oshima, S., Aoki, T., Higaki, N., et al. Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features. Clin Cancer Res 4 (1998), 1527–1532.
    • (1998) Clin Cancer Res , vol.4 , pp. 1527-1532
    • Yamada, T.1    Nakamori, S.2    Ohzato, H.3    Oshima, S.4    Aoki, T.5    Higaki, N.6
  • 196
    • 0031904866 scopus 로고    scopus 로고
    • Detection of chromosome 3p alterations in serum DNA of non-small-cell lung cancer patients
    • [196] Sanchez-Cespedes, M., Monzo, M., Rosell, R., Pifarre, A., Calvo, R., Lopez-Cabrerizo, M.P., et al. Detection of chromosome 3p alterations in serum DNA of non-small-cell lung cancer patients. Ann Oncol 9 (1998), 113–116.
    • (1998) Ann Oncol , vol.9 , pp. 113-116
    • Sanchez-Cespedes, M.1    Monzo, M.2    Rosell, R.3    Pifarre, A.4    Calvo, R.5    Lopez-Cabrerizo, M.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.